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The map label for this gene is atoC [H]

Identifier: 39997139

GI number: 39997139

Start: 2235760

End: 2237127

Strand: Reverse

Name: atoC [H]

Synonym: GSU2041

Alternate gene names: 39997139

Gene position: 2237127-2235760 (Counterclockwise)

Preceding gene: 39997140

Following gene: 39997137

Centisome position: 58.65

GC content: 60.75

Gene sequence:

>1368_bases
ATGAAAAAGCGGATACTGGTCGTCGACGACGAAGAAAACATGAGGCACATGCTGTGCGCCATGCTCCGCAAGCAGGGCTA
CGAGGCGGTGGAGGCCGCCGATGGCGAAGCGGCCCTGGCCCAGGCATCCGCTGCTGCCTACGACTTTATCCTCTGTGACA
TCCGGATGCCGATCATGGATGGTGTCGGGTTTCTGCGGACCTTTCAGAAGGCCGAACTCCCCGGCACCGTTATCATGATG
TCCGCCTATGGTACCGTGGATGCCGCCATCGCCTGCATGAAGGAAGGGGCCTACGATTACGTTTCGAAACCGTTTAAAAA
CGACGAGATCCTGCTGGTCCTCAGGAAGGCGGAGGAGCGCGAGCGACTTAAAAATGAAAACCGCCGGTTGCGGGAAGTGG
TGGGGCGAGAGTATGCGTTCGGCAGCATTGTAAGCCGTAACCCGCGCATGCGCGAGATCTTCAACCTTATCCGCAAGGTG
TGCGACGTGCGGACCACCGTTCTCATCCTCGGCGAGTCGGGAACCGGCAAGGAGCTGGTGGCGCGGGCCATCCACCATAA
CGGCAGCCGCAGTGACGGACCCTTTGTGGCGGTCAACTGCGGCGCAATTCCCGAAAGCCTTCTGGAGTCGGAACTGTTCG
GTCACGTTCGCGGCGCCTTTACCGATGCCTCGTCGGACCGCGCCGGGCTTTTCGAGGAGGCCAACGGCGGGACGCTTTTT
CTCGACGAGATCGGTGAAATGCCCCCGGCGCTCCAGGTGAAGCTTTTGCGCGTACTGCAGGAGGGTGAGGTCCGGCGAGT
GGGCGGATCCAAAGCCCAGCGCGTCGATGTCCGGATCATTTCCGCCACCTCTCGGGATCTGGCCCGGGATGCCGCGGAGG
GGCGTTTTCGCGAGGACCTTTTTTTCCGCCTCAATGTGTTCGCCATTACCCTGCCTCCCCTGAGGGAGCGGTTGGAAGAC
ATCCCTCTACTCGTGAACCACTTCCTGCACAAGTACGGTGAGTCTTTCGGCCGGTCCGGAATGGTCGTGTCGCCGGAGGC
CATGAAGCTGCTTGCTGCCTATGGCTGGCCCGGCAATGTGCGAGAACTTGAAAACTGCATTGAGCGCGCGTTCATTCTCA
GCGACGGAGAAATCCTCGATGCCGGAAGCCTGCCCGATGTTGTGCGGGGAGACTCGGCCGCATCGGCGGCGGGGTTCCAC
CTGCCCGAGGATACCCTTTCCATCAAGCGGGCCGAAGAGTGCCTTGAGCGGGAATTCATCCGCAGAGCCCTGGCCAAAAC
CGGCGGGAACAGGACCCATGCCGCGCGTTTGCTGGAAATCAGCCATCGGGCGTTGCTCTACAAGCTCAAGGAATTCGGCA
TCGATTAA

Upstream 100 bases:

>100_bases
GACGGTCGAAAGTGCGGTGGGCGAAGGATCGCGGTTCGAGATATGGCTTCCAGTCTCGAAATGAAATGAAATACAATGGG
TTATGGGCGAGGGGTATGAG

Downstream 100 bases:

>100_bases
AGTAAAATTATTTAATAAAATATTGTAAATGCAAAAGGGCTGTGCAATTATTGCGGAGCCCTTTTATCGTCACAGGGAGG
TGACCGGGATGAGCGGGATG

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKRILVVDDEENMRHMLCAMLRKQGYEAVEAADGEAALAQASAAAYDFILCDIRMPIMDGVGFLRTFQKAELPGTVIMM
SAYGTVDAAIACMKEGAYDYVSKPFKNDEILLVLRKAEERERLKNENRRLREVVGREYAFGSIVSRNPRMREIFNLIRKV
CDVRTTVLILGESGTGKELVARAIHHNGSRSDGPFVAVNCGAIPESLLESELFGHVRGAFTDASSDRAGLFEEANGGTLF
LDEIGEMPPALQVKLLRVLQEGEVRRVGGSKAQRVDVRIISATSRDLARDAAEGRFREDLFFRLNVFAITLPPLRERLED
IPLLVNHFLHKYGESFGRSGMVVSPEAMKLLAAYGWPGNVRELENCIERAFILSDGEILDAGSLPDVVRGDSAASAAGFH
LPEDTLSIKRAEECLEREFIRRALAKTGGNRTHAARLLEISHRALLYKLKEFGID

Sequences:

>Translated_455_residues
MKKRILVVDDEENMRHMLCAMLRKQGYEAVEAADGEAALAQASAAAYDFILCDIRMPIMDGVGFLRTFQKAELPGTVIMM
SAYGTVDAAIACMKEGAYDYVSKPFKNDEILLVLRKAEERERLKNENRRLREVVGREYAFGSIVSRNPRMREIFNLIRKV
CDVRTTVLILGESGTGKELVARAIHHNGSRSDGPFVAVNCGAIPESLLESELFGHVRGAFTDASSDRAGLFEEANGGTLF
LDEIGEMPPALQVKLLRVLQEGEVRRVGGSKAQRVDVRIISATSRDLARDAAEGRFREDLFFRLNVFAITLPPLRERLED
IPLLVNHFLHKYGESFGRSGMVVSPEAMKLLAAYGWPGNVRELENCIERAFILSDGEILDAGSLPDVVRGDSAASAAGFH
LPEDTLSIKRAEECLEREFIRRALAKTGGNRTHAARLLEISHRALLYKLKEFGID
>Mature_455_residues
MKKRILVVDDEENMRHMLCAMLRKQGYEAVEAADGEAALAQASAAAYDFILCDIRMPIMDGVGFLRTFQKAELPGTVIMM
SAYGTVDAAIACMKEGAYDYVSKPFKNDEILLVLRKAEERERLKNENRRLREVVGREYAFGSIVSRNPRMREIFNLIRKV
CDVRTTVLILGESGTGKELVARAIHHNGSRSDGPFVAVNCGAIPESLLESELFGHVRGAFTDASSDRAGLFEEANGGTLF
LDEIGEMPPALQVKLLRVLQEGEVRRVGGSKAQRVDVRIISATSRDLARDAAEGRFREDLFFRLNVFAITLPPLRERLED
IPLLVNHFLHKYGESFGRSGMVVSPEAMKLLAAYGWPGNVRELENCIERAFILSDGEILDAGSLPDVVRGDSAASAAGFH
LPEDTLSIKRAEECLEREFIRRALAKTGGNRTHAARLLEISHRALLYKLKEFGID

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=48.1236203090508, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=45.3932584269663, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=39.1025641025641, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=41.5730337078652, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1789087, Length=340, Percent_Identity=46.4705882352941, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=45.3488372093023, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789233, Length=310, Percent_Identity=45.8064516129032, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=46.1059190031153, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786524, Length=349, Percent_Identity=42.1203438395415, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787583, Length=332, Percent_Identity=39.1566265060241, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87081872, Length=306, Percent_Identity=40.5228758169935, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87081858, Length=318, Percent_Identity=32.7044025157233, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789828, Length=237, Percent_Identity=37.9746835443038, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=33.6283185840708, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788191, Length=107, Percent_Identity=38.3177570093458, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=29.6610169491525, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI1786911, Length=118, Percent_Identity=34.7457627118644, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50544; Mature: 50544

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRILVVDDEENMRHMLCAMLRKQGYEAVEAADGEAALAQASAAAYDFILCDIRMPIMD
CCCCEEEECCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHEEEEEECCHHHH
GVGFLRTFQKAELPGTVIMMSAYGTVDAAIACMKEGAYDYVSKPFKNDEILLVLRKAEER
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECHHHH
ERLKNENRRLREVVGREYAFGSIVSRNPRMREIFNLIRKVCDVRTTVLILGESGTGKELV
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
ARAIHHNGSRSDGPFVAVNCGAIPESLLESELFGHVRGAFTDASSDRAGLFEEANGGTLF
HHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
LDEIGEMPPALQVKLLRVLQEGEVRRVGGSKAQRVDVRIISATSRDLARDAAEGRFREDL
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEECCHHHHHHHHHCCCHHHHH
FFRLNVFAITLPPLRERLEDIPLLVNHFLHKYGESFGRSGMVVSPEAMKLLAAYGWPGNV
HEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHCCCCCCH
RELENCIERAFILSDGEILDAGSLPDVVRGDSAASAAGFHLPEDTLSIKRAEECLEREFI
HHHHHHHHHHHEECCCCEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RRALAKTGGNRTHAARLLEISHRALLYKLKEFGID
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKRILVVDDEENMRHMLCAMLRKQGYEAVEAADGEAALAQASAAAYDFILCDIRMPIMD
CCCCEEEECCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHEEEEEECCHHHH
GVGFLRTFQKAELPGTVIMMSAYGTVDAAIACMKEGAYDYVSKPFKNDEILLVLRKAEER
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECHHHH
ERLKNENRRLREVVGREYAFGSIVSRNPRMREIFNLIRKVCDVRTTVLILGESGTGKELV
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
ARAIHHNGSRSDGPFVAVNCGAIPESLLESELFGHVRGAFTDASSDRAGLFEEANGGTLF
HHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
LDEIGEMPPALQVKLLRVLQEGEVRRVGGSKAQRVDVRIISATSRDLARDAAEGRFREDL
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEECCHHHHHHHHHCCCHHHHH
FFRLNVFAITLPPLRERLEDIPLLVNHFLHKYGESFGRSGMVVSPEAMKLLAAYGWPGNV
HEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHCCCCCCH
RELENCIERAFILSDGEILDAGSLPDVVRGDSAASAAGFHLPEDTLSIKRAEECLEREFI
HHHHHHHHHHHEECCCCEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RRALAKTGGNRTHAARLLEISHRALLYKLKEFGID
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]