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The map label for this gene is gyaR [H]

Identifier: 41406227

GI number: 41406227

Start: 136726

End: 137781

Strand: Direct

Name: gyaR [H]

Synonym: MAP0129

Alternate gene names: 41406227

Gene position: 136726-137781 (Clockwise)

Preceding gene: 41406225

Following gene: 41406228

Centisome position: 2.83

GC content: 72.16

Gene sequence:

>1056_bases
ATGCGCATTCGCGGTTCAACCGCGTCCCGACGCGATTCCTTCCCGCATCGCCGCGTCGGCGATGATGGAGGCGTGGCGGT
GACAAAGCTCAGCGGCGTGTTCCGGGTCGGCGAATTGGAGCCGGCGTTCGCAGAAGAGCTGGCCGCGCGCTACGACGTCC
CGAGACTGCCCGACGGCGCCGCGCGCGACCGGTTCCTGGCCGAGCACGCCGCCGAGGTGCGGGCGCTGCTGACCTGGGGA
CGGCCCGGAGTGGACGCCGCCCTGATCGCGGCGTTGCCCAACCTGGAGGTCATCGTCAACAACGGCGCCGGCGTGGACCT
GATCGACACCGCGGCCGCCGACCGCCGCGGAATCGGCGTCAGCAACACCCCGGACGTGCTCTCCGATACCGTCGCCGACA
CCGCGCTGGGCCTGATCCTCATGACGCTGCGCCGGTTGGGCGCCGCCGACCGGTATGTGCGGGCCGGGCGGTGGGCGCGC
GAGGGGCCGTTCCCGTACGGCCGGGACGTCAGCGGGCTCCAGGTCGGCATCCTGGGCCTGGGGCGCATCGGCTCGGCGAT
CGCTACCAGGCTGCGCGGATTCGACTGCGCCATCGCCTATCACAACCGCCGCCGCATCGACGGCTCCCCGTATCGCTATG
CCGCCTCCGCCGTCGAGCTCGCCGAATCGGTCGACGTGCTGGTGGTCGCCACCACCGGCGACCACCAGGCCCACAAACTC
GTCGACCGCGCCGTGCTGCGCGCCCTGGGCCCCGAGGGTTACCTGATCAACATCGCCCGGGGCAGCGTCGTCGACCAGGA
GGCGCTGGTGGAGATGCTGGCCGGCGGTGAACTGGCCGGCGCTGGGCTGGACGTGTTCGCCGACGAGCCGCACGTGCCCG
CCGAGTTGGTCGGCCTGGACAACGTGGTGCTGCTGCCGCACGTCGGCAGCGCCACCGCCCGGACCCGGCGGGCGATGGCT
TCGTTGGCGCTGCGCAATCTCGACAGCTACCTGGCCACGGGTCAACTGGTGACGCCGGTGCTGCGGCCGCGCCGCCGGAT
TCCGGACCGCAACTGA

Upstream 100 bases:

>100_bases
GGCCAGGATGTGGGTGAACCCGAGCTCCTCGACCCGCTGCGCGTAGCTGCGCAGCACCGCGGGGTCCGATCCGATCTCGG
TCTGGGGGAAGACGACTCCG

Downstream 100 bases:

>100_bases
TCCGTGGTCGAAGCGATACCCGGAAAAGGTTATCGCCGCCCCCGCAACGGGGTATGCGGCACTCATGAGCCCACTACCGT
CGCAGACTGCCACGCCGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MRIRGSTASRRDSFPHRRVGDDGGVAVTKLSGVFRVGELEPAFAEELAARYDVPRLPDGAARDRFLAEHAAEVRALLTWG
RPGVDAALIAALPNLEVIVNNGAGVDLIDTAAADRRGIGVSNTPDVLSDTVADTALGLILMTLRRLGAADRYVRAGRWAR
EGPFPYGRDVSGLQVGILGLGRIGSAIATRLRGFDCAIAYHNRRRIDGSPYRYAASAVELAESVDVLVVATTGDHQAHKL
VDRAVLRALGPEGYLINIARGSVVDQEALVEMLAGGELAGAGLDVFADEPHVPAELVGLDNVVLLPHVGSATARTRRAMA
SLALRNLDSYLATGQLVTPVLRPRRRIPDRN

Sequences:

