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The map label for this gene is kdsA

Identifier: 39996992

GI number: 39996992

Start: 2071420

End: 2072238

Strand: Reverse

Name: kdsA

Synonym: GSU1894

Alternate gene names: 39996992

Gene position: 2072238-2071420 (Counterclockwise)

Preceding gene: 39996993

Following gene: 39996991

Centisome position: 54.33

GC content: 59.58

Gene sequence:

>819_bases
ATGACCAGGGAAATTACCATAGGTTCCGTAAAGATTGGTGGCGACCGACCGCTGGTGCTCATCGCCGGCCCCTGTGTGAT
CGAAAATGAGGCGGCAACCCTGCGTTGCGCCGAGCGCCTAATGACCATCTGCAACGGCGTATCCGTGTCGCTTGTCTTCA
AGGCATCCTATGACAAGGCGAATCGCACGTCGGTTACCTCGTTTCGCGGCCCAGGCATGCAGGAGGGGTTGCGCATTCTC
CAGAAGGTGAAAGACTCCCTCGGCATCCCTGTCATCTCGGACATCCACTCAATCGAGCAGGTAAAGCCGGCTGCCGAGGT
GCTCGACATCATTCAGGTTCCCGCGTTTCTCTGCCGCCAGACCGACCTGGTGGTGGAAGTCGGCCGGACCAATCGGGTGG
TTAATGTCAAGAAGGGCCAGTTCATGGCCCCATGGGACATGGAGAACGTCGTCGGCAAGATTCTGTCAACCGGCAATGAG
CGTATCATCCTGACGGAGCGCGGGGTAACATTCGGCTACAACAATCTCGTTTCCGACATGCGGAGTCTTCCCATCATGCG
CCGCATCGGCTTCCCGGTGGTCTTCGACGCCACCCACAGCGTTCAACTGCCCGGCGGCCAGGGCGGTTCGTCCGGCGGTC
AGCGCGAGTTTGTGGAGTACTTGTCCCGGGCCGCGGTCGCCACCGGCATCGACGGCATCTTCATGGAAGTCCACGAAGAC
CCCGAAAAGGCCCTGTGCGACGGCCCCAACTCGGTGAAGCTCGATGACCTGCCCGCACTGCTCAAGAAGCTGAAGGCAAT
AGACGCCATCGTAAAATAG

Upstream 100 bases:

>100_bases
AACCCCCACCCTCTGTTCAGGGCATTTATCGCAGCCGCCCTTGATCGGAAAGACAAAAGGCGATAGGCTGTCAGCCTATC
CCCACAGATAAGAGGTTTGC

Downstream 100 bases:

>100_bases
ATCCCGGGCCAGTCAGTGGCCGGTTACTGAAACGGAAGCATAATGATTCTCGAAGAAGCACGAAAAGTCATACGAATTGA
AGCAGAAGCACTCACACGCC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTREITIGSVKIGGDRPLVLIAGPCVIENEAATLRCAERLMTICNGVSVSLVFKASYDKANRTSVTSFRGPGMQEGLRIL
QKVKDSLGIPVISDIHSIEQVKPAAEVLDIIQVPAFLCRQTDLVVEVGRTNRVVNVKKGQFMAPWDMENVVGKILSTGNE
RIILTERGVTFGYNNLVSDMRSLPIMRRIGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGIFMEVHED
PEKALCDGPNSVKLDDLPALLKKLKAIDAIVK

Sequences:

>Translated_272_residues
MTREITIGSVKIGGDRPLVLIAGPCVIENEAATLRCAERLMTICNGVSVSLVFKASYDKANRTSVTSFRGPGMQEGLRIL
QKVKDSLGIPVISDIHSIEQVKPAAEVLDIIQVPAFLCRQTDLVVEVGRTNRVVNVKKGQFMAPWDMENVVGKILSTGNE
RIILTERGVTFGYNNLVSDMRSLPIMRRIGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGIFMEVHED
PEKALCDGPNSVKLDDLPALLKKLKAIDAIVK
>Mature_271_residues
TREITIGSVKIGGDRPLVLIAGPCVIENEAATLRCAERLMTICNGVSVSLVFKASYDKANRTSVTSFRGPGMQEGLRILQ
KVKDSLGIPVISDIHSIEQVKPAAEVLDIIQVPAFLCRQTDLVVEVGRTNRVVNVKKGQFMAPWDMENVVGKILSTGNER
IILTERGVTFGYNNLVSDMRSLPIMRRIGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGIFMEVHEDP
EKALCDGPNSVKLDDLPALLKKLKAIDAIVK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=270, Percent_Identity=45.9259259259259, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_GEOSL (P61655)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952943.1
- ProteinModelPortal:   P61655
- SMR:   P61655
- GeneID:   2686233
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1894
- NMPDR:   fig|243231.1.peg.1881
- TIGR:   GSU1894
- HOGENOM:   HBG575990
- OMA:   RSLPIMA
- ProtClustDB:   PRK05198
- BioCyc:   GSUL243231:GSU_1894-MONOMER
- BRENDA:   2.5.1.55
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 29489; Mature: 29358

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREITIGSVKIGGDRPLVLIAGPCVIENEAATLRCAERLMTICNGVSVSLVFKASYDKA
CCCEEEEEEEEECCCCCEEEEECCEEECCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
NRTSVTSFRGPGMQEGLRILQKVKDSLGIPVISDIHSIEQVKPAAEVLDIIQVPAFLCRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
TDLVVEVGRTNRVVNVKKGQFMAPWDMENVVGKILSTGNERIILTERGVTFGYNNLVSDM
CCEEEEECCCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
RSLPIMRRIGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGIFMEVHED
HHCCHHHHCCCCEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
PEKALCDGPNSVKLDDLPALLKKLKAIDAIVK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TREITIGSVKIGGDRPLVLIAGPCVIENEAATLRCAERLMTICNGVSVSLVFKASYDKA
CCEEEEEEEEECCCCCEEEEECCEEECCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
NRTSVTSFRGPGMQEGLRILQKVKDSLGIPVISDIHSIEQVKPAAEVLDIIQVPAFLCRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
TDLVVEVGRTNRVVNVKKGQFMAPWDMENVVGKILSTGNERIILTERGVTFGYNNLVSDM
CCEEEEECCCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
RSLPIMRRIGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGIFMEVHED
HHCCHHHHCCCCEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
PEKALCDGPNSVKLDDLPALLKKLKAIDAIVK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA