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The map label for this gene is yogA [H]

Identifier: 39997731

GI number: 39997731

Start: 2907815

End: 2908801

Strand: Reverse

Name: yogA [H]

Synonym: GSU2637

Alternate gene names: 39997731

Gene position: 2908801-2907815 (Counterclockwise)

Preceding gene: 39997732

Following gene: 39997730

Centisome position: 76.26

GC content: 61.7

Gene sequence:

>987_bases
ATGAAAGCAGTACTGCTCGACGGCTTCGGCGGGCTTGATGTTCTCAAGGTAGGGGAGGCGGAGAGGCCGAAACCGGCGGA
AGGGCAGGTGCTCGTCAAAGTGGTGGCCACCTCCGTCAATCGTCCCGACCTCGTTCAGCGGGAGGGAAAGTATCCGCCTC
CGCCGGGTGATTCGGAAATTCTCGGCCTGGAAGTTTCGGGCACCATCGAGGAACTGGGTCCGGGCGTCACCGGCTGGCAG
GTGGGCGACCGGGTCATGTCCCTGGTCGGAGGGGGCGGCTACGCGGAGTACGCGGTGGCCTACGCGAGCCACCTCATGCG
GATTCCCGAAAGCATGAGCTTCGAAGAGGCGGCCTGCGTCTGCGAGTCCTACATTACGGCATTCCTGAACGTCTTCATGA
TCGGCGGGCTCAAGGACAATAACAGCGTCATCCTCCACGGCGGCGGCGGCGGGGTGAACACTGCCGGCATCCAGCTCTGC
AAGGCCCTGGTTCCCAACACGAAGATCGTCGCTACCGCCCATCCGTCAAAGATCGACCGGGTCAAGGCCCTGGGGGCTGA
TCTGGTCGTCGACTTCACCCAGACTCCCGACTTCTCCGAGGCGGTGAAGGAGTTCACCAACAAGAAGGGGGTCGACGTGA
TCCTCGATCACGTGGGCGCCAAGTACCTGGCCCCCAACATGAATTCACTGGCCTACGCCGGGCGGCTCGTCATCATTGGC
GTCATCAGCGGCATCAAGGCTGAGCTCAACCTGGCCCTGATGATGGTGAAGCGGCAACAAATCATCGGCTCCGTGCTCCG
CTCTCGCCCCGTTAAGGACAAGGGGGAGATCGTGGCCGAGTTCACCAGGACGGCGCTGCCGAAGTTCGCCGACCGGACCA
TCGTGCCGATCATCGAGAAGGTCTTCCCCATGGATCAGGTGGTTGAAGCCCACCGGATGATGGAAGAAGACAAGCACTTC
GGGAAGATCGTGCTGAAGATCAGCTAA

Upstream 100 bases:

>100_bases
GACACGGGCTTTCCTCTGGATTTTGTGTTTACAGAACGCTGTTTGTTGGCTAGAGTGTCGGGATTGATTCCGTGACTTTT
CCACTCAAGGAGGAACAGCT

Downstream 100 bases:

>100_bases
CGTTCGATTCACCGGCTGTTTCAGGCCCTCTCCCCTTGTCGGGAGAGGGCTTTTCTCTTTCAGCGGAACAAGGAGGATCA
CGCCATGACGGCACCGCAAT

Product: alcohol dehydrogenase, zinc-containing

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKAVLLDGFGGLDVLKVGEAERPKPAEGQVLVKVVATSVNRPDLVQREGKYPPPPGDSEILGLEVSGTIEELGPGVTGWQ
VGDRVMSLVGGGGYAEYAVAYASHLMRIPESMSFEEAACVCESYITAFLNVFMIGGLKDNNSVILHGGGGGVNTAGIQLC
KALVPNTKIVATAHPSKIDRVKALGADLVVDFTQTPDFSEAVKEFTNKKGVDVILDHVGAKYLAPNMNSLAYAGRLVIIG
VISGIKAELNLALMMVKRQQIIGSVLRSRPVKDKGEIVAEFTRTALPKFADRTIVPIIEKVFPMDQVVEAHRMMEEDKHF
GKIVLKIS

Sequences:

>Translated_328_residues
MKAVLLDGFGGLDVLKVGEAERPKPAEGQVLVKVVATSVNRPDLVQREGKYPPPPGDSEILGLEVSGTIEELGPGVTGWQ
VGDRVMSLVGGGGYAEYAVAYASHLMRIPESMSFEEAACVCESYITAFLNVFMIGGLKDNNSVILHGGGGGVNTAGIQLC
KALVPNTKIVATAHPSKIDRVKALGADLVVDFTQTPDFSEAVKEFTNKKGVDVILDHVGAKYLAPNMNSLAYAGRLVIIG
VISGIKAELNLALMMVKRQQIIGSVLRSRPVKDKGEIVAEFTRTALPKFADRTIVPIIEKVFPMDQVVEAHRMMEEDKHF
GKIVLKIS
>Mature_328_residues
MKAVLLDGFGGLDVLKVGEAERPKPAEGQVLVKVVATSVNRPDLVQREGKYPPPPGDSEILGLEVSGTIEELGPGVTGWQ
VGDRVMSLVGGGGYAEYAVAYASHLMRIPESMSFEEAACVCESYITAFLNVFMIGGLKDNNSVILHGGGGGVNTAGIQLC
KALVPNTKIVATAHPSKIDRVKALGADLVVDFTQTPDFSEAVKEFTNKKGVDVILDHVGAKYLAPNMNSLAYAGRLVIIG
VISGIKAELNLALMMVKRQQIIGSVLRSRPVKDKGEIVAEFTRTALPKFADRTIVPIIEKVFPMDQVVEAHRMMEEDKHF
GKIVLKIS

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=334, Percent_Identity=40.1197604790419, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI22538444, Length=334, Percent_Identity=40.1197604790419, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI24308257, Length=347, Percent_Identity=28.5302593659942, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI18379349, Length=342, Percent_Identity=31.8713450292398, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI194239674, Length=332, Percent_Identity=31.0240963855422, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI13236495, Length=332, Percent_Identity=31.0240963855422, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI194239676, Length=331, Percent_Identity=28.3987915407855, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI47519420, Length=376, Percent_Identity=27.6595744680851, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI41872631, Length=310, Percent_Identity=26.7741935483871, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI28557745, Length=234, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1790485, Length=328, Percent_Identity=28.0487804878049, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=369, Percent_Identity=27.3712737127371, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI226510941, Length=333, Percent_Identity=23.1231231231231, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=329, Percent_Identity=28.2674772036474, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71987554, Length=382, Percent_Identity=26.1780104712042, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=354, Percent_Identity=24.0112994350282, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212642053, Length=321, Percent_Identity=25.2336448598131, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536829, Length=224, Percent_Identity=29.9107142857143, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=337, Percent_Identity=27.893175074184, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=335, Percent_Identity=24.1791044776119, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19920632, Length=300, Percent_Identity=24.6666666666667, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221330659, Length=300, Percent_Identity=24.6666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581345, Length=330, Percent_Identity=23.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581341, Length=366, Percent_Identity=25.6830601092896, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24581339, Length=366, Percent_Identity=25.6830601092896, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550423, Length=156, Percent_Identity=30.1282051282051, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35180; Mature: 35180

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVLLDGFGGLDVLKVGEAERPKPAEGQVLVKVVATSVNRPDLVQREGKYPPPPGDSEI
CCEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEEHHCCCCCHHHHHCCCCCCCCCCCCE
LGLEVSGTIEELGPGVTGWQVGDRVMSLVGGGGYAEYAVAYASHLMRIPESMSFEEAACV
EEEEECCCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
CESYITAFLNVFMIGGLKDNNSVILHGGGGGVNTAGIQLCKALVPNTKIVATAHPSKIDR
HHHHHHHHHHHHHHCCEECCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHH
VKALGADLVVDFTQTPDFSEAVKEFTNKKGVDVILDHVGAKYLAPNMNSLAYAGRLVIIG
HHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCHHHHHHCCEEEEE
VISGIKAELNLALMMVKRQQIIGSVLRSRPVKDKGEIVAEFTRTALPKFADRTIVPIIEK
EHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
VFPMDQVVEAHRMMEEDKHFGKIVLKIS
HCCHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKAVLLDGFGGLDVLKVGEAERPKPAEGQVLVKVVATSVNRPDLVQREGKYPPPPGDSEI
CCEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEEHHCCCCCHHHHHCCCCCCCCCCCCE
LGLEVSGTIEELGPGVTGWQVGDRVMSLVGGGGYAEYAVAYASHLMRIPESMSFEEAACV
EEEEECCCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
CESYITAFLNVFMIGGLKDNNSVILHGGGGGVNTAGIQLCKALVPNTKIVATAHPSKIDR
HHHHHHHHHHHHHHCCEECCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHH
VKALGADLVVDFTQTPDFSEAVKEFTNKKGVDVILDHVGAKYLAPNMNSLAYAGRLVIIG
HHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCHHHHHHCCEEEEE
VISGIKAELNLALMMVKRQQIIGSVLRSRPVKDKGEIVAEFTRTALPKFADRTIVPIIEK
EHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
VFPMDQVVEAHRMMEEDKHFGKIVLKIS
HCCHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]