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The map label for this gene is hisE

Identifier: 39998184

GI number: 39998184

Start: 3399456

End: 3399782

Strand: Reverse

Name: hisE

Synonym: GSU3094

Alternate gene names: 39998184

Gene position: 3399782-3399456 (Counterclockwise)

Preceding gene: 39998185

Following gene: 39998183

Centisome position: 89.14

GC content: 55.05

Gene sequence:

>327_bases
ATGAACGAGCGTGACGACATCCTGCAGGCAGTCTATGAGGTGATTCTCGACCGGAAAGGTGCTCTGCCCGAGAGCTCCTA
TACGGCGTCCCTCTTTCACAAGGGGATCGACAAGATTCTCAAGAAGGTCGGTGAAGAGGCGACGGAAGTCATTATCGCCG
GTAAAGGGGGGAAGCGGGAGGAGATCGTTTACGAGACCGCTGACCTGCTTTTTCATACGCTGGTTCTTCTCGGTCATTAT
GATATTGCCCCGGCAGATGTGTACAATGAGCTCCGCCGTCGTTTCGGTACCTCCGGGCACGCCGAAAAGGCGAGCAGAAA
CGAGTAG

Upstream 100 bases:

>100_bases
GGGCAAGCGCCTGTCTTGCTGCGTCCATCTTTCACTATAAGGAGTACACCATCGGCGAGGCCAAGGAGTATCTCCGTCAA
CGGGGGGTTCCGGTCCGGTT

Downstream 100 bases:

>100_bases
TAGCGCCTCGGTATCCGAATAAAAACTTGACATTGACGCTTCTGCTGCTATTATGTCTCTTCTCGTAAAATTTTTCCGGC
TCGTCGTCTGACTCTATCAG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MNERDDILQAVYEVILDRKGALPESSYTASLFHKGIDKILKKVGEEATEVIIAGKGGKREEIVYETADLLFHTLVLLGHY
DIAPADVYNELRRRFGTSGHAEKASRNE

Sequences:

>Translated_108_residues
MNERDDILQAVYEVILDRKGALPESSYTASLFHKGIDKILKKVGEEATEVIIAGKGGKREEIVYETADLLFHTLVLLGHY
DIAPADVYNELRRRFGTSGHAEKASRNE
>Mature_108_residues
MNERDDILQAVYEVILDRKGALPESSYTASLFHKGIDKILKKVGEEATEVIIAGKGGKREEIVYETADLLFHTLVLLGHY
DIAPADVYNELRRRFGTSGHAEKASRNE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=82, Percent_Identity=40.2439024390244, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_GEOSL (P60536)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954135.1
- ProteinModelPortal:   P60536
- SMR:   P60536
- GeneID:   2686487
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3094
- NMPDR:   fig|243231.1.peg.3073
- TIGR:   GSU3094
- HOGENOM:   HBG646527
- OMA:   EMRRREN
- ProtClustDB:   PRK00400
- BioCyc:   GSUL243231:GSU_3094-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12103; Mature: 12103

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERDDILQAVYEVILDRKGALPESSYTASLFHKGIDKILKKVGEEATEVIIAGKGGKRE
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCH
EIVYETADLLFHTLVLLGHYDIAPADVYNELRRRFGTSGHAEKASRNE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNERDDILQAVYEVILDRKGALPESSYTASLFHKGIDKILKKVGEEATEVIIAGKGGKRE
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCH
EIVYETADLLFHTLVLLGHYDIAPADVYNELRRRFGTSGHAEKASRNE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA