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The map label for this gene is uvrC

Identifier: 39998368

GI number: 39998368

Start: 3598194

End: 3600035

Strand: Direct

Name: uvrC

Synonym: GSU3279

Alternate gene names: 39998368

Gene position: 3598194-3600035 (Clockwise)

Preceding gene: 39998365

Following gene: 39998371

Centisome position: 94.34

GC content: 61.67

Gene sequence:

>1842_bases
ATGTTCGACACCAAGCGACTGACAACCCTCCCCGATGCACCGGGTGTCTACCTCATGAAGGGGAACGGCGGGGACATTCT
TTACGTGGGAAAGGCCAAGAGCCTCCGTAAACGGGTCCGCTCCTATTTCAGCAAGGGGGGAGAGTCACGCTACCATATCC
GGTTCCTGGTGGGCCGGGTCGCCGACATCGACGTAATCGTCACCGACACAGAGAAGGAAGCCCTCCTCCTCGAGAACACC
CTTATCAAGGAACATCGCCCCCGGTACAATCTGGACCTGCGGGACGACAAAACCTACTTTTCCCTCCGACTCGACATGAA
CGAGGAGTTTCCCCGCCTGACCATCGTGAGACGGCCGGGCAGGGACGGAGCCCGCTACTTCGGCCCCTATTCCTCTGCTT
CTGCCGCGCGGGAGGTCCTCAAGCAGCTGTACAAGCTCTTCCCGCTCCGCCACTACCCGCTGGAGAGCTGCCGCCGTCGC
AGACGCCCCTGCCTCTTTTACCAGCTCAGGCAGTGCGCCGCCCCCTGTCACGGGCTCATCTCGGGCGAAGATTACCAATC
ACTGGCAGAAGGCGCGGCCTTGTTCCTTGCAGGAAAAAACAGCGACCTAACCCGCCTCTACAGGCAGCGCATGGCCGCAG
CAGCAGCGGATGAACGGTATGAGGACGCCGCCCGCTACAGGGACTTGATCCGCGCCATTGAGGTCACCGTAGAGAAGCAG
AAGATGGTAGCCGGCGACGGCGACACGGACGTAGTCGGATTCTTTCGCGACGCCACAGACCTTTCCGTCTCGATCCTCTT
CTACCGCGGCGGCCGCCTCATGGGGAGCCGCAACTACCTCCTGGACTGGGAAATGGATGACGCCGAAGGGCTCTCGTCGT
TCCTGTCCGGCTACTACAACAGGGATGTCGTCATCCCCGATGAAATCCTCATCCCCTTCACCGTGGACGACACGGACCCC
CTCGGCGAACTGCTAACGGAACGGCGAGGGAAAAAGACCGTTCTCCGCCACCCCGTGCGAGGGACCAAGGCAGAACTGGT
CAGGCTGGCGGCGAGAAACGCCGAGGCGTACCTGCATGAAAAGCGGGAAAAGGACTCCGGCATGGAGCAGGTCCTCGGAG
AGCTCAAGGAGAAGCTCCACCTGACCAATCTCCCCCGACGAATCGAATGCTACGACATCTCCACCATCCAGGGACGCTAT
TCCGTGGGAAGCAGGGTCCGGTTTCAAAATGGCGCTCCGGACAAGGCGGGGTACCGCCGCTACCGGATACGGACCGTTCC
CGGCACCGACGACTTCGCCATGATGCACGAAGTTCTGTCCCGGCGCTTCAGGGACGGACACGGCGGGGACGGTCGGCCGG
ACCTCATTGTGATTGACGGGGGAATGGGGCAGTTGAATGTGCTGACCGCAATCCTGGAGGAGCTGGGGCTTCACGGCATT
GACGCCGTCTCCTTGGCAAAAAGCAGGGTAGAGCGAAATATGTCCGATAATGAGGTGGTCCGGAGCGACGAACGGGTCTT
TCTCCCCGGCCGCCGCAACCCGGTGGTGCTCCGGCAGAACGGTGCACCGCTTCTGCTCCTGGCACGAATCCGGGACGAAG
CTCATCGCTTTGCCATAACCTATCACCAGAAGCTGCGCGGTAAAGGATCGATCCGATCGAGCCTGGAAGGCATTCCCGGC
ATCGGTGAAAAGCGCAAGCGTGAACTGCTGAAACGTTTCGGCAGCATCAGGGCACTGCGCCAGGCGGACCGAGAACAGCT
TGCCGCCGTCCCCTCCGTCTCCCCCGCCTTGGCGGATGCCATCTGGAAGGCCCTTCACGGCGAAGAGCCCGAGGCGCCAT
GA

Upstream 100 bases:

>100_bases
GAACCCCTGTAATTACGCGATAAACGGCCCAACGAATCGACGGCTGCCCGTGGATGGCTTCGCCTTCCCAAAACTGCTGC
CTGCCGCTATACTAGCATTC

Downstream 100 bases:

>100_bases
CGCAGGCACTGAAAACAGAAGGCGGCCCCCCGTGTGGGAGGCCGCCTTGTATGCGGACAGCGTGAATAGAAGCGCCTTAC
TTCTCAGCCAGCAGCTTCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MFDTKRLTTLPDAPGVYLMKGNGGDILYVGKAKSLRKRVRSYFSKGGESRYHIRFLVGRVADIDVIVTDTEKEALLLENT
LIKEHRPRYNLDLRDDKTYFSLRLDMNEEFPRLTIVRRPGRDGARYFGPYSSASAAREVLKQLYKLFPLRHYPLESCRRR
RRPCLFYQLRQCAAPCHGLISGEDYQSLAEGAALFLAGKNSDLTRLYRQRMAAAAADERYEDAARYRDLIRAIEVTVEKQ
KMVAGDGDTDVVGFFRDATDLSVSILFYRGGRLMGSRNYLLDWEMDDAEGLSSFLSGYYNRDVVIPDEILIPFTVDDTDP
LGELLTERRGKKTVLRHPVRGTKAELVRLAARNAEAYLHEKREKDSGMEQVLGELKEKLHLTNLPRRIECYDISTIQGRY
SVGSRVRFQNGAPDKAGYRRYRIRTVPGTDDFAMMHEVLSRRFRDGHGGDGRPDLIVIDGGMGQLNVLTAILEELGLHGI
DAVSLAKSRVERNMSDNEVVRSDERVFLPGRRNPVVLRQNGAPLLLLARIRDEAHRFAITYHQKLRGKGSIRSSLEGIPG
IGEKRKRELLKRFGSIRALRQADREQLAAVPSVSPALADAIWKALHGEEPEAP

Sequences:

>Translated_613_residues
MFDTKRLTTLPDAPGVYLMKGNGGDILYVGKAKSLRKRVRSYFSKGGESRYHIRFLVGRVADIDVIVTDTEKEALLLENT
LIKEHRPRYNLDLRDDKTYFSLRLDMNEEFPRLTIVRRPGRDGARYFGPYSSASAAREVLKQLYKLFPLRHYPLESCRRR
RRPCLFYQLRQCAAPCHGLISGEDYQSLAEGAALFLAGKNSDLTRLYRQRMAAAAADERYEDAARYRDLIRAIEVTVEKQ
KMVAGDGDTDVVGFFRDATDLSVSILFYRGGRLMGSRNYLLDWEMDDAEGLSSFLSGYYNRDVVIPDEILIPFTVDDTDP
LGELLTERRGKKTVLRHPVRGTKAELVRLAARNAEAYLHEKREKDSGMEQVLGELKEKLHLTNLPRRIECYDISTIQGRY
SVGSRVRFQNGAPDKAGYRRYRIRTVPGTDDFAMMHEVLSRRFRDGHGGDGRPDLIVIDGGMGQLNVLTAILEELGLHGI
DAVSLAKSRVERNMSDNEVVRSDERVFLPGRRNPVVLRQNGAPLLLLARIRDEAHRFAITYHQKLRGKGSIRSSLEGIPG
IGEKRKRELLKRFGSIRALRQADREQLAAVPSVSPALADAIWKALHGEEPEAP
>Mature_613_residues
MFDTKRLTTLPDAPGVYLMKGNGGDILYVGKAKSLRKRVRSYFSKGGESRYHIRFLVGRVADIDVIVTDTEKEALLLENT
LIKEHRPRYNLDLRDDKTYFSLRLDMNEEFPRLTIVRRPGRDGARYFGPYSSASAAREVLKQLYKLFPLRHYPLESCRRR
RRPCLFYQLRQCAAPCHGLISGEDYQSLAEGAALFLAGKNSDLTRLYRQRMAAAAADERYEDAARYRDLIRAIEVTVEKQ
KMVAGDGDTDVVGFFRDATDLSVSILFYRGGRLMGSRNYLLDWEMDDAEGLSSFLSGYYNRDVVIPDEILIPFTVDDTDP
LGELLTERRGKKTVLRHPVRGTKAELVRLAARNAEAYLHEKREKDSGMEQVLGELKEKLHLTNLPRRIECYDISTIQGRY
SVGSRVRFQNGAPDKAGYRRYRIRTVPGTDDFAMMHEVLSRRFRDGHGGDGRPDLIVIDGGMGQLNVLTAILEELGLHGI
DAVSLAKSRVERNMSDNEVVRSDERVFLPGRRNPVVLRQNGAPLLLLARIRDEAHRFAITYHQKLRGKGSIRSSLEGIPG
IGEKRKRELLKRFGSIRALRQADREQLAAVPSVSPALADAIWKALHGEEPEAP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=37.8246753246753, Blast_Score=354, Evalue=7e-99,
Organism=Escherichia coli, GI1788037, Length=190, Percent_Identity=33.1578947368421, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_GEOSL (Q747I7)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954319.1
- ProteinModelPortal:   Q747I7
- GeneID:   2688274
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3279
- NMPDR:   fig|243231.1.peg.3257
- TIGR:   GSU3279
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   GSUL243231:GSU_3279-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69542; Mature: 69542

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTKRLTTLPDAPGVYLMKGNGGDILYVGKAKSLRKRVRSYFSKGGESRYHIRFLVGRV
CCCCCCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCC
ADIDVIVTDTEKEALLLENTLIKEHRPRYNLDLRDDKTYFSLRLDMNEEFPRLTIVRRPG
CEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCC
RDGARYFGPYSSASAAREVLKQLYKLFPLRHYPLESCRRRRRPCLFYQLRQCAAPCHGLI
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCC
SGEDYQSLAEGAALFLAGKNSDLTRLYRQRMAAAAADERYEDAARYRDLIRAIEVTVEKQ
CCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMVAGDGDTDVVGFFRDATDLSVSILFYRGGRLMGSRNYLLDWEMDDAEGLSSFLSGYYN
HEECCCCCCCEEEEEECCCCCEEEEEEEECCEEECCCCEEEEECCCCHHHHHHHHHHHCC
RDVVIPDEILIPFTVDDTDPLGELLTERRGKKTVLRHPVRGTKAELVRLAARNAEAYLHE
CCEECCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCHHHHHHH
KREKDSGMEQVLGELKEKLHLTNLPRRIECYDISTIQGRYSVGSRVRFQNGAPDKAGYRR
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCEEEECCCCCCCCCCEE
YRIRTVPGTDDFAMMHEVLSRRFRDGHGGDGRPDLIVIDGGMGQLNVLTAILEELGLHGI
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
DAVSLAKSRVERNMSDNEVVRSDERVFLPGRRNPVVLRQNGAPLLLLARIRDEAHRFAIT
HHHHHHHHHHHCCCCCCHHHCCCCEEECCCCCCCEEEECCCCCEEEEEHHHHHHHHEEEE
YHQKLRGKGSIRSSLEGIPGIGEKRKRELLKRFGSIRALRQADREQLAAVPSVSPALADA
EHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IWKALHGEEPEAP
HHHHHCCCCCCCC
>Mature Secondary Structure
MFDTKRLTTLPDAPGVYLMKGNGGDILYVGKAKSLRKRVRSYFSKGGESRYHIRFLVGRV
CCCCCCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCC
ADIDVIVTDTEKEALLLENTLIKEHRPRYNLDLRDDKTYFSLRLDMNEEFPRLTIVRRPG
CEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCC
RDGARYFGPYSSASAAREVLKQLYKLFPLRHYPLESCRRRRRPCLFYQLRQCAAPCHGLI
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCC
SGEDYQSLAEGAALFLAGKNSDLTRLYRQRMAAAAADERYEDAARYRDLIRAIEVTVEKQ
CCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMVAGDGDTDVVGFFRDATDLSVSILFYRGGRLMGSRNYLLDWEMDDAEGLSSFLSGYYN
HEECCCCCCCEEEEEECCCCCEEEEEEEECCEEECCCCEEEEECCCCHHHHHHHHHHHCC
RDVVIPDEILIPFTVDDTDPLGELLTERRGKKTVLRHPVRGTKAELVRLAARNAEAYLHE
CCEECCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCHHHHHHH
KREKDSGMEQVLGELKEKLHLTNLPRRIECYDISTIQGRYSVGSRVRFQNGAPDKAGYRR
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCEEEECCCCCCCCCCEE
YRIRTVPGTDDFAMMHEVLSRRFRDGHGGDGRPDLIVIDGGMGQLNVLTAILEELGLHGI
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
DAVSLAKSRVERNMSDNEVVRSDERVFLPGRRNPVVLRQNGAPLLLLARIRDEAHRFAIT
HHHHHHHHHHHCCCCCCHHHCCCCEEECCCCCCCEEEECCCCCEEEEEHHHHHHHHEEEE
YHQKLRGKGSIRSSLEGIPGIGEKRKRELLKRFGSIRALRQADREQLAAVPSVSPALADA
EHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IWKALHGEEPEAP
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA