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The map label for this gene is tlpB [H]

Identifier: 39996804

GI number: 39996804

Start: 1866651

End: 1868642

Strand: Direct

Name: tlpB [H]

Synonym: GSU1704

Alternate gene names: 39996804

Gene position: 1866651-1868642 (Clockwise)

Preceding gene: 39996803

Following gene: 39996805

Centisome position: 48.94

GC content: 58.03

Gene sequence:

>1992_bases
ATGGAATCCGGTGCTGTATTCAAAAACAGGAGCAGTCTGTACGGGGTTCTCGGCTGTGCGTTGGGAATCGGCGCTCCCAT
CGCGTGGACTTTTATCCGTCTCGTTTTCTTTTCCGACCCCGGTCAGCCCCTTCTTGGGCAGGTATTCTCCGATATAACCC
GCTCAACCTACCAAGTAGCCCTCTATACATATATGGGCATGGGCACTGCCCTGGTCCTGGCCGTGGTGGGGCACCACATC
GGCAAGACGAGCGACGAACTCCACAAGCGCGCCGCCGAGTTGAACCTGTTGCATCAGGAAGTTGCATCCCAAAAGGAGAT
TTTTGAAAACCGCTACCGGATCCTTGACAACAACATCAAGAATTTCCACCAGATCAGCAGCAGGATTCAGAAATCGATCG
ATGTGGACGAGGTCCTCCGGCTGTGCGCCGAGGGGCTTCACGATGTTCTTGGCTACGAGCGGGTAAATATACTCATGGCG
GATACTGCGCGGACCTCACTTTCCTTTGTGGCCGCCGTGGGCACCGCCGACTTCAACCCGGCCGGCGTGGTGCTGCCCCT
GGATCAGCGGGGGGGCGTAATCACTAAGTGCTTTACCGACCGCCAGGTCTACATGATCGATGATGTCAGTGCCTATCCGA
CCGATTTCCGGCTCCAATCACCCTATGATGCCATCCGGGCCCTGAGATCAAAAAGCTTCGTGATCTGCCCCATTGTCGTC
AAGGGAGAGGCCATCGGTGTGTTTGCCGTGGACAACCGTTCGAGCCGCCGGTCGCTCAACGATACGGACGTGGACACCAT
CAAGCTCTTTGCCGACCAGGCTTCGTCGGCGATCGTCCGCATCAATCTGCTCAAGGCCATTGGAACCCTCACCTCGGAAC
TGGAGACCACCTTTGCCGATCTGCTCAAGAACCGCGACCATTATTCCCGCTACGTGGTCAATCTGAAGGATGCGGTCAAC
TCCGTGGCCGACGGCACCGCCCACATCGCGTCAGCATCAGAGAGCGTTCTCTCGGCGGTGGATGAGACGAGTTCCGCCGT
AAGCAACATCTATGTGGCCATCGAGCAGGTGACGCGGAACATCGACTACCTGTCGGAGTCCATCGACAAGTCGGTGTCTG
CCATGGAGGAGCTGAACTCTTCCATCAAGAACGTTGAGCAGAGCGCCGCCATCTCGCACCAGGTATCGAGTACGGTCAAG
GAAAAGGCCGACAGCGGCCGGGCCGTGGTGGATGAAACCATCCAGGCCCTGGACGAGATCCAGCGTTCGGTTGACCAGTC
CTTCGAGGCCATGAAACGCCTTTCCGAGAACAGCGGCAAGATCGAGAGCATTGTCGGCGTGATCAACGACATCACCAAGC
GAACCAACCTCCTGGCGCTGAACGCGTCCATCATTGCGGCCCAGGCGGGAGAGTACGGCAAGAGCTTCGGCGTCGTGGCC
GACGAGATCCGCAACCTGTCGCTCCAGACCGGCCAGTCCACCGGCGAGATAACCGGCATTATCGAGGAGATCATGCGGGA
ATCCCGCTCAGCGGCCCAGAACATAACCGCCTCCAAGGATCTGGTCCAGCGAGGGGTTGAACTGGGCGGCATCATGGGTC
AGTCGCTCCAGGTCATTCACGAGAGCTCCACCCGCTCCATGGACATGACCCATGAGATCAAGACCGCGACCGAGGAGCAG
GCGCGCAGCGTCCAGCTGGTCACCAACTCCATCGAGAACGTGAGCAGCATGAGCACGCAGATCTACAAGGCCTCAAAGGA
GCAATCCGACGCCGCCATGAGCATTGTCCGCTCCGTTGACACCATCAAGGAGATGGCCCAGGAGATGGTAAGGGCAACCG
TCAAACAAGTCGAGGACGGATCGGAAATCAAGAAGTCGGTGGAAGCGGTGGGCGAGATGGTAACGCGGATCTTCGAGGAT
ATGGAAGTTCGGCGCGAGGAGAGCGGTGAGGTGGTAAAAGAGCTCGAACTGATGAAGAAGATAGCCAGCTGA

