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The map label for this gene is ahpC [C]

Identifier: 39998336

GI number: 39998336

Start: 3559499

End: 3560104

Strand: Reverse

Name: ahpC [C]

Synonym: GSU3246

Alternate gene names: 39998336

Gene position: 3560104-3559499 (Counterclockwise)

Preceding gene: 39998337

Following gene: 39998335

Centisome position: 93.34

GC content: 57.76

Gene sequence:

>606_bases
ATGTGCATGTGTACGCTTGTTACCAAGGAGGCCCCTGACTTCACCGCCGACGCGGTTATGCCCGACAATACCTTCGGCAC
GGTCAAGCTGTCGAGCTACCGCGGAAAATATGTGGTCCTCTTTTTCTATCCTCTTGATTTCACTTTTGTCTGCCCGTCTG
AGATTCTTGCATTCAATAAGAAGCTGGATCAGTTCAAGGCTAAGAACTGCGAGGTGATCGGGGTTTCAGTCGATTCCAAG
TTCACCCACATGGCGTGGAAGAACACCCCGGTGGAGAACGGCGGTATCGGCAACATCCAGTATCCGCTGGTAGCCGATCT
CAAGAAGGAGATCGCCACCCAGTACGGCGTCCTCTTCGAAGGCGCAGGGGTTGCCCTGCGCGGCCTGTTCCTTATCGATA
CCAAGGGGGTTGTCCGTCACGCCGTGATCAACGACCTGCCTCTCGGCCGCAGCGTTGACGAGGCCCTCCGCATGGTCGAT
GCGCTTCAGTTCGTGGAAACCCACGGCGATCAGGTTTGCCCGGCCAACTGGAAGGAAGGGGACGAGGCCATGAAGCCGAC
CGCTTCCGGCGTGGCCGAGTACCTGGCAAAGCACTCCGTGGGGTAG

Upstream 100 bases:

>100_bases
AAAGGATTGTTTTTGTCTTTTTTGATTGACAAGCCCCAGTATGGCTGGTATGAGTTTTTCTTGTCTGCAACTTCATTTCA
AAGAAAGGAGAAACGATACC

Downstream 100 bases:

>100_bases
CCTCCGGCGCAGTGCATCCGAATGAACGGCACGGTCCCACACCGTGCCGTTTGTTTTTGGGGAGGCGCATGACATGAACG
ACCTGGAACGGACCGACAAT

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MCMCTLVTKEAPDFTADAVMPDNTFGTVKLSSYRGKYVVLFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSK
FTHMAWKNTPVENGGIGNIQYPLVADLKKEIATQYGVLFEGAGVALRGLFLIDTKGVVRHAVINDLPLGRSVDEALRMVD
ALQFVETHGDQVCPANWKEGDEAMKPTASGVAEYLAKHSVG

Sequences:

>Translated_201_residues
MCMCTLVTKEAPDFTADAVMPDNTFGTVKLSSYRGKYVVLFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSK
FTHMAWKNTPVENGGIGNIQYPLVADLKKEIATQYGVLFEGAGVALRGLFLIDTKGVVRHAVINDLPLGRSVDEALRMVD
ALQFVETHGDQVCPANWKEGDEAMKPTASGVAEYLAKHSVG
>Mature_201_residues
MCMCTLVTKEAPDFTADAVMPDNTFGTVKLSSYRGKYVVLFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSK
FTHMAWKNTPVENGGIGNIQYPLVADLKKEIATQYGVLFEGAGVALRGLFLIDTKGVVRHAVINDLPLGRSVDEALRMVD
ALQFVETHGDQVCPANWKEGDEAMKPTASGVAEYLAKHSVG

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=56.4766839378238, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI4505591, Length=188, Percent_Identity=56.3829787234042, Blast_Score=235, Evalue=2e-62,
Organism=Homo sapiens, GI32455266, Length=188, Percent_Identity=56.3829787234042, Blast_Score=235, Evalue=2e-62,
Organism=Homo sapiens, GI32455264, Length=188, Percent_Identity=56.3829787234042, Blast_Score=235, Evalue=2e-62,
Organism=Homo sapiens, GI5802974, Length=196, Percent_Identity=54.0816326530612, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI32483377, Length=190, Percent_Identity=54.2105263157895, Blast_Score=227, Evalue=5e-60,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=52.8795811518325, Blast_Score=221, Evalue=3e-58,
Organism=Homo sapiens, GI33188454, Length=80, Percent_Identity=65, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=28.042328042328, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786822, Length=154, Percent_Identity=33.1168831168831, Blast_Score=114, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=193, Percent_Identity=52.8497409326425, Blast_Score=214, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32565831, Length=193, Percent_Identity=52.8497409326425, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=48.9247311827957, Blast_Score=200, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI25153706, Length=190, Percent_Identity=27.8947368421053, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=193, Percent_Identity=49.740932642487, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320661, Length=193, Percent_Identity=45.0777202072539, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319407, Length=200, Percent_Identity=31, Blast_Score=101, Evalue=8e-23,
Organism=Drosophila melanogaster, GI17738015, Length=194, Percent_Identity=53.6082474226804, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=51.5463917525773, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=51.5463917525773, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17157991, Length=193, Percent_Identity=51.2953367875648, Blast_Score=210, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24641739, Length=193, Percent_Identity=51.2953367875648, Blast_Score=210, Evalue=5e-55,
Organism=Drosophila melanogaster, GI21357347, Length=194, Percent_Identity=47.4226804123711, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17975518, Length=186, Percent_Identity=31.7204301075269, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652436, Length=186, Percent_Identity=31.7204301075269, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652434, Length=186, Percent_Identity=31.7204301075269, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581278, Length=180, Percent_Identity=28.8888888888889, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22034; Mature: 22034

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCMCTLVTKEAPDFTADAVMPDNTFGTVKLSSYRGKYVVLFFYPLDFTFVCPSEILAFNK
CEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECHHHHHHHHH
KLDQFKAKNCEVIGVSVDSKFTHMAWKNTPVENGGIGNIQYPLVADLKKEIATQYGVLFE
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEE
GAGVALRGLFLIDTKGVVRHAVINDLPLGRSVDEALRMVDALQFVETHGDQVCPANWKEG
CCCCEEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEAMKPTASGVAEYLAKHSVG
HHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MCMCTLVTKEAPDFTADAVMPDNTFGTVKLSSYRGKYVVLFFYPLDFTFVCPSEILAFNK
CEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECHHHHHHHHH
KLDQFKAKNCEVIGVSVDSKFTHMAWKNTPVENGGIGNIQYPLVADLKKEIATQYGVLFE
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEE
GAGVALRGLFLIDTKGVVRHAVINDLPLGRSVDEALRMVDALQFVETHGDQVCPANWKEG
CCCCEEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEAMKPTASGVAEYLAKHSVG
HHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]