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The map label for this gene is serS

Identifier: 41406295

GI number: 41406295

Start: 202154

End: 203431

Strand: Direct

Name: serS

Synonym: MAP0197

Alternate gene names: 41406295

Gene position: 202154-203431 (Clockwise)

Preceding gene: 41406292

Following gene: 41406297

Centisome position: 4.19

GC content: 72.38

Gene sequence:

>1278_bases
GTGATCGACCTGAAGCTGCTCCGGGAAGACCCCGACGCCGTGCGCCGCTCCCAACAAAGCCGCGGCGAAGACCCGTCGCT
GGTGGACGCGCTGCTGGCCGCCGACGCCGCCCGCCGGGCCGCCATCTCGACCGCCGACACGCTGCGCGCCGAACAGAAGT
CGGCCAGCAAGAGCGTCGGCGCCGCCTCGCCCGAGCAGCGCCCGGCCCTGCTGGCCCGCGCCAAGGAGCTGGCCGAGCAG
GTCAAGGCCGCCGAAACCGCCCAGGCCGAGGCCGAGGCGGCGTTCACCGCCGCGCACCTGGCCATCTCGAACGTCGTCAT
CGACGGCGTCCCCGCCGGCGGCGAGGACGACTTCGCCGTGCTGGACGTCGTCGGGGAGCCAACGGCGCTGGAAAACCCCC
GCGACCACCTGGAACTGGGCGAGACGCTGGGCCTGATCGACATGGCCCGCGGGGCCAAGGTGTCCGGTTCGCGGTTCTAC
TTCCTGACCGGCAAGGGCGCGCTGCTGCAGCTCGGCCTGCTGCAGCTGGCGCTGCGCCTGGCCGTCGAGAACGGCTTCGT
GCCGATGATCCCGCCGGTGCTGGTGCGCCCGGAGGTGATGGCAGGCACCGGATTCCTGGGCGCGCACGCCGAGGAGGTCT
ACCGGATCGAGGCCGACGACCTCTATCTGGTGGGCACCTCCGAGGTGCCGCTGGCCGGCTACCACGCCGACGAGATCCTG
GACCTGTCCGCCGGCCCGCTGCGCTACGCGGGCTGGTCGTCGTGCTTTCGCCGCGAGGCCGGCAGCTACGGTAAGGACAC
CCGCGGCGTCATCCGGGTGCACCAGTTCGACAAGGTCGAGGGCTTCGTCTACTGCACGCCCGCCGACGCCGAGGCCGAAC
ACCAGCGGCTGCTGGGCTGGCAGCGCGAGATGCTGGCCCGCATCGAGGTGCCCTACCGGGTGATCGACGTGGCCGCGGGC
GATCTCGGCTCGTCGGCGGCGCGCAAGTTCGACTGCGAGGCGTGGGTGCCCACCCAGCAGACCTACCGCGAGCTGACGTC
GACGTCGAACTGCACCACCTTCCAGGCGCGCCGGCTGTCCACCCGCTACCGCGACGGCGGGGACGCCAAGGGCAAGCCGC
AGATCGCGGCCACCCTGAACGGCACGCTGGGCACCACCCGCTGGCTGGTGGCGATCCTGGAAAACCACCAACAGCCCGAC
GGCAGCGTGCGGGTTCCCGAGGCGCTGGTGCCGTTCGTCGGCACCGAGCTGCTCGAGCCCGTCGGCCCGCGCGGCTAG

Upstream 100 bases:

>100_bases
AGCGCCGCAGCGCCGTTACAAAAGTTACTGATGTGAGTCCTGAGGCTCCAGGGGGGTGCTGCGCCGGTCGGCCGGGCCGG
GTGAAAGTAGGCTTCGGGCC

Downstream 100 bases:

>100_bases
GACGGGCGGGGGGCGAGCCGGCCCGGGGTGTGCCCGAACGCGCGTCGGTAGGTGTCGATGAACGCACTCGGTGTGGCCCA
ACCGCATTCGGCCGCCACCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MIDLKLLREDPDAVRRSQQSRGEDPSLVDALLAADAARRAAISTADTLRAEQKSASKSVGAASPEQRPALLARAKELAEQ
VKAAETAQAEAEAAFTAAHLAISNVVIDGVPAGGEDDFAVLDVVGEPTALENPRDHLELGETLGLIDMARGAKVSGSRFY
FLTGKGALLQLGLLQLALRLAVENGFVPMIPPVLVRPEVMAGTGFLGAHAEEVYRIEADDLYLVGTSEVPLAGYHADEIL
DLSAGPLRYAGWSSCFRREAGSYGKDTRGVIRVHQFDKVEGFVYCTPADAEAEHQRLLGWQREMLARIEVPYRVIDVAAG
DLGSSAARKFDCEAWVPTQQTYRELTSTSNCTTFQARRLSTRYRDGGDAKGKPQIAATLNGTLGTTRWLVAILENHQQPD
GSVRVPEALVPFVGTELLEPVGPRG

Sequences:

