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The map label for this gene is gcp

Identifier: 39996963

GI number: 39996963

Start: 2041368

End: 2042390

Strand: Reverse

Name: gcp

Synonym: GSU1865

Alternate gene names: 39996963

Gene position: 2042390-2041368 (Counterclockwise)

Preceding gene: 39996964

Following gene: 39996962

Centisome position: 53.55

GC content: 64.71

Gene sequence:

>1023_bases
ATGCTCGTACTTGCCATCGAAACATCGTGTGACGAAACCGCTGCCGCCTTGGTGCGCGACGGGCGCTCCATCCTGTCAAG
CGTGGTTTCCTCCCAGGTGAAGGATCACGCCGTCTACGGCGGGGTTGTACCCGAAATTGCCTCGCGCAAACACCTGGAGA
CCATTCCCGCGGTTATCGGCGAGGCCCTGCGCTTGGCGGACGTGACCCTCGATCACGTGGAAGGGGTTGCGGTGACCCAG
GGGCCCGGACTGGCCGGCGCTCTCCTGGTCGGCCTGTCCGTGGCCAAATCCATCGCCTTTGCCAGGAGACTGCCCCTGGT
AGGAGTCAATCACATTGAAGCGCACCTTGCCGCTATTTTTCTTGAACGCGAGGTCGCCTATCCCTATCTGGCCCTGGTGG
TGTCGGGGGGGCATTCCCACCTGTACCGGGTCGACGGTATCGGCCGGTGCACCACCCTCGGCCAGACCCTGGACGATGCT
GCTGGCGAAGCCTTCGACAAGGTGGCCAAGCTGCTGGGCCTCCCCTATCCGGGCGGCATCGAGATTGATCGCCTGGCCTC
CGCCGGTGACCCGGATGCCATCGCCTTTCCGCGGCCTCTGCTCCACGACGGCAGCTTCAACTTCAGCTTCAGCGGCCTCA
AGACCGCGGTGCTCTCTGCGGTGAAGAAGCAGGGGCTTCCCGAGGGAAAATCCCTGGCCGACTTCTGCGCTTCGTTCCAG
AAGGCCGTCTGTCATGTGTTGGTGGAAAAGACCTTTCGTGCCGCGGAGGCGGCAGGTATTGACCGGGTCGTGGTGGCAGG
TGGGGTGGCCTGCAACAGTGCGCTGCGGCGGGAAATGGCCCATGCCGCCGCTGCGCGGGGCGTGGAGCTCATGATCCCGT
CGCCGTCGCTATGCGGAGACAATGCCGCCATGATCGCCGTGCCGGGTGACTATTACCTGCGCTGTGGGGAGCAGGGCGGT
CTCGCGCTTGACGCACGGGTGAACTGGCCACTTGACCTGCTCGGGTCGGGGAGGGAGGGGTGA

Upstream 100 bases:

>100_bases
GGAGCGCTTCAAAGGGGTGCCCATCGCCGGCCATGTCACCATGACCAAGGGTGAGCGGTCGGAGCTGGCGGAACTGGCGG
CGAACCTCCTCTAGCGTTCC

Downstream 100 bases:

>100_bases
GAGGGGACGGCATCCGTGCCCGGAAGGCGCTCGGGCAGAATTTTCTCACTGACCGTTCGGTTCTTTCCCGCATTGCGGCC
CTAGTGAGTGCCGGTGCCGG

Product: DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLVLAIETSCDETAAALVRDGRSILSSVVSSQVKDHAVYGGVVPEIASRKHLETIPAVIGEALRLADVTLDHVEGVAVTQ
GPGLAGALLVGLSVAKSIAFARRLPLVGVNHIEAHLAAIFLEREVAYPYLALVVSGGHSHLYRVDGIGRCTTLGQTLDDA
AGEAFDKVAKLLGLPYPGGIEIDRLASAGDPDAIAFPRPLLHDGSFNFSFSGLKTAVLSAVKKQGLPEGKSLADFCASFQ
KAVCHVLVEKTFRAAEAAGIDRVVVAGGVACNSALRREMAHAAAARGVELMIPSPSLCGDNAAMIAVPGDYYLRCGEQGG
LALDARVNWPLDLLGSGREG

Sequences:

>Translated_340_residues
MLVLAIETSCDETAAALVRDGRSILSSVVSSQVKDHAVYGGVVPEIASRKHLETIPAVIGEALRLADVTLDHVEGVAVTQ
GPGLAGALLVGLSVAKSIAFARRLPLVGVNHIEAHLAAIFLEREVAYPYLALVVSGGHSHLYRVDGIGRCTTLGQTLDDA
AGEAFDKVAKLLGLPYPGGIEIDRLASAGDPDAIAFPRPLLHDGSFNFSFSGLKTAVLSAVKKQGLPEGKSLADFCASFQ
KAVCHVLVEKTFRAAEAAGIDRVVVAGGVACNSALRREMAHAAAARGVELMIPSPSLCGDNAAMIAVPGDYYLRCGEQGG
LALDARVNWPLDLLGSGREG
>Mature_340_residues
MLVLAIETSCDETAAALVRDGRSILSSVVSSQVKDHAVYGGVVPEIASRKHLETIPAVIGEALRLADVTLDHVEGVAVTQ
GPGLAGALLVGLSVAKSIAFARRLPLVGVNHIEAHLAAIFLEREVAYPYLALVVSGGHSHLYRVDGIGRCTTLGQTLDDA
AGEAFDKVAKLLGLPYPGGIEIDRLASAGDPDAIAFPRPLLHDGSFNFSFSGLKTAVLSAVKKQGLPEGKSLADFCASFQ
KAVCHVLVEKTFRAAEAAGIDRVVVAGGVACNSALRREMAHAAAARGVELMIPSPSLCGDNAAMIAVPGDYYLRCGEQGG
LALDARVNWPLDLLGSGREG

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=36.3905325443787, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI8923380, Length=331, Percent_Identity=30.8157099697885, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789445, Length=332, Percent_Identity=44.8795180722892, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17557464, Length=324, Percent_Identity=32.4074074074074, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71995670, Length=323, Percent_Identity=30.9597523219814, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320099, Length=371, Percent_Identity=28.3018867924528, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322891, Length=298, Percent_Identity=29.1946308724832, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI20129063, Length=334, Percent_Identity=37.125748502994, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21357207, Length=329, Percent_Identity=29.483282674772, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_GEOSL (Q74C11)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952914.1
- ProteinModelPortal:   Q74C11
- SMR:   Q74C11
- MEROPS:   M22.001
- GeneID:   2688523
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1865
- NMPDR:   fig|243231.1.peg.1852
- TIGR:   GSU1865
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   GSUL243231:GSU_1865-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35363; Mature: 35363

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLAIETSCDETAAALVRDGRSILSSVVSSQVKDHAVYGGVVPEIASRKHLETIPAVIG
CEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EALRLADVTLDHVEGVAVTQGPGLAGALLVGLSVAKSIAFARRLPLVGVNHIEAHLAAIF
HHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LEREVAYPYLALVVSGGHSHLYRVDGIGRCTTLGQTLDDAAGEAFDKVAKLLGLPYPGGI
HHHHHCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EIDRLASAGDPDAIAFPRPLLHDGSFNFSFSGLKTAVLSAVKKQGLPEGKSLADFCASFQ
CHHHHCCCCCCCCCCCCCCHHCCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KAVCHVLVEKTFRAAEAAGIDRVVVAGGVACNSALRREMAHAAAARGVELMIPSPSLCGD
HHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
NAAMIAVPGDYYLRCGEQGGLALDARVNWPLDLLGSGREG
CEEEEEECCHHEEEECCCCCEEEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MLVLAIETSCDETAAALVRDGRSILSSVVSSQVKDHAVYGGVVPEIASRKHLETIPAVIG
CEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EALRLADVTLDHVEGVAVTQGPGLAGALLVGLSVAKSIAFARRLPLVGVNHIEAHLAAIF
HHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LEREVAYPYLALVVSGGHSHLYRVDGIGRCTTLGQTLDDAAGEAFDKVAKLLGLPYPGGI
HHHHHCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EIDRLASAGDPDAIAFPRPLLHDGSFNFSFSGLKTAVLSAVKKQGLPEGKSLADFCASFQ
CHHHHCCCCCCCCCCCCCCHHCCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KAVCHVLVEKTFRAAEAAGIDRVVVAGGVACNSALRREMAHAAAARGVELMIPSPSLCGD
HHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
NAAMIAVPGDYYLRCGEQGGLALDARVNWPLDLLGSGREG
CEEEEEECCHHEEEECCCCCEEEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA