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The map label for this gene is livM [H]

Identifier: 39998482

GI number: 39998482

Start: 3730410

End: 3731333

Strand: Reverse

Name: livM [H]

Synonym: GSU3393

Alternate gene names: 39998482

Gene position: 3731333-3730410 (Counterclockwise)

Preceding gene: 39998483

Following gene: 39998481

Centisome position: 97.83

GC content: 60.06

Gene sequence:

>924_bases
ATGGGAGAGTCCCTGCAGAGTATCGTCAACCTGGTTGACCCATATACCCTCCAGATCCTGGTGAACATCGGGATCGCCAT
TGTCCTGGCCCTGGGACTCAACGTCATTACCGGCATCACCGGCCAGCTCTCACTGGGGCACGCGGCGTTCATGAGTATCG
GCGCCTTCACCAGTGCCGTGATAACCCTGCGCACGGGGCTTCCCTTCAGCGCCAATCTCCTCCTCTCCGGACTGATAACC
GCCTTTGTCGGCGCAGCCATCGGCTATCCCATTCTCCGGCTCACCGGCGACTATCTGGCCATCTGTACCCTCGGTTTCGC
CGAGATCGTCAAGGTTGTCTTTCTTAATCTCGACATCACCAACAAGGCCTTGGGGTTGTCGGTTCCCCCGGCCCGGTCGC
CGATCCCGATGCCGATCATCGTCTGGGTGGTGGCAATACTCTCGATCATCTTCGTCTGCTTCATGAAGGAGTCACGCTTC
GGCCGGGCGCTGAAGGCGATCCGCGACGACGAGATCGCCGCCGAGGCAATGGGGATCAACATCGCCCGCTACAAGGTCCA
ATCCTTTGCCGTCGGCTCATTTCTGGCCGGGGTGGGGGGATGCCTGTACGCTCATTTTCTCAGTTACATCAATCCATCAG
ACTTCGGCTTCCTCAAGTCGGTCGACATCCTGAGCATGGTCGTTCTCGGAGGGCTCGGCAGCATTGCCGGCACCGTCTTC
GGCGCGTCCATCCTGGCGGCGGCCCCGGAGTTCCTTCGCTTCATGTCCCAGTACCGGATGCTCGTCTACGGTGGATTGCT
CGTCTTCCTCATGGTATTCCGCCCCAACGGCCTGCTCGGCGGAATCAACTTCACCGACCTGGTGCTGCGGGCCATCGGCC
GCAAGCCCGCTACGGCGGAAGTCAATGAACGGCACAGAAAATAA

Upstream 100 bases:

>100_bases
TACCGCGATGCCATCGCCTTCGCGATACTTGTCCTGGTCCTCCTGGTAAAGCCCACGGGCCTGCTGGGGCAGAAAATTCA
GAAAAAGGTGTAACGAGCGT

Downstream 100 bases:

>100_bases
ACGGATTGGCGAGGTTCCATGTCGCTTCTGAAACTCGATAACGTAACCATCCGCTTCGGCGGTCTGGTGGCCGTCGACAG
CGTCAACCTGACGGTGGAGC

Product: branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGESLQSIVNLVDPYTLQILVNIGIAIVLALGLNVITGITGQLSLGHAAFMSIGAFTSAVITLRTGLPFSANLLLSGLIT
AFVGAAIGYPILRLTGDYLAICTLGFAEIVKVVFLNLDITNKALGLSVPPARSPIPMPIIVWVVAILSIIFVCFMKESRF
GRALKAIRDDEIAAEAMGINIARYKVQSFAVGSFLAGVGGCLYAHFLSYINPSDFGFLKSVDILSMVVLGGLGSIAGTVF
GASILAAAPEFLRFMSQYRMLVYGGLLVFLMVFRPNGLLGGINFTDLVLRAIGRKPATAEVNERHRK

Sequences:

>Translated_307_residues
MGESLQSIVNLVDPYTLQILVNIGIAIVLALGLNVITGITGQLSLGHAAFMSIGAFTSAVITLRTGLPFSANLLLSGLIT
AFVGAAIGYPILRLTGDYLAICTLGFAEIVKVVFLNLDITNKALGLSVPPARSPIPMPIIVWVVAILSIIFVCFMKESRF
GRALKAIRDDEIAAEAMGINIARYKVQSFAVGSFLAGVGGCLYAHFLSYINPSDFGFLKSVDILSMVVLGGLGSIAGTVF
GASILAAAPEFLRFMSQYRMLVYGGLLVFLMVFRPNGLLGGINFTDLVLRAIGRKPATAEVNERHRK
>Mature_306_residues
GESLQSIVNLVDPYTLQILVNIGIAIVLALGLNVITGITGQLSLGHAAFMSIGAFTSAVITLRTGLPFSANLLLSGLITA
FVGAAIGYPILRLTGDYLAICTLGFAEIVKVVFLNLDITNKALGLSVPPARSPIPMPIIVWVVAILSIIFVCFMKESRFG
RALKAIRDDEIAAEAMGINIARYKVQSFAVGSFLAGVGGCLYAHFLSYINPSDFGFLKSVDILSMVVLGGLGSIAGTVFG
ASILAAAPEFLRFMSQYRMLVYGGLLVFLMVFRPNGLLGGINFTDLVLRAIGRKPATAEVNERHRK

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=287, Percent_Identity=35.191637630662, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789866, Length=279, Percent_Identity=27.2401433691756, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 32675; Mature: 32544

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGESLQSIVNLVDPYTLQILVNIGIAIVLALGLNVITGITGQLSLGHAAFMSIGAFTSAV
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ITLRTGLPFSANLLLSGLITAFVGAAIGYPILRLTGDYLAICTLGFAEIVKVVFLNLDIT
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
NKALGLSVPPARSPIPMPIIVWVVAILSIIFVCFMKESRFGRALKAIRDDEIAAEAMGIN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IARYKVQSFAVGSFLAGVGGCLYAHFLSYINPSDFGFLKSVDILSMVVLGGLGSIAGTVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
GASILAAAPEFLRFMSQYRMLVYGGLLVFLMVFRPNGLLGGINFTDLVLRAIGRKPATAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCC
VNERHRK
HHHHCCC
>Mature Secondary Structure 
GESLQSIVNLVDPYTLQILVNIGIAIVLALGLNVITGITGQLSLGHAAFMSIGAFTSAV
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH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HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]