>Translated_425_residues
MIDLKLLREDPDAVRRSQQSRGEDPSLVDALLAADAARRAAISTADTLRAEQKSASKSVGAASPEQRPALLARAKELAEQ
VKAAETAQAEAEAAFTAAHLAISNVVIDGVPAGGEDDFAVLDVVGEPTALENPRDHLELGETLGLIDMARGAKVSGSRFY
FLTGKGALLQLGLLQLALRLAVENGFVPMIPPVLVRPEVMAGTGFLGAHAEEVYRIEADDLYLVGTSEVPLAGYHADEIL
DLSAGPLRYAGWSSCFRREAGSYGKDTRGVIRVHQFDKVEGFVYCTPADAEAEHQRLLGWQREMLARIEVPYRVIDVAAG
DLGSSAARKFDCEAWVPTQQTYRELTSTSNCTTFQARRLSTRYRDGGDAKGKPQIAATLNGTLGTTRWLVAILENHQQPD
GSVRVPEALVPFVGTELLEPVGPRG
>Mature_425_residues
MIDLKLLREDPDAVRRSQQSRGEDPSLVDALLAADAARRAAISTADTLRAEQKSASKSVGAASPEQRPALLARAKELAEQ
VKAAETAQAEAEAAFTAAHLAISNVVIDGVPAGGEDDFAVLDVVGEPTALENPRDHLELGETLGLIDMARGAKVSGSRFY
FLTGKGALLQLGLLQLALRLAVENGFVPMIPPVLVRPEVMAGTGFLGAHAEEVYRIEADDLYLVGTSEVPLAGYHADEIL
DLSAGPLRYAGWSSCFRREAGSYGKDTRGVIRVHQFDKVEGFVYCTPADAEAEHQRLLGWQREMLARIEVPYRVIDVAAG
DLGSSAARKFDCEAWVPTQQTYRELTSTSNCTTFQARRLSTRYRDGGDAKGKPQIAATLNGTLGTTRWLVAILENHQQPD
GSVRVPEALVPFVGTELLEPVGPRG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=463, Percent_Identity=33.0453563714903, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI8923421, Length=355, Percent_Identity=38.8732394366197, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI225579074, Length=337, Percent_Identity=39.7626112759644, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=37.7011494252874, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17539260, Length=471, Percent_Identity=32.2717622080679, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=33.4384858044164, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=32.3529411764706, Blast_Score=242, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6321799, Length=286, Percent_Identity=36.7132867132867, Blast_Score=206, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24581334, Length=461, Percent_Identity=32.3210412147505, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17737985, Length=283, Percent_Identity=36.0424028268551, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 45741; Mature: 45741

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKLLREDPDAVRRSQQSRGEDPSLVDALLAADAARRAAISTADTLRAEQKSASKSVG
CCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AASPEQRPALLARAKELAEQVKAAETAQAEAEAAFTAAHLAISNVVIDGVPAGGEDDFAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEE
LDVVGEPTALENPRDHLELGETLGLIDMARGAKVSGSRFYFLTGKGALLQLGLLQLALRL
EEECCCCCCCCCCHHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
AVENGFVPMIPPVLVRPEVMAGTGFLGAHAEEVYRIEADDLYLVGTSEVPLAGYHADEIL
HHHCCCCCCCCCHHCCCCHHCCCCCCCCCHHHEEEEECCCEEEEECCCCCCCCCCHHHHE
DLSAGPLRYAGWSSCFRREAGSYGKDTRGVIRVHQFDKVEGFVYCTPADAEAEHQRLLGW
ECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHH
QREMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQQTYRELTSTSNCTTFQARRLS
HHHHHHHHCCCEEEEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
TRYRDGGDAKGKPQIAATLNGTLGTTRWLVAILENHQQPDGSVRVPEALVPFVGTELLEP
HHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHCC
VGPRG
CCCCC
>Mature Secondary Structure
MIDLKLLREDPDAVRRSQQSRGEDPSLVDALLAADAARRAAISTADTLRAEQKSASKSVG
CCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AASPEQRPALLARAKELAEQVKAAETAQAEAEAAFTAAHLAISNVVIDGVPAGGEDDFAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEE
LDVVGEPTALENPRDHLELGETLGLIDMARGAKVSGSRFYFLTGKGALLQLGLLQLALRL
EEECCCCCCCCCCHHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
AVENGFVPMIPPVLVRPEVMAGTGFLGAHAEEVYRIEADDLYLVGTSEVPLAGYHADEIL
HHHCCCCCCCCCHHCCCCHHCCCCCCCCCHHHEEEEECCCEEEEECCCCCCCCCCHHHHE
DLSAGPLRYAGWSSCFRREAGSYGKDTRGVIRVHQFDKVEGFVYCTPADAEAEHQRLLGW
ECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHH
QREMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQQTYRELTSTSNCTTFQARRLS
HHHHHHHHCCCEEEEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
TRYRDGGDAKGKPQIAATLNGTLGTTRWLVAILENHQQPDGSVRVPEALVPFVGTELLEP
HHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHCC
VGPRG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA