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The map label for this gene is hpt

Identifier: 41406537

GI number: 41406537

Start: 467053

End: 467664

Strand: Direct

Name: hpt

Synonym: MAP0439

Alternate gene names: 41406537

Gene position: 467053-467664 (Clockwise)

Preceding gene: 41406536

Following gene: 41406539

Centisome position: 9.67

GC content: 66.67

Gene sequence:

>612_bases
GTGGGCGTGGCCCAGATCTCCTCGGCGATCACCCCCGCTCAGCCCGCGGAGCTGTACCCCGGGGATATCAAGTCTGTCCT
GCTGACGGCGGAGCAAATTCAGGCCCGCATCGCCGAACTCGGCCGCGAAATCGGGGACAACTACCGCGACGCCGCGACCG
AGACCGGACAGGACCTGCTGCTGATCACCGTGCTCAAGGGCGCTGTGATCTTTGTCACCGACCTGGCCCGGGCGATTCCG
CTGCCCACCCAGTTCGAATTCATGGCCGTCAGCTCCTACGGGTCGTCGACGTCGTCGTCGGGCGTGGTGCGCATCCTCAA
GGACCTGGACCGTGACATCCAGGGCCGCGACGTGCTGATCGTCGAGGACGTCGTGGACTCGGGGCTGACGCTGTCCTGGC
TGCTGCGCAACCTGAGCACCCGTCATCCGCGGTCGCTGCGGGTGTGCACGCTGTTGCGCAAGCCCGACGCCAGGGGCGCC
CACGTCGACATCGCCTACGTGGGGTTCGACATCCCCAACGACTTCGTGGTGGGATACGGCCTCGACTACGACGAGCGCTA
CCGCGACCTGTCCTACATCGGCACCCTGGACCCCCGGGTCTACCAGCAGTAG

Upstream 100 bases:

>100_bases
CGGGGCGCCGCGACGGCGTGTTGACGCTGTGGCGCGAGCCGGTCCGTTAACCGCAATGCCGGAGCCGCCGTTGGTTATTC
GCCCGCCGGCGTGGCACGCT

Downstream 100 bases:

>100_bases
CTCCCGCTCAGTCCAGCTCCCAGGACGCGGTGACGGTGAACTTCACCGTCTGCTGGCCCGGTTCCAGCGGCACCGCCATC
GGCATCGCGCGCGGCGACGG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MGVAQISSAITPAQPAELYPGDIKSVLLTAEQIQARIAELGREIGDNYRDAATETGQDLLLITVLKGAVIFVTDLARAIP
LPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIQGRDVLIVEDVVDSGLTLSWLLRNLSTRHPRSLRVCTLLRKPDARGA
HVDIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQQ

Sequences:

>Translated_203_residues
MGVAQISSAITPAQPAELYPGDIKSVLLTAEQIQARIAELGREIGDNYRDAATETGQDLLLITVLKGAVIFVTDLARAIP
LPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIQGRDVLIVEDVVDSGLTLSWLLRNLSTRHPRSLRVCTLLRKPDARGA
HVDIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQQ
>Mature_202_residues
GVAQISSAITPAQPAELYPGDIKSVLLTAEQIQARIAELGREIGDNYRDAATETGQDLLLITVLKGAVIFVTDLARAIPL
PTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIQGRDVLIVEDVVDSGLTLSWLLRNLSTRHPRSLRVCTLLRKPDARGAH
VDIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=188, Percent_Identity=34.0425531914894, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4504483, Length=187, Percent_Identity=31.0160427807487, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=50, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17510817, Length=189, Percent_Identity=32.8042328042328, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 22360; Mature: 22228

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVAQISSAITPAQPAELYPGDIKSVLLTAEQIQARIAELGREIGDNYRDAATETGQDLL
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEE
LITVLKGAVIFVTDLARAIPLPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIQGRDVLI
EEEEHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEE
VEDVVDSGLTLSWLLRNLSTRHPRSLRVCTLLRKPDARGAHVDIAYVGFDIPNDFVVGYG
EHHHHCCCCHHHHHHHHHCCCCCCCCCEEHEEECCCCCCCEEEEEEEEECCCCCEEEEEC
LDYDERYRDLSYIGTLDPRVYQQ
CCHHHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure 
GVAQISSAITPAQPAELYPGDIKSVLLTAEQIQARIAELGREIGDNYRDAATETGQDLL
CHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEE
LITVLKGAVIFVTDLARAIPLPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIQGRDVLI
EEEEHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEE
VEDVVDSGLTLSWLLRNLSTRHPRSLRVCTLLRKPDARGAHVDIAYVGFDIPNDFVVGYG
EHHHHCCCCHHHHHHHHHCCCCCCCCCEEHEEECCCCCCCEEEEEEEEECCCCCEEEEEC
LDYDERYRDLSYIGTLDPRVYQQ
CCHHHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA