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The map label for this gene is hemH

Identifier: 39998401

GI number: 39998401

Start: 3636130

End: 3637083

Strand: Reverse

Name: hemH

Synonym: GSU3312

Alternate gene names: 39998401

Gene position: 3637083-3636130 (Counterclockwise)

Preceding gene: 39998402

Following gene: 39998399

Centisome position: 95.36

GC content: 61.74

Gene sequence:

>954_bases
ATGTCCGACAAAACCGCTGTCCTGCTCCTCCAGATGGGAGGTCCCGATTCCCTCGACGCCGTGGAGCCGTTCCTGCTGAA
CCTTTTCTCCGACCGGGACATCATCCGGATCGGTCCCGCCTTTCTCCAGCCGTTCATCGCTCGGCTCATCGCCAAGCGCC
GCTCGCCGGGGGTGGAGCGCAAATACGAGGAGATCGGCGGCAAATCACCCATCCGCGAGCTGACCGAGAGCCAGGCCCGG
GCACTGGAGGATGTGCTGGGGGACGGGTATCGCTGCTTCGTGGCCATGCGCTACTGGAAACCCTCAACCATGGAGGCGCT
GGCGGCCATCAGGAGGGAGGGGATTTCGCGGGTGATTGCGCTTTCCCTCTACCCCCACTACTCCCGTGCCACCACCGGCT
CGAGCGTGAATGAACTGAAGCGGGTGCTGTCTCAATCGGGTGTGCAGTTCCAGATGATGTACGTGGACCGTTTTTTCGAC
CACCCCCTTTACATTGATGCCCTGGCAGAGAAAATCCGGGAAGGGCTCGACGATTTCCACCCCCTGGCCGAGGTGCAGGT
CCTGTTTTCGGCCCATTCGCTCCCTCAATCCTTCATCGACGAGGGTGACCCCTACCTGGACCATATCCGGGAGACGGTAC
GTCTCGTCATGGAGCGGTTCGAGGGGGTCACCCACCATCTGGCCTTCCAGTCCCGGGCAGGGCCGGTCAAGTGGCTGGAA
CCCTCAACCGACGAGATGCTGGAGCACCTGGCGGCCCACCAGGTGAAAAACCTGCTCATCGTTCCGCTTTCCTTTGTCTC
GGACCATATCGAAACCCTGCACGAGATTGACATCGAGTATGCCCAGGAGGCGCATAAGCTGGGCTATTCCCGGTTCCGGC
GGAGCCCTTCCCTCAACACGTCGCCCACTTTTATCTCCTGCCTGGCGGATCTGGTGCGGCGGGTGGAGGGCTGA

Upstream 100 bases:

>100_bases
AGGCACCCCGTTTCCGCCTTGACCGCAGTCGTTCATTAGGGTATCAGGGAGGAAGATGTGGGTGTCATGAAATTGTCCGT
TTGCCATGCCGGAGGTGACC

Downstream 100 bases:

>100_bases
GGGGGGGACGGAGCCAGCCGCCGGCGCAGGCGCAAAGCTCAGTGGGGAGTGTAGGGCTGCTGGCTCTTGGAAACAAGGAA
GTAGACCACCCCGAGGACCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSDKTAVLLLQMGGPDSLDAVEPFLLNLFSDRDIIRIGPAFLQPFIARLIAKRRSPGVERKYEEIGGKSPIRELTESQAR
ALEDVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIALSLYPHYSRATTGSSVNELKRVLSQSGVQFQMMYVDRFFD
HPLYIDALAEKIREGLDDFHPLAEVQVLFSAHSLPQSFIDEGDPYLDHIRETVRLVMERFEGVTHHLAFQSRAGPVKWLE
PSTDEMLEHLAAHQVKNLLIVPLSFVSDHIETLHEIDIEYAQEAHKLGYSRFRRSPSLNTSPTFISCLADLVRRVEG

Sequences:

>Translated_317_residues
MSDKTAVLLLQMGGPDSLDAVEPFLLNLFSDRDIIRIGPAFLQPFIARLIAKRRSPGVERKYEEIGGKSPIRELTESQAR
ALEDVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIALSLYPHYSRATTGSSVNELKRVLSQSGVQFQMMYVDRFFD
HPLYIDALAEKIREGLDDFHPLAEVQVLFSAHSLPQSFIDEGDPYLDHIRETVRLVMERFEGVTHHLAFQSRAGPVKWLE
PSTDEMLEHLAAHQVKNLLIVPLSFVSDHIETLHEIDIEYAQEAHKLGYSRFRRSPSLNTSPTFISCLADLVRRVEG
>Mature_316_residues
SDKTAVLLLQMGGPDSLDAVEPFLLNLFSDRDIIRIGPAFLQPFIARLIAKRRSPGVERKYEEIGGKSPIRELTESQARA
LEDVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIALSLYPHYSRATTGSSVNELKRVLSQSGVQFQMMYVDRFFDH
PLYIDALAEKIREGLDDFHPLAEVQVLFSAHSLPQSFIDEGDPYLDHIRETVRLVMERFEGVTHHLAFQSRAGPVKWLEP
STDEMLEHLAAHQVKNLLIVPLSFVSDHIETLHEIDIEYAQEAHKLGYSRFRRSPSLNTSPTFISCLADLVRRVEG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=322, Percent_Identity=43.4782608695652, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI60499025, Length=322, Percent_Identity=43.4782608695652, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324750, Length=322, Percent_Identity=38.5093167701863, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17864156, Length=321, Percent_Identity=38.3177570093458, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=37.109375, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI45552018, Length=162, Percent_Identity=40.1234567901235, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_GEOSL (Q747F5)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954352.1
- ProteinModelPortal:   Q747F5
- SMR:   Q747F5
- GeneID:   2686646
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3312
- NMPDR:   fig|243231.1.peg.3290
- TIGR:   GSU3312
- HOGENOM:   HBG697135
- OMA:   EWLEPST
- ProtClustDB:   CLSK790160
- BioCyc:   GSUL243231:GSU_3312-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36024; Mature: 35893

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKTAVLLLQMGGPDSLDAVEPFLLNLFSDRDIIRIGPAFLQPFIARLIAKRRSPGVER
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCHHH
KYEEIGGKSPIRELTESQARALEDVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIA
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHH
LSLYPHYSRATTGSSVNELKRVLSQSGVQFQMMYVDRFFDHPLYIDALAEKIREGLDDFH
HHHCCCHHHHCCCCCHHHHHHHHHHCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHH
PLAEVQVLFSAHSLPQSFIDEGDPYLDHIRETVRLVMERFEGVTHHLAFQSRAGPVKWLE
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PSTDEMLEHLAAHQVKNLLIVPLSFVSDHIETLHEIDIEYAQEAHKLGYSRFRRSPSLNT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPTFISCLADLVRRVEG
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDKTAVLLLQMGGPDSLDAVEPFLLNLFSDRDIIRIGPAFLQPFIARLIAKRRSPGVER
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCHHH
KYEEIGGKSPIRELTESQARALEDVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIA
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHH
LSLYPHYSRATTGSSVNELKRVLSQSGVQFQMMYVDRFFDHPLYIDALAEKIREGLDDFH
HHHCCCHHHHCCCCCHHHHHHHHHHCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHH
PLAEVQVLFSAHSLPQSFIDEGDPYLDHIRETVRLVMERFEGVTHHLAFQSRAGPVKWLE
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PSTDEMLEHLAAHQVKNLLIVPLSFVSDHIETLHEIDIEYAQEAHKLGYSRFRRSPSLNT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPTFISCLADLVRRVEG
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA