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The map label for this gene is penA [H]

Identifier: 39998165

GI number: 39998165

Start: 3382710

End: 3384683

Strand: Reverse

Name: penA [H]

Synonym: GSU3075

Alternate gene names: 39998165

Gene position: 3384683-3382710 (Counterclockwise)

Preceding gene: 39998166

Following gene: 39998164

Centisome position: 88.74

GC content: 59.98

Gene sequence:

>1974_bases
ATGAGATATGACGCGGAGAAATGGATAACTCTGCGCATCCGCTTTATTGGCGGTTTCTTCGTTCTCTTTTTCTCTCTCGT
CGTTTGTCGGGCCTTTTATCTCCAGGTGGTCAAGCGCGACCACCTGCTCAAGCTTGCCGACCGCCAGCACCAGAAGATTG
TCCCTCTGACGCCTGCCCGAGGGACCATATACGACGCAAATGGTTCGGCCCTCGCCGTGTCGGTGGAGATGGACTCCTGT
TTCGCCGAGCCCAAGTCAATTGCGGACCTGGATGACGCGGCTGCGCGACTCTCCCCGGTTCTGGGTTTTCCGAAAGAAAC
CCTGCTCCGCAAGCTGCAGGGGAACAAGAATTTTGTCTGGCTCCAGCGCCGGCTGACGCCCGATGTGGTGAAAAGAATCC
GGGCTCTGAATATTGATGGGATCGGTTTCGTCAAGGAAACCAAGCGGTTTTATCCCAACTCTGAAGTGGCCGCCCATGTC
ATTGGTTTTACCGGAGTCGACCCTGAAGGACTTGAGGGCATCGAGCTGCGTTACGACTCAACCATCCTGGGCGGCACCGG
TTATCTGGTGACCGAGCGGGACGCCCTAGGCCGGGATGTGGCGCTGAAGGGGACAGTGATTCAGGACGGTGCCATGGGGC
ACAATGTCGTTCTGACCCTTGACAAGAATATCCAGTACATCGCTGAAAAGGAGCTTGCCAAGGCCGTTGACGGCAGCGGC
GCCCGGGCCGGCACCGCGATCGTTATGGATCCCCATACCGGGCGGGTCCTGGCCATGGCCAACTATCCGACATTCAATCT
GAACGCCCACGGCGCCTATCATCAGTCCCTCTGGCGCAACAGAGCAGTGGCCGACAGCTATGAGCCGGGATCAACCTTCA
AGGTGTTCCTCATCGCCTCGGCCCTTGAAGAAAAAGTGATCCGACCGGGCGACAGGATCAACTGCGAGGGGGGCAGTTTT
TCCATCGGCGGGCGGACCATTCACGATACCCACAAGTATGGGAGCCTGAGCATCCCGGAGATTTTGAAATATTCGAGCAA
CATCGGGTCAGCAAAGATCGGGAGTCGCCTCGGTGCCTCGAGGCTGTATTCATACCTGAGAAATTTCGGTTTCGGTGCGC
GGACCGGTATTGACCTCCCCGGAGAGGCGGGGGGGACCCTCAGGGACTGGAACCAGTGGTACGGCATCGATCTGGCCACC
GTCTCCTTCGGCCAGGGGGTGACCGCCAGTTCGATCCAGCTGGCCGCGGCCTTTTCCGCCATAGCCAATGGCGGAACGCT
CATGAAACCGTACCTAGTTGAACGTGTCGTCGACAGCGAGGGTAACGTCATCAAGAGCTCCTCGCCGCAACCGCTGCGGC
GGGTGGTTTCAGAGACAACTGCCAAAAACGTAGCCCGCATGATGGAAGGGGTAGCGGTGGAAGGCGGAACCGGTACCAAC
GCAGCAGTGGAAGGGTTCCGGGTGGCGGGCAAGACGGGAACGGCCCAGAAAGTCGACCCGGTGACGCGAGGCTACTCGCT
CACCAAGCGGACGGCCTCATTCATCGGCTTTGTCCCGGCCGACCGGCCCCGTCTCACTATCCTCGTCATGGTCGATGAGC
CCAAGACAAGCCCCTATGGCGGAGTTGTAGCGGCACCCGCCTTCAGCTCCATTGCGCTGCAGTCCCTCTGCTACCTGAAG
GTGCCGCCCGACGGCATTGTCAGGAGCAAGCCGAAGGTGGTCGAGGCAAAGGCGGACCAGCCCACTGGAGACGATCTGTC
CGCCGCGGAAGGAGAGATCGTCGACGCCGGGGAAGGGGTGGTGATGCCGAACTTTCGGGGTATGAGCATGCGTCAGGCGC
TCAAAACCATGGAGGAGCGGGGGATCAACGTGAGGCTCATGGGAAGCGGTCGGGCTGTCGAGCAAAGCCCGCTTCCCGGT
CACAGGGTTGGGCCGTCGGATCAGGTGTGGGTGAAGTTCGTACCATCGGCATGA

Upstream 100 bases:

>100_bases
TCGAGGTGGCTTCCCTCAAGACCCCGGCTCGAATTGAAGCTGTCGCCAAGGGTGAGTTGGGCATGGCACTTCCCACTGAT
CAGCAGGTGGTTGTTGTGAA

Downstream 100 bases:

>100_bases
CGCCATCAAATACGCTCAATGGCGAGGAACCATGCGACTAGAAGATCTGGCACGGGTTGTTGATCCCATCGCGGTACGGG
GGGATCTGACGCGGGAGATC

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MRYDAEKWITLRIRFIGGFFVLFFSLVVCRAFYLQVVKRDHLLKLADRQHQKIVPLTPARGTIYDANGSALAVSVEMDSC
FAEPKSIADLDDAAARLSPVLGFPKETLLRKLQGNKNFVWLQRRLTPDVVKRIRALNIDGIGFVKETKRFYPNSEVAAHV
IGFTGVDPEGLEGIELRYDSTILGGTGYLVTERDALGRDVALKGTVIQDGAMGHNVVLTLDKNIQYIAEKELAKAVDGSG
ARAGTAIVMDPHTGRVLAMANYPTFNLNAHGAYHQSLWRNRAVADSYEPGSTFKVFLIASALEEKVIRPGDRINCEGGSF
SIGGRTIHDTHKYGSLSIPEILKYSSNIGSAKIGSRLGASRLYSYLRNFGFGARTGIDLPGEAGGTLRDWNQWYGIDLAT
VSFGQGVTASSIQLAAAFSAIANGGTLMKPYLVERVVDSEGNVIKSSSPQPLRRVVSETTAKNVARMMEGVAVEGGTGTN
AAVEGFRVAGKTGTAQKVDPVTRGYSLTKRTASFIGFVPADRPRLTILVMVDEPKTSPYGGVVAAPAFSSIALQSLCYLK
VPPDGIVRSKPKVVEAKADQPTGDDLSAAEGEIVDAGEGVVMPNFRGMSMRQALKTMEERGINVRLMGSGRAVEQSPLPG
HRVGPSDQVWVKFVPSA

Sequences:

>Translated_657_residues
MRYDAEKWITLRIRFIGGFFVLFFSLVVCRAFYLQVVKRDHLLKLADRQHQKIVPLTPARGTIYDANGSALAVSVEMDSC
FAEPKSIADLDDAAARLSPVLGFPKETLLRKLQGNKNFVWLQRRLTPDVVKRIRALNIDGIGFVKETKRFYPNSEVAAHV
IGFTGVDPEGLEGIELRYDSTILGGTGYLVTERDALGRDVALKGTVIQDGAMGHNVVLTLDKNIQYIAEKELAKAVDGSG
ARAGTAIVMDPHTGRVLAMANYPTFNLNAHGAYHQSLWRNRAVADSYEPGSTFKVFLIASALEEKVIRPGDRINCEGGSF
SIGGRTIHDTHKYGSLSIPEILKYSSNIGSAKIGSRLGASRLYSYLRNFGFGARTGIDLPGEAGGTLRDWNQWYGIDLAT
VSFGQGVTASSIQLAAAFSAIANGGTLMKPYLVERVVDSEGNVIKSSSPQPLRRVVSETTAKNVARMMEGVAVEGGTGTN
AAVEGFRVAGKTGTAQKVDPVTRGYSLTKRTASFIGFVPADRPRLTILVMVDEPKTSPYGGVVAAPAFSSIALQSLCYLK
VPPDGIVRSKPKVVEAKADQPTGDDLSAAEGEIVDAGEGVVMPNFRGMSMRQALKTMEERGINVRLMGSGRAVEQSPLPG
HRVGPSDQVWVKFVPSA
>Mature_657_residues
MRYDAEKWITLRIRFIGGFFVLFFSLVVCRAFYLQVVKRDHLLKLADRQHQKIVPLTPARGTIYDANGSALAVSVEMDSC
FAEPKSIADLDDAAARLSPVLGFPKETLLRKLQGNKNFVWLQRRLTPDVVKRIRALNIDGIGFVKETKRFYPNSEVAAHV
IGFTGVDPEGLEGIELRYDSTILGGTGYLVTERDALGRDVALKGTVIQDGAMGHNVVLTLDKNIQYIAEKELAKAVDGSG
ARAGTAIVMDPHTGRVLAMANYPTFNLNAHGAYHQSLWRNRAVADSYEPGSTFKVFLIASALEEKVIRPGDRINCEGGSF
SIGGRTIHDTHKYGSLSIPEILKYSSNIGSAKIGSRLGASRLYSYLRNFGFGARTGIDLPGEAGGTLRDWNQWYGIDLAT
VSFGQGVTASSIQLAAAFSAIANGGTLMKPYLVERVVDSEGNVIKSSSPQPLRRVVSETTAKNVARMMEGVAVEGGTGTN
AAVEGFRVAGKTGTAQKVDPVTRGYSLTKRTASFIGFVPADRPRLTILVMVDEPKTSPYGGVVAAPAFSSIALQSLCYLK
VPPDGIVRSKPKVVEAKADQPTGDDLSAAEGEIVDAGEGVVMPNFRGMSMRQALKTMEERGINVRLMGSGRAVEQSPLPG
HRVGPSDQVWVKFVPSA

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=33.4507042253521, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1786854, Length=623, Percent_Identity=25.5216693418941, Blast_Score=142, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70916; Mature: 70916

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDAEKWITLRIRFIGGFFVLFFSLVVCRAFYLQVVKRDHLLKLADRQHQKIVPLTPAR
CCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
GTIYDANGSALAVSVEMDSCFAEPKSIADLDDAAARLSPVLGFPKETLLRKLQGNKNFVW
CEEEECCCCEEEEEEEHHHHHCCCCHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEE
LQRRLTPDVVKRIRALNIDGIGFVKETKRFYPNSEVAAHVIGFTGVDPEGLEGIELRYDS
EEECCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCEEEEECC
TILGGTGYLVTERDALGRDVALKGTVIQDGAMGHNVVLTLDKNIQYIAEKELAKAVDGSG
EEECCCEEEEECCHHCCCCEEEECEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
ARAGTAIVMDPHTGRVLAMANYPTFNLNAHGAYHQSLWRNRAVADSYEPGSTFKVFLIAS
CCCCEEEEECCCCCCEEEEECCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEHH
ALEEKVIRPGDRINCEGGSFSIGGRTIHDTHKYGSLSIPEILKYSSNIGSAKIGSRLGAS
HHHHHHCCCCCEEECCCCCEEECCEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHCCHH
RLYSYLRNFGFGARTGIDLPGEAGGTLRDWNQWYGIDLATVSFGQGVTASSIQLAAAFSA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEEECCCCCCHHHHHHHHHHHH
IANGGTLMKPYLVERVVDSEGNVIKSSSPQPLRRVVSETTAKNVARMMEGVAVEGGTGTN
HHCCCCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCC
AAVEGFRVAGKTGTAQKVDPVTRGYSLTKRTASFIGFVPADRPRLTILVMVDEPKTSPYG
HHHCCEEEECCCCCCCCCCHHHCCCHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCCC
GVVAAPAFSSIALQSLCYLKVPPDGIVRSKPKVVEAKADQPTGDDLSAAEGEIVDAGEGV
CEEECCCHHHHHHHHEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEECCCCE
VMPNFRGMSMRQALKTMEERGINVRLMGSGRAVEQSPLPGHRVGPSDQVWVKFVPSA
ECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MRYDAEKWITLRIRFIGGFFVLFFSLVVCRAFYLQVVKRDHLLKLADRQHQKIVPLTPAR
CCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
GTIYDANGSALAVSVEMDSCFAEPKSIADLDDAAARLSPVLGFPKETLLRKLQGNKNFVW
CEEEECCCCEEEEEEEHHHHHCCCCHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEE
LQRRLTPDVVKRIRALNIDGIGFVKETKRFYPNSEVAAHVIGFTGVDPEGLEGIELRYDS
EEECCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCEEEEECC
TILGGTGYLVTERDALGRDVALKGTVIQDGAMGHNVVLTLDKNIQYIAEKELAKAVDGSG
EEECCCEEEEECCHHCCCCEEEECEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
ARAGTAIVMDPHTGRVLAMANYPTFNLNAHGAYHQSLWRNRAVADSYEPGSTFKVFLIAS
CCCCEEEEECCCCCCEEEEECCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEHH
ALEEKVIRPGDRINCEGGSFSIGGRTIHDTHKYGSLSIPEILKYSSNIGSAKIGSRLGAS
HHHHHHCCCCCEEECCCCCEEECCEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHCCHH
RLYSYLRNFGFGARTGIDLPGEAGGTLRDWNQWYGIDLATVSFGQGVTASSIQLAAAFSA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEEECCCCCCHHHHHHHHHHHH
IANGGTLMKPYLVERVVDSEGNVIKSSSPQPLRRVVSETTAKNVARMMEGVAVEGGTGTN
HHCCCCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCC
AAVEGFRVAGKTGTAQKVDPVTRGYSLTKRTASFIGFVPADRPRLTILVMVDEPKTSPYG
HHHCCEEEECCCCCCCCCCHHHCCCHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCCC
GVVAAPAFSSIALQSLCYLKVPPDGIVRSKPKVVEAKADQPTGDDLSAAEGEIVDAGEGV
CEEECCCHHHHHHHHEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEECCCCE
VMPNFRGMSMRQALKTMEERGINVRLMGSGRAVEQSPLPGHRVGPSDQVWVKFVPSA
ECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]