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The map label for this gene is lutP [H]

Identifier: 39996722

GI number: 39996722

Start: 1776004

End: 1777953

Strand: Direct

Name: lutP [H]

Synonym: GSU1622

Alternate gene names: 39996722

Gene position: 1776004-1777953 (Clockwise)

Preceding gene: 39996712

Following gene: 39996723

Centisome position: 46.56

GC content: 58.41

Gene sequence:

>1950_bases
ATGCCATGGATTCAAGTGTACACGCCGGTCGCCGGGAGTCTCGGGTTGTCTGCCCTCGTGGCAGCTATCCCCCTCGTTGT
CATCTTCGTCTGTCTCGCCCTGTTCAAGATGAAAGCCCATAAGGCGGGGCTCCTGGCACTTGCCTCAGCCATGCTCATCG
CCATCACCGTCTGGGGGATGCCTGCAAAGCTGGCGGGACTTGCTACCGCCCAGGGGGCTGCCTTTGGCCTCTTCCCGGTC
TTCTATATCGTGATAACCACTATATTTCTCTACAATATCACGGTTAAGGGAGGGCAATTCGAAATCATCCGGGCATCACT
GGCCGGGGTGACTGCCGACCGGCGCCTCCAGGCACTGCTCATTGCATTCTGTTTTGGGGCGTTCATCGAGGGTGCCGCCG
GGTTCGGCACGCCAGTGGCAATCGCGGGTGCAACCCTGGCGGGTCTCGGCTTTCAGCCCCTCTATGCCGCTGGGGTCTGC
CTGGTGGCCAATACCGCGCCGGTCGCCTTCGGTGCCATCGGTATTCCGATTGTGGCACTGGCCGGGGTCATGGGGTACGG
TGATGACGGCATGATGAAGCTTTCCACCATGGTTGGCCGCCAGCTGCCATTCATCTCCGTCATTATTCCCTTCTACGTCA
TCATGATCATGGTCGGCTGGAAAAAAACCATCGAGATCCTTCCCGCCATCATCGTCTGTGGCGTTACATTCGCTCTGAGC
CAGTGGGCTACCGCCACCTACCTTGGCCCCTATCTGCCGGACGTCACCGCTTCGTTGGCCTCAATCATCGCACTAGTCCT
CCTGCTGCGGGTATGGCAGCCCAAGACCATCTACACCTTCGCCCACGAGGCTCCCGTCACCGGCGCGACCGAACACCACT
ACACGACTGGCGAGGTGTTCCGTGCCTGGTCTCCCTATCTTGCGCTCACCGTGATGGTGCTTCTCTGGGGTATTCCCTCC
ATCAAGACCGTGCTGGACAAGAGTACTGTGGAGATCGAGGTGAAGGGGCTCCACAACATGATCGTCAAAAAGGTGGCCAA
GCCCGAAGATACCCTTACTAAAATTGCTGCCGCCTCCGCCGAGATCGATCGCCAGTTGACCCTGCTCTCGCCGGCCGATC
CGAAGCAGGCCGCCATCGCTGCCAAACTTATGGAGCTCAAGGCGTTCGAAACCCAGCTCGCCGCGGTGGAGCAGGGGCTC
GTGGGGCAGGGAGCTGTTCTTACCGATGAACGGCTCAAGGCCTGTGATATCGTGTCCAAAAAGATGGCCGAAACCCAGAA
GCTCTGCAAGGAGCTCGTCAAGACCGCTGCTGTTCCCGCCAATCAGTTCAAGCCTCTTGACAAGGCACTGGCCGATCATC
TCCCGCTGAAGGTCGCTGCAAAATACAAATTCAACTTCATGTCTGCCGCCGGTACCGCCATTCTGATCGCCGCCTTCCTT
TCCGCTCTGATCTGCGGGGTAGGCTTTGCCGACACCTTCAGAATCCTCGGCAAGACCCTCTATGACATGCGCTTCCCGGC
TCTCACCGTTGCCTCGGTCCTTGGACTCGCCTATGTCATGAATGCATCGGGAATGACCAATTGCCTCGGCCTCATCTTCA
CCAAGACCGGTCATTGGTTCCCCTTCATCGCACCGTTCCTCGGTTGGCTCGGCGTGTTTCTCACCGGTTCGGACACTTCG
TCAAACGTACTTTTCGGCGGTCTGCAGAAAGCCACTGCCGAGCAACTCGGCATAAGCCCGATCCTAACCGGCGCAGCCAA
CACCAGCGGCGGCGTTATGGGCAAGATGATCTCTCCCCAGTCGCTGGCCGTGGCAACCGCGGCAACAGGCATGGTCGGGG
AGGAGGGGACACTCTTCAGGTTTACTCTCAAACACTCGATCTTCCTTACGATTCTGGTCGGTATAATTGTCTACTTGCAG
GCGTATGTGCTTCAGTGGATGATACCCTAG

Upstream 100 bases:

>100_bases
TTATTTTATTTTTTGGGTGGATGAGGCCGGCGGCCAATGGTATGGCAGGCTCTTCCCACACATCATACCCCTAAAGGCGC
AGTGAAAGGAGAGTATTCAA

Downstream 100 bases:

>100_bases
CGTCCCCTGTCGGTAGCCCTGCGAAGGGAGTTGGGACTAACCGCACGGCACACGGGCTTCACCGTTGGGTAACCTTGCAC
CGGGAGAGCAGATATGGACG

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MPWIQVYTPVAGSLGLSALVAAIPLVVIFVCLALFKMKAHKAGLLALASAMLIAITVWGMPAKLAGLATAQGAAFGLFPV
FYIVITTIFLYNITVKGGQFEIIRASLAGVTADRRLQALLIAFCFGAFIEGAAGFGTPVAIAGATLAGLGFQPLYAAGVC
LVANTAPVAFGAIGIPIVALAGVMGYGDDGMMKLSTMVGRQLPFISVIIPFYVIMIMVGWKKTIEILPAIIVCGVTFALS
QWATATYLGPYLPDVTASLASIIALVLLLRVWQPKTIYTFAHEAPVTGATEHHYTTGEVFRAWSPYLALTVMVLLWGIPS
IKTVLDKSTVEIEVKGLHNMIVKKVAKPEDTLTKIAAASAEIDRQLTLLSPADPKQAAIAAKLMELKAFETQLAAVEQGL
VGQGAVLTDERLKACDIVSKKMAETQKLCKELVKTAAVPANQFKPLDKALADHLPLKVAAKYKFNFMSAAGTAILIAAFL
SALICGVGFADTFRILGKTLYDMRFPALTVASVLGLAYVMNASGMTNCLGLIFTKTGHWFPFIAPFLGWLGVFLTGSDTS
SNVLFGGLQKATAEQLGISPILTGAANTSGGVMGKMISPQSLAVATAATGMVGEEGTLFRFTLKHSIFLTILVGIIVYLQ
AYVLQWMIP

Sequences:

>Translated_649_residues
MPWIQVYTPVAGSLGLSALVAAIPLVVIFVCLALFKMKAHKAGLLALASAMLIAITVWGMPAKLAGLATAQGAAFGLFPV
FYIVITTIFLYNITVKGGQFEIIRASLAGVTADRRLQALLIAFCFGAFIEGAAGFGTPVAIAGATLAGLGFQPLYAAGVC
LVANTAPVAFGAIGIPIVALAGVMGYGDDGMMKLSTMVGRQLPFISVIIPFYVIMIMVGWKKTIEILPAIIVCGVTFALS
QWATATYLGPYLPDVTASLASIIALVLLLRVWQPKTIYTFAHEAPVTGATEHHYTTGEVFRAWSPYLALTVMVLLWGIPS
IKTVLDKSTVEIEVKGLHNMIVKKVAKPEDTLTKIAAASAEIDRQLTLLSPADPKQAAIAAKLMELKAFETQLAAVEQGL
VGQGAVLTDERLKACDIVSKKMAETQKLCKELVKTAAVPANQFKPLDKALADHLPLKVAAKYKFNFMSAAGTAILIAAFL
SALICGVGFADTFRILGKTLYDMRFPALTVASVLGLAYVMNASGMTNCLGLIFTKTGHWFPFIAPFLGWLGVFLTGSDTS
SNVLFGGLQKATAEQLGISPILTGAANTSGGVMGKMISPQSLAVATAATGMVGEEGTLFRFTLKHSIFLTILVGIIVYLQ
AYVLQWMIP
>Mature_648_residues
PWIQVYTPVAGSLGLSALVAAIPLVVIFVCLALFKMKAHKAGLLALASAMLIAITVWGMPAKLAGLATAQGAAFGLFPVF
YIVITTIFLYNITVKGGQFEIIRASLAGVTADRRLQALLIAFCFGAFIEGAAGFGTPVAIAGATLAGLGFQPLYAAGVCL
VANTAPVAFGAIGIPIVALAGVMGYGDDGMMKLSTMVGRQLPFISVIIPFYVIMIMVGWKKTIEILPAIIVCGVTFALSQ
WATATYLGPYLPDVTASLASIIALVLLLRVWQPKTIYTFAHEAPVTGATEHHYTTGEVFRAWSPYLALTVMVLLWGIPSI
KTVLDKSTVEIEVKGLHNMIVKKVAKPEDTLTKIAAASAEIDRQLTLLSPADPKQAAIAAKLMELKAFETQLAAVEQGLV
GQGAVLTDERLKACDIVSKKMAETQKLCKELVKTAAVPANQFKPLDKALADHLPLKVAAKYKFNFMSAAGTAILIAAFLS
ALICGVGFADTFRILGKTLYDMRFPALTVASVLGLAYVMNASGMTNCLGLIFTKTGHWFPFIAPFLGWLGVFLTGSDTSS
NVLFGGLQKATAEQLGISPILTGAANTSGGVMGKMISPQSLAVATAATGMVGEEGTLFRFTLKHSIFLTILVGIIVYLQA
YVLQWMIP

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=380, Percent_Identity=44.4736842105263, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1790031, Length=350, Percent_Identity=43.7142857142857, Blast_Score=292, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 68683; Mature: 68552

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWIQVYTPVAGSLGLSALVAAIPLVVIFVCLALFKMKAHKAGLLALASAMLIAITVWGM
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAKLAGLATAQGAAFGLFPVFYIVITTIFLYNITVKGGQFEIIRASLAGVTADRRLQALL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHCCCHHHHHHHHH
IAFCFGAFIEGAAGFGTPVAIAGATLAGLGFQPLYAAGVCLVANTAPVAFGAIGIPIVAL
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHH
AGVMGYGDDGMMKLSTMVGRQLPFISVIIPFYVIMIMVGWKKTIEILPAIIVCGVTFALS
HHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QWATATYLGPYLPDVTASLASIIALVLLLRVWQPKTIYTFAHEAPVTGATEHHYTTGEVF
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHH
RAWSPYLALTVMVLLWGIPSIKTVLDKSTVEIEVKGLHNMIVKKVAKPEDTLTKIAAASA
HHCCHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHH
EIDRQLTLLSPADPKQAAIAAKLMELKAFETQLAAVEQGLVGQGAVLTDERLKACDIVSK
HHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHH
KMAETQKLCKELVKTAAVPANQFKPLDKALADHLPLKVAAKYKFNFMSAAGTAILIAAFL
HHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHHHHHHH
SALICGVGFADTFRILGKTLYDMRFPALTVASVLGLAYVMNASGMTNCLGLIFTKTGHWF
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCH
PFIAPFLGWLGVFLTGSDTSSNVLFGGLQKATAEQLGISPILTGAANTSGGVMGKMISPQ
HHHHHHHHHHHHEEECCCCCCCCEECCHHHHHHHHHCCCHHCCCCCCCCCCCEECCCCCC
SLAVATAATGMVGEEGTLFRFTLKHSIFLTILVGIIVYLQAYVLQWMIP
HHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PWIQVYTPVAGSLGLSALVAAIPLVVIFVCLALFKMKAHKAGLLALASAMLIAITVWGM
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAKLAGLATAQGAAFGLFPVFYIVITTIFLYNITVKGGQFEIIRASLAGVTADRRLQALL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHCCCHHHHHHHHH
IAFCFGAFIEGAAGFGTPVAIAGATLAGLGFQPLYAAGVCLVANTAPVAFGAIGIPIVAL
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHH
AGVMGYGDDGMMKLSTMVGRQLPFISVIIPFYVIMIMVGWKKTIEILPAIIVCGVTFALS
HHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QWATATYLGPYLPDVTASLASIIALVLLLRVWQPKTIYTFAHEAPVTGATEHHYTTGEVF
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHH
RAWSPYLALTVMVLLWGIPSIKTVLDKSTVEIEVKGLHNMIVKKVAKPEDTLTKIAAASA
HHCCHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHH
EIDRQLTLLSPADPKQAAIAAKLMELKAFETQLAAVEQGLVGQGAVLTDERLKACDIVSK
HHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHH
KMAETQKLCKELVKTAAVPANQFKPLDKALADHLPLKVAAKYKFNFMSAAGTAILIAAFL
HHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHHHHHHH
SALICGVGFADTFRILGKTLYDMRFPALTVASVLGLAYVMNASGMTNCLGLIFTKTGHWF
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCH
PFIAPFLGWLGVFLTGSDTSSNVLFGGLQKATAEQLGISPILTGAANTSGGVMGKMISPQ
HHHHHHHHHHHHEEECCCCCCCCEECCHHHHHHHHHCCCHHCCCCCCCCCCCEECCCCCC
SLAVATAATGMVGEEGTLFRFTLKHSIFLTILVGIIVYLQAYVLQWMIP
HHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]