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The map label for this gene is guaA [H]

Identifier: 39997292

GI number: 39997292

Start: 2405747

End: 2407309

Strand: Reverse

Name: guaA [H]

Synonym: GSU2194

Alternate gene names: 39997292

Gene position: 2407309-2405747 (Counterclockwise)

Preceding gene: 39997293

Following gene: 39997291

Centisome position: 63.12

GC content: 63.98

Gene sequence:

>1563_bases
ATGAGCACCGACATCCATACTGAAAAAATCCTGATCCTGGACTTCGGCTCCCAGTACACCCAGCTTATTGCCCGGCGGGT
GCGCGAGGCTCACGTCTACTGCGAGCTTCACCCCTTTGACATGGGGCTGGAAGCCATCCGCGCCTTCGCTCCCAAGGGAA
TCATCCTCTCGGGGGGGCCCAAGTCGGTCTACGAAGAAGGGGCGCCGGCTGTGGAAGAGGCGTTGTTTGATCTGGGGGTG
CCGGTGCTCGGCATCTGCTACGGCATGCAGCTCATGAGCCGCCACTTCGGCGGCGAGGTAGTACCCGCGGGCAAGCGCGA
GTTCGGCCACGCCGACCTCTTGGCCGCGGGAACTCCCGGTCCTCTCTTCGAAGGGTTCTTCGTGGAAGGGAAAAGCCCGG
TCTGGATGAGCCACGGCGACCATGTCTCCCGGATGCCCCAAGGGTTCCAGGTGGTGGCGGAGACGGCCAACGCGCCGGTC
TGCGCCATCCAGGACACGGCGCGCAACCTTTACGGCGTCCAGTTCCACCCGGAGGTAAATCACACGCCCCGGGGCGAGAT
CCTCATCGATACCTTTGTCCGCAAGATCTGCGGCTGCACCGGCCAGTGGACCCCCGGACACATCATCGAGGACGCCGTGA
ACCGTATCCGGGCCCAGGTGGGCCGGGAGCGGGTCATCCTCGGGCTTTCGGGCGGCGTCGATTCGTCGGTGGCGGCGGCC
CTTATCCATCGGGCCATCGGCGACCAGCTCACCTGCGTCTTCGTGGACAACGGCCTGCTGCGCCTCGCCGAGGGTGACCA
GGTGATGGCCACCTTTGCCGAGAACCTGGGCGTCAAGGTGATCCGGGTCGATGCCGAGCAGCGGTTCCTGACCGCCCTGG
CCGATGAGGCAGACCCGGAGAAAAAGCGCAAGATCATCGGCAATCTCTTCGTGGAGATCTTCGAAGAGGAGTCGAGCCGC
ATCGAGGGTGCCACCTGGCTGGCCCAGGGGACCATCTATCCGGATGTCATCGAGAGCGCCGGGGCCAAAACCGGCAAGGC
CCACAACATCAAGAGCCATCACAACGTGGGCGGGCTTCCCGAGTACATGAAGCTCAAGCTCCTCGAACCCCTGCGGGAGC
TGTTCAAGGACGAGGTGCGGGCCATCGGTGAGGAACTTGGACTGCCCCGCCAGATGGTCTGGCGCCATCCCTTCCCGGGG
CCGGGGCTGGGGGTCAGGATTCTGGGCGAGGTGAAGAAAGAGTACGCCGATATCCTGCGCCGGGCCGACGCCATCTATAT
CGAGGAGCTCTACGCCGCCGGCCACTATGACAAGATCAGTCAGGCCTTTGCCGTCTTCCTCCCCGTCAAGAGCGTGGGGG
TCATGGGGGATGGCCGGACCTACGAGTACGTGATCGCTCTGCGGGCCGTGGAGACCAAGGACTTCATGACCGCGGGCTGG
TATCCTTTGCCCTACGAGGACATGGCCCGCATCTCGGGCCGGATCATCAACGAGGTCAAGGGGGTCAATCGGGTCGTGTA
CGACATCTCCAGCAAGCCTCCCGCCACCATCGAGTGGGAATAG

