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The map label for this gene is rpfC [H]

Identifier: 39997026

GI number: 39997026

Start: 2107340

End: 2109721

Strand: Reverse

Name: rpfC [H]

Synonym: GSU1928

Alternate gene names: 39997026

Gene position: 2109721-2107340 (Counterclockwise)

Preceding gene: 39997027

Following gene: 39997025

Centisome position: 55.31

GC content: 59.87

Gene sequence:

>2382_bases
ATGGCCACCTGCGTGACGGTGCTGATACTGGCGTTTGCCGGGTTCGTGGTGCGGGACCTGACGATGGAGCCGCCAGAACT
TCTGAGGCGGTTGGAGATCATTGCAGGTGTTGTCGGTGACAAAAGTATGACCAGCATCGTTTTTAACGATGTCCGGGCTG
CCTCGGAGATGCTGGATGTCCTCAAGACGGATCCCCACATCATCGTTGGGCGCATCTACCTCAAGGATGGCTCGATTTTT
GCGCATTACCGACGGAAGGGGTCACTGGCATCGCCTGCCGCAAACTCGTCGGCGGATGACGCAACCACCTGGATCGAGTA
TCGGCAACAGATGGTGGAGAAGATGGGAGATTCCCTTCCCAGTCATCATTGGCATGGCGACCACCTCGATATGTTCAGGC
CGATAATACTAGACGGGGAGGTCATCGGCACCGTCTATCTGCGGGGCGATTACCGGGAGATATACTCGCGTTTGCGCTGG
TATGCGGTAAGCGGAGGAGTGCTGCTGCTTATGCTCTCCGCCTTTGCCTACGTTCTGTCTTCAAAGCTGCAGCGACGGGT
TTCTGCGCCGATTGCCGAATTGCTTGAGGTTACGCGGCGTGTTGCTGAGGAGCACAACTACTCGGTACGGGCCGCGGGGG
GAGGGGTCGACGAGATCGGCGAACTCGTGTCCGGCTTCAATAGGATGCTTCAGATCATCGAAGAAAGTGACGCGAATCTG
AAGCGGAACCGCGAAGACCTGGGGGAGGAAGTCGCCCGCCGCACCGAAGATCTGTCGCGGACCAACGAGGAACTGGAGCG
GGCTGTTGCCGACCTGAGCAAGGCGAAAGAAGCCGCAGATTCCGCCAGTCAGTCAAAATCGCGGTTCCTGGCCAATGTGA
GTCACGAGATCCGCACGCCCATGAACGGCGTCCTCGGCATGGTCAGTCTCCTTCTCGAAACCGACCTTCAAGCCAAACAG
CGCGAGTATGCTGAGATCATCCGGTCATCCGGTGAACTGCTCATGCAGGTCATTAACGATCTGCTCGATTTTTCCCGTAT
TGAGTCGGGAAAACTGAAGATGGAGCAGCTGCCCTTTGCGGCGCGCCGTGTCATTGAAGAAATGGCCACCATTTATGGTG
AGCGAGCCCGCCAGAAGGGGGTCTTCCTTGAATACTCCATGGCAGGAGAGGTGCCCGACCGCCTTCTGGGCGACCGCCAC
CGGCTCCGTCAGGTGTTGGGGAATCTTCTCGACAATGCCGTGAAATTCACCCTCAAGGGGACAATCACACTGACCGTTCG
CGGGAGCGTGGAGGGTGGAGTCTGCCGACTCAGCTGCATCGTAAGCGATACGGGGATCGGCATTCCCCAGGATATGCTGC
CCCGTTTGTTCCACCCGTTCACCCAGGCCGACGACTCCAATACCCGCCGTTTCGGAGGCACGGGGCTGGGGCTCGCCATT
GTCCGCCATCTTGTGGAGCTCATGGGGGGCACGGTCAGTTGCGACAGTGAGCCGGGGTGCGGATCCGTTTTCCGGTTCAC
GGTCGCCCTGTCGGTGGTGCCGGATACGGGTGAGCCGGAACCGGAACCGTCCCATGAAGCTGCTGGGTCTTTTCCTTCTC
GCCTATTGCTGGCAGAGGACAATGCCGTCAACCGAATGGTGTTGCAGGAGATGCTCCGAAGCCTCGGGGCGGATGTCATG
GTGGTCTCTGACGGAGCCGAAGCCGTGGCTGCCGTCTCGGCTGAGCGGTTCGACATGGTGTTCATGGATTGCCAGATGAC
CGGTATGAACGGGATTGTCGCCACAGCCGAAATTCGCCGCATGGAGCGTACCGGACAGCTCACAGGCCGAACTCACATCA
TCGCCCTTACCGGAAGGGTGGAGGTGGGCGACCGGGAGGCCTGTCTGGCGGCGGGAATGGACGATTACCTCATCAAGCCG
GTTATGCGCCACGATCTGGTGATGGTGCTCCGGCGCTGGCTGTCCCCGCATGACGAGACGATGCCATCCGCGGCATACGA
CAAGGCTCCCGGGGGAGTGAGTGAAGAGGCCGAATGTCTTCTCGACCGGGATATTCTGGATGGCATTCGTGCCTTGGAGG
CGGGCGGGTCCGAGGGGCTCCTCGACCGTGTCATTGATATTTTTATTTCCGATTCGCCACGGCACCTGCGTGATATGAGG
GAGGCCCTGGCGCGGGAGAACCTGCCTGCCGCCCGACGGGCTGCACATACTCTCAAATCCGGGTGCCTCAATCTGGGAGC
CGTTGCCCTCGCAGCCTTATGCGGGGAGATGGAGCGACTCGGCGAAGGAGAAGACGTCTTGCCGTTGCGGCTGCTCTCAC
GTATGGAGTCGGAATTCATAAGGGTGTGCGCCGCGCTGGAGCGCGAGCGCACCGGGGTGTAA

Upstream 100 bases:

>100_bases
GCGCGGTTGAAGGTGCCGCGTCAGAGCATAACAGCATGGGACAGTACCTATGATGAGGAGGATACCCTTGTCCCTTGACC
GCAGGCTGACACTGGTCACC

Downstream 100 bases:

>100_bases
GATGCGAAAAGAGGGCAAGGACGGCGCTTCAGCTACCGTGATGATCATTGACGACGATGAGCTGGTGCGCGTTCTTGCCC
GGCGCGCAGTAGAGCAGGGG

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 793; Mature: 792

Protein sequence:

>793_residues
MATCVTVLILAFAGFVVRDLTMEPPELLRRLEIIAGVVGDKSMTSIVFNDVRAASEMLDVLKTDPHIIVGRIYLKDGSIF
AHYRRKGSLASPAANSSADDATTWIEYRQQMVEKMGDSLPSHHWHGDHLDMFRPIILDGEVIGTVYLRGDYREIYSRLRW
YAVSGGVLLLMLSAFAYVLSSKLQRRVSAPIAELLEVTRRVAEEHNYSVRAAGGGVDEIGELVSGFNRMLQIIEESDANL
KRNREDLGEEVARRTEDLSRTNEELERAVADLSKAKEAADSASQSKSRFLANVSHEIRTPMNGVLGMVSLLLETDLQAKQ
REYAEIIRSSGELLMQVINDLLDFSRIESGKLKMEQLPFAARRVIEEMATIYGERARQKGVFLEYSMAGEVPDRLLGDRH
RLRQVLGNLLDNAVKFTLKGTITLTVRGSVEGGVCRLSCIVSDTGIGIPQDMLPRLFHPFTQADDSNTRRFGGTGLGLAI
VRHLVELMGGTVSCDSEPGCGSVFRFTVALSVVPDTGEPEPEPSHEAAGSFPSRLLLAEDNAVNRMVLQEMLRSLGADVM
VVSDGAEAVAAVSAERFDMVFMDCQMTGMNGIVATAEIRRMERTGQLTGRTHIIALTGRVEVGDREACLAAGMDDYLIKP
VMRHDLVMVLRRWLSPHDETMPSAAYDKAPGGVSEEAECLLDRDILDGIRALEAGGSEGLLDRVIDIFISDSPRHLRDMR
EALARENLPAARRAAHTLKSGCLNLGAVALAALCGEMERLGEGEDVLPLRLLSRMESEFIRVCAALERERTGV

Sequences:

>Translated_793_residues
MATCVTVLILAFAGFVVRDLTMEPPELLRRLEIIAGVVGDKSMTSIVFNDVRAASEMLDVLKTDPHIIVGRIYLKDGSIF
AHYRRKGSLASPAANSSADDATTWIEYRQQMVEKMGDSLPSHHWHGDHLDMFRPIILDGEVIGTVYLRGDYREIYSRLRW
YAVSGGVLLLMLSAFAYVLSSKLQRRVSAPIAELLEVTRRVAEEHNYSVRAAGGGVDEIGELVSGFNRMLQIIEESDANL
KRNREDLGEEVARRTEDLSRTNEELERAVADLSKAKEAADSASQSKSRFLANVSHEIRTPMNGVLGMVSLLLETDLQAKQ
REYAEIIRSSGELLMQVINDLLDFSRIESGKLKMEQLPFAARRVIEEMATIYGERARQKGVFLEYSMAGEVPDRLLGDRH
RLRQVLGNLLDNAVKFTLKGTITLTVRGSVEGGVCRLSCIVSDTGIGIPQDMLPRLFHPFTQADDSNTRRFGGTGLGLAI
VRHLVELMGGTVSCDSEPGCGSVFRFTVALSVVPDTGEPEPEPSHEAAGSFPSRLLLAEDNAVNRMVLQEMLRSLGADVM
VVSDGAEAVAAVSAERFDMVFMDCQMTGMNGIVATAEIRRMERTGQLTGRTHIIALTGRVEVGDREACLAAGMDDYLIKP
VMRHDLVMVLRRWLSPHDETMPSAAYDKAPGGVSEEAECLLDRDILDGIRALEAGGSEGLLDRVIDIFISDSPRHLRDMR
EALARENLPAARRAAHTLKSGCLNLGAVALAALCGEMERLGEGEDVLPLRLLSRMESEFIRVCAALERERTGV
>Mature_792_residues
ATCVTVLILAFAGFVVRDLTMEPPELLRRLEIIAGVVGDKSMTSIVFNDVRAASEMLDVLKTDPHIIVGRIYLKDGSIFA
HYRRKGSLASPAANSSADDATTWIEYRQQMVEKMGDSLPSHHWHGDHLDMFRPIILDGEVIGTVYLRGDYREIYSRLRWY
AVSGGVLLLMLSAFAYVLSSKLQRRVSAPIAELLEVTRRVAEEHNYSVRAAGGGVDEIGELVSGFNRMLQIIEESDANLK
RNREDLGEEVARRTEDLSRTNEELERAVADLSKAKEAADSASQSKSRFLANVSHEIRTPMNGVLGMVSLLLETDLQAKQR
EYAEIIRSSGELLMQVINDLLDFSRIESGKLKMEQLPFAARRVIEEMATIYGERARQKGVFLEYSMAGEVPDRLLGDRHR
LRQVLGNLLDNAVKFTLKGTITLTVRGSVEGGVCRLSCIVSDTGIGIPQDMLPRLFHPFTQADDSNTRRFGGTGLGLAIV
RHLVELMGGTVSCDSEPGCGSVFRFTVALSVVPDTGEPEPEPSHEAAGSFPSRLLLAEDNAVNRMVLQEMLRSLGADVMV
VSDGAEAVAAVSAERFDMVFMDCQMTGMNGIVATAEIRRMERTGQLTGRTHIIALTGRVEVGDREACLAAGMDDYLIKPV
MRHDLVMVLRRWLSPHDETMPSAAYDKAPGGVSEEAECLLDRDILDGIRALEAGGSEGLLDRVIDIFISDSPRHLRDMRE
ALARENLPAARRAAHTLKSGCLNLGAVALAALCGEMERLGEGEDVLPLRLLSRMESEFIRVCAALERERTGV

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=379, Percent_Identity=36.1477572559367, Blast_Score=238, Evalue=1e-63,
Organism=Escherichia coli, GI87081816, Length=641, Percent_Identity=30.1092043681747, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI48994928, Length=494, Percent_Identity=29.5546558704453, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=43.9330543933054, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI1788713, Length=372, Percent_Identity=31.1827956989247, Blast_Score=176, Evalue=7e-45,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=26.5560165975104, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=31.1688311688312, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=29.2887029288703, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=262, Percent_Identity=29.0076335877863, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1788549, Length=259, Percent_Identity=26.2548262548263, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787894, Length=253, Percent_Identity=26.8774703557312, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=29.004329004329, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=26.615969581749, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=313, Percent_Identity=26.8370607028754, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322000, Length=292, Percent_Identity=24.6575342465753, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322044, Length=209, Percent_Identity=33.0143540669856, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 87298; Mature: 87167

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50885 HAMP ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATCVTVLILAFAGFVVRDLTMEPPELLRRLEIIAGVVGDKSMTSIVFNDVRAASEMLDV
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LKTDPHIIVGRIYLKDGSIFAHYRRKGSLASPAANSSADDATTWIEYRQQMVEKMGDSLP
HCCCCCEEEEEEEEECCCEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
SHHWHGDHLDMFRPIILDGEVIGTVYLRGDYREIYSRLRWYAVSGGVLLLMLSAFAYVLS
CCCCCCCCHHHHCHHEECCCEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SKLQRRVSAPIAELLEVTRRVAEEHNYSVRAAGGGVDEIGELVSGFNRMLQIIEESDANL
HHHHHHHHCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KRNREDLGEEVARRTEDLSRTNEELERAVADLSKAKEAADSASQSKSRFLANVSHEIRTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MNGVLGMVSLLLETDLQAKQREYAEIIRSSGELLMQVINDLLDFSRIESGKLKMEQLPFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHH
ARRVIEEMATIYGERARQKGVFLEYSMAGEVPDRLLGDRHRLRQVLGNLLDNAVKFTLKG
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHEEEEEE
TITLTVRGSVEGGVCRLSCIVSDTGIGIPQDMLPRLFHPFTQADDSNTRRFGGTGLGLAI
EEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHH
VRHLVELMGGTVSCDSEPGCGSVFRFTVALSVVPDTGEPEPEPSHEAAGSFPSRLLLAED
HHHHHHHHCCEEECCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCHHCCCCCCEEEEECC
NAVNRMVLQEMLRSLGADVMVVSDGAEAVAAVSAERFDMVFMDCQMTGMNGIVATAEIRR
CHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCEEEEEEEECCCCCEEHHHHHHH
MERTGQLTGRTHIIALTGRVEVGDREACLAAGMDDYLIKPVMRHDLVMVLRRWLSPHDET
HHHHCCCCCCEEEEEEECEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
MPSAAYDKAPGGVSEEAECLLDRDILDGIRALEAGGSEGLLDRVIDIFISDSPRHLRDMR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
EALARENLPAARRAAHTLKSGCLNLGAVALAALCGEMERLGEGEDVLPLRLLSRMESEFI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RVCAALERERTGV
HHHHHHHHHCCCC
>Mature Secondary Structure 
ATCVTVLILAFAGFVVRDLTMEPPELLRRLEIIAGVVGDKSMTSIVFNDVRAASEMLDV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LKTDPHIIVGRIYLKDGSIFAHYRRKGSLASPAANSSADDATTWIEYRQQMVEKMGDSLP
HCCCCCEEEEEEEEECCCEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
SHHWHGDHLDMFRPIILDGEVIGTVYLRGDYREIYSRLRWYAVSGGVLLLMLSAFAYVLS
CCCCCCCCHHHHCHHEECCCEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SKLQRRVSAPIAELLEVTRRVAEEHNYSVRAAGGGVDEIGELVSGFNRMLQIIEESDANL
HHHHHHHHCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KRNREDLGEEVARRTEDLSRTNEELERAVADLSKAKEAADSASQSKSRFLANVSHEIRTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MNGVLGMVSLLLETDLQAKQREYAEIIRSSGELLMQVINDLLDFSRIESGKLKMEQLPFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHH
ARRVIEEMATIYGERARQKGVFLEYSMAGEVPDRLLGDRHRLRQVLGNLLDNAVKFTLKG
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHEEEEEE
TITLTVRGSVEGGVCRLSCIVSDTGIGIPQDMLPRLFHPFTQADDSNTRRFGGTGLGLAI
EEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHH
VRHLVELMGGTVSCDSEPGCGSVFRFTVALSVVPDTGEPEPEPSHEAAGSFPSRLLLAED
HHHHHHHHCCEEECCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCHHCCCCCCEEEEECC
NAVNRMVLQEMLRSLGADVMVVSDGAEAVAAVSAERFDMVFMDCQMTGMNGIVATAEIRR
CHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCEEEEEEEECCCCCEEHHHHHHH
MERTGQLTGRTHIIALTGRVEVGDREACLAAGMDDYLIKPVMRHDLVMVLRRWLSPHDET
HHHHCCCCCCEEEEEEECEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
MPSAAYDKAPGGVSEEAECLLDRDILDGIRALEAGGSEGLLDRVIDIFISDSPRHLRDMR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
EALARENLPAARRAAHTLKSGCLNLGAVALAALCGEMERLGEGEDVLPLRLLSRMESEFI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RVCAALERERTGV
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]