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The map label for this gene is folK

Identifier: 41406550

GI number: 41406550

Start: 480233

End: 480781

Strand: Direct

Name: folK

Synonym: MAP0452

Alternate gene names: 41406550

Gene position: 480233-480781 (Clockwise)

Preceding gene: 41406549

Following gene: 41406551

Centisome position: 9.94

GC content: 73.59

Gene sequence:

>549_bases
ATGACACGCGTTGTCTTATCCATCGGCTCCAATCTGGGGGACCGGCTGGCGCGGCTGCAGTCCGTCGTCGACGGGCTCGG
CGGCGCGGTGCGCGCCATCTCGCCGGTGTACGAAACCCAACCCTGGGGCCGGGTGGATCAGGCGCCGTTTCTCAACGCGG
TGCTGATCGCCGACGACCCGGCCTGCGACGGCCAGGGCTGGCTGCGCCGGGCGCAGGAATTCGAGCGGGCGGCGGGCCGG
GTGCGCGGCGAACGCTGGGGCCCGCGCACCCTCGACGTCGACCTGATCGCCTGCTACGGCGACGGCGAGGTGATCTCCCG
GGAGAACAACCTGACCCTGCCTCATCCGCTGGCGCATCTGCGGGCCTTCGTCCTGATCCCGTGGCTGGCCGTCGACCCGG
ACGCGCAGCTGACGGTGGCCGACGGGCCGCAACCGGTCGCCCGCCTGCTGGCCCAGCTGGACCAGGCCGACCGGGACGGT
GTCCGGCCGACCGGCCTGACGCTGACACCGCCCGCGGGCTCGCCGGCCGATTCGGGGGCGGGCAGCTGA

Upstream 100 bases:

>100_bases
GACGACGATGACGCCGGCGCAGCCGGGGTTGAGGAGCGGCGCCAATGACACGCGACGACGACGATGACGCCGGCGCAGCC
GCGGTTGAGGAGCGGCGCCA

Downstream 100 bases:

>100_bases
TGGGCCCCACCCGCAAGCGTGACCTGACGGCCGCGGTGGTCGGCGCTGCCGTCGTGGGTTATCTGCTGGTCCAGGGCCTG
TATCGGTGGTTCCCGCCGAT

Product: hypothetical protein

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDPACDGQGWLRRAQEFERAAGR
VRGERWGPRTLDVDLIACYGDGEVISRENNLTLPHPLAHLRAFVLIPWLAVDPDAQLTVADGPQPVARLLAQLDQADRDG
VRPTGLTLTPPAGSPADSGAGS

Sequences:

>Translated_182_residues
MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDPACDGQGWLRRAQEFERAAGR
VRGERWGPRTLDVDLIACYGDGEVISRENNLTLPHPLAHLRAFVLIPWLAVDPDAQLTVADGPQPVARLLAQLDQADRDG
VRPTGLTLTPPAGSPADSGAGS
>Mature_181_residues
TRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDPACDGQGWLRRAQEFERAAGRV
RGERWGPRTLDVDLIACYGDGEVISRENNLTLPHPLAHLRAFVLIPWLAVDPDAQLTVADGPQPVARLLAQLDQADRDGV
RPTGLTLTPPAGSPADSGAGS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=147, Percent_Identity=38.0952380952381, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19388; Mature: 19257

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDP
CCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECCC
ACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYGDGEVISRENNLTLPHPLAHL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEECCCCEEECCCCCCCCCHHHHH
RAFVLIPWLAVDPDAQLTVADGPQPVARLLAQLDQADRDGVRPTGLTLTPPAGSPADSGA
HHHHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCC
GS
CC
>Mature Secondary Structure 
TRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPFLNAVLIADDP
CEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECCC
ACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYGDGEVISRENNLTLPHPLAHL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEECCCCEEECCCCCCCCCHHHHH
RAFVLIPWLAVDPDAQLTVADGPQPVARLLAQLDQADRDGVRPTGLTLTPPAGSPADSGA
HHHHHHHHEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]