Upstream 100 bases:

>100_bases
GCCGCCGATGTTATACATAGTGCATATGAGCCGAACTGCCGGTGTGGCCGGGTCGGTGCCGCCCGTTGCCGGGTAATGCG
CACAATGGAGGGATATCCGC

Downstream 100 bases:

>100_bases
TTTAAATTAGTTCTGGACAAAACCACGATATTTGTGGTATTCATGCACGTATTCTAATGACGGCCCGCAACCCAGGTGGA
GCCGTCATCCTTTTTTTCGG

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MESGAVFKNRSSLYGVLGCALGIGAPIAWTFIRLVFFSDPGQPLLGQVFSDITRSTYQVALYTYMGMGTALVLAVVGHHI
GKTSDELHKRAAELNLLHQEVASQKEIFENRYRILDNNIKNFHQISSRIQKSIDVDEVLRLCAEGLHDVLGYERVNILMA
DTARTSLSFVAAVGTADFNPAGVVLPLDQRGGVITKCFTDRQVYMIDDVSAYPTDFRLQSPYDAIRALRSKSFVICPIVV
KGEAIGVFAVDNRSSRRSLNDTDVDTIKLFADQASSAIVRINLLKAIGTLTSELETTFADLLKNRDHYSRYVVNLKDAVN
SVADGTAHIASASESVLSAVDETSSAVSNIYVAIEQVTRNIDYLSESIDKSVSAMEELNSSIKNVEQSAAISHQVSSTVK
EKADSGRAVVDETIQALDEIQRSVDQSFEAMKRLSENSGKIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
DEIRNLSLQTGQSTGEITGIIEEIMRESRSAAQNITASKDLVQRGVELGGIMGQSLQVIHESSTRSMDMTHEIKTATEEQ
ARSVQLVTNSIENVSSMSTQIYKASKEQSDAAMSIVRSVDTIKEMAQEMVRATVKQVEDGSEIKKSVEAVGEMVTRIFED
MEVRREESGEVVKELELMKKIAS

Sequences:

>Translated_663_residues
MESGAVFKNRSSLYGVLGCALGIGAPIAWTFIRLVFFSDPGQPLLGQVFSDITRSTYQVALYTYMGMGTALVLAVVGHHI
GKTSDELHKRAAELNLLHQEVASQKEIFENRYRILDNNIKNFHQISSRIQKSIDVDEVLRLCAEGLHDVLGYERVNILMA
DTARTSLSFVAAVGTADFNPAGVVLPLDQRGGVITKCFTDRQVYMIDDVSAYPTDFRLQSPYDAIRALRSKSFVICPIVV
KGEAIGVFAVDNRSSRRSLNDTDVDTIKLFADQASSAIVRINLLKAIGTLTSELETTFADLLKNRDHYSRYVVNLKDAVN
SVADGTAHIASASESVLSAVDETSSAVSNIYVAIEQVTRNIDYLSESIDKSVSAMEELNSSIKNVEQSAAISHQVSSTVK
EKADSGRAVVDETIQALDEIQRSVDQSFEAMKRLSENSGKIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
DEIRNLSLQTGQSTGEITGIIEEIMRESRSAAQNITASKDLVQRGVELGGIMGQSLQVIHESSTRSMDMTHEIKTATEEQ
ARSVQLVTNSIENVSSMSTQIYKASKEQSDAAMSIVRSVDTIKEMAQEMVRATVKQVEDGSEIKKSVEAVGEMVTRIFED
MEVRREESGEVVKELELMKKIAS
>Mature_663_residues
MESGAVFKNRSSLYGVLGCALGIGAPIAWTFIRLVFFSDPGQPLLGQVFSDITRSTYQVALYTYMGMGTALVLAVVGHHI
GKTSDELHKRAAELNLLHQEVASQKEIFENRYRILDNNIKNFHQISSRIQKSIDVDEVLRLCAEGLHDVLGYERVNILMA
DTARTSLSFVAAVGTADFNPAGVVLPLDQRGGVITKCFTDRQVYMIDDVSAYPTDFRLQSPYDAIRALRSKSFVICPIVV
KGEAIGVFAVDNRSSRRSLNDTDVDTIKLFADQASSAIVRINLLKAIGTLTSELETTFADLLKNRDHYSRYVVNLKDAVN
SVADGTAHIASASESVLSAVDETSSAVSNIYVAIEQVTRNIDYLSESIDKSVSAMEELNSSIKNVEQSAAISHQVSSTVK
EKADSGRAVVDETIQALDEIQRSVDQSFEAMKRLSENSGKIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
DEIRNLSLQTGQSTGEITGIIEEIMRESRSAAQNITASKDLVQRGVELGGIMGQSLQVIHESSTRSMDMTHEIKTATEEQ
ARSVQLVTNSIENVSSMSTQIYKASKEQSDAAMSIVRSVDTIKEMAQEMVRATVKQVEDGSEIKKSVEAVGEMVTRIFED
MEVRREESGEVVKELELMKKIAS

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=296, Percent_Identity=26.3513513513513, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1787690, Length=215, Percent_Identity=32.5581395348837, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367378, Length=254, Percent_Identity=29.5275590551181, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788194, Length=197, Percent_Identity=34.010152284264, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789453, Length=276, Percent_Identity=25.3623188405797, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 72500; Mature: 72500

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGAVFKNRSSLYGVLGCALGIGAPIAWTFIRLVFFSDPGQPLLGQVFSDITRSTYQVA
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LYTYMGMGTALVLAVVGHHIGKTSDELHKRAAELNLLHQEVASQKEIFENRYRILDNNIK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
NFHQISSRIQKSIDVDEVLRLCAEGLHDVLGYERVNILMADTARTSLSFVAAVGTADFNP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHEEEEECCHHHHHHHHHHHCCCCCCC
AGVVLPLDQRGGVITKCFTDRQVYMIDDVSAYPTDFRLQSPYDAIRALRSKSFVICPIVV
CCEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCEECCHHHHHHHHHCCCEEEEEEEE
KGEAIGVFAVDNRSSRRSLNDTDVDTIKLFADQASSAIVRINLLKAIGTLTSELETTFAD
ECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLKNRDHYSRYVVNLKDAVNSVADGTAHIASASESVLSAVDETSSAVSNIYVAIEQVTRN
HHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDYLSESIDKSVSAMEELNSSIKNVEQSAAISHQVSSTVKEKADSGRAVVDETIQALDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QRSVDQSFEAMKRLSENSGKIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEECHHHHHHCCCCCCCCCCHHH
DEIRNLSLQTGQSTGEITGIIEEIMRESRSAAQNITASKDLVQRGVELGGIMGQSLQVIH
HHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHH
ESSTRSMDMTHEIKTATEEQARSVQLVTNSIENVSSMSTQIYKASKEQSDAAMSIVRSVD
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIKEMAQEMVRATVKQVEDGSEIKKSVEAVGEMVTRIFEDMEVRREESGEVVKELELMKK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAS
HCC
>Mature Secondary Structure
MESGAVFKNRSSLYGVLGCALGIGAPIAWTFIRLVFFSDPGQPLLGQVFSDITRSTYQVA
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LYTYMGMGTALVLAVVGHHIGKTSDELHKRAAELNLLHQEVASQKEIFENRYRILDNNIK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
NFHQISSRIQKSIDVDEVLRLCAEGLHDVLGYERVNILMADTARTSLSFVAAVGTADFNP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHEEEEECCHHHHHHHHHHHCCCCCCC
AGVVLPLDQRGGVITKCFTDRQVYMIDDVSAYPTDFRLQSPYDAIRALRSKSFVICPIVV
CCEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCEECCHHHHHHHHHCCCEEEEEEEE
KGEAIGVFAVDNRSSRRSLNDTDVDTIKLFADQASSAIVRINLLKAIGTLTSELETTFAD
ECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLKNRDHYSRYVVNLKDAVNSVADGTAHIASASESVLSAVDETSSAVSNIYVAIEQVTRN
HHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDYLSESIDKSVSAMEELNSSIKNVEQSAAISHQVSSTVKEKADSGRAVVDETIQALDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QRSVDQSFEAMKRLSENSGKIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEECHHHHHHCCCCCCCCCCHHH
DEIRNLSLQTGQSTGEITGIIEEIMRESRSAAQNITASKDLVQRGVELGGIMGQSLQVIH
HHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHH
ESSTRSMDMTHEIKTATEEQARSVQLVTNSIENVSSMSTQIYKASKEQSDAAMSIVRSVD
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIKEMAQEMVRATVKQVEDGSEIKKSVEAVGEMVTRIFEDMEVRREESGEVVKELELMKK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]