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The map label for this gene is livH [H]

Identifier: 39998483

GI number: 39998483

Start: 3731341

End: 3732216

Strand: Reverse

Name: livH [H]

Synonym: GSU3394

Alternate gene names: 39998483

Gene position: 3732216-3731341 (Counterclockwise)

Preceding gene: 39998484

Following gene: 39998482

Centisome position: 97.85

GC content: 61.64

Gene sequence:

>876_bases
ATGCTCCTGCAGCAGCTCATCAACGGGATCGCCCTCGGCAGCACCTATGCGCTCATCGCCTTGGGCTACACCATGGTCTA
CGGCATCATCGCCCTCATCAACTTCGCCCATGGAGAAATATTCATGGCGGGCGCGTTCGTGGGCCTGCTGATGGTAGCCG
TGTTCAAGATGAACATCTTCGTGGCCATGATCCTTGCCATGGCAACCTGCATGGTCATGGGGGTGGTCATCGAGTTGATC
GCCTACCGGCCCCTCAGGAAGTCGTCGCGGCTGTCGGCGCTCATCTCGGCCATCGGCGTCTCCATCTTCCTCTCGACTCT
GGCACTCATGATCTTCGGTGCCGACGCCAAGGGTTTCCCCGACACCGCCTTCCCGGTCCGGCAGGTGAAGGTCCTTGGGG
CCGAGATCTCGACCCTCCAACTCCTCATCATCGGCGTTTCGGCCCTCCTCATGCTCGGCCTCGAGTTCATCGTCCAGAAA
ACCAAGATCGGCAAGGCCATGCGCGCCACCTCCGAAGACTACAACACGGCAGCCCTCATGGGGATCAACGTGAACCGCGT
GATCTCCTTCACCTTTGCCCTCGGATCCTCCCTGGCGGCTGCCGGCGGGGTGCTGGTGGGGCTCCTGTTCAACGCGGTAA
GCTTCAACATGGGGCTCATGGCAGGGCTCAAGGCTTTCTCGGCCGCAGTCCTCGGCGGGATCGGCTCCATTCCCGGCGCC
ATGCTCGGCGGGCTGCTCCTGGGCGTGGCTGAGGTCATGGGGGTAGCTGCCGGGTATTCGTCCTACCGCGATGCCATCGC
CTTCGCGATACTTGTCCTGGTCCTCCTGGTAAAGCCCACGGGCCTGCTGGGGCAGAAAATTCAGAAAAAGGTGTAA

Upstream 100 bases:

>100_bases
GACGGTTTGACCGTTCAGGGGGGACTCCCCCGCACTCGCAGTTCGTTTCACCAATCCCAATAATACGTCATCGCTACACC
CCGGCGCAGAGAGGAACCGC

Downstream 100 bases:

>100_bases
CGAGCGTATGGGAGAGTCCCTGCAGAGTATCGTCAACCTGGTTGACCCATATACCCTCCAGATCCTGGTGAACATCGGGA
TCGCCATTGTCCTGGCCCTG

Product: branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLLQQLINGIALGSTYALIALGYTMVYGIIALINFAHGEIFMAGAFVGLLMVAVFKMNIFVAMILAMATCMVMGVVIELI
AYRPLRKSSRLSALISAIGVSIFLSTLALMIFGADAKGFPDTAFPVRQVKVLGAEISTLQLLIIGVSALLMLGLEFIVQK
TKIGKAMRATSEDYNTAALMGINVNRVISFTFALGSSLAAAGGVLVGLLFNAVSFNMGLMAGLKAFSAAVLGGIGSIPGA
MLGGLLLGVAEVMGVAAGYSSYRDAIAFAILVLVLLVKPTGLLGQKIQKKV

Sequences:

>Translated_291_residues
MLLQQLINGIALGSTYALIALGYTMVYGIIALINFAHGEIFMAGAFVGLLMVAVFKMNIFVAMILAMATCMVMGVVIELI
AYRPLRKSSRLSALISAIGVSIFLSTLALMIFGADAKGFPDTAFPVRQVKVLGAEISTLQLLIIGVSALLMLGLEFIVQK
TKIGKAMRATSEDYNTAALMGINVNRVISFTFALGSSLAAAGGVLVGLLFNAVSFNMGLMAGLKAFSAAVLGGIGSIPGA
MLGGLLLGVAEVMGVAAGYSSYRDAIAFAILVLVLLVKPTGLLGQKIQKKV
>Mature_291_residues
MLLQQLINGIALGSTYALIALGYTMVYGIIALINFAHGEIFMAGAFVGLLMVAVFKMNIFVAMILAMATCMVMGVVIELI
AYRPLRKSSRLSALISAIGVSIFLSTLALMIFGADAKGFPDTAFPVRQVKVLGAEISTLQLLIIGVSALLMLGLEFIVQK
TKIGKAMRATSEDYNTAALMGINVNRVISFTFALGSSLAAAGGVLVGLLFNAVSFNMGLMAGLKAFSAAVLGGIGSIPGA
MLGGLLLGVAEVMGVAAGYSSYRDAIAFAILVLVLLVKPTGLLGQKIQKKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=301, Percent_Identity=47.1760797342193, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30264; Mature: 30264

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLQQLINGIALGSTYALIALGYTMVYGIIALINFAHGEIFMAGAFVGLLMVAVFKMNIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VAMILAMATCMVMGVVIELIAYRPLRKSSRLSALISAIGVSIFLSTLALMIFGADAKGFP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTAFPVRQVKVLGAEISTLQLLIIGVSALLMLGLEFIVQKTKIGKAMRATSEDYNTAALM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GINVNRVISFTFALGSSLAAAGGVLVGLLFNAVSFNMGLMAGLKAFSAAVLGGIGSIPGA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
MLGGLLLGVAEVMGVAAGYSSYRDAIAFAILVLVLLVKPTGLLGQKIQKKV
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MLLQQLINGIALGSTYALIALGYTMVYGIIALINFAHGEIFMAGAFVGLLMVAVFKMNIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VAMILAMATCMVMGVVIELIAYRPLRKSSRLSALISAIGVSIFLSTLALMIFGADAKGFP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTAFPVRQVKVLGAEISTLQLLIIGVSALLMLGLEFIVQKTKIGKAMRATSEDYNTAALM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GINVNRVISFTFALGSSLAAAGGVLVGLLFNAVSFNMGLMAGLKAFSAAVLGGIGSIPGA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
MLGGLLLGVAEVMGVAAGYSSYRDAIAFAILVLVLLVKPTGLLGQKIQKKV
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]