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The map label for this gene is ilvD [H]

Identifier: 39997010

GI number: 39997010

Start: 2090783

End: 2092444

Strand: Reverse

Name: ilvD [H]

Synonym: GSU1912

Alternate gene names: 39997010

Gene position: 2092444-2090783 (Counterclockwise)

Preceding gene: 39997011

Following gene: 39997009

Centisome position: 54.86

GC content: 61.55

Gene sequence:

>1662_bases
ATGCGCAGCGACACTATAAAGAAGGGCGTTGAACGCACGCCGCACCGCGCTCTCATCAAGGGTACCGGCGTCCCCCAGAG
CCAGATGGACAAGCCGTTCATCGGCGTCGCCACCAGTTTCACCGATCTGATTCCCGGCCATGTGGGGATGCGCGATCTGG
AGCGTTTTATCGAAAAAGGCATCCACTCGGGCGGGGGATACGCCTTTTTCTTCGGCATTCCAGGTGTCTGCGACGGCATC
TCCATGGGACACAAGGGGATGCACTACTCGCTTCCCACCCGTGAACTCATTGCCGACATGGTGGAGTCGGTTGCTGAAGC
TCATCGGCTCGACGGCCTGGTGCTGCTCACCAATTGCGACAAGATCACGCCCGGCATGCTTATGGCGGCGGCACGACTCA
ACATTCCTTCGATCGTGGTTACCGCGGGTCCGATGATGGCTGGTCGCGGTACGGAAGGACGCCGTTATTCATTCGTTACC
GATACCTTTGAGGCCATGGCCCGCTACAAGGCCGGGGTCATCGACGAGCGTGAGCTTGGAGTCTGCGAGGACAATGCCTG
CCCCGGCATGGGATCTTGTCAGGGGCTTTTCACTGCCAATACCATGGCAATTCTGACCGAGACCATGGGCATGAGTCTCC
CCCGTTGCGGCACGGCTCTCGCGGTGTCAGCCCTCAAGCGGCGCATCGCCTTTGCGTCCGGGGAGAAGATCGTCGATCTT
GTCCGTAACGATATCACTCCGCGTCAGATCCTTACCCGCGATGCTTTTGAGAATGCCATCCGCGTGGACCTTGCGTTGGG
TGGCTCATCCAATACGGTGCTCCATCTCCTGGCCATTGCCCGGGAGGCTGGAGTGGACTTGCCACTGGAAACATTTGATA
CGCTAGCCAAGGAAACCCCCCAGATATCTTCGATGAATCCGGCGGGCGAGTACTTCATGGAGGATCTGGACGCCGGTGGC
GGCGTCATGGGTGTACTCCGGCAGCTTGGTTCTCTGGTCCGTGATAACCCGACGGTCATGGGGCTCTCCACTCTCCAGCT
CGCTTCAACCGTGGAGTCTGTGGACGAACGAGTCATTCGTCCCCTGTCGAACCCGGTGAAGAAAGAGGGGGGGATCGCCG
TCCTCTTCGGCAACCTGGCGCCCAAGGGTGCCGTTGTCAAACAGTCCGGCGTCTCGGATGCCATGATGACATTCGAGGGG
ACTGCCCGTTGCTTCGATTCTGAAGAGGCGGCCATGGCGGCTCTCATGGGGGGGAGGATCGTTGCCGGCGACGTAGTGGT
TATCCGCTACGAGGGCCCCAAGGGGGGGCCGGGCATGCGGGAAATGCTGGCACCCACGGCGACTCTGATGGGGCTCGGCC
TCGGCGACTCGGTTGCACTCATCACCGACGGCAGGTTCTCCGGGGGTACCCGCGGTCCCTGTATTGGGCACATTTCTCCC
GAGGCCGCTGAAGGCGGCCCCATTGCCCTCGTGGAGGAGGGTGACCGCATCCTGCTCGATATCCCCAACCGTCGGCTGGA
ACTCCTCGTTGACGAGGCGGTTCTGCAGGAGCGTCGCGCCCGTTGGACGGCGCCCGAGCCGAAGATCAAAACCGGCTGGC
TCGCCCGCTATGCGAAGGTGGTGACATCCGCCTACACCGGTGCGGTGACCTCGGCCGACTGA

Upstream 100 bases:

>100_bases
ATGTTCACACTTTACCTTACCGACCACGCCAGACTCATCCCCTCTCGACAGAGGGTGATTGGTGCCGGTCCATACTCTGC
CAGTCGCGAGGTAAGTTCCC

Downstream 100 bases:

>100_bases
AACTTTTTCCATTTGCCCGCAGGAGGCTTTGCATGAAAATGACAGGAGCGAGAATATTACTCGAATGCCTCAAGCTCGAA
GGGGTCGATACCGTGTTCGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRSDTIKKGVERTPHRALIKGTGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGI
SMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLNIPSIVVTAGPMMAGRGTEGRRYSFVT
DTFEAMARYKAGVIDERELGVCEDNACPGMGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVDL
VRNDITPRQILTRDAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDTLAKETPQISSMNPAGEYFMEDLDAGG
GVMGVLRQLGSLVRDNPTVMGLSTLQLASTVESVDERVIRPLSNPVKKEGGIAVLFGNLAPKGAVVKQSGVSDAMMTFEG
TARCFDSEEAAMAALMGGRIVAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EAAEGGPIALVEEGDRILLDIPNRRLELLVDEAVLQERRARWTAPEPKIKTGWLARYAKVVTSAYTGAVTSAD

Sequences:

>Translated_553_residues
MRSDTIKKGVERTPHRALIKGTGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGI
SMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLNIPSIVVTAGPMMAGRGTEGRRYSFVT
DTFEAMARYKAGVIDERELGVCEDNACPGMGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVDL
VRNDITPRQILTRDAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDTLAKETPQISSMNPAGEYFMEDLDAGG
GVMGVLRQLGSLVRDNPTVMGLSTLQLASTVESVDERVIRPLSNPVKKEGGIAVLFGNLAPKGAVVKQSGVSDAMMTFEG
TARCFDSEEAAMAALMGGRIVAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EAAEGGPIALVEEGDRILLDIPNRRLELLVDEAVLQERRARWTAPEPKIKTGWLARYAKVVTSAYTGAVTSAD
>Mature_553_residues
MRSDTIKKGVERTPHRALIKGTGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGI
SMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLNIPSIVVTAGPMMAGRGTEGRRYSFVT
DTFEAMARYKAGVIDERELGVCEDNACPGMGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVDL
VRNDITPRQILTRDAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDTLAKETPQISSMNPAGEYFMEDLDAGG
GVMGVLRQLGSLVRDNPTVMGLSTLQLASTVESVDERVIRPLSNPVKKEGGIAVLFGNLAPKGAVVKQSGVSDAMMTFEG
TARCFDSEEAAMAALMGGRIVAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EAAEGGPIALVEEGDRILLDIPNRRLELLVDEAVLQERRARWTAPEPKIKTGWLARYAKVVTSAYTGAVTSAD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=605, Percent_Identity=44.297520661157, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1788157, Length=511, Percent_Identity=32.0939334637965, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI2367371, Length=478, Percent_Identity=34.1004184100418, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786464, Length=483, Percent_Identity=33.1262939958592, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=548, Percent_Identity=42.1532846715328, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 58714; Mature: 58714

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDTIKKGVERTPHRALIKGTGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKG
CCCHHHHHHHHCCCCCEEEECCCCCHHHCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHH
IHSGGGYAFFFGIPGVCDGISMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCD
CCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
KITPGMLMAAARLNIPSIVVTAGPMMAGRGTEGRRYSFVTDTFEAMARYKAGVIDERELG
CCCHHHHHHHHHCCCCEEEEECCCEECCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCC
VCEDNACPGMGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVDL
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
VRNDITPRQILTRDAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDTLAKETP
HHCCCCHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
QISSMNPAGEYFMEDLDAGGGVMGVLRQLGSLVRDNPTVMGLSTLQLASTVESVDERVIR
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
PLSNPVKKEGGIAVLFGNLAPKGAVVKQSGVSDAMMTFEGTARCFDSEEAAMAALMGGRI
HHCCHHHHCCCEEEEECCCCCCCCEEECCCCCHHHHEECCHHHHCCCHHHHHHHHHCCEE
VAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCC
EAAEGGPIALVEEGDRILLDIPNRRLELLVDEAVLQERRARWTAPEPKIKTGWLARYAKV
CCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VTSAYTGAVTSAD
HHHHHCCCCCCCC
>Mature Secondary Structure
MRSDTIKKGVERTPHRALIKGTGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKG
CCCHHHHHHHHCCCCCEEEECCCCCHHHCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHH
IHSGGGYAFFFGIPGVCDGISMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCD
CCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
KITPGMLMAAARLNIPSIVVTAGPMMAGRGTEGRRYSFVTDTFEAMARYKAGVIDERELG
CCCHHHHHHHHHCCCCEEEEECCCEECCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCC
VCEDNACPGMGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVDL
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
VRNDITPRQILTRDAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDTLAKETP
HHCCCCHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
QISSMNPAGEYFMEDLDAGGGVMGVLRQLGSLVRDNPTVMGLSTLQLASTVESVDERVIR
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
PLSNPVKKEGGIAVLFGNLAPKGAVVKQSGVSDAMMTFEGTARCFDSEEAAMAALMGGRI
HHCCHHHHCCCEEEEECCCCCCCCEEECCCCCHHHHEECCHHHHCCCHHHHHHHHHCCEE
VAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCC
EAAEGGPIALVEEGDRILLDIPNRRLELLVDEAVLQERRARWTAPEPKIKTGWLARYAKV
CCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VTSAYTGAVTSAD
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA