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The map label for this gene is lpxK

Identifier: 39997356

GI number: 39997356

Start: 2472618

End: 2473679

Strand: Reverse

Name: lpxK

Synonym: GSU2258

Alternate gene names: 39997356

Gene position: 2473679-2472618 (Counterclockwise)

Preceding gene: 39997357

Following gene: 39997355

Centisome position: 64.86

GC content: 66.1

Gene sequence:

>1062_bases
GTGAGTTGCACGGGGTTCTGGCGAAAACTGGCTTCCGGTGAAGAGTGTGGCGCGGCTGCCCGGCTTCTCGGCGCGGTTCT
CGCCATCCCAGCCGCCCTCTATGGGCTGGTGGTCCGGCTCCGGGCGCTGGCCTACGCCAGGGGGCTGTCCACGGTCAGGC
ACCTGGACCGTCCGGTAATCTCCGTAGGTAACCTGACCGTGGGAGGCACGGGCAAGACCCCCATGGTGGCGTACCTGGCG
CGCCGGCTCATGGCACGGGGCAAGCGGGTTGCGGTCATCTCGCGGGGGTACGGCGGGTCGCTGGAAGGCGAAACACGCAT
TGTCTCCGACGGTCGGACTATCGTTCTCTCCGCCGCCGAGGCGGGTGACGAACCCGTGCATCTGGCAACATCAGTGCCCG
GACTCATGACGGTCATCGGCACGGACCGTTACACAGCCGGTCTCCTGGCGCTGGAACAGCTCGACCCGGACGTCTTCATT
CTGGATGACGGCTACCAGCACCTTCGGCTCCATCGTGACCTGAACATCCTGCTCATGGATTGCAACCGTCCCCTCGGCAA
CGGCCGGACACTGCCGGCGGGGCTGCTCCGGGAACCGCAGACGGCCGTCCGGCGAGCCGATCTGGTGGTCTACACCCGCT
GCACCGGTGGCAAAGCCCCGGCGGTTCACGGCATGATCCCTTCGTGCCGTGCCGGTCACGCACTGACGGGGGCGGCTCTT
CTTCCCGATGGAGAGGTGCAGCCGTTAGCAGCCCTGCGCGGCCTCAGAGGGGTTGCCTGTGCCGGCATCGCCGAGCCGGA
AGGTTTTTTCGATGCACTCCGCAGGGAGGGACTGGACATCGTGGCTGCCATTCCCTTTGCCGATCACGCCTCTTACGGCG
AGCGAGAGGTAAGCACGCTGCGGGAAGCGGCCGCGGGTGCCGATTATCTGATCACTACCGGCAAGGATGGGGTCAAGCTG
TCTGCCCATCTGGCGCGTCTGCTGCCGGTCTACGCAACAGTGCTCGAGATGCGCCCGCTGGACCCCGCTCCCCTTGAAGC
GGCCCTGGACAAAGTGCTTTAA

Upstream 100 bases:

>100_bases
CCATGGGTGAGCGCGGCATCCGCCTCATGACAGAGCAAGGGGGGGCCGCCGCCCGTCACCTGGAGATCATCGGGCGCCTG
CTTGTCACGGGGAGCGCCGA

Downstream 100 bases:

>100_bases
AAGGAATTTACGCTATGGCATTATCAATCGAATTATTCGAAATACTGGCATGTCCCCGCTGCACCGGGGAGGTGAAACCG
GTCAATAACGGTTCGGCCCT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSCTGFWRKLASGEECGAAARLLGAVLAIPAALYGLVVRLRALAYARGLSTVRHLDRPVISVGNLTVGGTGKTPMVAYLA
RRLMARGKRVAVISRGYGGSLEGETRIVSDGRTIVLSAAEAGDEPVHLATSVPGLMTVIGTDRYTAGLLALEQLDPDVFI
LDDGYQHLRLHRDLNILLMDCNRPLGNGRTLPAGLLREPQTAVRRADLVVYTRCTGGKAPAVHGMIPSCRAGHALTGAAL
LPDGEVQPLAALRGLRGVACAGIAEPEGFFDALRREGLDIVAAIPFADHASYGEREVSTLREAAAGADYLITTGKDGVKL
SAHLARLLPVYATVLEMRPLDPAPLEAALDKVL

Sequences:

>Translated_353_residues
MSCTGFWRKLASGEECGAAARLLGAVLAIPAALYGLVVRLRALAYARGLSTVRHLDRPVISVGNLTVGGTGKTPMVAYLA
RRLMARGKRVAVISRGYGGSLEGETRIVSDGRTIVLSAAEAGDEPVHLATSVPGLMTVIGTDRYTAGLLALEQLDPDVFI
LDDGYQHLRLHRDLNILLMDCNRPLGNGRTLPAGLLREPQTAVRRADLVVYTRCTGGKAPAVHGMIPSCRAGHALTGAAL
LPDGEVQPLAALRGLRGVACAGIAEPEGFFDALRREGLDIVAAIPFADHASYGEREVSTLREAAAGADYLITTGKDGVKL
SAHLARLLPVYATVLEMRPLDPAPLEAALDKVL
>Mature_352_residues
SCTGFWRKLASGEECGAAARLLGAVLAIPAALYGLVVRLRALAYARGLSTVRHLDRPVISVGNLTVGGTGKTPMVAYLAR
RLMARGKRVAVISRGYGGSLEGETRIVSDGRTIVLSAAEAGDEPVHLATSVPGLMTVIGTDRYTAGLLALEQLDPDVFIL
DDGYQHLRLHRDLNILLMDCNRPLGNGRTLPAGLLREPQTAVRRADLVVYTRCTGGKAPAVHGMIPSCRAGHALTGAALL
PDGEVQPLAALRGLRGVACAGIAEPEGFFDALRREGLDIVAAIPFADHASYGEREVSTLREAAAGADYLITTGKDGVKLS
AHLARLLPVYATVLEMRPLDPAPLEAALDKVL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=295, Percent_Identity=38.6440677966102, Blast_Score=145, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_GEOSL (Q74AU2)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953307.1
- GeneID:   2685771
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2258
- NMPDR:   fig|243231.1.peg.2245
- TIGR:   GSU2258
- HOGENOM:   HBG663914
- OMA:   PDHAGIT
- ProtClustDB:   CLSK828780
- BioCyc:   GSUL243231:GSU_2258-MONOMER
- BRENDA:   2.7.1.130
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37249; Mature: 37118

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCTGFWRKLASGEECGAAARLLGAVLAIPAALYGLVVRLRALAYARGLSTVRHLDRPVI
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
SVGNLTVGGTGKTPMVAYLARRLMARGKRVAVISRGYGGSLEGETRIVSDGRTIVLSAAE
EECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCEEEEEECC
AGDEPVHLATSVPGLMTVIGTDRYTAGLLALEQLDPDVFILDDGYQHLRLHRDLNILLMD
CCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCEEEEEE
CNRPLGNGRTLPAGLLREPQTAVRRADLVVYTRCTGGKAPAVHGMIPSCRAGHALTGAAL
CCCCCCCCCCCCHHHHCCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
LPDGEVQPLAALRGLRGVACAGIAEPEGFFDALRREGLDIVAAIPFADHASYGEREVSTL
CCCCCCCHHHHHCCCCCHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHH
REAAAGADYLITTGKDGVKLSAHLARLLPVYATVLEMRPLDPAPLEAALDKVL
HHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SCTGFWRKLASGEECGAAARLLGAVLAIPAALYGLVVRLRALAYARGLSTVRHLDRPVI
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
SVGNLTVGGTGKTPMVAYLARRLMARGKRVAVISRGYGGSLEGETRIVSDGRTIVLSAAE
EECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCEEEEEECC
AGDEPVHLATSVPGLMTVIGTDRYTAGLLALEQLDPDVFILDDGYQHLRLHRDLNILLMD
CCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCEEEEEE
CNRPLGNGRTLPAGLLREPQTAVRRADLVVYTRCTGGKAPAVHGMIPSCRAGHALTGAAL
CCCCCCCCCCCCHHHHCCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
LPDGEVQPLAALRGLRGVACAGIAEPEGFFDALRREGLDIVAAIPFADHASYGEREVSTL
CCCCCCCHHHHHCCCCCHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHH
REAAAGADYLITTGKDGVKLSAHLARLLPVYATVLEMRPLDPAPLEAALDKVL
HHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA