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The map label for this gene is mpg1 [H]

Identifier: 39997066

GI number: 39997066

Start: 2158267

End: 2159697

Strand: Reverse

Name: mpg1 [H]

Synonym: GSU1968

Alternate gene names: 39997066

Gene position: 2159697-2158267 (Counterclockwise)

Preceding gene: 39997067

Following gene: 39997065

Centisome position: 56.62

GC content: 63.17

Gene sequence:

>1431_bases
ATGACCTCCGATATCAAAGCCATTCTCGAACAGGTCGTCATTTCTCCCGACGTCCCCATTGCCGAGGCCATCGCCCAGCT
GGACAGGGCAGGTACCGGCTCCCTCGTGGTCTGCTCGGCGGACAAAAAGCTCTACGGCCTACTGACCGACGGTGACGTGC
GCCGCGCCTTGCTCAAGGCGGTCGACATGGGTGCGCCGTGCGGCGACATCGCCAACCGGAAGCCGGTAATCACGTTCGTG
CCGCTGCTGCCGATCGAAGCCCTCCGGCTCATGAACCATCACGACATCAACCACCTGCCGGTGCTGGATGCCGAGGGGAG
GGTTGTTGATTTCCTGTTGCGCCGCGACCTGGTTGCCGAGGACGAATTGGCCGCCCGGGCAAGACGCCGGCTCGACAGCG
TCGTCATCCCCTGTTCCGCCTCCATCGCCGAGGCCATCGCCCAGCTGGACAGGGCAGGGACCGGCGCGCTGGTGCTCTGC
TCGGAAGGGGACCGGCTCCACGGTCTCCTGACCGACGGCGACATCCGCCGGGCCGTGCTCCGCGGCATCTCCCTCGATGC
TCCCTGCCAGGATGTCGCCAGCCGCAGGCCCGTCACAGTGGAACCCTCGTTTTCGGCAGCCCAGGCCCTCCACCTGATGA
ACCAGCACGATATCAACCATCTGCCGGTGGTGGACGACACGGGCCGGGTCGTCGACTTCCTGCTTCGCAGGGATCTCATC
GCCGATGACCAACTCAATCTGTCGGCGGTTGTCATGGCGGGAGGGTACGGCAAGCGGTTGCTCCCCCTCACGGAACAGGT
TCCCAAGCCGATGCTCCCGGTGGGTGATCGGCCCCTGCTGGAGCGGACCATCGACCAGCTCCGCCGGTCGGGCATCAGGG
AGGTCAACCTGACCACCCACTACCTGCCCGACAGCATCGTGGAGCATTTCGGTGACGGTGATTCGTTCGGCGTGAAGCTG
AATTACCTGAAGGAAGACCATCCCCTGGGCACCGCCGGCGGGCTCAAGCTGATGAAAAAGGCGAGCGACCCCTTTCTGGT
GATGAACGGTGACATCCTCACCGGCGTTCCGTTCCAGGAGATGTTCGCCTACCACCGCAAAAACGGCGCCGAGATCACCG
TGGGGGTCCGGAAATACGAGGTTCAGGTCCCCTTCGGCGTGGTGGAATGTGATGATGTCAGGATCACGGGGCTGAAGGAA
AAACCGTCCCTCACGTTTTTCATCAACGCGGGAATCTATCTGCTGGAACCGTCGGTCTGCGATCTGATCCCTGAGGGGGA
GCGCTTCGACATGACCGACCTGATCCAGAAGCTGCTGGACGAGGGCCGCTCCGTGGTCAGCTTCCCCATCATGGAGTACT
GGCTCGATGTGGGGCGGCACGAGGACTACCAGAAGGCCCAGGAAGATGTGCGGAGCGGAAAGATACAGTGA

Upstream 100 bases:

>100_bases
CGCGGGCACTACGACCGTGGCCGTGATGGACACAGCGACCGGTACGGTTACCAGACGCCACTGGAATGGAACATCATCCG
CCAGCCACCAGGAGTGAGCC

Downstream 100 bases:

>100_bases
TGTGCGCCGACAACCATCCGTTGCCGGGCGGCATGGCGGGAGCCTGCTGACCATGGAGCGAGACCGGAGAATTGATACCA
TTCGCGGCCTGCTGGTGGCG

Product: nucleotidyltransferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTSDIKAILEQVVISPDVPIAEAIAQLDRAGTGSLVVCSADKKLYGLLTDGDVRRALLKAVDMGAPCGDIANRKPVITFV
PLLPIEALRLMNHHDINHLPVLDAEGRVVDFLLRRDLVAEDELAARARRRLDSVVIPCSASIAEAIAQLDRAGTGALVLC
SEGDRLHGLLTDGDIRRAVLRGISLDAPCQDVASRRPVTVEPSFSAAQALHLMNQHDINHLPVVDDTGRVVDFLLRRDLI
ADDQLNLSAVVMAGGYGKRLLPLTEQVPKPMLPVGDRPLLERTIDQLRRSGIREVNLTTHYLPDSIVEHFGDGDSFGVKL
NYLKEDHPLGTAGGLKLMKKASDPFLVMNGDILTGVPFQEMFAYHRKNGAEITVGVRKYEVQVPFGVVECDDVRITGLKE
KPSLTFFINAGIYLLEPSVCDLIPEGERFDMTDLIQKLLDEGRSVVSFPIMEYWLDVGRHEDYQKAQEDVRSGKIQ

Sequences:

>Translated_476_residues
MTSDIKAILEQVVISPDVPIAEAIAQLDRAGTGSLVVCSADKKLYGLLTDGDVRRALLKAVDMGAPCGDIANRKPVITFV
PLLPIEALRLMNHHDINHLPVLDAEGRVVDFLLRRDLVAEDELAARARRRLDSVVIPCSASIAEAIAQLDRAGTGALVLC
SEGDRLHGLLTDGDIRRAVLRGISLDAPCQDVASRRPVTVEPSFSAAQALHLMNQHDINHLPVVDDTGRVVDFLLRRDLI
ADDQLNLSAVVMAGGYGKRLLPLTEQVPKPMLPVGDRPLLERTIDQLRRSGIREVNLTTHYLPDSIVEHFGDGDSFGVKL
NYLKEDHPLGTAGGLKLMKKASDPFLVMNGDILTGVPFQEMFAYHRKNGAEITVGVRKYEVQVPFGVVECDDVRITGLKE
KPSLTFFINAGIYLLEPSVCDLIPEGERFDMTDLIQKLLDEGRSVVSFPIMEYWLDVGRHEDYQKAQEDVRSGKIQ
>Mature_475_residues
TSDIKAILEQVVISPDVPIAEAIAQLDRAGTGSLVVCSADKKLYGLLTDGDVRRALLKAVDMGAPCGDIANRKPVITFVP
LLPIEALRLMNHHDINHLPVLDAEGRVVDFLLRRDLVAEDELAARARRRLDSVVIPCSASIAEAIAQLDRAGTGALVLCS
EGDRLHGLLTDGDIRRAVLRGISLDAPCQDVASRRPVTVEPSFSAAQALHLMNQHDINHLPVVDDTGRVVDFLLRRDLIA
DDQLNLSAVVMAGGYGKRLLPLTEQVPKPMLPVGDRPLLERTIDQLRRSGIREVNLTTHYLPDSIVEHFGDGDSFGVKLN
YLKEDHPLGTAGGLKLMKKASDPFLVMNGDILTGVPFQEMFAYHRKNGAEITVGVRKYEVQVPFGVVECDDVRITGLKEK
PSLTFFINAGIYLLEPSVCDLIPEGERFDMTDLIQKLLDEGRSVVSFPIMEYWLDVGRHEDYQKAQEDVRSGKIQ

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=31.858407079646, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=31.858407079646, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI31881779, Length=188, Percent_Identity=31.3829787234043, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI45447090, Length=188, Percent_Identity=31.3829787234043, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790224, Length=243, Percent_Identity=29.2181069958848, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788351, Length=230, Percent_Identity=28.695652173913, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=228, Percent_Identity=32.0175438596491, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17509979, Length=233, Percent_Identity=32.1888412017167, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509981, Length=217, Percent_Identity=31.7972350230415, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=34.3612334801762, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21355443, Length=223, Percent_Identity=32.7354260089686, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24644084, Length=223, Percent_Identity=32.7354260089686, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24653912, Length=189, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 52408; Mature: 52277

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDIKAILEQVVISPDVPIAEAIAQLDRAGTGSLVVCSADKKLYGLLTDGDVRRALLKA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VDMGAPCGDIANRKPVITFVPLLPIEALRLMNHHDINHLPVLDAEGRVVDFLLRRDLVAE
HHCCCCCCHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHCCH
DELAARARRRLDSVVIPCSASIAEAIAQLDRAGTGALVLCSEGDRLHGLLTDGDIRRAVL
HHHHHHHHHHHHCEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCHHHHHHH
RGISLDAPCQDVASRRPVTVEPSFSAAQALHLMNQHDINHLPVVDDTGRVVDFLLRRDLI
HCCCCCCCHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
ADDQLNLSAVVMAGGYGKRLLPLTEQVPKPMLPVGDRPLLERTIDQLRRSGIREVNLTTH
CCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECEEE
YLPDSIVEHFGDGDSFGVKLNYLKEDHPLGTAGGLKLMKKASDPFLVMNGDILTGVPFQE
CCCHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCEEECCCHHH
MFAYHRKNGAEITVGVRKYEVQVPFGVVECDDVRITGLKEKPSLTFFINAGIYLLEPSVC
HHHHHCCCCCEEEEEEEEEEEECCCEEEEECCEEEECCCCCCCEEEEEECCEEEECCHHH
DLIPEGERFDMTDLIQKLLDEGRSVVSFPIMEYWLDVGRHEDYQKAQEDVRSGKIQ
HCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSDIKAILEQVVISPDVPIAEAIAQLDRAGTGSLVVCSADKKLYGLLTDGDVRRALLKA
CHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VDMGAPCGDIANRKPVITFVPLLPIEALRLMNHHDINHLPVLDAEGRVVDFLLRRDLVAE
HHCCCCCCHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHCCH
DELAARARRRLDSVVIPCSASIAEAIAQLDRAGTGALVLCSEGDRLHGLLTDGDIRRAVL
HHHHHHHHHHHHCEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCHHHHHHH
RGISLDAPCQDVASRRPVTVEPSFSAAQALHLMNQHDINHLPVVDDTGRVVDFLLRRDLI
HCCCCCCCHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
ADDQLNLSAVVMAGGYGKRLLPLTEQVPKPMLPVGDRPLLERTIDQLRRSGIREVNLTTH
CCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECEEE
YLPDSIVEHFGDGDSFGVKLNYLKEDHPLGTAGGLKLMKKASDPFLVMNGDILTGVPFQE
CCCHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCEEECCCHHH
MFAYHRKNGAEITVGVRKYEVQVPFGVVECDDVRITGLKEKPSLTFFINAGIYLLEPSVC
HHHHHCCCCCEEEEEEEEEEEECCCEEEEECCEEEECCCCCCCEEEEEECCEEEECCHHH
DLIPEGERFDMTDLIQKLLDEGRSVVSFPIMEYWLDVGRHEDYQKAQEDVRSGKIQ
HCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]