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The map label for this gene is relA [H]

Identifier: 39997334

GI number: 39997334

Start: 2450613

End: 2452763

Strand: Reverse

Name: relA [H]

Synonym: GSU2236

Alternate gene names: 39997334

Gene position: 2452763-2450613 (Counterclockwise)

Preceding gene: 39997335

Following gene: 39997333

Centisome position: 64.31

GC content: 57.46

Gene sequence:

>2151_bases
ATGATACGGCTCAACGATATCCTCGATAAGGTCGTCACCTACAATCCCGTAGCCGACCTGGACCTGATCCGCAAGGCCTA
TGTCTACTGTGCAAAGGTCCACCAGGGACAGACGCGTCTTTCGGGAGAGCCTTATCTCGTTCACCCCATGGAGGTGGCGG
GCGTACTGGCTGACCTGAAGCTCGACGTGCCGACAGTGGTGACCGGGCTGCTCCACGACACCATCGAGGATACCCTCACG
ACCCGGGAGGAGCTGGAGGGGATGTTCGGCGCCGAGGTGGCAAACCTGGTAGACGGCGTCACCAAAATCGGCAAGATCCA
CTTCAAGACCAAAGAGGAGAGTCAGGCCGAGAACTTCCGCAAGATGTTGCTGGCCATGGCCAACGACATCCGGGTAATCC
TCGTCAAGCTCGCCGACCGCCTCCACAACATGCGGACGCTCCAGTACCAGCCCGAGCCGAAGCAGCGCTCCATCTCCCGC
GAGACCCTCGATATCTATGCTCCTCTTGCCAATCGTCTCGGTATTTCATGGATCAAGAGCGAGCTGGAAGACCTTTCCTT
CCGTTACCTGGAACCACAGATCTACTACGACCTGGCTTCAAAGGTTGCCAAGAAGAAGAAGGAGCGGGAAAGCTATGTGG
AGGAGGTGCGGCAGATCATCGTCTCCAAGCTTGCCGAACACGACCTCAAGGGTGACGTATTCGGCCGGAGCAAACACCTT
TACTCCATCTGGCGCAAAATGCAGGCCCGCAATGTGGACATTGACCAGATCTATGACCTGGTGGCGATCCGGGTCATGGT
GAACGATATCCGGGAGTGCTATGAGGTCCTCGGGATCATCCATTCGACCTGGAAGCCGATCCCTGGCCGCTTCAAAGACT
ATATCGCCATGCCCAAGGGGAACATGTACCAGTCGCTCCATACGACGGTCATCGGTCCGCACGGGGAGCGCATGGAGGTC
CAGATCCGCACGTCCGACATGCACCGGGTGGCGGAAGCCGGTATCGCGGCTCACTGGAAGTATAAAGAAGGGAAGGGGTA
CGACGAAAAAGAGGTCAAGCGGTTCGCCTGGCTGAGGCAGCTGCTGGAGTGGCAGCAGGAGCTTCAGGATTCCCACGAGT
TCATGAATACGGTCAAGGTGGAACTTTTCCCCGAGGAGGTCTACGTCTTTACTCCCAGAGGGGACGTGAAGAGTTTTCCA
AAGGGGTCGACCCCCATTGATCTGGCCTATACCATCCACACCGACATCGGGCATCGCTGTGTGGGCGCCAAGGTGAACGG
CAAGCTGGTTCCCCTCAAGTATGAGCTGAAGAACGGCGATATCGTGGAGGTGATCACCTCTCCGCACCACACGCCGAGCA
AGGACTGGCTGAAGATCGTCAAGAGCTCCCGTGCCCGCAACAAGATCCGGGCATGGATCAAGACAGAGGAGCGGGTCCGG
AGCATCTCTCTCGGCAAGGAGATCCTTGAGAAGGAGTTCCGGCGTTATTCTCTCAATCTGGCCAAGCTGCAGAAGGCTGG
AGAGATTAAGCGAGTGGCCTCGGAGTTCGGCCTTTCCACCGATGATGACGTCATGGCCGCCGTTGGTTATGGCAAACTCT
CGGCAAACCAGGTGATCGGCAAGCTGCTTCCCGAGGAAAAGCTTCAGGAACGCCAGGAACAGAAGGAATCCCGTATCGGG
AAGATGATCGGCAAGCTCACCGGCTCGTCTCCCAGCGCCATCCAGATCGGCGGGGTCGACGATGTTCTTGTGCGTTTCGG
CAAGTGCTGCAACCCGGTTCCCGGAGACGATATCATCGGCTTCATCACCCGGGGAAGAGGGGTCACGATCCATACCGCCG
ACTGTCCCGTTGCCCTGGAAAACGACCCGGAGCGCCGTATCGCCGTCACCTGGAACCGTGAGCGCAAGGCTGCCCTGCCG
GTGAAAATCCGAGTTTCCTGTCACGACCAGAAGGGTATTCTCGCCAACATCACCCAGGCCATCACCGATTGTGAAGCAAA
CATCTCCAGCGCGTCGATCCAAAGCACGGTCGACAAGCGCGGGGTCAATATCTTTGAAGTGGACGTCACCGACCTGGATC
ACCTGAAGCGGGTAATGAACAACATCATGAAGCTGAGCGGTGTCATTTCGGTCGAGCGAATGAAAAATTGA

Upstream 100 bases:

>100_bases
GCAAGGTCGGATACGAACTGACCAGTCGTCGTTCCCGCTAATCACAGGACCTCCCAAGGGCAGAAGCACCAGGCTTCCGC
CCTTTTTTTGTCTTTTCCCC

Downstream 100 bases:

>100_bases
AGGGGGGAGCATGAAAGAGATTGTTGCGACAGAACAGGCACCCAAGGCGATCGGTCCCTATTCCCAGGCGGTGAGGGCAG
GGGGATTCCTGTTCCTGTCG

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 716; Mature: 716

Protein sequence:

>716_residues
MIRLNDILDKVVTYNPVADLDLIRKAYVYCAKVHQGQTRLSGEPYLVHPMEVAGVLADLKLDVPTVVTGLLHDTIEDTLT
TREELEGMFGAEVANLVDGVTKIGKIHFKTKEESQAENFRKMLLAMANDIRVILVKLADRLHNMRTLQYQPEPKQRSISR
ETLDIYAPLANRLGISWIKSELEDLSFRYLEPQIYYDLASKVAKKKKERESYVEEVRQIIVSKLAEHDLKGDVFGRSKHL
YSIWRKMQARNVDIDQIYDLVAIRVMVNDIRECYEVLGIIHSTWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGERMEV
QIRTSDMHRVAEAGIAAHWKYKEGKGYDEKEVKRFAWLRQLLEWQQELQDSHEFMNTVKVELFPEEVYVFTPRGDVKSFP
KGSTPIDLAYTIHTDIGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNKIRAWIKTEERVR
SISLGKEILEKEFRRYSLNLAKLQKAGEIKRVASEFGLSTDDDVMAAVGYGKLSANQVIGKLLPEEKLQERQEQKESRIG
KMIGKLTGSSPSAIQIGGVDDVLVRFGKCCNPVPGDDIIGFITRGRGVTIHTADCPVALENDPERRIAVTWNRERKAALP
VKIRVSCHDQKGILANITQAITDCEANISSASIQSTVDKRGVNIFEVDVTDLDHLKRVMNNIMKLSGVISVERMKN

Sequences:

>Translated_716_residues
MIRLNDILDKVVTYNPVADLDLIRKAYVYCAKVHQGQTRLSGEPYLVHPMEVAGVLADLKLDVPTVVTGLLHDTIEDTLT
TREELEGMFGAEVANLVDGVTKIGKIHFKTKEESQAENFRKMLLAMANDIRVILVKLADRLHNMRTLQYQPEPKQRSISR
ETLDIYAPLANRLGISWIKSELEDLSFRYLEPQIYYDLASKVAKKKKERESYVEEVRQIIVSKLAEHDLKGDVFGRSKHL
YSIWRKMQARNVDIDQIYDLVAIRVMVNDIRECYEVLGIIHSTWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGERMEV
QIRTSDMHRVAEAGIAAHWKYKEGKGYDEKEVKRFAWLRQLLEWQQELQDSHEFMNTVKVELFPEEVYVFTPRGDVKSFP
KGSTPIDLAYTIHTDIGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNKIRAWIKTEERVR
SISLGKEILEKEFRRYSLNLAKLQKAGEIKRVASEFGLSTDDDVMAAVGYGKLSANQVIGKLLPEEKLQERQEQKESRIG
KMIGKLTGSSPSAIQIGGVDDVLVRFGKCCNPVPGDDIIGFITRGRGVTIHTADCPVALENDPERRIAVTWNRERKAALP
VKIRVSCHDQKGILANITQAITDCEANISSASIQSTVDKRGVNIFEVDVTDLDHLKRVMNNIMKLSGVISVERMKN
>Mature_716_residues
MIRLNDILDKVVTYNPVADLDLIRKAYVYCAKVHQGQTRLSGEPYLVHPMEVAGVLADLKLDVPTVVTGLLHDTIEDTLT
TREELEGMFGAEVANLVDGVTKIGKIHFKTKEESQAENFRKMLLAMANDIRVILVKLADRLHNMRTLQYQPEPKQRSISR
ETLDIYAPLANRLGISWIKSELEDLSFRYLEPQIYYDLASKVAKKKKERESYVEEVRQIIVSKLAEHDLKGDVFGRSKHL
YSIWRKMQARNVDIDQIYDLVAIRVMVNDIRECYEVLGIIHSTWKPIPGRFKDYIAMPKGNMYQSLHTTVIGPHGERMEV
QIRTSDMHRVAEAGIAAHWKYKEGKGYDEKEVKRFAWLRQLLEWQQELQDSHEFMNTVKVELFPEEVYVFTPRGDVKSFP
KGSTPIDLAYTIHTDIGHRCVGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNKIRAWIKTEERVR
SISLGKEILEKEFRRYSLNLAKLQKAGEIKRVASEFGLSTDDDVMAAVGYGKLSANQVIGKLLPEEKLQERQEQKESRIG
KMIGKLTGSSPSAIQIGGVDDVLVRFGKCCNPVPGDDIIGFITRGRGVTIHTADCPVALENDPERRIAVTWNRERKAALP
VKIRVSCHDQKGILANITQAITDCEANISSASIQSTVDKRGVNIFEVDVTDLDHLKRVMNNIMKLSGVISVERMKN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=715, Percent_Identity=43.0769230769231, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1789147, Length=720, Percent_Identity=35.8333333333333, Blast_Score=508, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI25143118, Length=135, Percent_Identity=34.0740740740741, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81344; Mature: 81344

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLNDILDKVVTYNPVADLDLIRKAYVYCAKVHQGQTRLSGEPYLVHPMEVAGVLADLK
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHCC
LDVPTVVTGLLHDTIEDTLTTREELEGMFGAEVANLVDGVTKIGKIHFKTKEESQAENFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHH
KMLLAMANDIRVILVKLADRLHNMRTLQYQPEPKQRSISRETLDIYAPLANRLGISWIKS
HHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ELEDLSFRYLEPQIYYDLASKVAKKKKERESYVEEVRQIIVSKLAEHDLKGDVFGRSKHL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
YSIWRKMQARNVDIDQIYDLVAIRVMVNDIRECYEVLGIIHSTWKPIPGRFKDYIAMPKG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCC
NMYQSLHTTVIGPHGERMEVQIRTSDMHRVAEAGIAAHWKYKEGKGYDEKEVKRFAWLRQ
CHHHHHHHEEECCCCCEEEEEEECHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHHH
LLEWQQELQDSHEFMNTVKVELFPEEVYVFTPRGDVKSFPKGSTPIDLAYTIHTDIGHRC
HHHHHHHHHHHHHHHHHEEEEEEECEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEE
VGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNKIRAWIKTEERVR
ECCEECCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISLGKEILEKEFRRYSLNLAKLQKAGEIKRVASEFGLSTDDDVMAAVGYGKLSANQVIG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCHHHHHH
KLLPEEKLQERQEQKESRIGKMIGKLTGSSPSAIQIGGVDDVLVRFGKCCNPVPGDDIIG
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCEE
FITRGRGVTIHTADCPVALENDPERRIAVTWNRERKAALPVKIRVSCHDQKGILANITQA
EEECCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHH
ITDCEANISSASIQSTVDKRGVNIFEVDVTDLDHLKRVMNNIMKLSGVISVERMKN
HHHHHCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEHHHCCC
>Mature Secondary Structure
MIRLNDILDKVVTYNPVADLDLIRKAYVYCAKVHQGQTRLSGEPYLVHPMEVAGVLADLK
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHCC
LDVPTVVTGLLHDTIEDTLTTREELEGMFGAEVANLVDGVTKIGKIHFKTKEESQAENFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHH
KMLLAMANDIRVILVKLADRLHNMRTLQYQPEPKQRSISRETLDIYAPLANRLGISWIKS
HHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ELEDLSFRYLEPQIYYDLASKVAKKKKERESYVEEVRQIIVSKLAEHDLKGDVFGRSKHL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
YSIWRKMQARNVDIDQIYDLVAIRVMVNDIRECYEVLGIIHSTWKPIPGRFKDYIAMPKG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCC
NMYQSLHTTVIGPHGERMEVQIRTSDMHRVAEAGIAAHWKYKEGKGYDEKEVKRFAWLRQ
CHHHHHHHEEECCCCCEEEEEEECHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHHH
LLEWQQELQDSHEFMNTVKVELFPEEVYVFTPRGDVKSFPKGSTPIDLAYTIHTDIGHRC
HHHHHHHHHHHHHHHHHEEEEEEECEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEE
VGAKVNGKLVPLKYELKNGDIVEVITSPHHTPSKDWLKIVKSSRARNKIRAWIKTEERVR
ECCEECCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISLGKEILEKEFRRYSLNLAKLQKAGEIKRVASEFGLSTDDDVMAAVGYGKLSANQVIG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCHHHHHH
KLLPEEKLQERQEQKESRIGKMIGKLTGSSPSAIQIGGVDDVLVRFGKCCNPVPGDDIIG
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCEE
FITRGRGVTIHTADCPVALENDPERRIAVTWNRERKAALPVKIRVSCHDQKGILANITQA
EEECCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHH
ITDCEANISSASIQSTVDKRGVNIFEVDVTDLDHLKRVMNNIMKLSGVISVERMKN
HHHHHCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA