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The map label for this gene is acr3 [H]

Identifier: 39998045

GI number: 39998045

Start: 3252612

End: 3253664

Strand: Direct

Name: acr3 [H]

Synonym: GSU2954

Alternate gene names: 39998045

Gene position: 3252612-3253664 (Clockwise)

Preceding gene: 39998044

Following gene: 39998046

Centisome position: 85.28

GC content: 61.82

Gene sequence:

>1053_bases
ATGAGTGAGCATGTCTCCCGCAGGCTCTCCTTCCTCGACCGGTGGCTCACCGTGTGGATCTTTGCCGCCATGGCCCTGGG
CGTGGGGCTCGGCTGGCTTGTCCCCGGCGTGGAGCAGTTCATCAACCGCTTTCAGGTGGGGACCACCAACCTCCCCATCG
CCGCCGGCCTCATCCTCATGATGTATCCCCCCTTCGCCAAGGTGAAGTACGAGGAGATGCCCGAGGTCTTCAGGAACAAG
AAGATCCTCGCCCTGTCGCTGGTCCAGAACTGGCTCATCGGCCCCGTTCTCATGTTTGTCCTGGCCGTCGTATTTCTCCC
CGACAAGCCCGAATACATGGTAGGGCTCATCATGATCGGCCTGGCCCGCTGCATCGCCATGGTCATCGTCTGGAACGAAC
TGGCCAAAGGAAACACCGAGTACGCCGCCGGGCTCGTGGCCTTCAACAGCATTTTCCAGGTCCTCTTCTACAGCGCCTAC
GCCTGGGTCTTCATCACAGTGCTCCCCCCCCTCTTCGGCCTGTCGGGGAGCCTTGTGGAAGTGAGCATCGGCCAGATCGC
GGAAAGCGTCTTCGTTTACCTGGGGATTCCGTGCCTCGCCGGAGCGCTGACCCGCCTCATCGGCGTTAACGTTATGGGTA
AAGAGCGCTACCACCGGGAGGTTGTCCCCCGCATCGGCCCCATCACCCTCATCGCGCTCCTCTTCACGATCGTGGTCATG
TTCAGCCTCAAGGGGAACCTCATCGTCCAGCTTCCCTTTGATGTGGTGCGGATCGCCATGCCGCTGCTCATCTACTTCGT
GGTGATGTTCCTGATCTCCTTTTGGATGGGAAAGCGGCTCGGGGCCGACTACTCGAAGACCACCACCCTCGCCTTCACGG
CGGCCAGCAACAACTTCGAGCTGGCCATAGCCGTAGCGGTGGCGGTCTTCGGTCTCAACTCGGGGGCGGCTTTCGCGGCA
GTCATCGGCCCCCTGGTGGAGGTGCCGGTGATGATCGGGCTGGTGAACGTGGCGTTCTGGCTGCAACGACACTGGTTCCG
GGCCGCTGCCTGA

Upstream 100 bases:

>100_bases
TCACGGGCGGCGGGCACGGACGAGGAGATCATGGACGAGTATCGCCGGGTGCGGGACGAGATGAGGTGCATACTAATCTC
CTGCCTGAACAGAGGCGACC

Downstream 100 bases:

>100_bases
AAAGGGAGTATCACGTGTTCAAACCCTTCGCCGACTACCTTGTTTTCGATCTCTTCGGCCTCACCCCCGGCAGCCACCTG
GGAGATGCCCTCAATTTCTT

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSEHVSRRLSFLDRWLTVWIFAAMALGVGLGWLVPGVEQFINRFQVGTTNLPIAAGLILMMYPPFAKVKYEEMPEVFRNK
KILALSLVQNWLIGPVLMFVLAVVFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSAY
AWVFITVLPPLFGLSGSLVEVSIGQIAESVFVYLGIPCLAGALTRLIGVNVMGKERYHREVVPRIGPITLIALLFTIVVM
FSLKGNLIVQLPFDVVRIAMPLLIYFVVMFLISFWMGKRLGADYSKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAA
VIGPLVEVPVMIGLVNVAFWLQRHWFRAAA

Sequences:

>Translated_350_residues
MSEHVSRRLSFLDRWLTVWIFAAMALGVGLGWLVPGVEQFINRFQVGTTNLPIAAGLILMMYPPFAKVKYEEMPEVFRNK
KILALSLVQNWLIGPVLMFVLAVVFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSAY
AWVFITVLPPLFGLSGSLVEVSIGQIAESVFVYLGIPCLAGALTRLIGVNVMGKERYHREVVPRIGPITLIALLFTIVVM
FSLKGNLIVQLPFDVVRIAMPLLIYFVVMFLISFWMGKRLGADYSKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAA
VIGPLVEVPVMIGLVNVAFWLQRHWFRAAA
>Mature_349_residues
SEHVSRRLSFLDRWLTVWIFAAMALGVGLGWLVPGVEQFINRFQVGTTNLPIAAGLILMMYPPFAKVKYEEMPEVFRNKK
ILALSLVQNWLIGPVLMFVLAVVFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSAYA
WVFITVLPPLFGLSGSLVEVSIGQIAESVFVYLGIPCLAGALTRLIGVNVMGKERYHREVVPRIGPITLIALLFTIVVMF
SLKGNLIVQLPFDVVRIAMPLLIYFVVMFLISFWMGKRLGADYSKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAAV
IGPLVEVPVMIGLVNVAFWLQRHWFRAAA

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=320, Percent_Identity=35, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38648; Mature: 38517

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHVSRRLSFLDRWLTVWIFAAMALGVGLGWLVPGVEQFINRFQVGTTNLPIAAGLILM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MYPPFAKVKYEEMPEVFRNKKILALSLVQNWLIGPVLMFVLAVVFLPDKPEYMVGLIMIG
HCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSAYAWVFITVLPPLFGLSGSLVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VSIGQIAESVFVYLGIPCLAGALTRLIGVNVMGKERYHREVVPRIGPITLIALLFTIVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
FSLKGNLIVQLPFDVVRIAMPLLIYFVVMFLISFWMGKRLGADYSKTTTLAFTAASNNFE
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCH
LAIAVAVAVFGLNSGAAFAAVIGPLVEVPVMIGLVNVAFWLQRHWFRAAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEHVSRRLSFLDRWLTVWIFAAMALGVGLGWLVPGVEQFINRFQVGTTNLPIAAGLILM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MYPPFAKVKYEEMPEVFRNKKILALSLVQNWLIGPVLMFVLAVVFLPDKPEYMVGLIMIG
HCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSAYAWVFITVLPPLFGLSGSLVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VSIGQIAESVFVYLGIPCLAGALTRLIGVNVMGKERYHREVVPRIGPITLIALLFTIVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
FSLKGNLIVQLPFDVVRIAMPLLIYFVVMFLISFWMGKRLGADYSKTTTLAFTAASNNFE
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCH
LAIAVAVAVFGLNSGAAFAAVIGPLVEVPVMIGLVNVAFWLQRHWFRAAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]