>Translated_351_residues
MRIRGSTASRRDSFPHRRVGDDGGVAVTKLSGVFRVGELEPAFAEELAARYDVPRLPDGAARDRFLAEHAAEVRALLTWG
RPGVDAALIAALPNLEVIVNNGAGVDLIDTAAADRRGIGVSNTPDVLSDTVADTALGLILMTLRRLGAADRYVRAGRWAR
EGPFPYGRDVSGLQVGILGLGRIGSAIATRLRGFDCAIAYHNRRRIDGSPYRYAASAVELAESVDVLVVATTGDHQAHKL
VDRAVLRALGPEGYLINIARGSVVDQEALVEMLAGGELAGAGLDVFADEPHVPAELVGLDNVVLLPHVGSATARTRRAMA
SLALRNLDSYLATGQLVTPVLRPRRRIPDRN
>Mature_351_residues
MRIRGSTASRRDSFPHRRVGDDGGVAVTKLSGVFRVGELEPAFAEELAARYDVPRLPDGAARDRFLAEHAAEVRALLTWG
RPGVDAALIAALPNLEVIVNNGAGVDLIDTAAADRRGIGVSNTPDVLSDTVADTALGLILMTLRRLGAADRYVRAGRWAR
EGPFPYGRDVSGLQVGILGLGRIGSAIATRLRGFDCAIAYHNRRRIDGSPYRYAASAVELAESVDVLVVATTGDHQAHKL
VDRAVLRALGPEGYLINIARGSVVDQEALVEMLAGGELAGAGLDVFADEPHVPAELVGLDNVVLLPHVGSATARTRRAMA
SLALRNLDSYLATGQLVTPVLRPRRRIPDRN

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=40.8906882591093, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI23308577, Length=276, Percent_Identity=32.2463768115942, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=246, Percent_Identity=28.0487804878049, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI145580578, Length=244, Percent_Identity=28.6885245901639, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4557499, Length=244, Percent_Identity=28.6885245901639, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4557497, Length=246, Percent_Identity=28.0487804878049, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082289, Length=264, Percent_Identity=39.3939393939394, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789279, Length=311, Percent_Identity=26.6881028938907, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=25.4980079681275, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=254, Percent_Identity=32.2834645669291, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=247, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=317, Percent_Identity=34.7003154574132, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322116, Length=296, Percent_Identity=26.0135135135135, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=296, Percent_Identity=26.0135135135135, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=270, Percent_Identity=26.2962962962963, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324964, Length=269, Percent_Identity=23.7918215613383, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=195, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45552429, Length=271, Percent_Identity=36.90036900369, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574284, Length=271, Percent_Identity=36.90036900369, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585514, Length=271, Percent_Identity=36.90036900369, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574282, Length=271, Percent_Identity=36.90036900369, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=36.90036900369, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574286, Length=275, Percent_Identity=34.5454545454545, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=38.0769230769231, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585516, Length=276, Percent_Identity=31.1594202898551, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646446, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646448, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646452, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646450, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI62472511, Length=246, Percent_Identity=32.1138211382114, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19921140, Length=229, Percent_Identity=28.82096069869, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37418; Mature: 37418

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRGSTASRRDSFPHRRVGDDGGVAVTKLSGVFRVGELEPAFAEELAARYDVPRLPDGA
CCCCCCCCHHHCCCCCCCCCCCCCEEEEEECCEEEECCCCHHHHHHHHHHCCCCCCCCCH
ARDRFLAEHAAEVRALLTWGRPGVDAALIAALPNLEVIVNNGAGVDLIDTAAADRRGIGV
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCEEHHCCCCCCCCCC
SNTPDVLSDTVADTALGLILMTLRRLGAADRYVRAGRWAREGPFPYGRDVSGLQVGILGL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEH
GRIGSAIATRLRGFDCAIAYHNRRRIDGSPYRYAASAVELAESVDVLVVATTGDHQAHKL
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
VDRAVLRALGPEGYLINIARGSVVDQEALVEMLAGGELAGAGLDVFADEPHVPAELVGLD
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHCCC
NVVLLPHVGSATARTRRAMASLALRNLDSYLATGQLVTPVLRPRRRIPDRN
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRIRGSTASRRDSFPHRRVGDDGGVAVTKLSGVFRVGELEPAFAEELAARYDVPRLPDGA
CCCCCCCCHHHCCCCCCCCCCCCCEEEEEECCEEEECCCCHHHHHHHHHHCCCCCCCCCH
ARDRFLAEHAAEVRALLTWGRPGVDAALIAALPNLEVIVNNGAGVDLIDTAAADRRGIGV
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCEEHHCCCCCCCCCC
SNTPDVLSDTVADTALGLILMTLRRLGAADRYVRAGRWAREGPFPYGRDVSGLQVGILGL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEH
GRIGSAIATRLRGFDCAIAYHNRRRIDGSPYRYAASAVELAESVDVLVVATTGDHQAHKL
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
VDRAVLRALGPEGYLINIARGSVVDQEALVEMLAGGELAGAGLDVFADEPHVPAELVGLD
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHCCC
NVVLLPHVGSATARTRRAMASLALRNLDSYLATGQLVTPVLRPRRRIPDRN
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA