Click here to switch to the map view.

The map label for this gene is fadD33_1

Identifier: 41406124

GI number: 41406124

Start: 27908

End: 29464

Strand: Direct

Name: fadD33_1

Synonym: MAP0026

Alternate gene names: 41406124

Gene position: 27908-29464 (Clockwise)

Preceding gene: 41406123

Following gene: 41406125

Centisome position: 0.58

GC content: 69.3

Gene sequence:

>1557_bases
ATGAACGCCCTCGCCGCCGCGATGCGCGACGCGATGACACGATCACCGCACGACCTGGTGGTCCTGGACAAAGACTCCGA
CACATGGCGGTCCTGCCCCTGGCCCGAGGTACACGGCATGGCCGAAAGCATCGCCGCGCGTCTGCTTCAGCGGGACCGGC
TGGGAGCCGTGGGCCTGGTCGGTGAGCCGACCGTCGAACTGATCGCCGCCATTCAGGGTGCGTGGTTGGCCGGCGTCGCG
GTGTCCCTTCTCCCCCGGCCGCGGCGGGGCGCCGACCCGTCGGAATGGGCGCACAGCACCCTGCAGCGCTTCGGCGGGAT
CGGCGTCGACACGGTGCTGAGTCATGGCGGTGTGCTGCGCACCTTGGCCGCCGCCGACTCCGCCGTTTCCGTTTGCGACC
TGGCCCAGGCGGCTCGCACCCCGACGTCGACCGGCCTTGAGTACCAAGATGATTCGGGCGTTGCGATCCTGCAGGGCACG
GCGGGCTCGACGGGGAACCCGCGCACGGCGGTGCTGTCGCCGGCCGCGGTGTTGAGCAATATGCGCGGCCTCATCGAGCG
CCTGCGGCTCGACGGTGCTTCGGATCGGGCATGTTCGTGGCTGCCGCTCTACCACGACATGGGGTTGGCGTTCCTGCTCA
CCTCCGCGCTCAGCGGCATGCCACTCTGGCAGGCGCCGACGGGCGCCTTCTCGGCGGCGCCGCTGCGCTGGGCGGAGTGG
CTGTCCGACAGCCAGGCAACGTTCACCGCCGGCCCCAATTTCGGCTACTCGATGATCGGTCGCTACTCGGGGAGGGTGCG
CGACGTTGACCTCGGGGCGCTGCGGATTGCGATCAACGGGGGCGAACCGGTGGATTGCGAGGGGTTCCAGCGGTTCGCAA
CGGCGATGGCGCCGTTCGGCTTTCGGGCAGCGGCCGCCACTCCGGCCTACGGGATGGCCGAGGCGACGTGTGCGGTGACG
ATGCCCGGCTGCGGAGAGGGATTGCAGATCGACGAGCGAACGGAATCCGGTGTCCGCCAACGGTATGCCCTGCTGGGCGG
ACCCATCGCCGGGATGGAGCTACGCATAGCTGCGACCGACGAGCCGTCCGGCGAGGGCGTCGGGGAGGTCGAGATCCGCG
GATCGTCGACGATGACCGGCTATTTGGGCGACACGACGGGCCGATCCGACGGTGATTGGTTCCCGACCGGGGACATCGGC
TATCTGGTCGACGGCGCGCTGGTCATCTGCGGTCGGTCCAAAGAGGTCATCACCGTTGCCGGCCGCAACATCTTTCCCAC
CGAGATCGAACAGGTGGCCGCGCAAGTGGACGGCGTGCGGCACGGCGGCGTGGTCGCGGTGGGATCCAAATCCGGTGCGG
CACAATCCCGATTGCTGATCGCGGCCGAGTTCGTCGGAGCGGACCGTGATGTGACGCGCAGCGCCGTCATCAAGCGGGTC
ATCTCGGTCTGCGGGGTGACACCGGCGGACGTCGTGCTGATGCCGCCGGGGTCGCTGCCGCGCACGTCGTCGGGCAAACT
CAGGCGACTCGAGGTGCGCCGCCAACTGCTGGGCTGA

Upstream 100 bases:

>100_bases
CCATCGAAGAACGCTTCGGTACGCAGTTGAGCGAGGAAGACCTGCTGTATTGCACGACCGTCGGCGACCTGCAGTCCGCG
ATCGCCGCCAGGGTCAACGC

Downstream 100 bases:

>100_bases
GCGGACGGTTTTCGGCCGACCTGGCGGTTGTTCGGCTGTAGTGAATTGACCGGTGCGCCCGCGCCAGTACCCTCATGAGC
AGTTTGGGAGGGTTGCAGAT

Product: long-chain-fatty-acid--[acyl-carrier-protein] ligase

Products: NA

Alternate protein names: Fatty acyl-[acyl-carrier-protein] synthetase; Fatty acyl-ACP synthetase; Mycobactin synthetase protein M [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNALAAAMRDAMTRSPHDLVVLDKDSDTWRSCPWPEVHGMAESIAARLLQRDRLGAVGLVGEPTVELIAAIQGAWLAGVA
VSLLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLRTLAAADSAVSVCDLAQAARTPTSTGLEYQDDSGVAILQGT
AGSTGNPRTAVLSPAAVLSNMRGLIERLRLDGASDRACSWLPLYHDMGLAFLLTSALSGMPLWQAPTGAFSAAPLRWAEW
LSDSQATFTAGPNFGYSMIGRYSGRVRDVDLGALRIAINGGEPVDCEGFQRFATAMAPFGFRAAAATPAYGMAEATCAVT
MPGCGEGLQIDERTESGVRQRYALLGGPIAGMELRIAATDEPSGEGVGEVEIRGSSTMTGYLGDTTGRSDGDWFPTGDIG
YLVDGALVICGRSKEVITVAGRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSGAAQSRLLIAAEFVGADRDVTRSAVIKRV
ISVCGVTPADVVLMPPGSLPRTSSGKLRRLEVRRQLLG

Sequences:

>Translated_518_residues
MNALAAAMRDAMTRSPHDLVVLDKDSDTWRSCPWPEVHGMAESIAARLLQRDRLGAVGLVGEPTVELIAAIQGAWLAGVA
VSLLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLRTLAAADSAVSVCDLAQAARTPTSTGLEYQDDSGVAILQGT
AGSTGNPRTAVLSPAAVLSNMRGLIERLRLDGASDRACSWLPLYHDMGLAFLLTSALSGMPLWQAPTGAFSAAPLRWAEW
LSDSQATFTAGPNFGYSMIGRYSGRVRDVDLGALRIAINGGEPVDCEGFQRFATAMAPFGFRAAAATPAYGMAEATCAVT
MPGCGEGLQIDERTESGVRQRYALLGGPIAGMELRIAATDEPSGEGVGEVEIRGSSTMTGYLGDTTGRSDGDWFPTGDIG
YLVDGALVICGRSKEVITVAGRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSGAAQSRLLIAAEFVGADRDVTRSAVIKRV
ISVCGVTPADVVLMPPGSLPRTSSGKLRRLEVRRQLLG
>Mature_518_residues
MNALAAAMRDAMTRSPHDLVVLDKDSDTWRSCPWPEVHGMAESIAARLLQRDRLGAVGLVGEPTVELIAAIQGAWLAGVA
VSLLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLRTLAAADSAVSVCDLAQAARTPTSTGLEYQDDSGVAILQGT
AGSTGNPRTAVLSPAAVLSNMRGLIERLRLDGASDRACSWLPLYHDMGLAFLLTSALSGMPLWQAPTGAFSAAPLRWAEW
LSDSQATFTAGPNFGYSMIGRYSGRVRDVDLGALRIAINGGEPVDCEGFQRFATAMAPFGFRAAAATPAYGMAEATCAVT
MPGCGEGLQIDERTESGVRQRYALLGGPIAGMELRIAATDEPSGEGVGEVEIRGSSTMTGYLGDTTGRSDGDWFPTGDIG
YLVDGALVICGRSKEVITVAGRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSGAAQSRLLIAAEFVGADRDVTRSAVIKRV
ISVCGVTPADVVLMPPGSLPRTSSGKLRRLEVRRQLLG

Specific function: Activates lipidic moieties required for mycobactin biosynthesis. Converts medium- to long-chain aliphatic fatty acids into acyl adenylate, which is further transferred on to the phosphopantetheine arm of the carrier protein MbtL [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1788107, Length=378, Percent_Identity=26.4550264550265, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=475, Percent_Identity=27.1578947368421, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=420, Percent_Identity=24.5238095238095, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=395, Percent_Identity=23.2911392405063, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24581924, Length=370, Percent_Identity=25.4054054054054, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.20 [H]

Molecular weight: Translated: 54231; Mature: 54231

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALAAAMRDAMTRSPHDLVVLDKDSDTWRSCPWPEVHGMAESIAARLLQRDRLGAVGLV
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECC
GEPTVELIAAIQGAWLAGVAVSLLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCHHH
TLAAADSAVSVCDLAQAARTPTSTGLEYQDDSGVAILQGTAGSTGNPRTAVLSPAAVLSN
HHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEECHHHHHHH
MRGLIERLRLDGASDRACSWLPLYHDMGLAFLLTSALSGMPLWQAPTGAFSAAPLRWAEW
HHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LSDSQATFTAGPNFGYSMIGRYSGRVRDVDLGALRIAINGGEPVDCEGFQRFATAMAPFG
HCCCCEEEECCCCCCHHHHHHCCCCEEEEECEEEEEEECCCCCCCHHHHHHHHHHHCCCC
FRAAAATPAYGMAEATCAVTMPGCGEGLQIDERTESGVRQRYALLGGPIAGMELRIAATD
CHHHCCCCCCCCCCCEEEEECCCCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEEEEECC
EPSGEGVGEVEIRGSSTMTGYLGDTTGRSDGDWFPTGDIGYLVDGALVICGRSKEVITVA
CCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHEECCEEEEECCCCCEEEEE
GRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSGAAQSRLLIAAEFVGADRDVTRSAVIKRV
CCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHEEEEEEEHHCCCCHHHHHHHHHHH
ISVCGVTPADVVLMPPGSLPRTSSGKLRRLEVRRQLLG
HHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNALAAAMRDAMTRSPHDLVVLDKDSDTWRSCPWPEVHGMAESIAARLLQRDRLGAVGLV
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECC
GEPTVELIAAIQGAWLAGVAVSLLPRPRRGADPSEWAHSTLQRFGGIGVDTVLSHGGVLR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCHHH
TLAAADSAVSVCDLAQAARTPTSTGLEYQDDSGVAILQGTAGSTGNPRTAVLSPAAVLSN
HHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEECHHHHHHH
MRGLIERLRLDGASDRACSWLPLYHDMGLAFLLTSALSGMPLWQAPTGAFSAAPLRWAEW
HHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LSDSQATFTAGPNFGYSMIGRYSGRVRDVDLGALRIAINGGEPVDCEGFQRFATAMAPFG
HCCCCEEEECCCCCCHHHHHHCCCCEEEEECEEEEEEECCCCCCCHHHHHHHHHHHCCCC
FRAAAATPAYGMAEATCAVTMPGCGEGLQIDERTESGVRQRYALLGGPIAGMELRIAATD
CHHHCCCCCCCCCCCEEEEECCCCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEEEEECC
EPSGEGVGEVEIRGSSTMTGYLGDTTGRSDGDWFPTGDIGYLVDGALVICGRSKEVITVA
CCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHEECCEEEEECCCCCEEEEE
GRNIFPTEIEQVAAQVDGVRHGGVVAVGSKSGAAQSRLLIAAEFVGADRDVTRSAVIKRV
CCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHEEEEEEEHHCCCCHHHHHHHHHHH
ISVCGVTPADVVLMPPGSLPRTSSGKLRRLEVRRQLLG
HHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]