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The map label for this gene is strL [H]

Identifier: 39997345

GI number: 39997345

Start: 2462092

End: 2463006

Strand: Reverse

Name: strL [H]

Synonym: GSU2247

Alternate gene names: 39997345

Gene position: 2463006-2462092 (Counterclockwise)

Preceding gene: 39997346

Following gene: 39997344

Centisome position: 64.58

GC content: 51.69

Gene sequence:

>915_bases
ATGAGCCACAGAATTAATGTGCTGATTGTCGGGGCCAGCGGCATGCTGGGGCATACTTTGTTCGGTCGTTTATTTGAGAA
CGACAAGCTTGATACTCATGCGACTGTCCGTAGCGTTTCAGAATTGTCGCGATGGTTCACTGACGATCATCTGTTGAAAA
TTCATGGCGGAATTGATGCTGATAACTTCGATTCAGTGCTTGCAGTTCTTGCGCAGATAAAGCCGGACGTGGTCATCAAT
TGCGTTGGAGTAATCAAGCAGCTGCCAGCCGCAGAGGATCCGGTCGTCTGTATTGCAACCAACGCACTTTTCCCCCACCG
GCTCGCGGTTGCATGCAAGGCCGCCGGGGCTCGGCTCGTCCACATCAGCACGGACTGCGTTTTTTCCGGAGAGAAAGGTG
ATTATCGCGAAACCGACCGGTCAGACGCTACGGACCTGTATGGGCGCAGCAAGTTTCTCGGCGAAGTGACCTCCGACCAC
TGCGTAACCTTGCGCACCTCCATCATCGGCCATGAGTTGAAAGGAGGATACGGTCTCGTGGAGTGGTTCCTTTCTCGGAA
GGGACCGGTCAAAGGTTTCACCAATGCGATATACACCGGGTTTCCTACGATTGAGATCGCACGAATAATCGAGAAATACA
TTATTTGTGATATGAATCTGAAGGGACTTTATCAGGTGGCGTCGGAACCCATATCGAAGTATGAGTTACTGGAACTGATC
GCCGCGCAGTACGGCAAGAAGATCGAAATCATCCCCTTCGGTGATTTTCATTGTTACCGGTCGCTGAACTCGGATAAATT
CAGGAATGCCACGGGCTATAGCGCGCCCGCATGGCCGGAACTGATTGCGGAAATGCACAACGACTACGTGACATCACCAT
GGTATCGACATAAATTGCGGGAGGGGAGCCATTAG

Upstream 100 bases:

>100_bases
TCAGTTAAGCAAAAAATGTATTCTCTTGTTGACTACACGTTCAAGAAGATGTCAAAGCTTACAAGATAGCGCTTGAGACA
GTGTTACAAGTGGAGAGTTC

Downstream 100 bases:

>100_bases
GATGTTCAGGAATAAAGTGCTGCTTATCACCGGTGGGACCGGTTCTTTCGGTAATGCCGTTCTGAAGCGTTTTCTCGACA
CACGTATCAGTGAGGTGCGC

Product: carbohydrate oxidoreductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSHRINVLIVGASGMLGHTLFGRLFENDKLDTHATVRSVSELSRWFTDDHLLKIHGGIDADNFDSVLAVLAQIKPDVVIN
CVGVIKQLPAAEDPVVCIATNALFPHRLAVACKAAGARLVHISTDCVFSGEKGDYRETDRSDATDLYGRSKFLGEVTSDH
CVTLRTSIIGHELKGGYGLVEWFLSRKGPVKGFTNAIYTGFPTIEIARIIEKYIICDMNLKGLYQVASEPISKYELLELI
AAQYGKKIEIIPFGDFHCYRSLNSDKFRNATGYSAPAWPELIAEMHNDYVTSPWYRHKLREGSH

Sequences:

>Translated_304_residues
MSHRINVLIVGASGMLGHTLFGRLFENDKLDTHATVRSVSELSRWFTDDHLLKIHGGIDADNFDSVLAVLAQIKPDVVIN
CVGVIKQLPAAEDPVVCIATNALFPHRLAVACKAAGARLVHISTDCVFSGEKGDYRETDRSDATDLYGRSKFLGEVTSDH
CVTLRTSIIGHELKGGYGLVEWFLSRKGPVKGFTNAIYTGFPTIEIARIIEKYIICDMNLKGLYQVASEPISKYELLELI
AAQYGKKIEIIPFGDFHCYRSLNSDKFRNATGYSAPAWPELIAEMHNDYVTSPWYRHKLREGSH
>Mature_303_residues
SHRINVLIVGASGMLGHTLFGRLFENDKLDTHATVRSVSELSRWFTDDHLLKIHGGIDADNFDSVLAVLAQIKPDVVINC
VGVIKQLPAAEDPVVCIATNALFPHRLAVACKAAGARLVHISTDCVFSGEKGDYRETDRSDATDLYGRSKFLGEVTSDHC
VTLRTSIIGHELKGGYGLVEWFLSRKGPVKGFTNAIYTGFPTIEIARIIEKYIICDMNLKGLYQVASEPISKYELLELIA
AQYGKKIEIIPFGDFHCYRSLNSDKFRNATGYSAPAWPELIAEMHNDYVTSPWYRHKLREGSH

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33846; Mature: 33715

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHRINVLIVGASGMLGHTLFGRLFENDKLDTHATVRSVSELSRWFTDDHLLKIHGGIDA
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
DNFDSVLAVLAQIKPDVVINCVGVIKQLPAAEDPVVCIATNALFPHRLAVACKAAGARLV
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEE
HISTDCVFSGEKGDYRETDRSDATDLYGRSKFLGEVTSDHCVTLRTSIIGHELKGGYGLV
EEEECEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCHHHH
EWFLSRKGPVKGFTNAIYTGFPTIEIARIIEKYIICDMNLKGLYQVASEPISKYELLELI
HHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
AAQYGKKIEIIPFGDFHCYRSLNSDKFRNATGYSAPAWPELIAEMHNDYVTSPWYRHKLR
HHHHCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHC
EGSH
CCCC
>Mature Secondary Structure 
SHRINVLIVGASGMLGHTLFGRLFENDKLDTHATVRSVSELSRWFTDDHLLKIHGGIDA
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
DNFDSVLAVLAQIKPDVVINCVGVIKQLPAAEDPVVCIATNALFPHRLAVACKAAGARLV
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEE
HISTDCVFSGEKGDYRETDRSDATDLYGRSKFLGEVTSDHCVTLRTSIIGHELKGGYGLV
EEEECEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCHHHH
EWFLSRKGPVKGFTNAIYTGFPTIEIARIIEKYIICDMNLKGLYQVASEPISKYELLELI
HHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
AAQYGKKIEIIPFGDFHCYRSLNSDKFRNATGYSAPAWPELIAEMHNDYVTSPWYRHKLR
HHHHCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHC
EGSH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1661369 [H]