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The map label for this gene is pepQ-2 [H]

Identifier: 39997119

GI number: 39997119

Start: 2214096

End: 2215163

Strand: Reverse

Name: pepQ-2 [H]

Synonym: GSU2021

Alternate gene names: 39997119

Gene position: 2215163-2214096 (Counterclockwise)

Preceding gene: 39997120

Following gene: 39997118

Centisome position: 58.08

GC content: 60.21

Gene sequence:

>1068_bases
ATGTTACAAAACAGGCTCAATAAAGCCCGGAGTCATGCCGAAAAACACGATGTGGACGCCATCGTGTTTTTTAACATGAG
TAACGTTCGTTACCTTTCCGGCTTCACCGGAAGCGATGGCGCGGTGGTGCTCGGGAGAGACGCGAGCTGGTTTCTCACCG
ATTCACGCTACACCACCCAGGCGTCCCGCCAGGTTGTCGGACTCCCGACAGTCGAATATCGCATCAAGCTCGACGGAATC
ACCGAGCTGGTGCGGGAACAAGGATTCCGCCGGATCGGGTTCGAGTCCGAACACACGGCGTTTGCCGTGTACGAGTCGCT
GCGGCAAAAACTCCCCAAGACTGAACTGGTGCCCATCGGTGAGGAGTTGGCCCAGCTCCGGCTGATCAAGGACCCCTCGG
AATGTGAGCTTTTGTCCCGTGTCGCCCGGCTGGCTTCCGAGGCCCTGCTGTCAATCCTGCCGCTGGTAAAGCCGGGCGCC
GTGGAGCGTGAACTGGCCCTTGAGCTCGAATTTGCCATGCGCCGCGCCGGTGCGGAGAATGCATCCTTTGATTTCATTGT
GGCCTCCGGCGAGCGGGGATCTCTCCCCCACGGGCGTGCCAGCGACAAAGCACTGGCTGCGGGAGAGCTGGTCACCATCG
ATTTCGGCGCTAGGTACGAGGGCTACTGTTCGGACGAAACCGTGACCGTTGCCGTGGGCGTCCCCGATGAGCGCCAGTGC
CAGATTTACGGCATTGTCAAGGAAGCTCACGATCGGGCGATTGCCGCGGTCAGGCCCGGGGCCGAACTACGGGAGATCGA
CCGGATCGCCCGCGGCTATATTGAAGAGCAGGGCTACGGCGCCTTTTTCGGCCATGGTCTCGGCCATGGCGTCGGTCTTG
ACGTGCACGAGAAGCCGGTCGTATCCCCCCGGGGTGAGGGGGTGGCGGCTGTCGGCATGGTTTTCACTATCGAGCCGGGT
ATCTATATTCCCGGCTGGGGTGGCGTGCGGATTGAAGACACGGTCATCGTTACTGAGGACGGTTGCCGTCCCATTACCAT
GATTCCCAAGGAACTCATGATTTTGTAA

Upstream 100 bases:

>100_bases
GGTGGGGCAGATCACGGGGTTCGGCGCCGACAGCTACCTGCTCGGGTTGCGCGCCCTTTTTACCCACATTGAAAAAGGGA
TTGTCACCAAGGGTTGAAAC

Downstream 100 bases:

>100_bases
CGCCGTCGGCTTGTCCCGGCGGCGATACCCGTCAAAGGAGATACGATACATGGATATCAAGGATCTGAAGTCACTCATAA
AAATGGTTACCGAAACCGAC

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLQNRLNKARSHAEKHDVDAIVFFNMSNVRYLSGFTGSDGAVVLGRDASWFLTDSRYTTQASRQVVGLPTVEYRIKLDGI
TELVREQGFRRIGFESEHTAFAVYESLRQKLPKTELVPIGEELAQLRLIKDPSECELLSRVARLASEALLSILPLVKPGA
VERELALELEFAMRRAGAENASFDFIVASGERGSLPHGRASDKALAAGELVTIDFGARYEGYCSDETVTVAVGVPDERQC
QIYGIVKEAHDRAIAAVRPGAELREIDRIARGYIEEQGYGAFFGHGLGHGVGLDVHEKPVVSPRGEGVAAVGMVFTIEPG
IYIPGWGGVRIEDTVIVTEDGCRPITMIPKELMIL

Sequences:

>Translated_355_residues
MLQNRLNKARSHAEKHDVDAIVFFNMSNVRYLSGFTGSDGAVVLGRDASWFLTDSRYTTQASRQVVGLPTVEYRIKLDGI
TELVREQGFRRIGFESEHTAFAVYESLRQKLPKTELVPIGEELAQLRLIKDPSECELLSRVARLASEALLSILPLVKPGA
VERELALELEFAMRRAGAENASFDFIVASGERGSLPHGRASDKALAAGELVTIDFGARYEGYCSDETVTVAVGVPDERQC
QIYGIVKEAHDRAIAAVRPGAELREIDRIARGYIEEQGYGAFFGHGLGHGVGLDVHEKPVVSPRGEGVAAVGMVFTIEPG
IYIPGWGGVRIEDTVIVTEDGCRPITMIPKELMIL
>Mature_355_residues
MLQNRLNKARSHAEKHDVDAIVFFNMSNVRYLSGFTGSDGAVVLGRDASWFLTDSRYTTQASRQVVGLPTVEYRIKLDGI
TELVREQGFRRIGFESEHTAFAVYESLRQKLPKTELVPIGEELAQLRLIKDPSECELLSRVARLASEALLSILPLVKPGA
VERELALELEFAMRRAGAENASFDFIVASGERGSLPHGRASDKALAAGELVTIDFGARYEGYCSDETVTVAVGVPDERQC
QIYGIVKEAHDRAIAAVRPGAELREIDRIARGYIEEQGYGAFFGHGLGHGVGLDVHEKPVVSPRGEGVAAVGMVFTIEPG
IYIPGWGGVRIEDTVIVTEDGCRPITMIPKELMIL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=265, Percent_Identity=31.6981132075472, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI149589008, Length=295, Percent_Identity=27.7966101694915, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI260593665, Length=295, Percent_Identity=27.7966101694915, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI93141226, Length=367, Percent_Identity=26.158038147139, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI264681563, Length=292, Percent_Identity=29.1095890410959, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788728, Length=357, Percent_Identity=39.7759103641457, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789275, Length=250, Percent_Identity=32.4, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=30, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508215, Length=301, Percent_Identity=27.2425249169435, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71989583, Length=251, Percent_Identity=27.0916334661355, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=164, Percent_Identity=34.1463414634146, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320922, Length=259, Percent_Identity=26.6409266409266, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357079, Length=299, Percent_Identity=30.4347826086957, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19920384, Length=259, Percent_Identity=31.6602316602317, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355531, Length=171, Percent_Identity=29.2397660818713, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583427, Length=173, Percent_Identity=30.0578034682081, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 38884; Mature: 38884

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQNRLNKARSHAEKHDVDAIVFFNMSNVRYLSGFTGSDGAVVLGRDASWFLTDSRYTTQ
CCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCEEEECCCEEEEECCCEECH
ASRQVVGLPTVEYRIKLDGITELVREQGFRRIGFESEHTAFAVYESLRQKLPKTELVPIG
HCCEEECCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
EELAQLRLIKDPSECELLSRVARLASEALLSILPLVKPGAVERELALELEFAMRRAGAEN
HHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
ASFDFIVASGERGSLPHGRASDKALAAGELVTIDFGARYEGYCSDETVTVAVGVPDERQC
CCEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCE
QIYGIVKEAHDRAIAAVRPGAELREIDRIARGYIEEQGYGAFFGHGLGHGVGLDVHEKPV
EEEEEEHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCC
VSPRGEGVAAVGMVFTIEPGIYIPGWGGVRIEDTVIVTEDGCRPITMIPKELMIL
CCCCCCCEEEEEEEEEECCCEEECCCCCEEEEEEEEEECCCCCCEEECCHHHHCC
>Mature Secondary Structure
MLQNRLNKARSHAEKHDVDAIVFFNMSNVRYLSGFTGSDGAVVLGRDASWFLTDSRYTTQ
CCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCEEEECCCEEEEECCCEECH
ASRQVVGLPTVEYRIKLDGITELVREQGFRRIGFESEHTAFAVYESLRQKLPKTELVPIG
HCCEEECCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
EELAQLRLIKDPSECELLSRVARLASEALLSILPLVKPGAVERELALELEFAMRRAGAEN
HHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
ASFDFIVASGERGSLPHGRASDKALAAGELVTIDFGARYEGYCSDETVTVAVGVPDERQC
CCEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCE
QIYGIVKEAHDRAIAAVRPGAELREIDRIARGYIEEQGYGAFFGHGLGHGVGLDVHEKPV
EEEEEEHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCC
VSPRGEGVAAVGMVFTIEPGIYIPGWGGVRIEDTVIVTEDGCRPITMIPKELMIL
CCCCCCCEEEEEEEEEECCCEEECCCCCEEEEEEEEEECCCCCCEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]