BacMap

Definition	Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession	NC_002944
Length	4,829,781

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The map label for this gene is fabG [C]

Identifier: 41406616

GI number: 41406616

Start: 544757

End: 545662

Strand: Direct

Name: fabG [C]

Synonym: MAP0518

Alternate gene names: 41406616

Gene position: 544757-545662 (Clockwise)

Preceding gene: 41406615

Following gene: 41406620

Centisome position: 11.28

GC content: 70.86

Gene sequence:

>906_bases
ATGGGAGTGGTTGACGGCCGCGTCGTCATCGTCACCGGAGCGGGCGGCGGTATCGGTCGCGCGCACGCACTGGCCTTCGC
CGCCGAAGGGGCGCGTGTGGTGGTCAACGACATCGGGGTGGGCCTGGACGGTTCACCGGCCAGCGGCGGCAGCGCCGCCC
AGAGCGTGGTGGACGAGATCACCGCCGCCGGCGGGGAAGCCGTCGCCGACGGATCCAACGTCGCCGACTGGGACCAGGCC
GCCGGTCTGATCCAGACCGCCGTCGAAACCTTCGGTGGTCTCGACGTTTTGGTGAACAACGCCGGAATCGTGCGCGACAG
GATGATCGCCAACACCAGCGAGGAGGAGTTCGACGCCGTCATCGCCGTGCACCTCAAGGGGCGCTTCGCCACCATGCGGC
ACGCCGCGTCGTACTGGCGGGGGCTGTCCAAGGCGGGCGAGGCCGTCGACGGCCGGATCATCAACACCAGCTCGGGCGCC
GGCCTGCAGGGCAGCGTCGGGCAGGGCAACTACAGCGCCGCCAAGGCCGGTATCGCGACGCTGACGCTGGTCGGCGCGGC
GGAGATGGGCCGTTACGGCGTCACCGTCAACGCGATCGCGCCGTCGGCCCGCACCCGGATGACCGAGACCGTGTTCGCCG
AGATGATGGCAACCCAGGACCAGGATTTCGACGCGATGGCCCCGGAAAACGTGTCGCCCCTGGTGGTTTGGCTGGGCAGT
GCGGAGGCCCGCGACGTGACCGGCAAGGTGTTCGAGGTCGAGGGCGGCAAGATCCGGGTCGCCGAGGGTTGGGCGCACGG
CCCGCAGATCGACAAGGGCGCGAGGTGGGATCCCGCCGAGCTGGGGCCCGTCGTCGCCGACCTGCTCGCCAAGGCCCGCC
CGCCGGTCCCGGTCTACGGCGCCTAA

Upstream 100 bases:

>100_bases
ACATCAGCGGGGCCTCGCTGGAGGTGCACGGCGGCGGTGAGCCGCCGCACTATCTGGCCACCACGAACGCGAGCGCGATC
AAGTAGAGGAGACAAGGACT

Downstream 100 bases:

>100_bases
CGCGCCAGACGCGCCCAACGCACTCAACGCACCCGACGCACCCTCGCCGCCGAACGTGCACCCACCGCGAGAATTCCGCC
GATTCTTCGCTACCAGTGCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MGVVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQSVVDEITAAGGEAVADGSNVADWDQA
AGLIQTAVETFGGLDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGRFATMRHAASYWRGLSKAGEAVDGRIINTSSGA
GLQGSVGQGNYSAAKAGIATLTLVGAAEMGRYGVTVNAIAPSARTRMTETVFAEMMATQDQDFDAMAPENVSPLVVWLGS
AEARDVTGKVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVADLLAKARPPVPVYGA

Sequences:

>Translated_301_residues
MGVVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQSVVDEITAAGGEAVADGSNVADWDQA
AGLIQTAVETFGGLDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGRFATMRHAASYWRGLSKAGEAVDGRIINTSSGA
GLQGSVGQGNYSAAKAGIATLTLVGAAEMGRYGVTVNAIAPSARTRMTETVFAEMMATQDQDFDAMAPENVSPLVVWLGS
AEARDVTGKVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVADLLAKARPPVPVYGA
>Mature_300_residues
GVVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQSVVDEITAAGGEAVADGSNVADWDQAA
GLIQTAVETFGGLDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGRFATMRHAASYWRGLSKAGEAVDGRIINTSSGAG
LQGSVGQGNYSAAKAGIATLTLVGAAEMGRYGVTVNAIAPSARTRMTETVFAEMMATQDQDFDAMAPENVSPLVVWLGSA
EARDVTGKVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVADLLAKARPPVPVYGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=255, Percent_Identity=45.8823529411765, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=33.969465648855, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=29.8804780876494, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI31542939, Length=214, Percent_Identity=31.7757009345794, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=31.0077519379845, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4758504, Length=204, Percent_Identity=32.3529411764706, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI40254986, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=26.0223048327138, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI66933014, Length=270, Percent_Identity=29.2592592592593, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=31.8435754189944, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI83715985, Length=197, Percent_Identity=31.4720812182741, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=32.3308270676692, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI2367175, Length=264, Percent_Identity=31.4393939393939, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082100, Length=270, Percent_Identity=30.7407407407407, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790717, Length=272, Percent_Identity=27.5735294117647, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789057, Length=271, Percent_Identity=28.4132841328413, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=261, Percent_Identity=29.1187739463602, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787905, Length=267, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789378, Length=268, Percent_Identity=29.1044776119403, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082160, Length=198, Percent_Identity=29.2929292929293, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=265, Percent_Identity=28.3018867924528, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=248, Percent_Identity=40.3225806451613, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=34.375, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=265, Percent_Identity=31.3207547169811, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=204, Percent_Identity=32.843137254902, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=31.9526627218935, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982365, Length=199, Percent_Identity=29.6482412060301, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=272, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=27.4131274131274, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=26.3565891472868, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=209, Percent_Identity=31.1004784688995, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=177, Percent_Identity=30.5084745762712, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=206, Percent_Identity=29.126213592233, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=177, Percent_Identity=30.5084745762712, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=286, Percent_Identity=24.8251748251748, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=211, Percent_Identity=28.9099526066351, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=208, Percent_Identity=28.8461538461538, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558628, Length=206, Percent_Identity=27.6699029126214, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=25.4752851711027, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=296, Percent_Identity=26.0135135135135, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=24.2307692307692, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=256, Percent_Identity=25.390625, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=198, Percent_Identity=25.7575757575758, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=286, Percent_Identity=27.6223776223776, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=202, Percent_Identity=30.6930693069307, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=250, Percent_Identity=46, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324126, Length=277, Percent_Identity=27.7978339350181, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18859837, Length=282, Percent_Identity=42.9078014184397, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24639444, Length=261, Percent_Identity=31.4176245210728, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI23397609, Length=270, Percent_Identity=29.2592592592593, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357673, Length=252, Percent_Identity=29.3650793650794, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=265, Percent_Identity=29.0566037735849, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737361, Length=205, Percent_Identity=30.7317073170732, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571526, Length=272, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=27.0992366412214, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364892, Length=215, Percent_Identity=31.1627906976744, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24649181, Length=174, Percent_Identity=31.6091954022989, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30611; Mature: 30479

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQSVVDEI
CCCCCCEEEEEECCCCCCCHHHHHEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
TAAGGEAVADGSNVADWDQAAGLIQTAVETFGGLDVLVNNAGIVRDRMIANTSEEEFDAV
HHCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCHHHCCEE
IAVHLKGRFATMRHAASYWRGLSKAGEAVDGRIINTSSGAGLQGSVGQGNYSAAKAGIAT
EEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCHHE
LTLVGAAEMGRYGVTVNAIAPSARTRMTETVFAEMMATQDQDFDAMAPENVSPLVVWLGS
EEEECHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
AEARDVTGKVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVADLLAKARPPVPVYG
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
A
C
>Mature Secondary Structure 
GVVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQSVVDEI
CCCCCEEEEEECCCCCCCHHHHHEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
TAAGGEAVADGSNVADWDQAAGLIQTAVETFGGLDVLVNNAGIVRDRMIANTSEEEFDAV
HHCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCHHHCCEE
IAVHLKGRFATMRHAASYWRGLSKAGEAVDGRIINTSSGAGLQGSVGQGNYSAAKAGIAT
EEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCHHE
LTLVGAAEMGRYGVTVNAIAPSARTRMTETVFAEMMATQDQDFDAMAPENVSPLVVWLGS
EEEECHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
AEARDVTGKVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVADLLAKARPPVPVYG
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]