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The map label for this gene is gyrA

Identifier: 41406104

GI number: 41406104

Start: 7303

End: 9822

Strand: Direct

Name: gyrA

Synonym: MAP0006

Alternate gene names: 41406104

Gene position: 7303-9822 (Clockwise)

Preceding gene: 41406103

Following gene: 41406105

Centisome position: 0.15

GC content: 67.98

Gene sequence:

>2520_bases
ATGACTGACACCACGCTGCCACCCGGCGGTGACGCCGCCGACCGCGTCGAACCGGTCGACATCCAGCAGGAGATGCAGCG
CAGCTACATCGATTACGCGATGAGCGTAATCGTCGGCCGCGCGCTGCCCGAGGTGCGCGACGGCCTCAAGCCGGTGCACC
GCCGGGTACTTTACGCCATGTACGACTCGGGTTTCCGCCCGGACCGCAGCCACGCCAAGTCGGCGCGGTCGGTCGCCGAG
ACGATGGGCAACTACCACCCGCACGGCGACGCCTCGATCTACGACACCCTGGTGCGGATGGCCCAGCCGTGGTCGCTGCG
CTACCCGTTGGTCGACGGGCAGGGCAACTTTGGTTCGCCGGGCAACGACCCGCCGGCCGCGATGCGGTACACCGAGGCGC
GGCTGACCCCGCTGGCCATGGAGATGCTGCGCGAAATCGACGAGGAGACAGTCGATTTCATTCCCAACTACGACGGCCGG
GTGCAAGAGCCGACGGTGCTGCCCAGCCGGTTCCCCAACCTGCTGGCCAACGGGTCGGGGGGCATCGCGGTCGGCATGGC
CACGAACATCCCGCCGCACAACCTCGGCGAGCTCGCCGAGGCGGTGTTCTGGGCGCTGGACAATTACGAGGCCGACGAAG
AGGCCACCCTGGCCGCCGTGATGGAACGGGTGAAAGGACCCGACTTCCCGACCTCCGGCCTGATCGTCGGCACGCAGGGC
ATCGCCGACGCCTACAAGACCGGCCGCGGTTCCATCCGGATGCGCGGAGTCGTTGAGGTGGAAGAGGATTCGCGCGGCCG
CACCTCGCTGGTCATCACCGAGTTGCCGTATCAGGTCAACCACGACAACTTCATCACCTCGATCGCCGAGCAGGTGCGCG
ACGGCAAGCTGGCCGGCATCTCCAATATCGAGGACCAATCCAGCGACCGGGTCGGGCTGCGCATCGTCATCGAGCTCAAG
CGCGACGCCGTCGCCAAGGTGGTGCTGAACAACCTCTACAAGCACACCCAGCTGCAGACCAGCTTCGGCGCCAACATGCT
GGCCATCGTCGACGGGGTGCCGCGCACCCTGCGGCTCGACCAGCTGATCCGCCACTACGTCGACCACCAACTCGACGTCA
TCGTCCGGCGCACCACCTACCGGTTGCGCAAGGCCAACGAGCGGGCCCACATCCTGCGCGGTCTGGTCAAGGCGCTCGAT
GCGCTCGACGAGGTCATCGCCCTGATCCGGGCGTCGGAAACCGTCGACATCGCGCGGCAGGGCTTGATCGAGCTGCTCGA
CATCGACGAGATCCAGGCGCAGGCGATCCTGGACATGCAGCTGCGCCGGCTGGCCGCGCTGGAGCGGCAGCGCATCATCG
ACGACCTGGCCAAGATCGAGGCCGAGATCGCCGACCTGGAGGACATCCTGGCCAAGCCGGAACGGCAGCGCGGCATCGTG
CGCGACGAGCTCGCCGAGATCGTCGAAAAGCACGGCGACGCGCGGCGCACCCGGATCGTGGCCGCCGACGGCGACGTTAG
CGACGAGGATCTGATCGCTCGCGAGGACGTCGTCGTCACCATCACCGAGACCGGCTACGCCAAGCGCACCAAGACCGACC
TGTACCGCAGCCAGAAGCGCGGCGGCAAGGGCGTGCAGGGCGCCGGCCTCAACCAGGACGACATCGTGCGGCACTTCTTC
GTGTGCTCGACGCACGACTGGATCCTGTTCTTCACCACCCAGGGCCGGGTCTACCGCGCCAAGGCCTACGAACTGCCCGA
GGCGTCCCGCACCGCCCGCGGTCAGCACGTGGCCAACCTGCTGGCGTTCCAGCCCGAGGAGCGGATCGCTCAGGTGATCC
AGATCCGGAGCTATGAGGACGCTCCCTACCTGGTGCTGGCCACCCGCAACGGCCTGGTGAAGAAGACCAAGCTGACCGAC
TTCGACTCGAACCGCTCGGGCGGCATCGTGGCGATCAACCTGCGCGACAACGACGAACTCGTGGGCGCGGTGTTGTGCTC
GGCCGAGGACGATCTGCTGCTGGTGTCGGCCAACGGCCAGTCCATCCGGTTCTCGGCGACCGACGAGGCGCTGCGCCCGA
TGGGCCGCGCCACCTCCGGTGTGCAGGGCATGCGCTTCAACGCCGACGACTACCTGCTGTCGCTCAACGTGGTCCGCGAG
GGCACCTACCTGCTGGTGGCGACGTCCGGCGGGTACGCCAAGCGCACCGCGATCGAGGAGTATCCGGTGCAGGGCCGCGG
CGGCAAGGGCGTGCTGACCGTGATGTATGACCGCCGCCGTGGCAGGCTGGTGGGTGCGCTGATTGTGGACGAGGACAGCG
AGCTGTACGCGATCACCTCCGGCGGCGGTGTCATCCGCACCGCGGCGGGCCAGGTCCGTAAGGCGGGACGGCAGACCAAG
GGCGTCCGGCTGATGAATCTGGGTGAGGGCGACACGCTGCTGGCCATCGCTCGCAACGCCGAGGAAGCCGCGGACGAGGC
CGTCGACGAGAGCGACGGTGCCGCGGGGTCGGACGGCTAG

Upstream 100 bases:

>100_bases
TGTTCTCCATCCTGATGGGCGAGGACGTCGACGCGCGCCGCAGCTTCATCACCCGCAATGCCAAAGACGTTCGCTTCCTA
GACGTTTAAACGAGGAATAG

Downstream 100 bases:

>100_bases
CCGGTACCGCGCCACCGGGTCCGGGCAATAGACTCAGCCGGACCACACATAACGCGACTGCCACTGCCCTGGGCGGCCGG
CTAGGAGACTTAAGGAGTCG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 839; Mature: 838

Protein sequence:

>839_residues
MTDTTLPPGGDAADRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAE
TMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGR
VQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLGELAEAVFWALDNYEADEEATLAAVMERVKGPDFPTSGLIVGTQG
IADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIELK
RDAVAKVVLNNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRHYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALD
ALDEVIALIRASETVDIARQGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIV
RDELAEIVEKHGDARRTRIVAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLNQDDIVRHFF
VCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRNGLVKKTKLTD
FDSNRSGGIVAINLRDNDELVGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDYLLSLNVVRE
GTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDEDSELYAITSGGGVIRTAAGQVRKAGRQTK
GVRLMNLGEGDTLLAIARNAEEAADEAVDESDGAAGSDG

Sequences:

>Translated_839_residues
MTDTTLPPGGDAADRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAE
TMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGR
VQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLGELAEAVFWALDNYEADEEATLAAVMERVKGPDFPTSGLIVGTQG
IADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIELK
RDAVAKVVLNNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRHYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALD
ALDEVIALIRASETVDIARQGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIV
RDELAEIVEKHGDARRTRIVAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLNQDDIVRHFF
VCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRNGLVKKTKLTD
FDSNRSGGIVAINLRDNDELVGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDYLLSLNVVRE
GTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDEDSELYAITSGGGVIRTAAGQVRKAGRQTK
GVRLMNLGEGDTLLAIARNAEEAADEAVDESDGAAGSDG
>Mature_838_residues
TDTTLPPGGDAADRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAET
MGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRV
QEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLGELAEAVFWALDNYEADEEATLAAVMERVKGPDFPTSGLIVGTQGI
ADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIELKR
DAVAKVVLNNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRHYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDA
LDEVIALIRASETVDIARQGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVR
DELAEIVEKHGDARRTRIVAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLNQDDIVRHFFV
CSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRNGLVKKTKLTDF
DSNRSGGIVAINLRDNDELVGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDYLLSLNVVREG
TYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDEDSELYAITSGGGVIRTAAGQVRKAGRQTKG
VRLMNLGEGDTLLAIARNAEEAADEAVDESDGAAGSDG

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=377, Percent_Identity=25.7294429708223, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913408, Length=359, Percent_Identity=25.0696378830084, Blast_Score=84, Evalue=7e-16,
Organism=Escherichia coli, GI1788562, Length=861, Percent_Identity=45.7607433217189, Blast_Score=754, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=692, Percent_Identity=34.8265895953757, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=368, Percent_Identity=25, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=332, Percent_Identity=24.6987951807229, Blast_Score=74, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=31.3253012048193, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=322, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=324, Percent_Identity=25.3086419753086, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92314; Mature: 92182

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTLPPGGDAADRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAM
CCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSP
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEECCCCCCCCC
GNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSG
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHHHCCCCC
GIAVGMATNIPPHNLGELAEAVFWALDNYEADEEATLAAVMERVKGPDFPTSGLIVGTQG
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCH
IADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGI
HHHHHHCCCCCEEEEEEEEECCCCCCCEEEEEEECCCEECCCHHHHHHHHHHCCCCCCCC
SNIEDQSSDRVGLRIVIELKRDAVAKVVLNNLYKHTQLQTSFGANMLAIVDGVPRTLRLD
CCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
QLIRHYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARQ
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCH
RDELAEIVEKHGDARRTRIVAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKR
HHHHHHHHHHCCCCHHEEEEEECCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHC
GGKGVQGAGLNQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANL
CCCCCCCCCCCHHHHHHHHHEEECCCEEEEEECCCEEEEEEECCCCCHHHHHCHHHHHHH
LAFQPEERIAQVIQIRSYEDAPYLVLATRNGLVKKTKLTDFDSNRSGGIVAINLRDNDEL
HHCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCE
VGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDYLLSLNVVRE
EEEEEECCCCCEEEEECCCCEEEEECCHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEC
GTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDEDSELYAITS
CCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCEEEEEC
GGGVIRTAAGQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEEAADEAVDESDGAAGSDG
CCCEEEHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDTTLPPGGDAADRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAM
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSP
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEECCCCCCCCC
GNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSG
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHHHCCCCC
GIAVGMATNIPPHNLGELAEAVFWALDNYEADEEATLAAVMERVKGPDFPTSGLIVGTQG
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCH
IADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGI
HHHHHHCCCCCEEEEEEEEECCCCCCCEEEEEEECCCEECCCHHHHHHHHHHCCCCCCCC
SNIEDQSSDRVGLRIVIELKRDAVAKVVLNNLYKHTQLQTSFGANMLAIVDGVPRTLRLD
CCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
QLIRHYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARQ
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCH
RDELAEIVEKHGDARRTRIVAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKR
HHHHHHHHHHCCCCHHEEEEEECCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHC
GGKGVQGAGLNQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANL
CCCCCCCCCCCHHHHHHHHHEEECCCEEEEEECCCEEEEEEECCCCCHHHHHCHHHHHHH
LAFQPEERIAQVIQIRSYEDAPYLVLATRNGLVKKTKLTDFDSNRSGGIVAINLRDNDEL
HHCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCE
VGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDYLLSLNVVRE
EEEEEECCCCCEEEEECCCCEEEEECCHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEC
GTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDEDSELYAITS
CCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCEEEEEC
GGGVIRTAAGQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEEAADEAVDESDGAAGSDG
CCCEEEHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8031045; 9634230; 12218036; 8294019; 8035042 [H]