Upstream 100 bases:

>100_bases
GGCACTTCGTCCGGATCACCGGCGCGGGCCTCAAGGAATCCCACGTCCATGACGTCATGATCACCAAGGAAGCCCCGAAC
TACCGGGTCGAGAACGTTCG

Downstream 100 bases:

>100_bases
ACACACCGCAAAGGGCGCCGGCAACGGCGCCCTTTTCATATGCAACCCCTTCTTTCCCGCTCGGCCCCCGTGAAAAAAAC
GGAGTAATCTGGTATCCTTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSTDIHTEKILILDFGSQYTQLIARRVREAHVYCELHPFDMGLEAIRAFAPKGIILSGGPKSVYEEGAPAVEEALFDLGV
PVLGICYGMQLMSRHFGGEVVPAGKREFGHADLLAAGTPGPLFEGFFVEGKSPVWMSHGDHVSRMPQGFQVVAETANAPV
CAIQDTARNLYGVQFHPEVNHTPRGEILIDTFVRKICGCTGQWTPGHIIEDAVNRIRAQVGRERVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDNGLLRLAEGDQVMATFAENLGVKVIRVDAEQRFLTALADEADPEKKRKIIGNLFVEIFEEESSR
IEGATWLAQGTIYPDVIESAGAKTGKAHNIKSHHNVGGLPEYMKLKLLEPLRELFKDEVRAIGEELGLPRQMVWRHPFPG
PGLGVRILGEVKKEYADILRRADAIYIEELYAAGHYDKISQAFAVFLPVKSVGVMGDGRTYEYVIALRAVETKDFMTAGW
YPLPYEDMARISGRIINEVKGVNRVVYDISSKPPATIEWE

Sequences:

>Translated_520_residues
MSTDIHTEKILILDFGSQYTQLIARRVREAHVYCELHPFDMGLEAIRAFAPKGIILSGGPKSVYEEGAPAVEEALFDLGV
PVLGICYGMQLMSRHFGGEVVPAGKREFGHADLLAAGTPGPLFEGFFVEGKSPVWMSHGDHVSRMPQGFQVVAETANAPV
CAIQDTARNLYGVQFHPEVNHTPRGEILIDTFVRKICGCTGQWTPGHIIEDAVNRIRAQVGRERVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDNGLLRLAEGDQVMATFAENLGVKVIRVDAEQRFLTALADEADPEKKRKIIGNLFVEIFEEESSR
IEGATWLAQGTIYPDVIESAGAKTGKAHNIKSHHNVGGLPEYMKLKLLEPLRELFKDEVRAIGEELGLPRQMVWRHPFPG
PGLGVRILGEVKKEYADILRRADAIYIEELYAAGHYDKISQAFAVFLPVKSVGVMGDGRTYEYVIALRAVETKDFMTAGW
YPLPYEDMARISGRIINEVKGVNRVVYDISSKPPATIEWE
>Mature_519_residues
STDIHTEKILILDFGSQYTQLIARRVREAHVYCELHPFDMGLEAIRAFAPKGIILSGGPKSVYEEGAPAVEEALFDLGVP
VLGICYGMQLMSRHFGGEVVPAGKREFGHADLLAAGTPGPLFEGFFVEGKSPVWMSHGDHVSRMPQGFQVVAETANAPVC
AIQDTARNLYGVQFHPEVNHTPRGEILIDTFVRKICGCTGQWTPGHIIEDAVNRIRAQVGRERVILGLSGGVDSSVAAAL
IHRAIGDQLTCVFVDNGLLRLAEGDQVMATFAENLGVKVIRVDAEQRFLTALADEADPEKKRKIIGNLFVEIFEEESSRI
EGATWLAQGTIYPDVIESAGAKTGKAHNIKSHHNVGGLPEYMKLKLLEPLRELFKDEVRAIGEELGLPRQMVWRHPFPGP
GLGVRILGEVKKEYADILRRADAIYIEELYAAGHYDKISQAFAVFLPVKSVGVMGDGRTYEYVIALRAVETKDFMTAGWY
PLPYEDMARISGRIINEVKGVNRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=551, Percent_Identity=37.5680580762251, Blast_Score=321, Evalue=8e-88,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=61.9047619047619, Blast_Score=666, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=36.7775831873905, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=36.7775831873905, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=36.7775831873905, Blast_Score=312, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=52.9865125240848, Blast_Score=559, Evalue=1e-160,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=36.6120218579235, Blast_Score=318, Evalue=8e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57332; Mature: 57200

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDIHTEKILILDFGSQYTQLIARRVREAHVYCELHPFDMGLEAIRAFAPKGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCCEEEECCC
KSVYEEGAPAVEEALFDLGVPVLGICYGMQLMSRHFGGEVVPAGKREFGHADLLAAGTPG
HHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCC
PLFEGFFVEGKSPVWMSHGDHVSRMPQGFQVVAETANAPVCAIQDTARNLYGVQFHPEVN
CCCCCEEECCCCCEEECCCCHHHHCCCCHHHHHHCCCCCEEEEEHHHHCEEEEEECCCCC
HTPRGEILIDTFVRKICGCTGQWTPGHIIEDAVNRIRAQVGRERVILGLSGGVDSSVAAA
CCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDNGLLRLAEGDQVMATFAENLGVKVIRVDAEQRFLTALADEADPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCCHH
KKRKIIGNLFVEIFEEESSRIEGATWLAQGTIYPDVIESAGAKTGKAHNIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCH
EYMKLKLLEPLRELFKDEVRAIGEELGLPRQMVWRHPFPGPGLGVRILGEVKKEYADILR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIYIEELYAAGHYDKISQAFAVFLPVKSVGVMGDGRTYEYVIALRAVETKDFMTAGW
HCCHHHHHHHHHCCCHHHHHHHHHHEEEHHHHCCCCCCCCEEEEEEEEEECCCCHHCCCC
YPLPYEDMARISGRIINEVKGVNRVVYDISSKPPATIEWE
CCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEECC
>Mature Secondary Structure 
STDIHTEKILILDFGSQYTQLIARRVREAHVYCELHPFDMGLEAIRAFAPKGIILSGGP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCCEEEECCC
KSVYEEGAPAVEEALFDLGVPVLGICYGMQLMSRHFGGEVVPAGKREFGHADLLAAGTPG
HHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCC
PLFEGFFVEGKSPVWMSHGDHVSRMPQGFQVVAETANAPVCAIQDTARNLYGVQFHPEVN
CCCCCEEECCCCCEEECCCCHHHHCCCCHHHHHHCCCCCEEEEEHHHHCEEEEEECCCCC
HTPRGEILIDTFVRKICGCTGQWTPGHIIEDAVNRIRAQVGRERVILGLSGGVDSSVAAA
CCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDNGLLRLAEGDQVMATFAENLGVKVIRVDAEQRFLTALADEADPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCCHH
KKRKIIGNLFVEIFEEESSRIEGATWLAQGTIYPDVIESAGAKTGKAHNIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCH
EYMKLKLLEPLRELFKDEVRAIGEELGLPRQMVWRHPFPGPGLGVRILGEVKKEYADILR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIYIEELYAAGHYDKISQAFAVFLPVKSVGVMGDGRTYEYVIALRAVETKDFMTAGW
HCCHHHHHHHHHCCCHHHHHHHHHHEEEHHHHCCCCCCCCEEEEEEEEEECCCCHHCCCC
YPLPYEDMARISGRIINEVKGVNRVVYDISSKPPATIEWE
CCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA