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The map label for this gene is ahcY

Identifier: 39996973

GI number: 39996973

Start: 2053629

End: 2055056

Strand: Reverse

Name: ahcY

Synonym: GSU1875

Alternate gene names: 39996973

Gene position: 2055056-2053629 (Counterclockwise)

Preceding gene: 39996974

Following gene: 39996972

Centisome position: 53.88

GC content: 59.59

Gene sequence:

>1428_bases
ATGACCCAACCCGTTGCGCGGGACACCGCCGGAACGTTCAGCGACTATTGCATCAGCGATATTTCTCTTGCTGCCTGGGG
ACGCAAGGAGATGATCATTGCCGAGACCGAAATGCCGGGTCTCATGGCGATCCGCGAAGAGTACGCCGCCACCCGGCCCC
TCCAGGGTGCCCGCATCGCCGGCTCGCTCCACATGACCATCCAGACCGCCATGCTCATCGAGACCCTCGTGGCCCTCGGT
GCCGAGGTACGCTGGGCTTCGTGCAACATCTTCTCCACCCAGGACCACGCGGCCGCAGCCATCGCCGCCGCCGGTATCCC
CGTTTTTGCCTACAAGGGCGAATCGCTTGAGGAGTACTGGGAGTTCACCCACCGGATATTCGAGTGGCACGACGGCGGCA
CTCCCAACATGATCCTCGACGACGGAGGCGACGCTACACTGCTCCTGCACTTGGGGAGCGACGCCGAAAAAGATCCCTCG
GTTATCGCCAATCCCACCTGCGAGGAGGAGCAGTACCTCTTCGCCTCCATCAAAAAACGTCTCGCCGAGAAGCCGGGGTG
GTACTCGAAAACCGCCGCCGCAATCAAGGGGGTAACTGAAGAAACCACCACCGGCGTGCACCGCCTCTACCAGATGCATG
AGAAGGGAAAGCTCAAGTTCCCGGCCATCAACGTCAACGATTCGGTTACCAAGTCCAAATTCGACAATATCTACGGGTGC
CGCGAGTCGCTCGTGGACGGCATCAAGCGGGCCACCGACGTGATGATAGCCGGCAAGGTCGCCGTGATCTGCGGCTACGG
CGAGGTGGGCAAAGGGTGCGCCCAGGCCATGCGCGGGCTTCAGGCCCAGGTATGGGTAACTGAAATCGACCCCATCTGCG
CGCTTCAGGCTGCCATGGAAGGATACAGGGTAGTCACCATGGAATACGCCGCAGATAAGGCCGACATCTTCGTTACAACC
ACCGGCAACATCAACGTCATAACCCACGACCACATGAAGGCCATGCGGCACAACGCCATTGTCTGCAACATCGGCCATTT
CGACAACGAGATCGAAGTGGCGGCGCTGAAGCAGTACCAGTGGGAAAACATCAAGCCCCAAGTGGATCACATCATCTTTC
CCGACAGTAAGCGGATCATTCTGCTAGCCGAGGGTCGCCTTGTGAACCTCGGCTGCGCCACGGGACATCCGTCCTATGTC
ATGTCTTCTTCCTTTGCCAACCAGACCCTTGCCCAGATAGAACTCTTCTGTAACCCCGGCAAGTATCCGGTCGGCGTCTA
CATGCTTCCCAAGGAGCTGGACGAGAAGGTCGCACGGCTTCAGCTGAAGACGCTGGGAGCCATGCTGACCGAGCTCACCG
ACGAGCAGGCCGCCTACATCGGGGTGCCCAAAAACGGCCCCTACAAATCGGCTCACTACCGCTACTAA

Upstream 100 bases:

>100_bases
GGCCTTTTTCGTTGCAGGATGGTTTCTTTTTTGACCGGATTGGATGTGACGTGATATATAGTTCGTTTAAATTACTCTCT
CATCAGGATGGAGGCCTACA

Downstream 100 bases:

>100_bases
CCTAACATCGGTCGTGAAGCTTCCGGCCAGGCCGTCGGCGCGATGACGCCGGCGGCCTTTGTCATATTCCGGCGCTCTCC
CTAAATATATTACTCAAGAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTQPVARDTAGTFSDYCISDISLAAWGRKEMIIAETEMPGLMAIREEYAATRPLQGARIAGSLHMTIQTAMLIETLVALG
AEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPS
VIANPTCEEEQYLFASIKKRLAEKPGWYSKTAAAIKGVTEETTTGVHRLYQMHEKGKLKFPAINVNDSVTKSKFDNIYGC
RESLVDGIKRATDVMIAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTT
TGNINVITHDHMKAMRHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDSKRIILLAEGRLVNLGCATGHPSYV
MSSSFANQTLAQIELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTDEQAAYIGVPKNGPYKSAHYRY

