| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is hdhA [C]
Identifier: 41406701
GI number: 41406701
Start: 628304
End: 629053
Strand: Direct
Name: hdhA [C]
Synonym: MAP0603
Alternate gene names: 41406701
Gene position: 628304-629053 (Clockwise)
Preceding gene: 41406700
Following gene: 41406702
Centisome position: 13.01
GC content: 65.2
Gene sequence:
>750_bases ATGCGATTCGAGAACAAAGTCGGCATCGTCACCGGATCCGGGGGCGGCATCGGGCAGGCGTACGCCGAGGCGCTGGCCCG CGAGGGCGCGGCGGTGGTGGTCGCCGACATCAACGCCGAGGCGGCCGAGGCCGTCGCCAAACAGATTGTCGCCGACGGCG GTACGGCCATCAGCGTCGCGGTCGACGTGTCCGACCCCGAGTCGGCCAAGGCGATGGCCGACCGCACCCTGGCCGAATTC GGCGGCATCGACTACCTGGTCAACAACGCCGCGATCTTCGGGGGCATGAAGCTGGACTTTTTGCTCACCATCGACCCGGA GTACTACAAGAAATTCATGAGCGTGAACCTCGACGGGGCGCTGTGGTGCACCCGCGCGGTGTACAAGAAGATGACCAAGC GCGGCGGCGGGGCGATCGTCAACCAGTCGTCCACCGCGGCCTGGCTGTATTCGAACTACTACGGCCTGGCCAAGGTCGGC ATCAACGGCCTGACCCAGCAGCTGTCCCGCGAACTGGGCGGGCGCAACATCCGGATCAACGCGATCGCGCCCGGGCCCAT CGACACCGAGGCCAACCGGACCACCACACCCAAAGAGATGGTCGACGACATCGTCAAGGGACTTCCGTTGTCGCGCATGG GAACTCCCGACGACCTGGTCGGCATGTGCCTGTTCCTGCTGTCCGACGAGGCGTCGTGGATCACCGGGCAGATCTTCAAC GTCGACGGCGGGCAGATAATCCGATCATGA
Upstream 100 bases:
>100_bases GCGCGAAATGGGCCTGGCCGGCTTCGAGGAATACCTGGAAATCAAGACCATCGCCACGGCCGTGCAGTGACCGCGCCGCG CGGCTGACCGAGAGGAAATC
Downstream 100 bases:
>100_bases CGACGAACGCGGCGCACACGACCGAGCAGCTGAAGCTCGGCTACATCGGGCTGGGCAATATGGGCGCGCCGATGGCCACG AGGATGACCGAATGGCCGGG
Product: short chain dehydrogenase
Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 249; Mature: 249
Protein sequence:
>249_residues MRFENKVGIVTGSGGGIGQAYAEALAREGAAVVVADINAEAAEAVAKQIVADGGTAISVAVDVSDPESAKAMADRTLAEF GGIDYLVNNAAIFGGMKLDFLLTIDPEYYKKFMSVNLDGALWCTRAVYKKMTKRGGGAIVNQSSTAAWLYSNYYGLAKVG INGLTQQLSRELGGRNIRINAIAPGPIDTEANRTTTPKEMVDDIVKGLPLSRMGTPDDLVGMCLFLLSDEASWITGQIFN VDGGQIIRS
Sequences:
>Translated_249_residues MRFENKVGIVTGSGGGIGQAYAEALAREGAAVVVADINAEAAEAVAKQIVADGGTAISVAVDVSDPESAKAMADRTLAEF GGIDYLVNNAAIFGGMKLDFLLTIDPEYYKKFMSVNLDGALWCTRAVYKKMTKRGGGAIVNQSSTAAWLYSNYYGLAKVG INGLTQQLSRELGGRNIRINAIAPGPIDTEANRTTTPKEMVDDIVKGLPLSRMGTPDDLVGMCLFLLSDEASWITGQIFN VDGGQIIRS >Mature_249_residues MRFENKVGIVTGSGGGIGQAYAEALAREGAAVVVADINAEAAEAVAKQIVADGGTAISVAVDVSDPESAKAMADRTLAEF GGIDYLVNNAAIFGGMKLDFLLTIDPEYYKKFMSVNLDGALWCTRAVYKKMTKRGGGAIVNQSSTAAWLYSNYYGLAKVG INGLTQQLSRELGGRNIRINAIAPGPIDTEANRTTTPKEMVDDIVKGLPLSRMGTPDDLVGMCLFLLSDEASWITGQIFN VDGGQIIRS
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=36, Blast_Score=134, Evalue=8e-32, Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=32.6612903225806, Blast_Score=121, Evalue=7e-28, Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=31.496062992126, Blast_Score=119, Evalue=3e-27, Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=31.2252964426877, Blast_Score=119, Evalue=3e-27, Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=30.5220883534137, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=30.3643724696356, Blast_Score=99, Evalue=3e-21, Organism=Homo sapiens, GI4504505, Length=259, Percent_Identity=32.046332046332, Blast_Score=99, Evalue=5e-21, Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=31.1203319502075, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=29.5275590551181, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI66933014, Length=252, Percent_Identity=29.3650793650794, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=28.8659793814433, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI109715829, Length=200, Percent_Identity=30, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI142976729, Length=217, Percent_Identity=28.110599078341, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=30.0395256916996, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=30.8457711442786, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI210032110, Length=214, Percent_Identity=28.9719626168224, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=28.9340101522843, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI40254986, Length=188, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI7706318, Length=241, Percent_Identity=26.5560165975104, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI40807363, Length=160, Percent_Identity=32.5, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4503817, Length=198, Percent_Identity=29.2929292929293, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI166795268, Length=208, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI302344755, Length=109, Percent_Identity=38.5321100917431, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=28.0632411067194, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI4557649, Length=206, Percent_Identity=24.7572815533981, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=34.8178137651822, Blast_Score=144, Evalue=6e-36, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=32.7935222672065, Blast_Score=135, Evalue=3e-33, Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=31.9066147859922, Blast_Score=120, Evalue=6e-29, Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=32.2709163346614, Blast_Score=115, Evalue=2e-27, Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=29.9180327868852, Blast_Score=113, Evalue=1e-26, Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=34.0080971659919, Blast_Score=110, Evalue=6e-26, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=32.6530612244898, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=30.9803921568627, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1789378, Length=252, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=29.3436293436293, Blast_Score=91, Evalue=5e-20, Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=28.8461538461538, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=26.7206477732794, Blast_Score=78, Evalue=5e-16, Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=25, Blast_Score=77, Evalue=2e-15, Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=34.765625, Blast_Score=135, Evalue=3e-32, Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=34.0080971659919, Blast_Score=124, Evalue=5e-29, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=31.9548872180451, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=33.469387755102, Blast_Score=113, Evalue=7e-26, Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=30.1587301587302, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.4741035856574, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=32.421875, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=28.5171102661597, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=32.1969696969697, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30.3846153846154, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=29.277566539924, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=33.2075471698113, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=31.3207547169811, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=29.9212598425197, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=30.5343511450382, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=29.5454545454545, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=31.2977099236641, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=31.0756972111554, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=30.6513409961686, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=30.3030303030303, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17561272, Length=243, Percent_Identity=28.8065843621399, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=31.8007662835249, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=28.030303030303, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17568967, Length=257, Percent_Identity=27.6264591439689, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=29.2, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17565030, Length=275, Percent_Identity=29.8181818181818, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=26.9961977186312, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=27.5862068965517, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17564282, Length=143, Percent_Identity=34.965034965035, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17567345, Length=220, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI71997099, Length=222, Percent_Identity=27.9279279279279, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17555612, Length=208, Percent_Identity=31.25, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI193203115, Length=188, Percent_Identity=31.3829787234043, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193203117, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI71982365, Length=196, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17558628, Length=194, Percent_Identity=30.4123711340206, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=32, Blast_Score=115, Evalue=7e-27, Organism=Saccharomyces cerevisiae, GI6322861, Length=257, Percent_Identity=29.9610894941634, Blast_Score=103, Evalue=2e-23, Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=29.7979797979798, Blast_Score=62, Evalue=9e-11, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=4e-29, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=33.8775510204082, Blast_Score=117, Evalue=6e-27, Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=29.1338582677165, Blast_Score=110, Evalue=7e-25, Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=32.2834645669291, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=31.1023622047244, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=27.9527559055118, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI116007236, Length=241, Percent_Identity=26.1410788381743, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI18859837, Length=208, Percent_Identity=32.2115384615385, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24644337, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI116007234, Length=232, Percent_Identity=31.4655172413793, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI281364494, Length=204, Percent_Identity=29.9019607843137, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=27.8688524590164, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI24640492, Length=212, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24641232, Length=203, Percent_Identity=27.0935960591133, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI24648693, Length=241, Percent_Identity=29.4605809128631, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI21355889, Length=241, Percent_Identity=29.4605809128631, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=28.8557213930348, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI116007238, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI24649181, Length=196, Percent_Identity=29.0816326530612, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI281364892, Length=171, Percent_Identity=30.9941520467836, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI21357673, Length=188, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI116007232, Length=190, Percent_Identity=31.0526315789474, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24663911, Length=224, Percent_Identity=24.5535714285714, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI24640442, Length=192, Percent_Identity=29.6875, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=29.2397660818713, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24641388, Length=206, Percent_Identity=29.6116504854369, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100
Molecular weight: Translated: 26350; Mature: 26350
Theoretical pI: Translated: 4.66; Mature: 4.66
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRFENKVGIVTGSGGGIGQAYAEALAREGAAVVVADINAEAAEAVAKQIVADGGTAISVA CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEE VDVSDPESAKAMADRTLAEFGGIDYLVNNAAIFGGMKLDFLLTIDPEYYKKFMSVNLDGA EECCCCHHHHHHHHHHHHHHCCCCEEECCEEEECCCEEEEEEEECHHHHHHHHHCCCCHH LWCTRAVYKKMTKRGGGAIVNQSSTAAWLYSNYYGLAKVGINGLTQQLSRELGGRNIRIN HHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEE AIAPGPIDTEANRTTTPKEMVDDIVKGLPLSRMGTPDDLVGMCLFLLSDEASWITGQIFN EECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE VDGGQIIRS CCCCCEECC >Mature Secondary Structure MRFENKVGIVTGSGGGIGQAYAEALAREGAAVVVADINAEAAEAVAKQIVADGGTAISVA CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEE VDVSDPESAKAMADRTLAEFGGIDYLVNNAAIFGGMKLDFLLTIDPEYYKKFMSVNLDGA EECCCCHHHHHHHHHHHHHHCCCCEEECCEEEECCCEEEEEEEECHHHHHHHHHCCCCHH LWCTRAVYKKMTKRGGGAIVNQSSTAAWLYSNYYGLAKVGINGLTQQLSRELGGRNIRIN HHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEE AIAPGPIDTEANRTTTPKEMVDDIVKGLPLSRMGTPDDLVGMCLFLLSDEASWITGQIFN EECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE VDGGQIIRS CCCCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+
Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9655913; 12597275 [H]