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The map label for this gene is pyrE [H]

Identifier: 39996737

GI number: 39996737

Start: 1796556

End: 1797104

Strand: Direct

Name: pyrE [H]

Synonym: GSU1637

Alternate gene names: 39996737

Gene position: 1796556-1797104 (Clockwise)

Preceding gene: 39996736

Following gene: 39996738

Centisome position: 47.1

GC content: 57.19

Gene sequence:

>549_bases
ATGACTGACAAGGACCGACTGAAGCAGATCATCCTGGAGCTGTCCTACGAAAAGCGGAAAGTAATCCTCGCTTCGGGCCG
CGAAAGCGACTTCTATTTCGATGGTAAGCAGACCACCCTCCATGCCGAAGGGGGACTGCTGGTGGGCAAGCTCTTCTATG
AGGCCATCAAGGATGTGGAAGGGGTCCAGGGGGTAGGGGGGATCACCCTCGGCGCCGACCCCATTGCCACGGCAACCTCC
ATTGCCGCATTTCTGGATGGACGCCCGATGCACGCGTTCATCATCCGCAAAGAACCCAAGGGGCACGGCACGGGCCAGTG
GCTTGAAGGACGCAAGAATCTTCCTCCCGGATCAAAGGTGGTCATTGTGGAAGATGTTGTGACCACCGGCGGATCTTCCA
TGAAAGCCGTCAAGCGGGCTGAAGAGGAAGGGCTCAAGGTACTCTGCATCGTTTCCCTGGTTGACCGTGAAGAGGGGGGC
CGCGAGAATATCGAACAGGAAGGGTACGAACTCCGGACAATTTTTACCAAGTCCGAGCTGCTGGCTTGA

Upstream 100 bases:

>100_bases
CCTTCTGCAAAGCCTGTTTCTCCGGCGGCTACCCGATCACATTCCCGCGCCTCATGGCCGAACCCCAACTGGATCTTTTC
TGAAAGGAGTGAACCGACCA

Downstream 100 bases:

>100_bases
CAAGGGCCGGCGGCTTCGAAAGCATGAGGAGAAGGCAGGCGGGAGTGCACCCGCCTGCCTTTTTAATGGACCATGAAAGA
AATTCTCGACCACTACGGCA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MTDKDRLKQIILELSYEKRKVILASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVEGVQGVGGITLGADPIATATS
IAAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGSKVVIVEDVVTTGGSSMKAVKRAEEEGLKVLCIVSLVDREEGG
RENIEQEGYELRTIFTKSELLA

Sequences:

>Translated_182_residues
MTDKDRLKQIILELSYEKRKVILASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVEGVQGVGGITLGADPIATATS
IAAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGSKVVIVEDVVTTGGSSMKAVKRAEEEGLKVLCIVSLVDREEGG
RENIEQEGYELRTIFTKSELLA
>Mature_181_residues
TDKDRLKQIILELSYEKRKVILASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVEGVQGVGGITLGADPIATATSI
AAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGSKVVIVEDVVTTGGSSMKAVKRAEEEGLKVLCIVSLVDREEGGR
ENIEQEGYELRTIFTKSELLA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=161, Percent_Identity=32.2981366459627, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=196, Percent_Identity=33.6734693877551, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17933654, Length=184, Percent_Identity=33.695652173913, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19876; Mature: 19745

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKDRLKQIILELSYEKRKVILASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVE
CCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHC
GVQGVGGITLGADPIATATSIAAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGSKV
CCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
VIVEDVVTTGGSSMKAVKRAEEEGLKVLCIVSLVDREEGGRENIEQEGYELRTIFTKSEL
EEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHCCCEEEEEEEHHHH
LA
CC
>Mature Secondary Structure 
TDKDRLKQIILELSYEKRKVILASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVE
CCHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHC
GVQGVGGITLGADPIATATSIAAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGSKV
CCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
VIVEDVVTTGGSSMKAVKRAEEEGLKVLCIVSLVDREEGGRENIEQEGYELRTIFTKSEL
EEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHCCCEEEEEEEHHHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA