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The map label for this gene is aspS

Identifier: 41407161

GI number: 41407161

Start: 1113460

End: 1115235

Strand: Direct

Name: aspS

Synonym: MAP1063

Alternate gene names: 41407161

Gene position: 1113460-1115235 (Clockwise)

Preceding gene: 41407157

Following gene: 41407162

Centisome position: 23.05

GC content: 70.55

Gene sequence:

>1776_bases
GTGCTGCGCAGCCACGCCGCCGGTTCGCTGAGAAGTAGCGACGCCGGGCAGCAGGTGACGCTGGCGGGCTGGGTGGCGCG
CCGGCGCGACCACGGCGGCGTCATCTTCATCGACCTGCGCGACGCCTCCGGAATCACCCAGGTGGTGTTCCGCGACCCGG
ACGTCCTCAAGCAGGCGCACCGGCTGCGCGCCGAGTTCTGCGTCGCGGTGACCGGGTTGGTCGAGATCCGCCCGGAAGGC
AACGCCAACCCCGAAATCGCCACCGGCGACATCGAGGTCAACGCGTCGTCGCTGACCGTGCTGGGCGAAAGCGCGCCGCT
GCCGTTCCAGCTCGACGAGCCCGCCGGCGAGGAGCTGCGGCTGAAATACCGTTACCTGGACCTGCGCCGCGACGCGCCGG
CCTCGGCAATCCGGTTGCGCTCCAAGGTGAATGCCGCCGCGCGCGAAGTGCTGGACCGACACGACTTCGTCGAGATCGAG
ACCCCGACCATCACCCGCTCCACCCCGGAGGGGGCGCGCGACTTCCTGGTGCCGGCCCGGCTGCATCCCGGCTCGTTCTA
CGCGCTGCCGCAGAGCCCGCAGCTGTTCAAGCAGTTGCTGATGGTGGCCGGGATGGAGCGCTACTACCAGATCGCCCGCT
GCTACCGCGACGAGGATTTCCGCGCCGACCGCCAGCCCGAGTTCACCCAGCTCGACATGGAGATGAGCTTCGTCGACGCC
GAGGACGTCATCGCGATCTCCGAGGAGATCCTGGCCGCGCTGTGGGCGCTGATCGGCTATGACATCCCCCGGCCGATCCC
GCGGATCAGCTACGCCGACGCGATGGCCCGCTACGGCTCCGACAAGCCCGACCTGCGGTTCGGACTCGAGCTCGTCGAGT
GCTCGGAGTTCTTTAAAGACACCACATTTCGCGTCTTCCAGGCGCCGTACGTGGGTGCGGTGGTGATGCCCGGCGGGGCC
TCGCAGCCGCGCCGCACCCTGGACGGCTGGCAGGAGTGGGCCAAGCAGCGCGGCGCCAAGGGCCTGGCCTACGTGCTGGT
CGGCGAGGACGGCGAGCTGGGCGGGCCGGTGGCCAAGAACCTCTCCGAGGCCGAGCGCGCCGGGCTGGCCGGGCACGTCG
GCGCCGCACCGGGGGACTGCATCTTCTTCGCGGCCGGGCCGGCCAAGCCGTCGCGGGCGCTGCTGGGCGCGGCCCGCAGC
GAGATCGCCCACCGGCTGGGCCTGATCGACCCGCAGGCGTGGGCGTTCGTCTGGGTGGTGGACCCGCCGCTGTTCGAGCC
CGCCGACGACGCCACCGCCGCCGGTGACGTCGCCGTCGGCTCCGGGGCGTGGACCGCGGTGCACCACGCGTTCACCGCAC
CCAAGCCGGGATACGAGGACGCGATCGAGACCGACACCGGCAACGTGCTCGCCGACGCGTACGACATCGTCTGCAACGGC
AACGAGATCGGCGGCGGCTCGATCCGTATCCACCGCCGCGACATCCAGGAGCGGGTGTTCGCGGTGATGGGCCTGGACCA
CGCCGAGGCTCAGGAGAAGTTCGGATTCCTGTTGGAGGCGTTCACCTTTGGCGCGCCCCCGCACGGCGGGATCGCGTTCG
GCTGGGACCGGATCAACGCGCTGCTGTCCCGGGTCGACTCCATCCGCGAGGTGATCGCCTTCCCCAAGACCGGCGGCGGT
GTCGACCCGCTCACCGACGCGCCGGCGCCCATCACCGAACAGCAGCGCAAGGAGTCCGGAATAGACGTCAAGCCGGAGCC
CAGCAAACCCCATTGA

Upstream 100 bases:

>100_bases
CCGACGGCGCCGGGACCGACGAGTGCGATGGTGGTGGCAATAGGACCAAAGTTACCTCCTCTAGACTTGGCTTTCGTTTC
AGACCAAGGGGAGTGTTTTT

Downstream 100 bases:

>100_bases
CCTCAGCGAACGGCTCGCTCAGGTGCTCGTGGGCCGCAGCTGGTCCGCAGTGGTGTTCATCCGCTCCGCGATCACCGCGC
GGATAGCCGTGCGGGTGGAT

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MLRSHAAGSLRSSDAGQQVTLAGWVARRRDHGGVIFIDLRDASGITQVVFRDPDVLKQAHRLRAEFCVAVTGLVEIRPEG
NANPEIATGDIEVNASSLTVLGESAPLPFQLDEPAGEELRLKYRYLDLRRDAPASAIRLRSKVNAAAREVLDRHDFVEIE
TPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDA
EDVIAISEEILAALWALIGYDIPRPIPRISYADAMARYGSDKPDLRFGLELVECSEFFKDTTFRVFQAPYVGAVVMPGGA
SQPRRTLDGWQEWAKQRGAKGLAYVLVGEDGELGGPVAKNLSEAERAGLAGHVGAAPGDCIFFAAGPAKPSRALLGAARS
EIAHRLGLIDPQAWAFVWVVDPPLFEPADDATAAGDVAVGSGAWTAVHHAFTAPKPGYEDAIETDTGNVLADAYDIVCNG
NEIGGGSIRIHRRDIQERVFAVMGLDHAEAQEKFGFLLEAFTFGAPPHGGIAFGWDRINALLSRVDSIREVIAFPKTGGG
VDPLTDAPAPITEQQRKESGIDVKPEPSKPH

Sequences:

>Translated_591_residues
MLRSHAAGSLRSSDAGQQVTLAGWVARRRDHGGVIFIDLRDASGITQVVFRDPDVLKQAHRLRAEFCVAVTGLVEIRPEG
NANPEIATGDIEVNASSLTVLGESAPLPFQLDEPAGEELRLKYRYLDLRRDAPASAIRLRSKVNAAAREVLDRHDFVEIE
TPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDA
EDVIAISEEILAALWALIGYDIPRPIPRISYADAMARYGSDKPDLRFGLELVECSEFFKDTTFRVFQAPYVGAVVMPGGA
SQPRRTLDGWQEWAKQRGAKGLAYVLVGEDGELGGPVAKNLSEAERAGLAGHVGAAPGDCIFFAAGPAKPSRALLGAARS
EIAHRLGLIDPQAWAFVWVVDPPLFEPADDATAAGDVAVGSGAWTAVHHAFTAPKPGYEDAIETDTGNVLADAYDIVCNG
NEIGGGSIRIHRRDIQERVFAVMGLDHAEAQEKFGFLLEAFTFGAPPHGGIAFGWDRINALLSRVDSIREVIAFPKTGGG
VDPLTDAPAPITEQQRKESGIDVKPEPSKPH
>Mature_591_residues
MLRSHAAGSLRSSDAGQQVTLAGWVARRRDHGGVIFIDLRDASGITQVVFRDPDVLKQAHRLRAEFCVAVTGLVEIRPEG
NANPEIATGDIEVNASSLTVLGESAPLPFQLDEPAGEELRLKYRYLDLRRDAPASAIRLRSKVNAAAREVLDRHDFVEIE
TPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDA
EDVIAISEEILAALWALIGYDIPRPIPRISYADAMARYGSDKPDLRFGLELVECSEFFKDTTFRVFQAPYVGAVVMPGGA
SQPRRTLDGWQEWAKQRGAKGLAYVLVGEDGELGGPVAKNLSEAERAGLAGHVGAAPGDCIFFAAGPAKPSRALLGAARS
EIAHRLGLIDPQAWAFVWVVDPPLFEPADDATAAGDVAVGSGAWTAVHHAFTAPKPGYEDAIETDTGNVLADAYDIVCNG
NEIGGGSIRIHRRDIQERVFAVMGLDHAEAQEKFGFLLEAFTFGAPPHGGIAFGWDRINALLSRVDSIREVIAFPKTGGG
VDPLTDAPAPITEQQRKESGIDVKPEPSKPH

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=609, Percent_Identity=39.2446633825944, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI45439306, Length=239, Percent_Identity=29.2887029288703, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI5031815, Length=263, Percent_Identity=27.7566539923954, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI194272210, Length=259, Percent_Identity=27.7992277992278, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4758762, Length=281, Percent_Identity=25.2669039145907, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI226491502, Length=269, Percent_Identity=24.1635687732342, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788173, Length=582, Percent_Identity=48.4536082474227, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1790571, Length=303, Percent_Identity=26.7326732673267, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1789256, Length=285, Percent_Identity=25.6140350877193, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI32566633, Length=604, Percent_Identity=34.7682119205298, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17551876, Length=302, Percent_Identity=27.4834437086093, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71994340, Length=245, Percent_Identity=26.530612244898, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17535927, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71984122, Length=282, Percent_Identity=25.177304964539, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325153, Length=628, Percent_Identity=32.484076433121, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6321807, Length=317, Percent_Identity=25.8675078864353, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323011, Length=277, Percent_Identity=26.7148014440433, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=255, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584738, Length=615, Percent_Identity=38.3739837398374, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17136276, Length=239, Percent_Identity=26.3598326359833, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19921528, Length=286, Percent_Identity=25.1748251748252, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640851, Length=263, Percent_Identity=27.3764258555133, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640849, Length=265, Percent_Identity=27.5471698113208, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 64327; Mature: 64327

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSHAAGSLRSSDAGQQVTLAGWVARRRDHGGVIFIDLRDASGITQVVFRDPDVLKQAH
CCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCEEEEEECCCCCCEEEEECCHHHHHHHH
RLRAEFCVAVTGLVEIRPEGNANPEIATGDIEVNASSLTVLGESAPLPFQLDEPAGEELR
HHHHHHHHHEEEEEEECCCCCCCCCEEECEEEECCCEEEEEECCCCCCEEECCCCCCCEE
LKYRYLDLRRDAPASAIRLRSKVNAAAREVLDRHDFVEIETPTITRSTPEGARDFLVPAR
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCCCHHCEEEEE
LHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDA
ECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECH
EDVIAISEEILAALWALIGYDIPRPIPRISYADAMARYGSDKPDLRFGLELVECSEFFKD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
TTFRVFQAPYVGAVVMPGGASQPRRTLDGWQEWAKQRGAKGLAYVLVGEDGELGGPVAKN
CHHEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHH
LSEAERAGLAGHVGAAPGDCIFFAAGPAKPSRALLGAARSEIAHRLGLIDPQAWAFVWVV
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
DPPLFEPADDATAAGDVAVGSGAWTAVHHAFTAPKPGYEDAIETDTGNVLADAYDIVCNG
CCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECC
NEIGGGSIRIHRRDIQERVFAVMGLDHAEAQEKFGFLLEAFTFGAPPHGGIAFGWDRINA
CEECCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHH
LLSRVDSIREVIAFPKTGGGVDPLTDAPAPITEQQRKESGIDVKPEPSKPH
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLRSHAAGSLRSSDAGQQVTLAGWVARRRDHGGVIFIDLRDASGITQVVFRDPDVLKQAH
CCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCEEEEEECCCCCCEEEEECCHHHHHHHH
RLRAEFCVAVTGLVEIRPEGNANPEIATGDIEVNASSLTVLGESAPLPFQLDEPAGEELR
HHHHHHHHHEEEEEEECCCCCCCCCEEECEEEECCCEEEEEECCCCCCEEECCCCCCCEE
LKYRYLDLRRDAPASAIRLRSKVNAAAREVLDRHDFVEIETPTITRSTPEGARDFLVPAR
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCCCHHCEEEEE
LHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDA
ECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECH
EDVIAISEEILAALWALIGYDIPRPIPRISYADAMARYGSDKPDLRFGLELVECSEFFKD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
TTFRVFQAPYVGAVVMPGGASQPRRTLDGWQEWAKQRGAKGLAYVLVGEDGELGGPVAKN
CHHEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHH
LSEAERAGLAGHVGAAPGDCIFFAAGPAKPSRALLGAARSEIAHRLGLIDPQAWAFVWVV
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
DPPLFEPADDATAAGDVAVGSGAWTAVHHAFTAPKPGYEDAIETDTGNVLADAYDIVCNG
CCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECC
NEIGGGSIRIHRRDIQERVFAVMGLDHAEAQEKFGFLLEAFTFGAPPHGGIAFGWDRINA
CEECCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHH
LLSRVDSIREVIAFPKTGGGVDPLTDAPAPITEQQRKESGIDVKPEPSKPH
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA