Click here to switch to the map view.

The map label for this gene is acoA [H]

Identifier: 39998110

GI number: 39998110

Start: 3312678

End: 3314636

Strand: Direct

Name: acoA [H]

Synonym: GSU3019

Alternate gene names: 39998110

Gene position: 3312678-3314636 (Clockwise)

Preceding gene: 39998109

Following gene: 39998111

Centisome position: 86.85

GC content: 49.11

Gene sequence:

>1959_bases
ATGAACAAGCGCAAGATCGATATGCTCATGAAAGACTGCTATGAGCTGACTGTCACTGCCCTCACAATCAGAAAAGTTGA
AGAACGTCTATTGGAGCTCTTTTCTGAAGGAGTACTCAACGGAACAATCCACACCTGTATCGGACAGGAGTGGACCGGAG
TGGCGGTTGCAAACGCACTGCAAGCGGGAGATACAGTTTTCTCCAATCACCGCGGTCATGGACATTATATTGCCCTGACT
GGTGATGTTTATGGACTTATCGCAGAAATCATGGGCAAAGACGACGGTGTCTGCGGAGGCGTTGGAGGTAGCCAGCATCT
ACATACAGAAAACTTCTTCTCTAACGGGATTCAAGGCGGAATGGTGCCGGTCGCGGCTGGAAGAGCCTTGGCAAACGCGC
TTCAAGGCAACAATGCAATTTCAGTGGTTTTTATCGGAGATGGAACTCTTGGAGAAGGTGTTATCTATGAAACGTTTAAC
ATCGCATCCAAATGGCAGTTGCCACTGTTAGTTGTCCTGGAAAACAATCAGTACGCTCAGTCCACACCCACATCCCTGAC
ATTGGCAGGCAATATACGGGACCGCGTACGTGGCTTCGGCATAGAATATATCAAGTGTGACACATGGGACATCGCCGGGC
TGCTTGACTCTGCAAAAGAGGCCGTTGATTGCGTACGCAAGAACCAAAAGCCTGTATTGCTCGAAATTGATACATACCGG
CTGAAAGCCCACTCGAAGGGAGATGATCTTAGAGACCCTGTAGAGATCAGCCGCTACGCTGGGCAGGACAGCATAAATGC
TCTACTGGAATCTGACGTTCCAAGAGTCGCTGAAACCGTCAATCAAATCGACAGCAATATCCAACAGGCAATCACCAAAG
CCAGGGAAGCGACATTATGTTCTTTCGCTCCGGCATCGAACAGTGTTCGACAGTATCAATCAGTTACGTGGAGAACTGAA
TCCTTTGCCAGACAAAGAATAATCACCTCAATCAATTTATCATTGCAATCGCTTCTGGAAAACAACTCTAAGGCAGTAAT
TATCGGGGAGGACATTGAAGCCCCCTACGGAGGAGCTTTCAAAGCCACAAAGGATCTGAGTACGTTGTTCCCGGGAAGAG
TCAAGAACACCCCCATCAGCGAGGGAGCGATTACAGGCGTAGGCATCGGTCTGGCACTGAGCGGATTTCTTCCCGTTGTG
GAGATAATGTTCGGCGACTTCATGACTCTAACCTTTGACCAACTGCTTCAACACGCCGGTAAATTCTGTGAGATGTATGG
CAAGGATCTCGACGTACCCTTGATCATTCGCACTCCCATGGGCGGACGTCGGGGTTATGGCCCAACACACAGCCAATCTT
TGGAGAAATTTTTTCTCGGCATACCGAATCTGGAGGTCATTGCGTACAACCATAGAGTTTCTCCCGCCCTGATCTTTGGA
AATCTGTGCAAGACGATCCGCAGGCCAACTCTCATCATCGAAAACAAGGTCCTCTATACTCAGCACGTAGACAGTACTCC
CATGCCTGGATTCCGCATCAATATTTCCGACGAACTATTCCCAACCGTCAGAATATCGCCAAGTACCGGAGATCCGCAAG
TGACGCTTGTCTGTTACGGGGGAATGCTTGCGGAGGTTGAGATAGCCGCAGCCGCGGCTTTCGACGAAAACGAAATACTC
TGCGAGATCATATGTCCGAGCATTATCAATCCTCTCAATGCATACCCCATTCTTGAGTCGGCACGGAAAACCAGGAGGCT
GATAACCGTAGAAGAAGGACCGAGCATAGCCGCCCTGGGCAGCGAGGTAGCCGCCCGAATACTTGAACATTCGCTTCCCA
TTGCCCATTACAGTCGTATCGGTTACGACTCTACCATTCCATCATCAGCCAGCCGTGAATCCAGATTGATAACAAATGCC
GAATCAATCTTTGAACGTATTGTGGAGATTTTCAAATGA

Upstream 100 bases:

>100_bases
AGGCTGGGAATGGAATATCCTGATTTTTGCAGTGCCTTATATGCCATTTGCAAAAAATAGTATTTGTACACAGCTTGGTA
TTTTCAGGGATGGCGATTCA

Downstream 100 bases:

>100_bases
TGAAAACAATGGACATAATCATTCCCAGAGAATTTGTCAGCGACGACCAGTACCTGCTCCAGAAACTCTGTGTCGTGAAC
AATGACTTTGTAAAAGAAGG

Product: dehydrogenase, E1 component subunits alpha and beta

Products: NA

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MNKRKIDMLMKDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANALQAGDTVFSNHRGHGHYIALT
GDVYGLIAEIMGKDDGVCGGVGGSQHLHTENFFSNGIQGGMVPVAAGRALANALQGNNAISVVFIGDGTLGEGVIYETFN
IASKWQLPLLVVLENNQYAQSTPTSLTLAGNIRDRVRGFGIEYIKCDTWDIAGLLDSAKEAVDCVRKNQKPVLLEIDTYR
LKAHSKGDDLRDPVEISRYAGQDSINALLESDVPRVAETVNQIDSNIQQAITKAREATLCSFAPASNSVRQYQSVTWRTE
SFARQRIITSINLSLQSLLENNSKAVIIGEDIEAPYGGAFKATKDLSTLFPGRVKNTPISEGAITGVGIGLALSGFLPVV
EIMFGDFMTLTFDQLLQHAGKFCEMYGKDLDVPLIIRTPMGGRRGYGPTHSQSLEKFFLGIPNLEVIAYNHRVSPALIFG
NLCKTIRRPTLIIENKVLYTQHVDSTPMPGFRINISDELFPTVRISPSTGDPQVTLVCYGGMLAEVEIAAAAAFDENEIL
CEIICPSIINPLNAYPILESARKTRRLITVEEGPSIAALGSEVAARILEHSLPIAHYSRIGYDSTIPSSASRESRLITNA
ESIFERIVEIFK

Sequences:

>Translated_652_residues
MNKRKIDMLMKDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANALQAGDTVFSNHRGHGHYIALT
GDVYGLIAEIMGKDDGVCGGVGGSQHLHTENFFSNGIQGGMVPVAAGRALANALQGNNAISVVFIGDGTLGEGVIYETFN
IASKWQLPLLVVLENNQYAQSTPTSLTLAGNIRDRVRGFGIEYIKCDTWDIAGLLDSAKEAVDCVRKNQKPVLLEIDTYR
LKAHSKGDDLRDPVEISRYAGQDSINALLESDVPRVAETVNQIDSNIQQAITKAREATLCSFAPASNSVRQYQSVTWRTE
SFARQRIITSINLSLQSLLENNSKAVIIGEDIEAPYGGAFKATKDLSTLFPGRVKNTPISEGAITGVGIGLALSGFLPVV
EIMFGDFMTLTFDQLLQHAGKFCEMYGKDLDVPLIIRTPMGGRRGYGPTHSQSLEKFFLGIPNLEVIAYNHRVSPALIFG
NLCKTIRRPTLIIENKVLYTQHVDSTPMPGFRINISDELFPTVRISPSTGDPQVTLVCYGGMLAEVEIAAAAAFDENEIL
CEIICPSIINPLNAYPILESARKTRRLITVEEGPSIAALGSEVAARILEHSLPIAHYSRIGYDSTIPSSASRESRLITNA
ESIFERIVEIFK
>Mature_652_residues
MNKRKIDMLMKDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANALQAGDTVFSNHRGHGHYIALT
GDVYGLIAEIMGKDDGVCGGVGGSQHLHTENFFSNGIQGGMVPVAAGRALANALQGNNAISVVFIGDGTLGEGVIYETFN
IASKWQLPLLVVLENNQYAQSTPTSLTLAGNIRDRVRGFGIEYIKCDTWDIAGLLDSAKEAVDCVRKNQKPVLLEIDTYR
LKAHSKGDDLRDPVEISRYAGQDSINALLESDVPRVAETVNQIDSNIQQAITKAREATLCSFAPASNSVRQYQSVTWRTE
SFARQRIITSINLSLQSLLENNSKAVIIGEDIEAPYGGAFKATKDLSTLFPGRVKNTPISEGAITGVGIGLALSGFLPVV
EIMFGDFMTLTFDQLLQHAGKFCEMYGKDLDVPLIIRTPMGGRRGYGPTHSQSLEKFFLGIPNLEVIAYNHRVSPALIFG
NLCKTIRRPTLIIENKVLYTQHVDSTPMPGFRINISDELFPTVRISPSTGDPQVTLVCYGGMLAEVEIAAAAAFDENEIL
CEIICPSIINPLNAYPILESARKTRRLITVEEGPSIAALGSEVAARILEHSLPIAHYSRIGYDSTIPSSASRESRLITNA
ESIFERIVEIFK

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=288, Percent_Identity=32.6388888888889, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI291084742, Length=283, Percent_Identity=29.6819787985866, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI4505685, Length=283, Percent_Identity=29.6819787985866, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI4557353, Length=314, Percent_Identity=30.5732484076433, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI34101272, Length=314, Percent_Identity=30.5732484076433, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI291084744, Length=290, Percent_Identity=30, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI156564403, Length=295, Percent_Identity=27.7966101694915, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI291084858, Length=295, Percent_Identity=25.7627118644068, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI258645172, Length=233, Percent_Identity=29.1845493562232, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI11386135, Length=234, Percent_Identity=29.4871794871795, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17536047, Length=227, Percent_Identity=33.4801762114537, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32564172, Length=227, Percent_Identity=33.4801762114537, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=27.1341463414634, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17506935, Length=316, Percent_Identity=31.0126582278481, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI86563357, Length=235, Percent_Identity=30.6382978723404, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI86563355, Length=235, Percent_Identity=30.6382978723404, Blast_Score=93, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321026, Length=291, Percent_Identity=31.6151202749141, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319698, Length=321, Percent_Identity=28.0373831775701, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24639740, Length=228, Percent_Identity=32.8947368421053, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24639744, Length=228, Percent_Identity=32.8947368421053, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28571106, Length=228, Percent_Identity=32.8947368421053, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24639746, Length=228, Percent_Identity=32.8947368421053, Blast_Score=129, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24639748, Length=314, Percent_Identity=29.9363057324841, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21358145, Length=357, Percent_Identity=26.890756302521, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24650940, Length=357, Percent_Identity=26.890756302521, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI160714832, Length=315, Percent_Identity=29.8412698412698, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI160714828, Length=315, Percent_Identity=29.8412698412698, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355903, Length=211, Percent_Identity=29.8578199052133, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: NA

Molecular weight: Translated: 71140; Mature: 71140

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRKIDMLMKDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHH
QAGDTVFSNHRGHGHYIALTGDVYGLIAEIMGKDDGVCGGVGGSQHLHTENFFSNGIQGG
HCCCHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHCCCCCC
MVPVAAGRALANALQGNNAISVVFIGDGTLGEGVIYETFNIASKWQLPLLVVLENNQYAQ
CEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCC
STPTSLTLAGNIRDRVRGFGIEYIKCDTWDIAGLLDSAKEAVDCVRKNQKPVLLEIDTYR
CCCCEEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
LKAHSKGDDLRDPVEISRYAGQDSINALLESDVPRVAETVNQIDSNIQQAITKAREATLC
EEECCCCCCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEE
SFAPASNSVRQYQSVTWRTESFARQRIITSINLSLQSLLENNSKAVIIGEDIEAPYGGAF
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
KATKDLSTLFPGRVKNTPISEGAITGVGIGLALSGFLPVVEIMFGDFMTLTFDQLLQHAG
CCHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KFCEMYGKDLDVPLIIRTPMGGRRGYGPTHSQSLEKFFLGIPNLEVIAYNHRVSPALIFG
HHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
NLCKTIRRPTLIIENKVLYTQHVDSTPMPGFRINISDELFPTVRISPSTGDPQVTLVCYG
HHHHHHCCCEEEEECEEEEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEEC
GMLAEVEIAAAAAFDENEILCEIICPSIINPLNAYPILESARKTRRLITVEEGPSIAALG
CEEEEEEEHHHEECCCCCEEHEECCHHHCCCCCCCHHHHHHHHHHEEEEEECCCCEEHHH
SEVAARILEHSLPIAHYSRIGYDSTIPSSASRESRLITNAESIFERIVEIFK
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHC
>Mature Secondary Structure
MNKRKIDMLMKDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHH
QAGDTVFSNHRGHGHYIALTGDVYGLIAEIMGKDDGVCGGVGGSQHLHTENFFSNGIQGG
HCCCHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHCCCCCC
MVPVAAGRALANALQGNNAISVVFIGDGTLGEGVIYETFNIASKWQLPLLVVLENNQYAQ
CEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCC
STPTSLTLAGNIRDRVRGFGIEYIKCDTWDIAGLLDSAKEAVDCVRKNQKPVLLEIDTYR
CCCCEEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
LKAHSKGDDLRDPVEISRYAGQDSINALLESDVPRVAETVNQIDSNIQQAITKAREATLC
EEECCCCCCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEE
SFAPASNSVRQYQSVTWRTESFARQRIITSINLSLQSLLENNSKAVIIGEDIEAPYGGAF
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
KATKDLSTLFPGRVKNTPISEGAITGVGIGLALSGFLPVVEIMFGDFMTLTFDQLLQHAG
CCHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KFCEMYGKDLDVPLIIRTPMGGRRGYGPTHSQSLEKFFLGIPNLEVIAYNHRVSPALIFG
HHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
NLCKTIRRPTLIIENKVLYTQHVDSTPMPGFRINISDELFPTVRISPSTGDPQVTLVCYG
HHHHHHCCCEEEEECEEEEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEEC
GMLAEVEIAAAAAFDENEILCEIICPSIINPLNAYPILESARKTRRLITVEEGPSIAALG
CEEEEEEEHHHEECCCCCEEHEECCHHHCCCCCCCHHHHHHHHHHEEEEEECCCCEEHHH
SEVAARILEHSLPIAHYSRIGYDSTIPSSASRESRLITNAESIFERIVEIFK
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]