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The map label for this gene is zraS [H]

Identifier: 39997140

GI number: 39997140

Start: 2237164

End: 2238738

Strand: Reverse

Name: zraS [H]

Synonym: GSU2042

Alternate gene names: 39997140

Gene position: 2238738-2237164 (Counterclockwise)

Preceding gene: 39997141

Following gene: 39997139

Centisome position: 58.7

GC content: 63.37

Gene sequence:

>1575_bases
GTGAGGCGTCTGCGCTTCAGTCTCAGCTTCCTGATCCTCTCTTCCCTTACGTTCCTCCTGGTTCTTACCTGGTTTCTCCT
GAGCCTGATCTCGTTCAAGACCGCCGAAAGCGACCTCCTTCGCCAGAAAAGCGACAAGGCGCGTATCCTGCTCGCGTCTT
TCACCGCGCTGGTTCCCCCGTCGCTGGACGGGATAGGTTCTTCGGCGGCCGGCGTACTTGCCCGCCAGCTGGCGGGAGAA
CCGGAATTCACGGCCCTGGCCGTTGTGCGGGGTGACGGAGCACCGGTGTTCGCTCTGGGTGCCGGTTCACCCGCTGACGA
GCGTCTGGCGGCCTGTCTTCGCGACGGCGCCGAATCGGTCTGGCTCCCTGCGGGGGAGGGCGTCCTCATTCGCTATGCCC
CAATCATCCGTGAGGGGGCGACCGTTGGCGCGGCCAGGCTCGTCCTTTCCCTGGCGGGGGAGCGGCAGATGCTCGCCCAT
TCGCGTCACCTGTTCCTCGCCTACTTCGCCCTCGATTTCCTTCTCCTTCTGGCGGTGGGGTCACTGCTGCTTTCCCGCTT
CATCATCATCCCCATGCGCAAGCTTCTGGCCGCAACGGAGCGGATCGGCGCCGGCGACTATCACCATAAGGCCGCGGTTC
CGGGGAGCCGTGAGATAGCCGAACTGGCCGATTCATTCAACCAGATGGTGGACGCCCTGCGGGTCAAGGATGAAGAAGCG
GTGCGCCACGTGACCTCGCTGGAGCGGGCCAACCGGGAGCTCAAGGAGGCCCGCGAAGAAACCCTCAGATCCGAAAAAAT
GGCGTCGGTGGGAATGCTGGCCGCTGGGACGGCCCACGAGATCGGCACCCCGCTGGCAGCCATCATGGGGTACGTATCAC
TCTTGCGGGATGATGAATCCCTTGATCCGGAAAGGGCCGACTATCTCCGTCGAATTCAGCATGAGACCGAACGGATCGAC
CGGATCGTTCACGACCTGCTCGATTATGCCCGCCCCGTGCCCCTTGCCGCCGAAGAGGTTGACGTGGTCGCCCTGGTGGC
TGAAACTGTGGAGATGGTAAGCCGGCAGGGAGCCCTCAAACGGGTTCAGGTGCACATCGGGGCTGGCGAGGGGAGTGCTG
TGGCCGTGACCGATCCGCATCAGCTCCAACAGGTTTTGATCAACCTGCTGATCAATGCCCGTGACGCCATGCCCGACGGT
GGCCGCCTGGATGTCGCCGTATCGACCGGAGCGTTCATGCCGCCGGCAGGGCTTCCAGACAGCGGTCGCTGGTCTGTTAT
GGCCGGCCGGCGCAAGGATGACTTCGGCGGTGTGTTCCGCACACCGTTTGCCGGGGACGGGAGCGAGGTGCCGTGTATCC
GGATTGCCGTGACCGACACCGGGTCGGGAATCGCGCCCGAGCACCTGGAGAGGATCTTCGACCCCTTTTTTACCACCAAG
GAGCCGGGCAGGGGGACCGGACTGGGGCTATCCATCTCGGCCAGGATAGTTGATTCTCTTGGCGGGAGAATGACGGTCGA
AAGTGCGGTGGGCGAAGGATCGCGGTTCGAGATATGGCTTCCAGTCTCGAAATGA

Upstream 100 bases:

>100_bases
CGGCCCGTTCCTGGCGCTGGGGGCACTTCTCTACATCTTTTTCGGCAAGGCGATCATTCTCTGGTACCTGAGCATCGGCG
CCCGGTAGCGAGGTGCACCC

Downstream 100 bases:

>100_bases
AATGAAATACAATGGGTTATGGGCGAGGGGTATGAGATGAAAAAGCGGATACTGGTCGTCGACGACGAAGAAAACATGAG
GCACATGCTGTGCGCCATGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MRRLRFSLSFLILSSLTFLLVLTWFLLSLISFKTAESDLLRQKSDKARILLASFTALVPPSLDGIGSSAAGVLARQLAGE
PEFTALAVVRGDGAPVFALGAGSPADERLAACLRDGAESVWLPAGEGVLIRYAPIIREGATVGAARLVLSLAGERQMLAH
SRHLFLAYFALDFLLLLAVGSLLLSRFIIIPMRKLLAATERIGAGDYHHKAAVPGSREIAELADSFNQMVDALRVKDEEA
VRHVTSLERANRELKEAREETLRSEKMASVGMLAAGTAHEIGTPLAAIMGYVSLLRDDESLDPERADYLRRIQHETERID
RIVHDLLDYARPVPLAAEEVDVVALVAETVEMVSRQGALKRVQVHIGAGEGSAVAVTDPHQLQQVLINLLINARDAMPDG
GRLDVAVSTGAFMPPAGLPDSGRWSVMAGRRKDDFGGVFRTPFAGDGSEVPCIRIAVTDTGSGIAPEHLERIFDPFFTTK
EPGRGTGLGLSISARIVDSLGGRMTVESAVGEGSRFEIWLPVSK

Sequences:

>Translated_524_residues
MRRLRFSLSFLILSSLTFLLVLTWFLLSLISFKTAESDLLRQKSDKARILLASFTALVPPSLDGIGSSAAGVLARQLAGE
PEFTALAVVRGDGAPVFALGAGSPADERLAACLRDGAESVWLPAGEGVLIRYAPIIREGATVGAARLVLSLAGERQMLAH
SRHLFLAYFALDFLLLLAVGSLLLSRFIIIPMRKLLAATERIGAGDYHHKAAVPGSREIAELADSFNQMVDALRVKDEEA
VRHVTSLERANRELKEAREETLRSEKMASVGMLAAGTAHEIGTPLAAIMGYVSLLRDDESLDPERADYLRRIQHETERID
RIVHDLLDYARPVPLAAEEVDVVALVAETVEMVSRQGALKRVQVHIGAGEGSAVAVTDPHQLQQVLINLLINARDAMPDG
GRLDVAVSTGAFMPPAGLPDSGRWSVMAGRRKDDFGGVFRTPFAGDGSEVPCIRIAVTDTGSGIAPEHLERIFDPFFTTK
EPGRGTGLGLSISARIVDSLGGRMTVESAVGEGSRFEIWLPVSK
>Mature_524_residues
MRRLRFSLSFLILSSLTFLLVLTWFLLSLISFKTAESDLLRQKSDKARILLASFTALVPPSLDGIGSSAAGVLARQLAGE
PEFTALAVVRGDGAPVFALGAGSPADERLAACLRDGAESVWLPAGEGVLIRYAPIIREGATVGAARLVLSLAGERQMLAH
SRHLFLAYFALDFLLLLAVGSLLLSRFIIIPMRKLLAATERIGAGDYHHKAAVPGSREIAELADSFNQMVDALRVKDEEA
VRHVTSLERANRELKEAREETLRSEKMASVGMLAAGTAHEIGTPLAAIMGYVSLLRDDESLDPERADYLRRIQHETERID
RIVHDLLDYARPVPLAAEEVDVVALVAETVEMVSRQGALKRVQVHIGAGEGSAVAVTDPHQLQQVLINLLINARDAMPDG
GRLDVAVSTGAFMPPAGLPDSGRWSVMAGRRKDDFGGVFRTPFAGDGSEVPCIRIAVTDTGSGIAPEHLERIFDPFFTTK
EPGRGTGLGLSISARIVDSLGGRMTVESAVGEGSRFEIWLPVSK

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=266, Percent_Identity=33.0827067669173, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1788549, Length=271, Percent_Identity=32.4723247232472, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081816, Length=373, Percent_Identity=26.8096514745308, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789149, Length=471, Percent_Identity=23.3545647558386, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56451; Mature: 56451

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRFSLSFLILSSLTFLLVLTWFLLSLISFKTAESDLLRQKSDKARILLASFTALVPP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHEEHHHHHHHCCC
SLDGIGSSAAGVLARQLAGEPEFTALAVVRGDGAPVFALGAGSPADERLAACLRDGAESV
CCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCE
WLPAGEGVLIRYAPIIREGATVGAARLVLSLAGERQMLAHSRHLFLAYFALDFLLLLAVG
EECCCCCEEEEECHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLLSRFIIIPMRKLLAATERIGAGDYHHKAAVPGSREIAELADSFNQMVDALRVKDEEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
VRHVTSLERANRELKEAREETLRSEKMASVGMLAAGTAHEIGTPLAAIMGYVSLLRDDES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCC
LDPERADYLRRIQHETERIDRIVHDLLDYARPVPLAAEEVDVVALVAETVEMVSRQGALK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
RVQVHIGAGEGSAVAVTDPHQLQQVLINLLINARDAMPDGGRLDVAVSTGAFMPPAGLPD
EEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCC
SGRWSVMAGRRKDDFGGVFRTPFAGDGSEVPCIRIAVTDTGSGIAPEHLERIFDPFFTTK
CCCEEEEECCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
EPGRGTGLGLSISARIVDSLGGRMTVESAVGEGSRFEIWLPVSK
CCCCCCCCCEEHHHHHHHHCCCCEEEHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRLRFSLSFLILSSLTFLLVLTWFLLSLISFKTAESDLLRQKSDKARILLASFTALVPP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHEEHHHHHHHCCC
SLDGIGSSAAGVLARQLAGEPEFTALAVVRGDGAPVFALGAGSPADERLAACLRDGAESV
CCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCE
WLPAGEGVLIRYAPIIREGATVGAARLVLSLAGERQMLAHSRHLFLAYFALDFLLLLAVG
EECCCCCEEEEECHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLLSRFIIIPMRKLLAATERIGAGDYHHKAAVPGSREIAELADSFNQMVDALRVKDEEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
VRHVTSLERANRELKEAREETLRSEKMASVGMLAAGTAHEIGTPLAAIMGYVSLLRDDES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCC
LDPERADYLRRIQHETERIDRIVHDLLDYARPVPLAAEEVDVVALVAETVEMVSRQGALK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
RVQVHIGAGEGSAVAVTDPHQLQQVLINLLINARDAMPDGGRLDVAVSTGAFMPPAGLPD
EEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCC
SGRWSVMAGRRKDDFGGVFRTPFAGDGSEVPCIRIAVTDTGSGIAPEHLERIFDPFFTTK
CCCEEEEECCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
EPGRGTGLGLSISARIVDSLGGRMTVESAVGEGSRFEIWLPVSK
CCCCCCCCCEEHHHHHHHHCCCCEEEHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]