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The map label for this gene is dxr

Identifier: 39997013

GI number: 39997013

Start: 2094368

End: 2095528

Strand: Reverse

Name: dxr

Synonym: GSU1915

Alternate gene names: 39997013

Gene position: 2095528-2094368 (Counterclockwise)

Preceding gene: 39997014

Following gene: 39997012

Centisome position: 54.94

GC content: 59.43

Gene sequence:

>1161_bases
ATGAAAAACATCACCATACTCGGATCAACAGGCTCCATTGGGGTCAGCACGCTGGAAGTTGTCTCCGCCCACCCCGACCG
CTTCCGTGTCGTTGCTCTCACTGCCGGCAACAACCTTGAGATGCTGAGACAGCAGATCGAGACGTTCCGTCCGCAAATGG
TCAGCGTTCTGAGCGAAAAACTGGCCGTTGAACTGGACCGGAGTCTGCCGGGGTACAAGCCGGAGATCCATTATGGCGTT
GAAGGGCTTATCGCCGCAGCCACGGCGGGGGATGCCCATATGGTTGTTGCTGCAATAGTCGGTGCCGCCGGGCTGGTTCC
GACCGCTGCGGCTATACGGGCTGGCAAAGATGTGGCTCTTGCCAACAAGGAAACCCTGGTCACTGCCGGCAGGCTCATCA
TGGATCTTGTGCGGGACAAGAATGTCAGACTCTATCCCGTTGACAGTGAACACAGCGCCGTGTTCCAGTCCATGGAAGGA
CAGAGCCGCAAGGATGTATTGCGGATCATCCTGACCGCTTCGGGCGGGCCCTTCCTGAATCTGCCGCTTGATCAGCTGTC
CCGGGTTTCGATCGACGACGCCCTGAACCACCCCAACTGGTCCATGGGGCGCAAGATAACCATCGATTCGGCCACCATGA
TGAACAAGGGGCTGGAGGTGATCGAGGCTCGCTGGCTTTTCGATACGCCGGCGGAGCGGATCGACGTGAACATTCATCCC
CAGAGCATCATCCATTCCATGGTCGAGTATGTGGACGGCAGTGTCATGGCTCAGTTGGGTGTTCCCGACATGAAGGCTCC
CATCGCCTATGCGCTGACCTATCCCGAGCGGGTCCCCACCGGGGTGAATCCCCTTGACCTCACCGCTCTGTCCGGGCTCA
CCTTTTTCAAGCCGGACTATCGCCGCTTTCCCGCCCTGAAGCTTGCCTACGACGCTTTGGCGGCAGGGGAAAGCATGCCC
GCGGTCATGAACGCTGCCAATGAGGTGGCGGTAGAGGCTTTTCTGTCCGGGGTGATCGGATTCATCGACATTGCCGCCAC
TATCGCACGAATCATGGACGCCCATGAGGCACACACCCTTTCCACCATCGAGGAGGCGCTCATCACCGATCGTTGGGCGC
GTGAGAAGGCGCGTGAGCTCGTAGGGCTCGTCCGCCGCTAG

Upstream 100 bases:

>100_bases
GGCATTCTCGACCGATTGGACAGTATTCTGTTTGCTGTGCCGGCTGCCTACTACTACGCTCTTTTCGTGTTCATGAACCG
ATAGGTTTGACAGGGTATCC

Downstream 100 bases:

>100_bases
CCGCAGTACGAGAGGAGACTATGGTCAGCATCATCTCCGCCATCATCGTTTTAGGAATACTGATCTTCGTTCACGAGTTG
GGGCACTTCATTTTTGCCAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKNITILGSTGSIGVSTLEVVSAHPDRFRVVALTAGNNLEMLRQQIETFRPQMVSVLSEKLAVELDRSLPGYKPEIHYGV
EGLIAAATAGDAHMVVAAIVGAAGLVPTAAAIRAGKDVALANKETLVTAGRLIMDLVRDKNVRLYPVDSEHSAVFQSMEG
QSRKDVLRIILTASGGPFLNLPLDQLSRVSIDDALNHPNWSMGRKITIDSATMMNKGLEVIEARWLFDTPAERIDVNIHP
QSIIHSMVEYVDGSVMAQLGVPDMKAPIAYALTYPERVPTGVNPLDLTALSGLTFFKPDYRRFPALKLAYDALAAGESMP
AVMNAANEVAVEAFLSGVIGFIDIAATIARIMDAHEAHTLSTIEEALITDRWAREKARELVGLVRR

Sequences:

>Translated_386_residues
MKNITILGSTGSIGVSTLEVVSAHPDRFRVVALTAGNNLEMLRQQIETFRPQMVSVLSEKLAVELDRSLPGYKPEIHYGV
EGLIAAATAGDAHMVVAAIVGAAGLVPTAAAIRAGKDVALANKETLVTAGRLIMDLVRDKNVRLYPVDSEHSAVFQSMEG
QSRKDVLRIILTASGGPFLNLPLDQLSRVSIDDALNHPNWSMGRKITIDSATMMNKGLEVIEARWLFDTPAERIDVNIHP
QSIIHSMVEYVDGSVMAQLGVPDMKAPIAYALTYPERVPTGVNPLDLTALSGLTFFKPDYRRFPALKLAYDALAAGESMP
AVMNAANEVAVEAFLSGVIGFIDIAATIARIMDAHEAHTLSTIEEALITDRWAREKARELVGLVRR
>Mature_386_residues
MKNITILGSTGSIGVSTLEVVSAHPDRFRVVALTAGNNLEMLRQQIETFRPQMVSVLSEKLAVELDRSLPGYKPEIHYGV
EGLIAAATAGDAHMVVAAIVGAAGLVPTAAAIRAGKDVALANKETLVTAGRLIMDLVRDKNVRLYPVDSEHSAVFQSMEG
QSRKDVLRIILTASGGPFLNLPLDQLSRVSIDDALNHPNWSMGRKITIDSATMMNKGLEVIEARWLFDTPAERIDVNIHP
QSIIHSMVEYVDGSVMAQLGVPDMKAPIAYALTYPERVPTGVNPLDLTALSGLTFFKPDYRRFPALKLAYDALAAGESMP
AVMNAANEVAVEAFLSGVIGFIDIAATIARIMDAHEAHTLSTIEEALITDRWAREKARELVGLVRR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=50, Blast_Score=370, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_GEOSL (Q74BW4)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952964.1
- ProteinModelPortal:   Q74BW4
- SMR:   Q74BW4
- GeneID:   2688386
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1915
- NMPDR:   fig|243231.1.peg.1902
- TIGR:   GSU1915
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   GSUL243231:GSU_1915-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41800; Mature: 41800

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNITILGSTGSIGVSTLEVVSAHPDRFRVVALTAGNNLEMLRQQIETFRPQMVSVLSEK
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LAVELDRSLPGYKPEIHYGVEGLIAAATAGDAHMVVAAIVGAAGLVPTAAAIRAGKDVAL
HHHHHHCCCCCCCCCEEECCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVTAGRLIMDLVRDKNVRLYPVDSEHSAVFQSMEGQSRKDVLRIILTASGGPFLN
CCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHEEEEEECCCCCEEE
LPLDQLSRVSIDDALNHPNWSMGRKITIDSATMMNKGLEVIEARWLFDTPAERIDVNIHP
CCHHHHHHCCHHHHCCCCCCCCCCEEEECHHHHHHCCHHHHHHHHCCCCCHHHEEEEECH
QSIIHSMVEYVDGSVMAQLGVPDMKAPIAYALTYPERVPTGVNPLDLTALSGLTFFKPDY
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHCCCEEECCCH
RRFPALKLAYDALAAGESMPAVMNAANEVAVEAFLSGVIGFIDIAATIARIMDAHEAHTL
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STIEEALITDRWAREKARELVGLVRR
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNITILGSTGSIGVSTLEVVSAHPDRFRVVALTAGNNLEMLRQQIETFRPQMVSVLSEK
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LAVELDRSLPGYKPEIHYGVEGLIAAATAGDAHMVVAAIVGAAGLVPTAAAIRAGKDVAL
HHHHHHCCCCCCCCCEEECCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVTAGRLIMDLVRDKNVRLYPVDSEHSAVFQSMEGQSRKDVLRIILTASGGPFLN
CCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHEEEEEECCCCCEEE
LPLDQLSRVSIDDALNHPNWSMGRKITIDSATMMNKGLEVIEARWLFDTPAERIDVNIHP
CCHHHHHHCCHHHHCCCCCCCCCCEEEECHHHHHHCCHHHHHHHHCCCCCHHHEEEEECH
QSIIHSMVEYVDGSVMAQLGVPDMKAPIAYALTYPERVPTGVNPLDLTALSGLTFFKPDY
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHCCCEEECCCH
RRFPALKLAYDALAAGESMPAVMNAANEVAVEAFLSGVIGFIDIAATIARIMDAHEAHTL
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STIEEALITDRWAREKARELVGLVRR
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA