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The map label for this gene is pdhA [H]

Identifier: 39997538

GI number: 39997538

Start: 2677711

End: 2678688

Strand: Reverse

Name: pdhA [H]

Synonym: GSU2443

Alternate gene names: 39997538

Gene position: 2678688-2677711 (Counterclockwise)

Preceding gene: 39997539

Following gene: 39997537

Centisome position: 70.23

GC content: 65.24

Gene sequence:

>978_bases
ATGGCAACCACGCTCCGCGCCATCCTTCCCGATTCCGAGCTGCTGAAGATGCACGAACAGATGGTCCTCTCCCGCGAGTT
CGAGGAATCGTGCGCCGAACAGTACACCAAGGGGCATATCACCGGCTTCCTCCACCTCTACAGCGGCCAGGAGGCAGTGG
CGGTGGGCGCAACCGCGGCGCTGCGCAAGGACGACTACATCCTCTCCGCCTACCGGGAGCACGCCCAGGCCATCGTTCGG
GGGGCCGAGCCGCGGCGGGTCATGGCCGAACTCTTCGGCAAGGCCACCGGCATGTGCAAGGGGAAGGGGGGCTCCATGCA
CCTCTTCGACCCGAGCCTCGCCTTCATGGGAGGATACGCCATCGTCGGCGGCCAGTTCCCCATCGCCGTCGGGCTTGCCT
TTGCCTCCAAATACCGGAAGGAAGGACGGATCTCCGCCTGCTTCTTCGGCGACGGCGCCGTCAACCAGGGCACCTTCCAC
GAATCCCTCAACTGGGCCCGGCTCTGGGAGCTGCCGGTCCTCTTCATCTGCGAGAACAACTTCTACGGCATCGGCACCGC
CGTCTCCCGGGCCTCGGCCCTCTCCGACATCCACAAACGCACCTGCGGCTACGACATCCCCTCCGTGCGGGTGGACGGCA
TGGACGTCATGGCGGTCCACGAGGCCGTCAAATGGGGCGCCGAGTGGGTCCGGGAGCACAGCCGGCCCTACCTGATCGAA
GCCATGACCTACCGCTTCCGGGGCCACTCCATGGCCGACCCCGGCAAGTACCGCAGCGCCGCCGAAGTGGAGCTCTGGAA
AAGCCGCGACCCGATCCCGAACTTCGAGAAACGCCTCGTGGAAGAAGGCATCGCCACCGAAGCCGAACTGGCCGCCGTGC
TGGAGAAATGCCGGGGCGTCGTGGCCGACGCCGTGGCATTTGCCGAAGAATCGCCGTGGCCGGAGGATGATGAGGTTTAT
TCGGATATTTATGTGTGA

Upstream 100 bases:

>100_bases
TTATCCACCGGCACCGCGGCAGGGTCTGGGCCTTCTCCGAGCCCGGCCGGGGGGCATGTTTCTTCTTTACCCTGAATACC
GAAACCGCATGAGGTGACCC

Downstream 100 bases:

>100_bases
GGGGCAGAAACTGTTAGCCGCAGAGACATGTTTGATCTGTTCCAATACGGGGGGATGAGCGGTTCACGCACGTGTGCGTG
AACCGTTTAATGATGAGTTG

Product: dehydrogenase complex, E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MATTLRAILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDYILSAYREHAQAIVR
GAEPRRVMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYAIVGGQFPIAVGLAFASKYRKEGRISACFFGDGAVNQGTFH
ESLNWARLWELPVLFICENNFYGIGTAVSRASALSDIHKRTCGYDIPSVRVDGMDVMAVHEAVKWGAEWVREHSRPYLIE
AMTYRFRGHSMADPGKYRSAAEVELWKSRDPIPNFEKRLVEEGIATEAELAAVLEKCRGVVADAVAFAEESPWPEDDEVY
SDIYV

Sequences:

>Translated_325_residues
MATTLRAILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDYILSAYREHAQAIVR
GAEPRRVMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYAIVGGQFPIAVGLAFASKYRKEGRISACFFGDGAVNQGTFH
ESLNWARLWELPVLFICENNFYGIGTAVSRASALSDIHKRTCGYDIPSVRVDGMDVMAVHEAVKWGAEWVREHSRPYLIE
AMTYRFRGHSMADPGKYRSAAEVELWKSRDPIPNFEKRLVEEGIATEAELAAVLEKCRGVVADAVAFAEESPWPEDDEVY
SDIYV
>Mature_324_residues
ATTLRAILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDYILSAYREHAQAIVRG
AEPRRVMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYAIVGGQFPIAVGLAFASKYRKEGRISACFFGDGAVNQGTFHE
SLNWARLWELPVLFICENNFYGIGTAVSRASALSDIHKRTCGYDIPSVRVDGMDVMAVHEAVKWGAEWVREHSRPYLIEA
MTYRFRGHSMADPGKYRSAAEVELWKSRDPIPNFEKRLVEEGIATEAELAAVLEKCRGVVADAVAFAEESPWPEDDEVYS
DIYV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=320, Percent_Identity=42.5, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI4505685, Length=320, Percent_Identity=41.5625, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI291084742, Length=320, Percent_Identity=41.5625, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI291084744, Length=327, Percent_Identity=40.6727828746177, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI291084757, Length=320, Percent_Identity=37.8125, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=33.9622641509434, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI258645172, Length=318, Percent_Identity=33.9622641509434, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17536047, Length=318, Percent_Identity=42.7672955974843, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI32564172, Length=318, Percent_Identity=42.7672955974843, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI86563357, Length=313, Percent_Identity=32.9073482428115, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI86563355, Length=313, Percent_Identity=32.9073482428115, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=45.5696202531646, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=43.3962264150943, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=43.3962264150943, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=43.3962264150943, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24639748, Length=323, Percent_Identity=43.6532507739938, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=43.7908496732026, Blast_Score=250, Evalue=7e-67,
Organism=Drosophila melanogaster, GI21355903, Length=313, Percent_Identity=30.6709265175719, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36050; Mature: 35919

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLRAILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAA
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECHHHH
LRKDDYILSAYREHAQAIVRGAEPRRVMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYA
HCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCEEEEECCHHHHHCCEE
IVGGQFPIAVGLAFASKYRKEGRISACFFGDGAVNQGTFHESLNWARLWELPVLFICENN
EECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHCCCHHHHHCCCEEEEECCC
FYGIGTAVSRASALSDIHKRTCGYDIPSVRVDGMDVMAVHEAVKWGAEWVREHSRPYLIE
CEECHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEH
AMTYRFRGHSMADPGKYRSAAEVELWKSRDPIPNFEKRLVEEGIATEAELAAVLEKCRGV
HHHHHCCCCCCCCCCCCCCCHHHEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VADAVAFAEESPWPEDDEVYSDIYV
HHHHHHHHCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
ATTLRAILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECHHHH
LRKDDYILSAYREHAQAIVRGAEPRRVMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYA
HCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCEEEEECCHHHHHCCEE
IVGGQFPIAVGLAFASKYRKEGRISACFFGDGAVNQGTFHESLNWARLWELPVLFICENN
EECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHCCCHHHHHCCCEEEEECCC
FYGIGTAVSRASALSDIHKRTCGYDIPSVRVDGMDVMAVHEAVKWGAEWVREHSRPYLIE
CEECHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEH
AMTYRFRGHSMADPGKYRSAAEVELWKSRDPIPNFEKRLVEEGIATEAELAAVLEKCRGV
HHHHHCCCCCCCCCCCCCCCHHHEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VADAVAFAEESPWPEDDEVYSDIYV
HHHHHHHHCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA