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The map label for this gene is guaB [H]

Identifier: 39997293

GI number: 39997293

Start: 2407306

End: 2408781

Strand: Reverse

Name: guaB [H]

Synonym: GSU2195

Alternate gene names: 39997293

Gene position: 2408781-2407306 (Counterclockwise)

Preceding gene: 39997294

Following gene: 39997292

Centisome position: 63.15

GC content: 62.53

Gene sequence:

>1476_bases
ATGTTAGATGAATTGATTCCGGAAGGTCTGACTTTCGACGACGTTCTGCTCGTTCCCGCCCACTCTCAGGTCCTTCCCCG
CGATGTCTCCCTCAACACCCGTCTGACCAGGAACATTACCCTCAACATTCCCCTCGTCTCGGCAGCCATGGACACGGTCA
CCGAGGCACGGACCGCCATCTGCATGGCTCGCGAGGGGGGACTCGGCATTATTCACAAGAACCTCACCATCGAAGAGCAG
GCCATGGAGGTGGACAAGGTCAAAAAGAGCGAGTCCGGCATGATCGTGGACCCCATCACTATGCGGCCCAACCAGAAAAT
CCACGAGGCCCTGGCCATCATGGAGAAATACCGGATTTCCGGCGTACCCGTCACCAACTCCAAGGGGAAACTGGTCGGCA
TCCTCACCAACCGCGACCTCCGTTTCGAAACCAACCTGGACCTTCCCATTTCCGCCCGCATGACCAAGCGCCGGCTCGTG
ACCGTAGCGGTCGGCACTACCCTTGAAGAAGCCAAGGAACACCTCAAGCATACCCGGGTCGAGAAACTGCTGGTGGTGGA
TGAGGAGAAGAACCTGAAGGGGCTCATCACCATCAAGGATATCGAGAAGGTCAGAAAATACCCCAATGCCTGCAAGGATG
CCCTGGGTCGCCTGCGGGTCGGCGCCGCCGTCGGCCCCTCCGGCGACATGGAGGCCCGGGTGGACGCCCTGGTCAAGGCC
GGGGTCGACGTTATCGTGGTGGACACGGCCCATGGTCACTCCCAGGGGGTCCTCGATGCCATCCGGACCGTCAAGGCGAA
CTTTCCCGGGGTCGAGCTCATCGCCGGCAACATTGCCACTGCCGAGGCCGCCGAGGCACTCATCAAGGCCGGTGTCGACG
CCATCAAGGTGGGCATCGGACCGGGTTCCATCTGCACCACCCGCGTGGTTGCCGGCGTCGGCGTGCCCCAGATAAGCGCC
ATCGCCCAGTGCGCCAAGGTTGCCCGCAAGTATGACGTCCCCCTCATCGCGGATGGCGGCGTCAAGTACTCCGGTGACGT
GACCAAGGCAGTGGCCGCCGGTGCCGATGTCATCATGATCGGCTCTCTCTTTGCCGGCACCGAGGAGTCGCCCGGCGACA
CCATCCTCTATCAGGGCCGGGCCTACAAGAGCTACCGCGGCATGGGCTCCATCGGCGCCATGAAGCAGGGGAGCAAGGAC
CGCTACTTCCAGAGCGATGTGGAAAGCGAAGTGAAGCTCGTTCCCGAGGGGATCGAGGGGATGGTGCCGCTGCGTGGACC
GCTCTCCGCCAACGTCCATCAGCTCATGGGCGGACTGCGGGCCGGCATGGGCTACACCGGCTGCCGCACCGTGCGGGAGC
TCCAGGAAAAGGGGCACTTCGTCCGGATCACCGGCGCGGGCCTCAAGGAATCCCACGTCCATGACGTCATGATCACCAAG
GAAGCCCCGAACTACCGGGTCGAGAACGTTCGATGA

Upstream 100 bases:

>100_bases
GTATACTCTCCGGCCCCGGTTTTTCCCCTTGACTCATCCTTGTCCCTCCACTATTCTTTTCGGTTAATACTTTGAGACCC
ACCACTAAAAGGAGTCCGCG

Downstream 100 bases:

>100_bases
GCACCGACATCCATACTGAAAAAATCCTGATCCTGGACTTCGGCTCCCAGTACACCCAGCTTATTGCCCGGCGGGTGCGC
GAGGCTCACGTCTACTGCGA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MLDELIPEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNITLNIPLVSAAMDTVTEARTAICMAREGGLGIIHKNLTIEEQ
AMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNSKGKLVGILTNRDLRFETNLDLPISARMTKRRLV
TVAVGTTLEEAKEHLKHTRVEKLLVVDEEKNLKGLITIKDIEKVRKYPNACKDALGRLRVGAAVGPSGDMEARVDALVKA
GVDVIVVDTAHGHSQGVLDAIRTVKANFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISA
IAQCAKVARKYDVPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKQGSKD
RYFQSDVESEVKLVPEGIEGMVPLRGPLSANVHQLMGGLRAGMGYTGCRTVRELQEKGHFVRITGAGLKESHVHDVMITK
EAPNYRVENVR

Sequences:

>Translated_491_residues
MLDELIPEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNITLNIPLVSAAMDTVTEARTAICMAREGGLGIIHKNLTIEEQ
AMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNSKGKLVGILTNRDLRFETNLDLPISARMTKRRLV
TVAVGTTLEEAKEHLKHTRVEKLLVVDEEKNLKGLITIKDIEKVRKYPNACKDALGRLRVGAAVGPSGDMEARVDALVKA
GVDVIVVDTAHGHSQGVLDAIRTVKANFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISA
IAQCAKVARKYDVPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKQGSKD
RYFQSDVESEVKLVPEGIEGMVPLRGPLSANVHQLMGGLRAGMGYTGCRTVRELQEKGHFVRITGAGLKESHVHDVMITK
EAPNYRVENVR
>Mature_491_residues
MLDELIPEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNITLNIPLVSAAMDTVTEARTAICMAREGGLGIIHKNLTIEEQ
AMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNSKGKLVGILTNRDLRFETNLDLPISARMTKRRLV
TVAVGTTLEEAKEHLKHTRVEKLLVVDEEKNLKGLITIKDIEKVRKYPNACKDALGRLRVGAAVGPSGDMEARVDALVKA
GVDVIVVDTAHGHSQGVLDAIRTVKANFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISA
IAQCAKVARKYDVPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKQGSKD
RYFQSDVESEVKLVPEGIEGMVPLRGPLSANVHQLMGGLRAGMGYTGCRTVRELQEKGHFVRITGAGLKESHVHDVMITK
EAPNYRVENVR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.0414937759336, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=41.4473684210526, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=41.4473684210526, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=41.4473684210526, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=41.4473684210526, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=41.3333333333333, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=40.5701754385965, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=38.1578947368421, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI50541956, Length=256, Percent_Identity=38.28125, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541954, Length=256, Percent_Identity=38.28125, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541952, Length=256, Percent_Identity=38.28125, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541948, Length=256, Percent_Identity=38.28125, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=39.1111111111111, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=481, Percent_Identity=59.2515592515593, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1786293, Length=222, Percent_Identity=37.3873873873874, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=36.8421052631579, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=37.8823529411765, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=40.2489626556017, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=41.5478615071283, Blast_Score=350, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6323585, Length=466, Percent_Identity=41.8454935622318, Blast_Score=339, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=491, Percent_Identity=40.5295315682281, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=43.6416184971098, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=38.7931034482759, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.7163561076605, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.7163561076605, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=38.3219954648526, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52674; Mature: 52674

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDELIPEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNITLNIPLVSAAMDTVTEARTAI
CCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHE
CMAREGGLGIIHKNLTIEEQAMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRIS
EEEECCCEEEEEECCEEHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPVTNSKGKLVGILTNRDLRFETNLDLPISARMTKRRLVTVAVGTTLEEAKEHLKHTRV
CCEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
EKLLVVDEEKNLKGLITIKDIEKVRKYPNACKDALGRLRVGAAVGPSGDMEARVDALVKA
HEEEEEECCCCCEEEEEHHHHHHHHHCCHHHHHHHHHEEECEECCCCCCHHHHHHHHHHC
GVDVIVVDTAHGHSQGVLDAIRTVKANFPGVELIAGNIATAEAAEALIKAGVDAIKVGIG
CCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGVGVPQISAIAQCAKVARKYDVPLIADGGVKYSGDVTKAVAAGADVIMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEE
GSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKQGSKDRYFQSDVESEVKLVPEGIEG
EEECCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCC
MVPLRGPLSANVHQLMGGLRAGMGYTGCRTVRELQEKGHFVRITGAGLKESHVHDVMITK
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEE
EAPNYRVENVR
CCCCCCCCCCC
>Mature Secondary Structure
MLDELIPEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNITLNIPLVSAAMDTVTEARTAI
CCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHE
CMAREGGLGIIHKNLTIEEQAMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRIS
EEEECCCEEEEEECCEEHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPVTNSKGKLVGILTNRDLRFETNLDLPISARMTKRRLVTVAVGTTLEEAKEHLKHTRV
CCEEECCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
EKLLVVDEEKNLKGLITIKDIEKVRKYPNACKDALGRLRVGAAVGPSGDMEARVDALVKA
HEEEEEECCCCCEEEEEHHHHHHHHHCCHHHHHHHHHEEECEECCCCCCHHHHHHHHHHC
GVDVIVVDTAHGHSQGVLDAIRTVKANFPGVELIAGNIATAEAAEALIKAGVDAIKVGIG
CCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGVGVPQISAIAQCAKVARKYDVPLIADGGVKYSGDVTKAVAAGADVIMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEE
GSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKQGSKDRYFQSDVESEVKLVPEGIEG
EEECCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCC
MVPLRGPLSANVHQLMGGLRAGMGYTGCRTVRELQEKGHFVRITGAGLKESHVHDVMITK
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEE
EAPNYRVENVR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]