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The map label for this gene is mcl1 [H]

Identifier: 41406391

GI number: 41406391

Start: 309902

End: 310828

Strand: Direct

Name: mcl1 [H]

Synonym: MAP0293

Alternate gene names: 41406391

Gene position: 309902-310828 (Clockwise)

Preceding gene: 41406390

Following gene: 41406396

Centisome position: 6.42

GC content: 68.72

Gene sequence:

>927_bases
ATGACCCAGCTTCTTCGCCGCTCGGAGCTCGCGGTGCCCGCCAGCAACGACAACATGTTCGACAAGGCCGCCGGAAGCGG
TGCCGACCTGGTGTTCCTCGACCTCGAGGATGCGGTGCCGCCGGCTTTCAAGGAGGAGTCGCGCGGCAAGGCGATCAGCG
CGCTCAACGACCTGGACTGGGGACGCACCGCGCGGGCGGTGCGGATCAACGGCCTCGACACCCCGTGGTGCCACGACGAC
CTCATCGAGGTGGTGACCGCGGCCGGCCGCAACCTCGACACCGTCATCATCCCCAAGGCGCGCCGGGCCCGCGACGTCTG
GTGGGTCGACGTCCTGCTCAGCCAGCTGGAGGCAAAGCTCAACCTGGGCAACAAGATCCGGCTCGAGGTGTTGATCGAGG
AGGTCGAGGGGCTGGCCAACGCCGAAGAGATCGCGGTGGCCAGTCCGCGGTTGGACGCGCTGATCTTCGGCGTCGGCGAC
TTCTCGCTGTCCCAGGGGGCGCGGGTGGACACCAACTTCGTGCCGCTGGGCGAATATCCCGGCGATTTCTGGCAATACGC
CCGCAACAAGGTGATCGTCGCCGCGCGGATCGCCGGCATCGACGCGATCGACGCGCCCTATCCCGACTACCGCGACCTGA
CGGGATATGAGCGCGACGCCCGGCGGGCCGCACTGATGGGATACACCGGCAAATGGGCGATCCACCCCGACCAGGTTCCT
GTCGCCAACCAGGTTTATGCGCCCACCGCCGACGAAATCGCCCGCGCCGAGGCCAATCTCGCCGCCTACCGGGAGGCCGA
GAGCAACGGCCGCGGCGCCGTCGGGGTCAACGGCGTGCTGGTGGACGCCGCGCACGTGAAGATGGCGCAGCAGACGCTGG
CGCGCGCCGCCCTGATCAACGGCACCGGCGGATCGAACGACCGCTAG

Upstream 100 bases:

>100_bases
AGCACAACGCCGAGGTCTACGGGGAGCTGCTCGGCCTCACCCCTGACGAAATCGACCAGCTACGCGCCCGGGGCGTGGTG
TGACAGAAGGAATTTGATCG

Downstream 100 bases:

>100_bases
TCGATCACCATCAGGAGGTCGCCGCCCTCGACTTGAGCGGTCCGCGACACGGCGATGCGCGCCACCTTGCCCGACTTCGG
GCTGGTGACCGCGGCTTCCA

Product: hypothetical protein

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTQLLRRSELAVPASNDNMFDKAAGSGADLVFLDLEDAVPPAFKEESRGKAISALNDLDWGRTARAVRINGLDTPWCHDD
LIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKLNLGNKIRLEVLIEEVEGLANAEEIAVASPRLDALIFGVGD
FSLSQGARVDTNFVPLGEYPGDFWQYARNKVIVAARIAGIDAIDAPYPDYRDLTGYERDARRAALMGYTGKWAIHPDQVP
VANQVYAPTADEIARAEANLAAYREAESNGRGAVGVNGVLVDAAHVKMAQQTLARAALINGTGGSNDR

Sequences:

>Translated_308_residues
MTQLLRRSELAVPASNDNMFDKAAGSGADLVFLDLEDAVPPAFKEESRGKAISALNDLDWGRTARAVRINGLDTPWCHDD
LIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKLNLGNKIRLEVLIEEVEGLANAEEIAVASPRLDALIFGVGD
FSLSQGARVDTNFVPLGEYPGDFWQYARNKVIVAARIAGIDAIDAPYPDYRDLTGYERDARRAALMGYTGKWAIHPDQVP
VANQVYAPTADEIARAEANLAAYREAESNGRGAVGVNGVLVDAAHVKMAQQTLARAALINGTGGSNDR
>Mature_307_residues
TQLLRRSELAVPASNDNMFDKAAGSGADLVFLDLEDAVPPAFKEESRGKAISALNDLDWGRTARAVRINGLDTPWCHDDL
IEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKLNLGNKIRLEVLIEEVEGLANAEEIAVASPRLDALIFGVGDF
SLSQGARVDTNFVPLGEYPGDFWQYARNKVIVAARIAGIDAIDAPYPDYRDLTGYERDARRAALMGYTGKWAIHPDQVPV
ANQVYAPTADEIARAEANLAAYREAESNGRGAVGVNGVLVDAAHVKMAQQTLARAALINGTGGSNDR

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=304, Percent_Identity=31.5789473684211, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI87081764, Length=294, Percent_Identity=31.9727891156463, Blast_Score=110, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17557458, Length=290, Percent_Identity=30.6896551724138, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 33363; Mature: 33232

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLLRRSELAVPASNDNMFDKAAGSGADLVFLDLEDAVPPAFKEESRGKAISALNDLDW
CCCHHHHCCCCCCCCCCCCHHHCCCCCCCEEEEECHHCCCCCCCHHHCCCHHHHHHCCCC
GRTARAVRINGLDTPWCHDDLIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKL
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
NLGNKIRLEVLIEEVEGLANAEEIAVASPRLDALIFGVGDFSLSQGARVDTNFVPLGEYP
CCCCEEEHHHHHHHHHCCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCC
GDFWQYARNKVIVAARIAGIDAIDAPYPDYRDLTGYERDARRAALMGYTGKWAIHPDQVP
HHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCC
VANQVYAPTADEIARAEANLAAYREAESNGRGAVGVNGVLVDAAHVKMAQQTLARAALIN
CCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEEHHHHHHHHHHHHHHHEEE
GTGGSNDR
CCCCCCCC
>Mature Secondary Structure 
TQLLRRSELAVPASNDNMFDKAAGSGADLVFLDLEDAVPPAFKEESRGKAISALNDLDW
CCHHHHCCCCCCCCCCCCHHHCCCCCCCEEEEECHHCCCCCCCHHHCCCHHHHHHCCCC
GRTARAVRINGLDTPWCHDDLIEVVTAAGRNLDTVIIPKARRARDVWWVDVLLSQLEAKL
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
NLGNKIRLEVLIEEVEGLANAEEIAVASPRLDALIFGVGDFSLSQGARVDTNFVPLGEYP
CCCCEEEHHHHHHHHHCCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCC
GDFWQYARNKVIVAARIAGIDAIDAPYPDYRDLTGYERDARRAALMGYTGKWAIHPDQVP
HHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCC
VANQVYAPTADEIARAEANLAAYREAESNGRGAVGVNGVLVDAAHVKMAQQTLARAALIN
CCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEEHHHHHHHHHHHHHHHEEE
GTGGSNDR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA