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The map label for this gene is uvrC

Identifier: 41407244

GI number: 41407244

Start: 1200287

End: 1202230

Strand: Direct

Name: uvrC

Synonym: MAP1146

Alternate gene names: 41407244

Gene position: 1200287-1202230 (Clockwise)

Preceding gene: 41407240

Following gene: 41407245

Centisome position: 24.85

GC content: 68.36

Gene sequence:

>1944_bases
GTGCCAGATCCCGCCACCTATCGCCCCGCACCCGGGTCCATCCCGGTCGAGCCGGGCGTGTACCGATTCCGGGATCCGCA
CGGGCGGGTCATCTACGTCGGCAAGGCCAAGAGCCTGCGCAGCCGGCTGACGTCCTACTTCGCCGACGTCGCCAACCTGC
ACCCGCGCACCCGGCAGATGGTGACCACCGCGGCCAAGGTCGAGTGGACGGTGGTCAACACCGAGGTCGAGGCGCTGCAG
CTCGAATACAACTGGATCAAGGAATTCGACCCGCGCTTCAACGTCCGCTACCGCGACGACAAGTCCTACCCGGTGCTGGC
CGTCACCCTCAACGAGGAGTTCCCGCGGCTGATGGTCTATCGCGGCCCGCGCCGCAAGGGGGTGCGCTATTTCGGGCCGT
ACTCGCACGCCTGGGCCATCCGCGAGACGCTGGACCTGCTCACCCGGGTGTTTCCGGCCCGCACCTGCTCGGCGGGAGTG
TTCAAGCGGCACAAGCAGATTGACCGGCCCTGCCTGCTCGGCTACATCGACAAGTGCTCGGCGCCGTGCATCGGCCGGGT
CAGCGCCGAGCAGCACCGCCAGATCGTGGACGACTTCTGCGACTTCTTGTCCGGCAAGACCGACCGGTTCGCCCGGGAGC
TGGAACAGCAGATGAACGCCGCGGCCGCCGAACTCGATTTCGAGCGGGCCGCCCGGCTGCGCGACGACCTGGGCGCGCTC
AAGCGGGCGATGGAGAAACAGGCCGTGGTGCTCGGCGACGGCACCGACGCCGACGTGGTGGCCTTCGCCGACGACGAACT
CGAGGCCGCGGTGCAGGTGTTCCATGTGCGGGGCGGCCGGGTGCGCGGTCAGCGCGGCTGGATCGTGGAGAAGTCCGCCG
ACCCCGGCGATTCCGGCGAGGAACAGTTGGTGGAGCAGTTCTTGACCCAGTTCTACGGCGAGCAGGCCGAATTGGGTGGC
GCCGCAGACGAATCGGTGAACCCAGTGCCGCGCGAGGTGCTGGTGCCCTGCCTGCCGTCCAACGCCGACGAGCTGACCAG
CTGGCTGTCCGGCCTGCGCGGGTCGCGGGTGGCGTTGCGGGTGCCGCGCCGCGGCGACAAGCGGGCGCTTGCCGAAACCG
TGCAGCGCAACGCGAAAGAGGCTCTGCAGCAACACAAGCTGAAGCGGGCCGGCGACTTCAACGCCAGATCGGCTGCGTTG
CAGAACATTCAGGAGGCCCTCGGCCTGTCCGAGGCGCCGCTACGCATCGAGTGCGTGGACATCAGCCACGTGCAGGGCAC
CGACGTGGTGGGGTCGTTGGTGGTGTTCGAGGACGGCCTGCCGCGCAAATCGGACTACCGCCACTTCGCGATCCGGGAAG
CCGCCGGGCAGGGGCGCTCCGACGACGTCGCCTCCATCGCCGAGGTGACCCGGCGCCGGTTCGCGCGACACCTGAGCGAG
CAGAACGACCCGAATATGCTTTCGCCGGAAGGAAAATCGCGCCGGTTCGCCTACCCGCCCAACCTGTACGTGGTCGACGG
CGGCGCGCCGCAGGTCAATGCGGCCAGCGCGGTGCTGGAGGAGCTCGGCATCACCGACGTCGCGGTGATCGGCCTGGCCA
AGCGGCTGGAAGAGGTGTGGGTGCCCTCGGAGCCCGATCCGGTCATCATGCCGCGCAACAGCGAGGGGTTGTACCTGCTG
CAACGCGTCCGTGACGAGGCGCACCGGTTCGCCATCACCTACCATCGCAGCAAGCGATCCAAGCGAATGACGGCATCGGT
GCTGGATTCGGTGCCAGGATTGGGAGAACATCGCCGCAAGGCGTTGGTAAGCCATTTCGGATCGATAGCCCGCCTCAAGG
AGGCCACCGTCGACCAGATCACCGCCGTACCCGGCATCGGGGTGGCCACCGCGACCGCCGTCCTGGAGGCGTTGCGGCCC
GACGAGTCCAAGGCCGCGCCGTGA

Upstream 100 bases:

>100_bases
CTCAGTCGCAACGAGTCGCCCGTGGCGAGCGGTATGCCCCACAGTAGACCGGCCGCCGCACCGTGCCGGCCGCGTCGCCG
CCGGCTACTAGCCTGGATCT

Downstream 100 bases:

>100_bases
CGGGCCCGGGTGAGCTCGCGGGGAGCCGGCCGGTGGACGCGCACCTGGAAAACGGGGCCGGCATCGACGTCGTCCTGGTG
ACCGGATTGTCCGGCGCCGG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MPDPATYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLTSYFADVANLHPRTRQMVTTAAKVEWTVVNTEVEALQ
LEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGV
FKRHKQIDRPCLLGYIDKCSAPCIGRVSAEQHRQIVDDFCDFLSGKTDRFARELEQQMNAAAAELDFERAARLRDDLGAL
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKSADPGDSGEEQLVEQFLTQFYGEQAELGG
AADESVNPVPREVLVPCLPSNADELTSWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEALQQHKLKRAGDFNARSAAL
QNIQEALGLSEAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFAIREAAGQGRSDDVASIAEVTRRRFARHLSE
QNDPNMLSPEGKSRRFAYPPNLYVVDGGAPQVNAASAVLEELGITDVAVIGLAKRLEEVWVPSEPDPVIMPRNSEGLYLL
QRVRDEAHRFAITYHRSKRSKRMTASVLDSVPGLGEHRRKALVSHFGSIARLKEATVDQITAVPGIGVATATAVLEALRP
DESKAAP

Sequences:

>Translated_647_residues
MPDPATYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLTSYFADVANLHPRTRQMVTTAAKVEWTVVNTEVEALQ
LEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGV
FKRHKQIDRPCLLGYIDKCSAPCIGRVSAEQHRQIVDDFCDFLSGKTDRFARELEQQMNAAAAELDFERAARLRDDLGAL
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKSADPGDSGEEQLVEQFLTQFYGEQAELGG
AADESVNPVPREVLVPCLPSNADELTSWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEALQQHKLKRAGDFNARSAAL
QNIQEALGLSEAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFAIREAAGQGRSDDVASIAEVTRRRFARHLSE
QNDPNMLSPEGKSRRFAYPPNLYVVDGGAPQVNAASAVLEELGITDVAVIGLAKRLEEVWVPSEPDPVIMPRNSEGLYLL
QRVRDEAHRFAITYHRSKRSKRMTASVLDSVPGLGEHRRKALVSHFGSIARLKEATVDQITAVPGIGVATATAVLEALRP
DESKAAP
>Mature_646_residues
PDPATYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLTSYFADVANLHPRTRQMVTTAAKVEWTVVNTEVEALQL
EYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVF
KRHKQIDRPCLLGYIDKCSAPCIGRVSAEQHRQIVDDFCDFLSGKTDRFARELEQQMNAAAAELDFERAARLRDDLGALK
RAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKSADPGDSGEEQLVEQFLTQFYGEQAELGGA
ADESVNPVPREVLVPCLPSNADELTSWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEALQQHKLKRAGDFNARSAALQ
NIQEALGLSEAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFAIREAAGQGRSDDVASIAEVTRRRFARHLSEQ
NDPNMLSPEGKSRRFAYPPNLYVVDGGAPQVNAASAVLEELGITDVAVIGLAKRLEEVWVPSEPDPVIMPRNSEGLYLLQ
RVRDEAHRFAITYHRSKRSKRMTASVLDSVPGLGEHRRKALVSHFGSIARLKEATVDQITAVPGIGVATATAVLEALRPD
ESKAAP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=651, Percent_Identity=35.0230414746544, Blast_Score=359, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71933; Mature: 71802

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPATYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLTSYFADVANLHPRTRQM
CCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCHHHHHH
VTTAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEFPRLMVY
HHHHHEEEEEEEECEEEEEEEEHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCEEEEE
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHKQIDRPCLLGYIDKCS
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHCC
APCIGRVSAEQHRQIVDDFCDFLSGKTDRFARELEQQMNAAAAELDFERAARLRDDLGAL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKSADPGDSGE
HHHHHHCEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCH
EQLVEQFLTQFYGEQAELGGAADESVNPVPREVLVPCLPSNADELTSWLSGLRGSRVALR
HHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEE
VPRRGDKRALAETVQRNAKEALQQHKLKRAGDFNARSAALQNIQEALGLSEAPLRIECVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
ISHVQGTDVVGSLVVFEDGLPRKSDYRHFAIREAAGQGRSDDVASIAEVTRRRFARHLSE
CCCCCCCHHHHEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
QNDPNMLSPEGKSRRFAYPPNLYVVDGGAPQVNAASAVLEELGITDVAVIGLAKRLEEVW
CCCCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHC
VPSEPDPVIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSKRMTASVLDSVPGLGEHRRK
CCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
ALVSHFGSIARLKEATVDQITAVPGIGVATATAVLEALRPDESKAAP
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PDPATYRPAPGSIPVEPGVYRFRDPHGRVIYVGKAKSLRSRLTSYFADVANLHPRTRQM
CCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCHHHHHH
VTTAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEFPRLMVY
HHHHHEEEEEEEECEEEEEEEEHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCEEEEE
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHKQIDRPCLLGYIDKCS
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHCC
APCIGRVSAEQHRQIVDDFCDFLSGKTDRFARELEQQMNAAAAELDFERAARLRDDLGAL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKSADPGDSGE
HHHHHHCEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCH
EQLVEQFLTQFYGEQAELGGAADESVNPVPREVLVPCLPSNADELTSWLSGLRGSRVALR
HHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEE
VPRRGDKRALAETVQRNAKEALQQHKLKRAGDFNARSAALQNIQEALGLSEAPLRIECVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
ISHVQGTDVVGSLVVFEDGLPRKSDYRHFAIREAAGQGRSDDVASIAEVTRRRFARHLSE
CCCCCCCHHHHEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
QNDPNMLSPEGKSRRFAYPPNLYVVDGGAPQVNAASAVLEELGITDVAVIGLAKRLEEVW
CCCCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHC
VPSEPDPVIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSKRMTASVLDSVPGLGEHRRK
CCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
ALVSHFGSIARLKEATVDQITAVPGIGVATATAVLEALRPDESKAAP
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA