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The map label for this gene is tkt [H]

Identifier: 39998512

GI number: 39998512

Start: 3767539

End: 3769545

Strand: Reverse

Name: tkt [H]

Synonym: GSU3423

Alternate gene names: 39998512

Gene position: 3769545-3767539 (Counterclockwise)

Preceding gene: 39998515

Following gene: 39998511

Centisome position: 98.83

GC content: 69.51

Gene sequence:

>2007_bases
ATGGCCGCGGTAAGCCTTACCAACGAAGATGCCCGCCTGGGCGCCGATACCCTCAGGATGCTGGCGGTGGACGCGGTTGA
AGCCGCCGCCTCCGGTCACCCGGGGCTGCCCATGGGGGCCGCCGACTACGCCTTTCTCCTCTGGCACTCCCACCTCCGCT
TCGACCCCGCCGACCCGGAGTGGCCGGGGAGGGACCGGTTCATCCTCTCGGCGGGGCATGGTTCCATGCTTCTCTACGGT
CTGCTCCACCTCTTCGGCTTCGATCTTCCCCTGGATGAACTGAAGCGGTTCCGCCAGTGGGGGAGCCGCACCCCGGGCCA
TCCGGAATACGGCCATACCCCCGGCGTGGAGGTGACCACCGGTCCCCTGGGGCAGGGGTTCGCCATGGGGGTCGGCATGG
CCCTGGCGGCGCGCATGGGCTCGGCCCGCTTTGCCGACGAGCGGTTTGATCCCTGCGCCCACCACATCTACGCCTTGGTG
AGCGACGGCGACCTCATGGAGGGAGTCAGCCAGGAGGCGGCATCCCTGGCCGGTCACCTGAAGCTCGGCAACCTGGTCTA
CCTGTACGACGACAACCGGATCACCATCGAGGGTTCCACGGACCTCGCCTTTTCCGAAGACACGGCGGGGCGCTTCGCGG
CTCTTGGCTGGCACGTGCAGGCCGTTGACGGCCACGATGTCCGCCAGGTGGACGAGGCCCTCTGGCGGGCCCGGGTGGAA
CGGGAGCGGCCCTCCCTCATCATCGCCCGGACCCATATCGCCCAGGGCTCGCCCGGCAAGCACGACTCCGCCGCCGCCCA
CGGCTCGCCCCTGGGTGCCGAGGAGGCCGCAGCCACGCGCAGGAGCCTGGGGTGGCCCGATGAGTTGTTTCACGTGCCGG
AGCGGATTCGGGAGCTCTGCGAACAGAGGCGGGAAGCGCTCGCCGAGGCGCGCGCCGCCTGGCAGGATGAGCTCCGCCGC
TGGCGCCGCCGCAATTCCGACAAGGGACGGCTCTGGGATCTGATGGCGGAAAAGGGGGTGCCCAGGGATCTGGAGTCCCG
GCTGCTGGCGGCGGTGGGAGCCGAAGCCGGCGCCACGCGCTCCCTTGCGGGCAAGGTCCTCCAGGCGGCCGCCGCCGTAG
TGCCCTCCCTGGTCGGGGGCTCGGCGGACCTCGAGCCCTCCACCAACACCCGGATCAAGGATTCCTCCTCCGTGCTCCCC
GGTAGCTACGGGGGGCGCAATCTTCACTTCGGCGTGCGCGAGCATGCCATGGCCGCAATCATGAACGGCATGGCCCGCCA
CGGCGGGTTCATCCCCTACGGCGCCACCTTCCTGGTCTTTGCCGACTACTGCCGGCCGGCTATCCGGTTGGCGGCGCTCA
TGAAGCAGCAGGCGGTGTACGTGTTCACCCACGATTCCCTCTTCGTGGGTGAGGACGGTCCCACCCACCAGCCCGTGGAG
CAGCTCTCGTCACTGCGGCTCATCCCTAACCTCCGGGTGATCCGGCCAGCGGACGGCCCCGAAACGGCCTTGGCCTGGGC
TGCGGCTCTGCGGCGCACGGACGGCCCCACGGCCCTTGTCCTGACCCGCCAGAAAGTGCCGGCCATCGCCCGGGAGGAGA
CCCTTGACCCCAGAACCTTTGCCAAGGGGGGCTACGTGGTCCGTTCCGGCGGGGCGGCCCCGGCCGTGGTTCTCATGGCG
AGCGGGTCCGAGGTAGGACTGGCTCTGGCCGCGGCAGAGATTATGGCCGGTAACGGGGTTGCGGCTCGCGTGGTATCTAT
CCCCTGTATGGAGGCATTCCTGGCCCAGCCGGAAAGCTACCGGCGCCGCTGTCTGCCGGGACGTGTCCCACGAGTTGCGG
TGGAGGCGGGGCACGGCGGCCTCTGGTGGCGGCTCCTGGGTCCGGCTGGCCTGTTCATTGGCCTGGAGACCTTCGGCGCT
TCGGCCCCGGAAAAGGTACTGGCCGAGCAGTACGGTTTCACCCCTGAGCTGGTTGCCCGGCGTGTGGCCGAGTTCGTGGA
GCGCTGA

Upstream 100 bases:

>100_bases
TGAGGTCGTGTTTGTCGGACATGGCATGGTTCTCCCTGGTTCTGACAGTGTACCCGAATGCGTGCGTTTGAGAAGTACGT
TATGGCAACAAGGAGGATTC

Downstream 100 bases:

>100_bases
GACACCGTGGGTACCAGATCGAAACGGAGCGAGCGCTGTGCGCGGTGCCGCTTGCATATCCACCGGTGCGTCTGCCCGGC
TATGCCGCGGTATTCCCTTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MAAVSLTNEDARLGADTLRMLAVDAVEAAASGHPGLPMGAADYAFLLWHSHLRFDPADPEWPGRDRFILSAGHGSMLLYG
LLHLFGFDLPLDELKRFRQWGSRTPGHPEYGHTPGVEVTTGPLGQGFAMGVGMALAARMGSARFADERFDPCAHHIYALV
SDGDLMEGVSQEAASLAGHLKLGNLVYLYDDNRITIEGSTDLAFSEDTAGRFAALGWHVQAVDGHDVRQVDEALWRARVE
RERPSLIIARTHIAQGSPGKHDSAAAHGSPLGAEEAAATRRSLGWPDELFHVPERIRELCEQRREALAEARAAWQDELRR
WRRRNSDKGRLWDLMAEKGVPRDLESRLLAAVGAEAGATRSLAGKVLQAAAAVVPSLVGGSADLEPSTNTRIKDSSSVLP
GSYGGRNLHFGVREHAMAAIMNGMARHGGFIPYGATFLVFADYCRPAIRLAALMKQQAVYVFTHDSLFVGEDGPTHQPVE
QLSSLRLIPNLRVIRPADGPETALAWAAALRRTDGPTALVLTRQKVPAIAREETLDPRTFAKGGYVVRSGGAAPAVVLMA
SGSEVGLALAAAEIMAGNGVAARVVSIPCMEAFLAQPESYRRRCLPGRVPRVAVEAGHGGLWWRLLGPAGLFIGLETFGA
SAPEKVLAEQYGFTPELVARRVAEFVER

Sequences:

>Translated_668_residues
MAAVSLTNEDARLGADTLRMLAVDAVEAAASGHPGLPMGAADYAFLLWHSHLRFDPADPEWPGRDRFILSAGHGSMLLYG
LLHLFGFDLPLDELKRFRQWGSRTPGHPEYGHTPGVEVTTGPLGQGFAMGVGMALAARMGSARFADERFDPCAHHIYALV
SDGDLMEGVSQEAASLAGHLKLGNLVYLYDDNRITIEGSTDLAFSEDTAGRFAALGWHVQAVDGHDVRQVDEALWRARVE
RERPSLIIARTHIAQGSPGKHDSAAAHGSPLGAEEAAATRRSLGWPDELFHVPERIRELCEQRREALAEARAAWQDELRR
WRRRNSDKGRLWDLMAEKGVPRDLESRLLAAVGAEAGATRSLAGKVLQAAAAVVPSLVGGSADLEPSTNTRIKDSSSVLP
GSYGGRNLHFGVREHAMAAIMNGMARHGGFIPYGATFLVFADYCRPAIRLAALMKQQAVYVFTHDSLFVGEDGPTHQPVE
QLSSLRLIPNLRVIRPADGPETALAWAAALRRTDGPTALVLTRQKVPAIAREETLDPRTFAKGGYVVRSGGAAPAVVLMA
SGSEVGLALAAAEIMAGNGVAARVVSIPCMEAFLAQPESYRRRCLPGRVPRVAVEAGHGGLWWRLLGPAGLFIGLETFGA
SAPEKVLAEQYGFTPELVARRVAEFVER
>Mature_667_residues
AAVSLTNEDARLGADTLRMLAVDAVEAAASGHPGLPMGAADYAFLLWHSHLRFDPADPEWPGRDRFILSAGHGSMLLYGL
LHLFGFDLPLDELKRFRQWGSRTPGHPEYGHTPGVEVTTGPLGQGFAMGVGMALAARMGSARFADERFDPCAHHIYALVS
DGDLMEGVSQEAASLAGHLKLGNLVYLYDDNRITIEGSTDLAFSEDTAGRFAALGWHVQAVDGHDVRQVDEALWRARVER
ERPSLIIARTHIAQGSPGKHDSAAAHGSPLGAEEAAATRRSLGWPDELFHVPERIRELCEQRREALAEARAAWQDELRRW
RRRNSDKGRLWDLMAEKGVPRDLESRLLAAVGAEAGATRSLAGKVLQAAAAVVPSLVGGSADLEPSTNTRIKDSSSVLPG
SYGGRNLHFGVREHAMAAIMNGMARHGGFIPYGATFLVFADYCRPAIRLAALMKQQAVYVFTHDSLFVGEDGPTHQPVEQ
LSSLRLIPNLRVIRPADGPETALAWAAALRRTDGPTALVLTRQKVPAIAREETLDPRTFAKGGYVVRSGGAAPAVVLMAS
GSEVGLALAAAEIMAGNGVAARVVSIPCMEAFLAQPESYRRRCLPGRVPRVAVEAGHGGLWWRLLGPAGLFIGLETFGAS
APEKVLAEQYGFTPELVARRVAEFVER

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=576, Percent_Identity=27.6041666666667, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4507521, Length=576, Percent_Identity=27.6041666666667, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI133778974, Length=271, Percent_Identity=32.8413284132841, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI225637459, Length=619, Percent_Identity=23.1017770597738, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI225637463, Length=588, Percent_Identity=22.9591836734694, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI225637461, Length=588, Percent_Identity=22.9591836734694, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=47.175572519084, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=45.6060606060606, Blast_Score=577, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17539652, Length=592, Percent_Identity=27.7027027027027, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=41.7664670658683, Blast_Score=504, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=39.1952309985097, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45551847, Length=672, Percent_Identity=26.3392857142857, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45550715, Length=672, Percent_Identity=26.3392857142857, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24645119, Length=633, Percent_Identity=26.0663507109005, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24666278, Length=662, Percent_Identity=23.8670694864048, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72005; Mature: 71873

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVSLTNEDARLGADTLRMLAVDAVEAAASGHPGLPMGAADYAFLLWHSHLRFDPADPE
CCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
WPGRDRFILSAGHGSMLLYGLLHLFGFDLPLDELKRFRQWGSRTPGHPEYGHTPGVEVTT
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEC
GPLGQGFAMGVGMALAARMGSARFADERFDPCAHHIYALVSDGDLMEGVSQEAASLAGHL
CCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHE
KLGNLVYLYDDNRITIEGSTDLAFSEDTAGRFAALGWHVQAVDGHDVRQVDEALWRARVE
EECCEEEEEECCEEEEECCCCCEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
RERPSLIIARTHIAQGSPGKHDSAAAHGSPLGAEEAAATRRSLGWPDELFHVPERIRELC
HCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EQRREALAEARAAWQDELRRWRRRNSDKGRLWDLMAEKGVPRDLESRLLAAVGAEAGATR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHH
SLAGKVLQAAAAVVPSLVGGSADLEPSTNTRIKDSSSVLPGSYGGRNLHFGVREHAMAAI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
MNGMARHGGFIPYGATFLVFADYCRPAIRLAALMKQQAVYVFTHDSLFVGEDGPTHQPVE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECEEEECCCCCCCHHHH
QLSSLRLIPNLRVIRPADGPETALAWAAALRRTDGPTALVLTRQKVPAIAREETLDPRTF
HHHHEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCCHHC
AKGGYVVRSGGAAPAVVLMASGSEVGLALAAAEIMAGNGVAARVVSIPCMEAFLAQPESY
CCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCHHH
RRRCLPGRVPRVAVEAGHGGLWWRLLGPAGLFIGLETFGASAPEKVLAEQYGFTPELVAR
HHHCCCCCCCEEEEECCCCCEEEEEECCCHHEEEHHHHCCCCHHHHHHHHHCCCHHHHHH
RVAEFVER
HHHHHHCC
>Mature Secondary Structure 
AAVSLTNEDARLGADTLRMLAVDAVEAAASGHPGLPMGAADYAFLLWHSHLRFDPADPE
CEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
WPGRDRFILSAGHGSMLLYGLLHLFGFDLPLDELKRFRQWGSRTPGHPEYGHTPGVEVTT
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEC
GPLGQGFAMGVGMALAARMGSARFADERFDPCAHHIYALVSDGDLMEGVSQEAASLAGHL
CCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHE
KLGNLVYLYDDNRITIEGSTDLAFSEDTAGRFAALGWHVQAVDGHDVRQVDEALWRARVE
EECCEEEEEECCEEEEECCCCCEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
RERPSLIIARTHIAQGSPGKHDSAAAHGSPLGAEEAAATRRSLGWPDELFHVPERIRELC
HCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EQRREALAEARAAWQDELRRWRRRNSDKGRLWDLMAEKGVPRDLESRLLAAVGAEAGATR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHH
SLAGKVLQAAAAVVPSLVGGSADLEPSTNTRIKDSSSVLPGSYGGRNLHFGVREHAMAAI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
MNGMARHGGFIPYGATFLVFADYCRPAIRLAALMKQQAVYVFTHDSLFVGEDGPTHQPVE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECEEEECCCCCCCHHHH
QLSSLRLIPNLRVIRPADGPETALAWAAALRRTDGPTALVLTRQKVPAIAREETLDPRTF
HHHHEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCCHHC
AKGGYVVRSGGAAPAVVLMASGSEVGLALAAAEIMAGNGVAARVVSIPCMEAFLAQPESY
CCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCHHH
RRRCLPGRVPRVAVEAGHGGLWWRLLGPAGLFIGLETFGASAPEKVLAEQYGFTPELVAR
HHHCCCCCCCEEEEECCCCCEEEEEECCCHHEEEHHHHCCCCHHHHHHHHHCCCHHHHHH
RVAEFVER
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]