Sequences:

>Translated_475_residues
MTQPVARDTAGTFSDYCISDISLAAWGRKEMIIAETEMPGLMAIREEYAATRPLQGARIAGSLHMTIQTAMLIETLVALG
AEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPS
VIANPTCEEEQYLFASIKKRLAEKPGWYSKTAAAIKGVTEETTTGVHRLYQMHEKGKLKFPAINVNDSVTKSKFDNIYGC
RESLVDGIKRATDVMIAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTT
TGNINVITHDHMKAMRHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDSKRIILLAEGRLVNLGCATGHPSYV
MSSSFANQTLAQIELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTDEQAAYIGVPKNGPYKSAHYRY
>Mature_474_residues
TQPVARDTAGTFSDYCISDISLAAWGRKEMIIAETEMPGLMAIREEYAATRPLQGARIAGSLHMTIQTAMLIETLVALGA
EVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPSV
IANPTCEEEQYLFASIKKRLAEKPGWYSKTAAAIKGVTEETTTGVHRLYQMHEKGKLKFPAINVNDSVTKSKFDNIYGCR
ESLVDGIKRATDVMIAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTTT
GNINVITHDHMKAMRHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDSKRIILLAEGRLVNLGCATGHPSYVM
SSSFANQTLAQIELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTDEQAAYIGVPKNGPYKSAHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=61.038961038961, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=60.9090909090909, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=50.9677419354839, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=50.9677419354839, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=50.9677419354839, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=50.9677419354839, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=49.4623655913978, Blast_Score=453, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.7096774193548, Blast_Score=529, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=58.9958158995816, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=60.1731601731602, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24656245, Length=477, Percent_Identity=50.104821802935, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45553387, Length=471, Percent_Identity=51.1677282377919, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45553385, Length=470, Percent_Identity=51.063829787234, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_GEOSL (P61617)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952924.1
- ProteinModelPortal:   P61617
- SMR:   P61617
- GeneID:   2685778
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1875
- NMPDR:   fig|243231.1.peg.1862
- TIGR:   GSU1875
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BioCyc:   GSUL243231:GSU_1875-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52284; Mature: 52153

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 66-66 BINDING 141-141 BINDING 201-201 BINDING 231-231 BINDING 235-235 BINDING 236-236 BINDING 288-288 BINDING 323-323 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPVARDTAGTFSDYCISDISLAAWGRKEMIIAETEMPGLMAIREEYAATRPLQGARIA
CCCCCCCCCCCCCHHHHHHCCEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEE
GSLHMTIQTAMLIETLVALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYW
CEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHH
EFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPSVIANPTCEEEQYLFASIKKR
HHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHH
LAEKPGWYSKTAAAIKGVTEETTTGVHRLYQMHEKGKLKFPAINVNDSVTKSKFDNIYGC
HHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHH
RESLVDGIKRATDVMIAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAME
HHHHHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHHC
GYRVVTMEYAADKADIFVTTTGNINVITHDHMKAMRHNAIVCNIGHFDNEIEVAALKQYQ
CCEEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCEEEEEEHHHC
WENIKPQVDHIIFPDSKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQIELFCNPG
CCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHCCEEEEEEEECCC
KYPVGVYMLPKELDEKVARLQLKTLGAMLTELTDEQAAYIGVPKNGPYKSAHYRY
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TQPVARDTAGTFSDYCISDISLAAWGRKEMIIAETEMPGLMAIREEYAATRPLQGARIA
CCCCCCCCCCCCHHHHHHCCEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEE
GSLHMTIQTAMLIETLVALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYW
CEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHH
EFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPSVIANPTCEEEQYLFASIKKR
HHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHH
LAEKPGWYSKTAAAIKGVTEETTTGVHRLYQMHEKGKLKFPAINVNDSVTKSKFDNIYGC
HHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHH
RESLVDGIKRATDVMIAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAME
HHHHHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHHC
GYRVVTMEYAADKADIFVTTTGNINVITHDHMKAMRHNAIVCNIGHFDNEIEVAALKQYQ
CCEEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCEEEEEEHHHC
WENIKPQVDHIIFPDSKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQIELFCNPG
CCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHCCEEEEEEEECCC
KYPVGVYMLPKELDEKVARLQLKTLGAMLTELTDEQAAYIGVPKNGPYKSAHYRY
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA