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The map label for this gene is czcR [H]

Identifier: 39998037

GI number: 39998037

Start: 3243689

End: 3244360

Strand: Direct

Name: czcR [H]

Synonym: GSU2946

Alternate gene names: 39998037

Gene position: 3243689-3244360 (Clockwise)

Preceding gene: 39998036

Following gene: 39998038

Centisome position: 85.04

GC content: 62.95

Gene sequence:

>672_bases
ATGCGCGTCCTGATCATCGAAGACGAAAAGAAGGCCGCCGCCTACCTCCAAAAGGGGTTCGCGGAGAACGGCTTCACGGC
CGACACCGCCGCATCCGGCGACGACGGCCTCCACTTGGCGCGTACCGAGAACTATGACCTGATCATCCTCGACATCATGC
TGCCCGGCCGGGACGGATGGGAAGTACTGGAAGAGCTGCGGAAAGAAGGGAGCGAGGTGCCGGTCATCTACCTGTCGGCC
CGGGATGCGGTGCACGACCGGGTGCGAGGGCTTGAACTGGGGGCCGACGACTACCTGGTGAAGCCCTTCGCCTTCTCGGA
ACTCCTGGCGCGGGCACGGACCATTCTCCGGCGAGGGCCGTCCCGCCAGCCGGAACGTCTGCGGGCTGACGACCTGGAGA
TGGATCTCGTGGGGCACAAGGCCCGGCGGGAGGGAAGGCCCATCGACCTCACCGCCAAGGAATTCATCCTGTTATCGCTG
CTTTTGCGCCGTAAAGGCGAGGTACTTTCCCGCACCCTCATCGCCGAACAGGTGTGGGGAATCAATTTCGACAGCGACAC
TAACATCGTCGACGTAGCGATCCGTCGGCTACGGCGCAAGGTCGACGACCCCTTCGAGAGGAAGCTCATCCACACCGTCC
GCGGAGCAGGCTATGTACTTGAAGCGAAGTGA

Upstream 100 bases:

>100_bases
GGGCGCTCCCTCAGTTAAAATGGTTGCGACATCCCGACGCAGACGCTAAAATCACCAGAAAAATCCACCCCATCCGCCAC
CCCGGCGCCCCGACATCTCC

Downstream 100 bases:

>100_bases
CGGCCCCTCCCCGGGAACGCTCTCCCTTGCCGCGCGTCTCACCGTCCTCTCCACCCTCGCCACCACCGGCGTCCTCCTCT
TTGCCATCGTGTTTCAGTTC

Product: DNA-binding heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLIIEDEKKAAAYLQKGFAENGFTADTAASGDDGLHLARTENYDLIILDIMLPGRDGWEVLEELRKEGSEVPVIYLSA
RDAVHDRVRGLELGADDYLVKPFAFSELLARARTILRRGPSRQPERLRADDLEMDLVGHKARREGRPIDLTAKEFILLSL
LLRRKGEVLSRTLIAEQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLIHTVRGAGYVLEAK

Sequences:

>Translated_223_residues
MRVLIIEDEKKAAAYLQKGFAENGFTADTAASGDDGLHLARTENYDLIILDIMLPGRDGWEVLEELRKEGSEVPVIYLSA
RDAVHDRVRGLELGADDYLVKPFAFSELLARARTILRRGPSRQPERLRADDLEMDLVGHKARREGRPIDLTAKEFILLSL
LLRRKGEVLSRTLIAEQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLIHTVRGAGYVLEAK
>Mature_223_residues
MRVLIIEDEKKAAAYLQKGFAENGFTADTAASGDDGLHLARTENYDLIILDIMLPGRDGWEVLEELRKEGSEVPVIYLSA
RDAVHDRVRGLELGADDYLVKPFAFSELLARARTILRRGPSRQPERLRADDLEMDLVGHKARREGRPIDLTAKEFILLSL
LLRRKGEVLSRTLIAEQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLIHTVRGAGYVLEAK

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=57.3991031390135, Blast_Score=255, Evalue=2e-69,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=55.4054054054054, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=41.2556053811659, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.9090909090909, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.2422907488987, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.0807174887892, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=36.1233480176211, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=38.8127853881278, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=35.0877192982456, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.1479820627803, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.036036036036, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=38.1974248927039, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.9734513274336, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=27.7372262773723, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=108, Percent_Identity=30.5555555555556, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=30.5555555555556, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25302; Mature: 25302

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIIEDEKKAAAYLQKGFAENGFTADTAASGDDGLHLARTENYDLIILDIMLPGRDGW
CEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCHH
EVLEELRKEGSEVPVIYLSARDAVHDRVRGLELGADDYLVKPFAFSELLARARTILRRGP
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
SRQPERLRADDLEMDLVGHKARREGRPIDLTAKEFILLSLLLRRKGEVLSRTLIAEQVWG
CCCCCHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INFDSDTNIVDVAIRRLRRKVDDPFERKLIHTVRGAGYVLEAK
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRVLIIEDEKKAAAYLQKGFAENGFTADTAASGDDGLHLARTENYDLIILDIMLPGRDGW
CEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCHH
EVLEELRKEGSEVPVIYLSARDAVHDRVRGLELGADDYLVKPFAFSELLARARTILRRGP
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
SRQPERLRADDLEMDLVGHKARREGRPIDLTAKEFILLSLLLRRKGEVLSRTLIAEQVWG
CCCCCHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INFDSDTNIVDVAIRRLRRKVDDPFERKLIHTVRGAGYVLEAK
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]