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The map label for this gene is lpxB

Identifier: 39997359

GI number: 39997359

Start: 2476750

End: 2477904

Strand: Reverse

Name: lpxB

Synonym: GSU2261

Alternate gene names: 39997359

Gene position: 2477904-2476750 (Counterclockwise)

Preceding gene: 39997360

Following gene: 39997358

Centisome position: 64.97

GC content: 63.2

Gene sequence:

>1155_bases
ATGACAGAAAACACATCACATCGAATCATGATCGTTGCCGGCGAGGCCTCGGGCGACCTCCACGGGGCCGGACTGGTCAG
GGAAGCGCTCCGTCTTGACCCGACTCTCTCTTTCTTCGGCATCGGGGGCCCCCGCATGCGGGAAGCCGGGGTGGAGACCC
TGGTGGACTCCTCGGAGATGGCGGTGGTGGGTATCGTGGAGGTGCTGGCCCACATCGGGGTGATCTCCCGCGCCTTCATG
ACGCTCAGGCAGGTCATCGTTTCGAATCCGCCCGACCTCCTGATTCTCATCGACTACCCCGATTTCAACATGCTTCTTGC
CCGGGTGGCCCGACGCCACGGCGTCAAGGTACTCTACTACATCAGTCCCCAGGTCTGGGCCTGGCGGACCGGGCGGGTCA
AGACCATCGGCCGGCTGGTGGACCGGATGGCCGTGGTGTTTCCCTTTGAGGTGCCCTTTTACGAACGGGCCGGGGTGCCG
GTCAGCTTCGTGGGACATCCGCTGGCGGACCGGGTGCGTCCGACCATGGGGCGTGACGAAGCCCTGGCCTCCTTCGGGCT
CGATCCGGGGCGGCGAGTGGTGGGACTCTTCCCCGGCAGCCGCCGCGGGGAGATCGCCAAGCTTTTCCCGGTAATCCTCG
AAAGCGCGCAGCAGCTGCGGGAACGCTATCCCGACATCCAGTTCATCCTGCCGCTGGCATCGAGCCTCACCGATGGAGAC
ATTGCTCCCCTGCTGGCGGCATCGGGCCTTGACGTTACTGTGACTCAAGACCGGGTGTACGACGTGATGCAGGTCTGTGA
CGCCATAATTACCGTCTCCGGCACCGTGACCCTGGAGATCGCCCTCATGGGCGTGCCCATGGTGATCATCTACAAGGTGT
CTCCGCTTACCTACCAGGTGGGGAAGCGGCTCATCCGCGTCGACCATATCGGCATCTGCAACATCGTTGCGGGCGAGCGG
GTGGTTCCAGAACTGATCCAGGACGATGCCTCGGCCGACCGGATCGCCGCCGAGATCGGACGCTATCTGGATGATCCCGC
CTATGCGGAGAAAACTCGCGCCGGCCTTGCCATGGTCAAGGAAAAGCTCGGTACCGGCGGCTGCTCGGAACGGGTAGCAG
GAATCGTTCTGGAAATGCTCGGAAAGCAGGTTTAA

Upstream 100 bases:

>100_bases
CGAGGTGGTCGGGGTCATCAAGAGCGCGCTCTAGCTGCGACACCTGCCACGACACTGAACACGGAGACGCCCTGCGGGGC
GTCTCTGCCATTTTTGACGG

Downstream 100 bases:

>100_bases
TGGATACCTTCAAGCGCATTCTGCATTACAGCAAGCCCTACTGGTGGCGGATCGTCATCTCCATGGCGGCGTCACTCTGC
GTCGGCGGCACCGATGCGGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTENTSHRIMIVAGEASGDLHGAGLVREALRLDPTLSFFGIGGPRMREAGVETLVDSSEMAVVGIVEVLAHIGVISRAFM
TLRQVIVSNPPDLLILIDYPDFNMLLARVARRHGVKVLYYISPQVWAWRTGRVKTIGRLVDRMAVVFPFEVPFYERAGVP
VSFVGHPLADRVRPTMGRDEALASFGLDPGRRVVGLFPGSRRGEIAKLFPVILESAQQLRERYPDIQFILPLASSLTDGD
IAPLLAASGLDVTVTQDRVYDVMQVCDAIITVSGTVTLEIALMGVPMVIIYKVSPLTYQVGKRLIRVDHIGICNIVAGER
VVPELIQDDASADRIAAEIGRYLDDPAYAEKTRAGLAMVKEKLGTGGCSERVAGIVLEMLGKQV

Sequences:

>Translated_384_residues
MTENTSHRIMIVAGEASGDLHGAGLVREALRLDPTLSFFGIGGPRMREAGVETLVDSSEMAVVGIVEVLAHIGVISRAFM
TLRQVIVSNPPDLLILIDYPDFNMLLARVARRHGVKVLYYISPQVWAWRTGRVKTIGRLVDRMAVVFPFEVPFYERAGVP
VSFVGHPLADRVRPTMGRDEALASFGLDPGRRVVGLFPGSRRGEIAKLFPVILESAQQLRERYPDIQFILPLASSLTDGD
IAPLLAASGLDVTVTQDRVYDVMQVCDAIITVSGTVTLEIALMGVPMVIIYKVSPLTYQVGKRLIRVDHIGICNIVAGER
VVPELIQDDASADRIAAEIGRYLDDPAYAEKTRAGLAMVKEKLGTGGCSERVAGIVLEMLGKQV
>Mature_383_residues
TENTSHRIMIVAGEASGDLHGAGLVREALRLDPTLSFFGIGGPRMREAGVETLVDSSEMAVVGIVEVLAHIGVISRAFMT
LRQVIVSNPPDLLILIDYPDFNMLLARVARRHGVKVLYYISPQVWAWRTGRVKTIGRLVDRMAVVFPFEVPFYERAGVPV
SFVGHPLADRVRPTMGRDEALASFGLDPGRRVVGLFPGSRRGEIAKLFPVILESAQQLRERYPDIQFILPLASSLTDGDI
APLLAASGLDVTVTQDRVYDVMQVCDAIITVSGTVTLEIALMGVPMVIIYKVSPLTYQVGKRLIRVDHIGICNIVAGERV
VPELIQDDASADRIAAEIGRYLDDPAYAEKTRAGLAMVKEKLGTGGCSERVAGIVLEMLGKQV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=336, Percent_Identity=36.0119047619048, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_GEOSL (Q74AT9)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953310.1
- ProteinModelPortal:   Q74AT9
- GeneID:   2685733
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2261
- NMPDR:   fig|243231.1.peg.2248
- TIGR:   GSU2261
- HOGENOM:   HBG584837
- OMA:   EFAFICS
- ProtClustDB:   PRK00025
- BioCyc:   GSUL243231:GSU_2261-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41843; Mature: 41711

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENTSHRIMIVAGEASGDLHGAGLVREALRLDPTLSFFGIGGPRMREAGVETLVDSSEM
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCH
AVVGIVEVLAHIGVISRAFMTLRQVIVSNPPDLLILIDYPDFNMLLARVARRHGVKVLYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEE
ISPQVWAWRTGRVKTIGRLVDRMAVVFPFEVPFYERAGVPVSFVGHPLADRVRPTMGRDE
ECCCEEEEECCCHHHHHHHHHHHHHEEECCCCCHHCCCCCHHHCCCCHHHHCCCCCCCHH
ALASFGLDPGRRVVGLFPGSRRGEIAKLFPVILESAQQLRERYPDIQFILPLASSLTDGD
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCC
IAPLLAASGLDVTVTQDRVYDVMQVCDAIITVSGTVTLEIALMGVPMVIIYKVSPLTYQV
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHEECCEEEEEEEEECCCEEEEEECCCHHHHH
GKRLIRVDHIGICNIVAGERVVPELIQDDASADRIAAEIGRYLDDPAYAEKTRAGLAMVK
HHHHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EKLGTGGCSERVAGIVLEMLGKQV
HHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TENTSHRIMIVAGEASGDLHGAGLVREALRLDPTLSFFGIGGPRMREAGVETLVDSSEM
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCH
AVVGIVEVLAHIGVISRAFMTLRQVIVSNPPDLLILIDYPDFNMLLARVARRHGVKVLYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEE
ISPQVWAWRTGRVKTIGRLVDRMAVVFPFEVPFYERAGVPVSFVGHPLADRVRPTMGRDE
ECCCEEEEECCCHHHHHHHHHHHHHEEECCCCCHHCCCCCHHHCCCCHHHHCCCCCCCHH
ALASFGLDPGRRVVGLFPGSRRGEIAKLFPVILESAQQLRERYPDIQFILPLASSLTDGD
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCC
IAPLLAASGLDVTVTQDRVYDVMQVCDAIITVSGTVTLEIALMGVPMVIIYKVSPLTYQV
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHEECCEEEEEEEEECCCEEEEEECCCHHHHH
GKRLIRVDHIGICNIVAGERVVPELIQDDASADRIAAEIGRYLDDPAYAEKTRAGLAMVK
HHHHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EKLGTGGCSERVAGIVLEMLGKQV
HHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA