Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 39997087

GI number: 39997087

Start: 2182011

End: 2183345

Strand: Reverse

Name: atoC [H]

Synonym: GSU1989

Alternate gene names: 39997087

Gene position: 2183345-2182011 (Counterclockwise)

Preceding gene: 39997088

Following gene: 39997086

Centisome position: 57.24

GC content: 57.45

Gene sequence:

>1335_bases
GTGCAGGGTCTTGTTCTTATCGTCGACGATGAGCCGAATGCGGCCAGGGTTCTTTCGGCAATCCTGGCCGGTGAAGGGCA
TACCGTACTTACCGCTTCTGATGCCTCAAAGGCAGAGCATATCCTCAAGTCGCGCGACGTTGACGCTATCATAACCGACC
TGCGCATGCCGGGCAGGGATGGCATGCAGTTGTTCGAGCACGTGACCGAACATCTGCCGGATATTCCGGTGATTTTTCTG
ACCGCCTACGGAACGGTCGACTCCGCCGTCAACGCCATCACCCGTGGCGCCTTTTACTATTTCATCAAACCTCCTGATTA
CGTGAAGCTCAAGAGCATGGTTGCGCGAGCCGTGGAGCAGCGCGCACTCAAGCGCGAAGTGGCCGAGCTGCGCAAACGGG
TGGCTGCGGGCAGCGGGGCTGATCGGATTATCGGTGTCAGTCCGGGAATGCTCAAAATATTCAATACGATCGAGGCGGTC
AAGGACTCCATGAGCAGTGTGCTGGTCAGTGGGGAAACCGGAACCGGCAAGGAGCTCATCGCCCGTTCGCTCCATTACGG
CAGTGTGCGGCGCGATCGCCCTTTCGTGGCCGTAAACTGTGCAGCCATACCCCGCGAGCTCATGGAGTCAGAGCTGTTCG
GTTATGAGAAAGGAGCGTTCAGCGGCGCTTCCGCCCGTCGAATCGGGCGCTTCGAAGCTGCTGCCGATGGCACTATATTT
CTCGATGAAATCAGCGAGTTGGAGCTCTCTCTCCAGGCAAAGCTGCTGAGAGTGCTCCAGGAAAAGGAGGTTGAGCGGCT
CGGCAGCAATCGCAAGATCAAGGTTAACTTCCGGGTGATTTCATCCACAAACCGTGATCTCATGCGTGAAATAGCTGCCG
GTACGTTCCGGGAAGATCTTTACTACCGGCTCAATGTCGTCCAGTTGAATGTACCGTCTCTGCGCGAACGCAGAGAGGAT
ATTCCTCTCCTGGTCTCCGAGTTCGTCAAAGAGTTTGGTCTCAGGGAGGGCAAGTCCCTTACTCTTTCTGACGATGTGTT
GCGCGCTCTTGTCGGCTACGAGTGGCCCGGCAATATCAGGCAGCTGCGTAACACCATCGAACGGGCCGTCGTCCTCGCCC
GCGGAGCTAAGATCACCCTGAAGCACTTGCCTGAGGAGGTTGCCGCTGGTGCCGGTTGTCGCGACGTAGCCGAGCCGCGG
ACGCTCCGCGAACTTGAGGAGGAGGCAATCCAGAGTGCCCTGCGGGAATGCCGGGGCAATAAATCACTGGTTGCGAAGAA
GCTCGGCATATCCCGCAAGACCCTTTATAAGCGTCTGGAGCAACTGGGACTTTGA

Upstream 100 bases:

>100_bases
AGGGGAAGATTGAAATAACCGGGAATCATGAAGGCGGAACCACCGTCAAGATCATGTTGCCGGCGGTATAGCCGGATCGG
TGCGGTCCAGGAGGAGCGAA

Downstream 100 bases:

>100_bases
GGGGCGGGCAGGCAAAAGGGCGGGCAGTGTTACCATTGGAGACATTGCCAGGTTGAATACGTGGGAAGTTTCGAAGGCTC
CGTTAAAAAGGTGTATCCAT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MQGLVLIVDDEPNAARVLSAILAGEGHTVLTASDASKAEHILKSRDVDAIITDLRMPGRDGMQLFEHVTEHLPDIPVIFL
TAYGTVDSAVNAITRGAFYYFIKPPDYVKLKSMVARAVEQRALKREVAELRKRVAAGSGADRIIGVSPGMLKIFNTIEAV
KDSMSSVLVSGETGTGKELIARSLHYGSVRRDRPFVAVNCAAIPRELMESELFGYEKGAFSGASARRIGRFEAAADGTIF
LDEISELELSLQAKLLRVLQEKEVERLGSNRKIKVNFRVISSTNRDLMREIAAGTFREDLYYRLNVVQLNVPSLRERRED
IPLLVSEFVKEFGLREGKSLTLSDDVLRALVGYEWPGNIRQLRNTIERAVVLARGAKITLKHLPEEVAAGAGCRDVAEPR
TLRELEEEAIQSALRECRGNKSLVAKKLGISRKTLYKRLEQLGL

Sequences:

>Translated_444_residues
MQGLVLIVDDEPNAARVLSAILAGEGHTVLTASDASKAEHILKSRDVDAIITDLRMPGRDGMQLFEHVTEHLPDIPVIFL
TAYGTVDSAVNAITRGAFYYFIKPPDYVKLKSMVARAVEQRALKREVAELRKRVAAGSGADRIIGVSPGMLKIFNTIEAV
KDSMSSVLVSGETGTGKELIARSLHYGSVRRDRPFVAVNCAAIPRELMESELFGYEKGAFSGASARRIGRFEAAADGTIF
LDEISELELSLQAKLLRVLQEKEVERLGSNRKIKVNFRVISSTNRDLMREIAAGTFREDLYYRLNVVQLNVPSLRERRED
IPLLVSEFVKEFGLREGKSLTLSDDVLRALVGYEWPGNIRQLRNTIERAVVLARGAKITLKHLPEEVAAGAGCRDVAEPR
TLRELEEEAIQSALRECRGNKSLVAKKLGISRKTLYKRLEQLGL
>Mature_444_residues
MQGLVLIVDDEPNAARVLSAILAGEGHTVLTASDASKAEHILKSRDVDAIITDLRMPGRDGMQLFEHVTEHLPDIPVIFL
TAYGTVDSAVNAITRGAFYYFIKPPDYVKLKSMVARAVEQRALKREVAELRKRVAAGSGADRIIGVSPGMLKIFNTIEAV
KDSMSSVLVSGETGTGKELIARSLHYGSVRRDRPFVAVNCAAIPRELMESELFGYEKGAFSGASARRIGRFEAAADGTIF
LDEISELELSLQAKLLRVLQEKEVERLGSNRKIKVNFRVISSTNRDLMREIAAGTFREDLYYRLNVVQLNVPSLRERRED
IPLLVSEFVKEFGLREGKSLTLSDDVLRALVGYEWPGNIRQLRNTIERAVVLARGAKITLKHLPEEVAAGAGCRDVAEPR
TLRELEEEAIQSALRECRGNKSLVAKKLGISRKTLYKRLEQLGL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=43.141592920354, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1790437, Length=440, Percent_Identity=43.1818181818182, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=39.4067796610169, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1788905, Length=436, Percent_Identity=41.5137614678899, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=45.1612903225806, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1789087, Length=348, Percent_Identity=45.1149425287356, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87082152, Length=322, Percent_Identity=45.0310559006211, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=42.9906542056075, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1786524, Length=340, Percent_Identity=40.5882352941176, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87081872, Length=308, Percent_Identity=38.3116883116883, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1787583, Length=313, Percent_Identity=36.741214057508, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI87081858, Length=288, Percent_Identity=32.9861111111111, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789828, Length=252, Percent_Identity=36.5079365079365, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49241; Mature: 49241

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGLVLIVDDEPNAARVLSAILAGEGHTVLTASDASKAEHILKSRDVDAIITDLRMPGRD
CCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCCCCC
GMQLFEHVTEHLPDIPVIFLTAYGTVDSAVNAITRGAFYYFIKPPDYVKLKSMVARAVEQ
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHH
RALKREVAELRKRVAAGSGADRIIGVSPGMLKIFNTIEAVKDSMSSVLVSGETGTGKELI
HHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHH
ARSLHYGSVRRDRPFVAVNCAAIPRELMESELFGYEKGAFSGASARRIGRFEAAADGTIF
HHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHCCCCCCEE
LDEISELELSLQAKLLRVLQEKEVERLGSNRKIKVNFRVISSTNRDLMREIAAGTFREDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
YYRLNVVQLNVPSLRERREDIPLLVSEFVKEFGLREGKSLTLSDDVLRALVGYEWPGNIR
EEEEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCHHH
QLRNTIERAVVLARGAKITLKHLPEEVAAGAGCRDVAEPRTLRELEEEAIQSALRECRGN
HHHHHHHHHHHHHCCCEEEHHHCCHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCC
KSLVAKKLGISRKTLYKRLEQLGL
HHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQGLVLIVDDEPNAARVLSAILAGEGHTVLTASDASKAEHILKSRDVDAIITDLRMPGRD
CCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCCCCC
GMQLFEHVTEHLPDIPVIFLTAYGTVDSAVNAITRGAFYYFIKPPDYVKLKSMVARAVEQ
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHH
RALKREVAELRKRVAAGSGADRIIGVSPGMLKIFNTIEAVKDSMSSVLVSGETGTGKELI
HHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHH
ARSLHYGSVRRDRPFVAVNCAAIPRELMESELFGYEKGAFSGASARRIGRFEAAADGTIF
HHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHCCCCCCEE
LDEISELELSLQAKLLRVLQEKEVERLGSNRKIKVNFRVISSTNRDLMREIAAGTFREDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
YYRLNVVQLNVPSLRERREDIPLLVSEFVKEFGLREGKSLTLSDDVLRALVGYEWPGNIR
EEEEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCHHH
QLRNTIERAVVLARGAKITLKHLPEEVAAGAGCRDVAEPRTLRELEEEAIQSALRECRGN
HHHHHHHHHHHHHCCCEEEHHHCCHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCC
KSLVAKKLGISRKTLYKRLEQLGL
HHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]