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The map label for this gene is hisA [H]

Identifier: 39998186

GI number: 39998186

Start: 3400542

End: 3401276

Strand: Reverse

Name: hisA [H]

Synonym: GSU3096

Alternate gene names: 39998186

Gene position: 3401276-3400542 (Counterclockwise)

Preceding gene: 39998187

Following gene: 39998185

Centisome position: 89.18

GC content: 64.49

Gene sequence:

>735_bases
GTGATCGTCATACCTGCCATTGACCTGAAAGAAGGAAAGTGCGTCCGCCTCGAACAGGGGCTCATGGAAAAGGATACCGT
TTTCTGTGACAATCCCGCCGACCAGGCCAGGGAGTGGGAGCGCCAGGGGGCGGAGCTGCTCCACATTGTCGACCTGGACG
GCGCCTTTGCCGGCGAACCCAAGAACCGCGCCTCCATCGAGGCCATCGTCAAGGCCATTGCCATCCCAACCCAGCTGGGG
GGCGGCATCCGGGACATTCCCACCATCGAGGCGTATCTCTCCCTCGGCATTGGCCGGGTGATCCTCGGTACTGCGGCCCA
GCGGAACCCCGAACTGGTGGAGGAGGCCTGCCGCCTCTTCCCCGGCCGGATCGTGGTGGGGATCGACGCAAAGAACGGCA
TGGTGGCGGTCCAGGGGTGGGCCGAGGTCACCGGCGTCACGGCGGTGGATCTGGCAAAACGGTTCGAGGGATACGGCGTC
GCCGCCATCATTTACACCGACATCGCCCGGGACGGCATGATGCAGGGGCCGAACATTGAAGCGACCAGGGCTCTGGCCGA
GGCGATCTCGATCCCGGTCATCGCCTCCGGAGGGGTGTCGTCCCTGAAGGATATCGAGAACCTTATGGCCATTGAGACGA
GCGGCATCGCCGGCGCCATCACCGGCAAGGCGGTCTACACCGGGGCCATCAATCTGGCTGAAGCGGTAGCACTCACGAAG
CGGGGAGGGGCCTGA

Upstream 100 bases:

>100_bases
GCGCCGCCATCTGGAAGGACAACATCGTCGCCACCCAGTTCCATCCCGAGAAGTCACAGGCGGTGGGGCTGTCCATACTC
AAGAACTTCGGAGAGATGAA

Downstream 100 bases:

>100_bases
GATGCTGACCAAGCGGATCATCCCGTGTCTGGACGTGAAGGGCGGCCGGGTCGTCAAAGGGGTCCAGTTCCTGGAGCTGC
GTGATGCCGGCGATCCGGTT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQAREWERQGAELLHIVDLDGAFAGEPKNRASIEAIVKAIAIPTQLG
GGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLFPGRIVVGIDAKNGMVAVQGWAEVTGVTAVDLAKRFEGYGV
AAIIYTDIARDGMMQGPNIEATRALAEAISIPVIASGGVSSLKDIENLMAIETSGIAGAITGKAVYTGAINLAEAVALTK
RGGA

Sequences:

>Translated_244_residues
MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQAREWERQGAELLHIVDLDGAFAGEPKNRASIEAIVKAIAIPTQLG
GGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLFPGRIVVGIDAKNGMVAVQGWAEVTGVTAVDLAKRFEGYGV
AAIIYTDIARDGMMQGPNIEATRALAEAISIPVIASGGVSSLKDIENLMAIETSGIAGAITGKAVYTGAINLAEAVALTK
RGGA
>Mature_244_residues
MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQAREWERQGAELLHIVDLDGAFAGEPKNRASIEAIVKAIAIPTQLG
GGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLFPGRIVVGIDAKNGMVAVQGWAEVTGVTAVDLAKRFEGYGV
AAIIYTDIARDGMMQGPNIEATRALAEAISIPVIASGGVSSLKDIENLMAIETSGIAGAITGKAVYTGAINLAEAVALTK
RGGA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.0987654320988, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1788336, Length=243, Percent_Identity=23.8683127572016, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25537; Mature: 25537

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQAREWERQGAELLHIVDLDGAFAGEP
CEEECCCCCCCCCEEEHHHCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCCC
KNRASIEAIVKAIAIPTQLGGGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLF
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHEECCCCCCCHHHHHHHHHHC
PGRIVVGIDAKNGMVAVQGWAEVTGVTAVDLAKRFEGYGVAAIIYTDIARDGMMQGPNIE
CCEEEEEEECCCCEEEEECHHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCCCHH
ATRALAEAISIPVIASGGVSSLKDIENLMAIETSGIAGAITGKAVYTGAINLAEAVALTK
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHEECCCCCEEEECCEEEECHHHHHHHHHHHC
RGGA
CCCC
>Mature Secondary Structure
MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQAREWERQGAELLHIVDLDGAFAGEP
CEEECCCCCCCCCEEEHHHCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCCC
KNRASIEAIVKAIAIPTQLGGGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLF
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHEECCCCCCCHHHHHHHHHHC
PGRIVVGIDAKNGMVAVQGWAEVTGVTAVDLAKRFEGYGVAAIIYTDIARDGMMQGPNIE
CCEEEEEEECCCCEEEEECHHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCCCHH
ATRALAEAISIPVIASGGVSSLKDIENLMAIETSGIAGAITGKAVYTGAINLAEAVALTK
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHEECCCCCEEEECCEEEECHHHHHHHHHHHC
RGGA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA