Click here to switch to the map view.

The map label for this gene is arlS [H]

Identifier: 41407199

GI number: 41407199

Start: 1154491

End: 1155894

Strand: Direct

Name: arlS [H]

Synonym: MAP1101

Alternate gene names: 41407199

Gene position: 1154491-1155894 (Clockwise)

Preceding gene: 41407198

Following gene: 41407203

Centisome position: 23.9

GC content: 72.86

Gene sequence:

>1404_bases
GTGTTCTCCGGCGGGGCGCGGGCCTGCAGAATCGAAGGCGTGCACCTGGGTATCTCCGCCCGCTCGGCGGCGGTCGCGGC
GATCGTCGTCTTCTGCGCGCTGACGGTGGCCGGCGCGGGATTGGACGCCATCCTGTACCGGTCGTTGCTGTCCGGCGTGG
ATTACGCTGCGGCCGAACGGGTTCGCGACATCGCCAAGGCGCTGCAGTCGGATTCGCGCGAGGAACTCGACAACGCCCTG
CTGACCACCGACCAGCGGGTGGTGGCCACCCAGTTGATCGGTCCGGACGGCAGCGTGGTCAAGCGGTCCGGCTCCGCGCC
GGCCACCCCGTTGGTGCCGACCGCCGATTTCGACTTCACCCTGCGTCGCGGCCTGCCCGACGACGCGGTGTCCGGCGACG
ACATGCGGGTCAGCGGCCAGAAGGTCGCCACCCGGTCGGGGGTGTACACGGTGCTGGTCGGCGGGGGCAGCGAGGCGGTC
GAGGCGACCGCACGCACCCTGGCGATCCTGTTGGCCACCACCGCACCGGTCATCGTCGCGGTGGCGGCCGGCGCGACGTA
CTGGCTGGTGCGCCGATCGCTGAAGTCGGTGGACGCCATCCGCGCCCGGGTGGCCGACATCTCGGCGTCGGACCTGGCCG
AGCGGGTGCCGGTCCCGGACGGCCGCGACGAGATCGCGGCCCTGGCGGTCACCATGAACGAGATGCTGTCCCGGCTGGAA
GCGGGACACCGTGCGCAGCAACGCTTTGTCGGCGACGCGTCACACGAGCTGCGCAGCCCGCTGACCACCATCATCTCCGG
GCTGGAGGTGGCCGAGGCGCACCCCGAGCTGCTCGACGCCGAGCTGGCGGTCAACACCCTGCTGCCCGAGGCGCACCGGA
TGCGCGCCCTGATCGACGACCTGCTGCTGCTGGCCCGCGCCGACGAGCGAAACCTGTTGCGGCGCAAGGAGCCGGTGGCC
CTCGACGACCTCGCCGAGGCGGAAGCTGCCCGGGTGCGCCGCGACGCCGACTGCGCGGTCCACACCGACATCCGCCCGGC
GCGGCTGCTCGCCGACCCGACGGCCATGACGCGCATGATCCGCAACCTGGTGGATAACGCTGTGCGCCACGCGGTTTCGT
GCGTCGCCATCGAGGTCGGCAGCCGTGACGGGACGGCGGTGCTCACCGTCGGCGATGACGGCCCGGGCATACCGCCGGCG
CAGCGAAGCCGGGTGTTCGAGCGGTTCGTGCGGCTGGACACCGATCGCGCGCGCAGCGGCGGTGGGGCCGGGCTGGGCCT
GGCCATCGTCGCCGAGGTGGTCGCCGCGCACGGCGGCACCGTCACCATCGGCGACCGGCCGGGCGGGGGCACCACCCTGA
CGGTGGCCCTGCCGCAACACCCGGCTCAGCACAGCAGCCGGTAA

Upstream 100 bases:

>100_bases
CGCTCGATGCTCACCGCGCGGCGGGCGTGCAGTACCAACCATGTCGGTGCCAGCCTAGGACGGGGCCGCTGAGAGGCCGC
TGAGAAGCGCACCGTTCTCG

Downstream 100 bases:

>100_bases
CCGACCCCCCGGATCGTCTCAATGGTGTTGGTGCCGAACGGAACATCGATCTTGCGGCGCAGGTAGCCCACGTACACCTC
GACCACGTTGTCCGGCCCGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MFSGGARACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNAL
LTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVSGQKVATRSGVYTVLVGGGSEAV
EATARTLAILLATTAPVIVAVAAGATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDEIAALAVTMNEMLSRLE
AGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLDAELAVNTLLPEAHRMRALIDDLLLLARADERNLLRRKEPVA
LDDLAEAEAARVRRDADCAVHTDIRPARLLADPTAMTRMIRNLVDNAVRHAVSCVAIEVGSRDGTAVLTVGDDGPGIPPA
QRSRVFERFVRLDTDRARSGGGAGLGLAIVAEVVAAHGGTVTIGDRPGGGTTLTVALPQHPAQHSSR

Sequences:

>Translated_467_residues
MFSGGARACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNAL
LTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVSGQKVATRSGVYTVLVGGGSEAV
EATARTLAILLATTAPVIVAVAAGATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDEIAALAVTMNEMLSRLE
AGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLDAELAVNTLLPEAHRMRALIDDLLLLARADERNLLRRKEPVA
LDDLAEAEAARVRRDADCAVHTDIRPARLLADPTAMTRMIRNLVDNAVRHAVSCVAIEVGSRDGTAVLTVGDDGPGIPPA
QRSRVFERFVRLDTDRARSGGGAGLGLAIVAEVVAAHGGTVTIGDRPGGGTTLTVALPQHPAQHSSR
>Mature_467_residues
MFSGGARACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNAL
LTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVSGQKVATRSGVYTVLVGGGSEAV
EATARTLAILLATTAPVIVAVAAGATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDEIAALAVTMNEMLSRLE
AGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLDAELAVNTLLPEAHRMRALIDDLLLLARADERNLLRRKEPVA
LDDLAEAEAARVRRDADCAVHTDIRPARLLADPTAMTRMIRNLVDNAVRHAVSCVAIEVGSRDGTAVLTVGDDGPGIPPA
QRSRVFERFVRLDTDRARSGGGAGLGLAIVAEVVAAHGGTVTIGDRPGGGTTLTVALPQHPAQHSSR

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=34.1085271317829, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=32.8301886792453, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=28.8753799392097, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787894, Length=350, Percent_Identity=29.4285714285714, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1786600, Length=248, Percent_Identity=31.0483870967742, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790861, Length=308, Percent_Identity=31.1688311688312, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1789403, Length=345, Percent_Identity=29.5652173913043, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=25.7142857142857, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=29.9595141700405, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788279, Length=453, Percent_Identity=21.8543046357616, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789808, Length=213, Percent_Identity=31.4553990610329, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=26.8199233716475, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=27.2401433691756, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=26, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=31.1926605504587, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=260, Percent_Identity=25.3846153846154, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=26.6393442622951, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=24.3589743589744, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=255, Percent_Identity=24.3137254901961, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082128, Length=251, Percent_Identity=23.5059760956175, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49013; Mature: 49013

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGGARACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRSLLSGVDYAAAER
CCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
VRDIAKALQSDSREELDNALLTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFT
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHEECCCCCCCCCCCCCCCCCHH
LRRGLPDDAVSGDDMRVSGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVA
HHCCCCCCCCCCCCEEECCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VAAGATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDEIAALAVTMNEMLSRLE
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLDAELAVNTLLPEAHRMRALIDD
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
LLLLARADERNLLRRKEPVALDDLAEAEAARVRRDADCAVHTDIRPARLLADPTAMTRMI
HHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHCCHHHHHHHH
RNLVDNAVRHAVSCVAIEVGSRDGTAVLTVGDDGPGIPPAQRSRVFERFVRLDTDRARSG
HHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHCCCC
GGAGLGLAIVAEVVAAHGGTVTIGDRPGGGTTLTVALPQHPAQHSSR
CCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MFSGGARACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRSLLSGVDYAAAER
CCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
VRDIAKALQSDSREELDNALLTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFT
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHEECCCCCCCCCCCCCCCCCHH
LRRGLPDDAVSGDDMRVSGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVA
HHCCCCCCCCCCCCEEECCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VAAGATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDEIAALAVTMNEMLSRLE
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLDAELAVNTLLPEAHRMRALIDD
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
LLLLARADERNLLRRKEPVALDDLAEAEAARVRRDADCAVHTDIRPARLLADPTAMTRMI
HHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHCCHHHHHHHH
RNLVDNAVRHAVSCVAIEVGSRDGTAVLTVGDDGPGIPPAQRSRVFERFVRLDTDRARSG
HHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHCCCC
GGAGLGLAIVAEVVAAHGGTVTIGDRPGGGTTLTVALPQHPAQHSSR
CCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA