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The map label for this gene is atoC [H]

Identifier: 39996595

GI number: 39996595

Start: 1640718

End: 1642094

Strand: Direct

Name: atoC [H]

Synonym: GSU1495

Alternate gene names: 39996595

Gene position: 1640718-1642094 (Clockwise)

Preceding gene: 39996594

Following gene: 39996596

Centisome position: 43.02

GC content: 58.46

Gene sequence:

>1377_bases
ATGGAAATTCATGTTCTCGTAGTGGACGATGAACTGAGCATGCGCGAATTCCTCGCCATCCTGCTCGACCGGGAGGGCTA
TACCGTCGACCAGGCCGCCAGCGCCGAAGAGGCGCTGGCCTGTCTTGAACGCAAGACGTATGATCTGGTCATCTCCGACG
TAAAGATGCCGGGGCTTGATGGCATTACCCTCCTGGGCCGCATCAAGGAGATGACGCCCGACACTGCCGTCCTCCTCATG
ACGGCCTTTTCCACTGCCGAGCAGGCCGTGGAAGCCATGAAGCTCGGGGCGTACGACTACATTGCCAAACCCTTCAAGGT
GGAAGAGGTCAAGATTCTCGCCCGCAACGCCCTGGAAAAGAGGGATCTCAAGAGGGAGAACCTGCGGCTTCGCCAGGAGG
TGCAGGAGCGGTACAGCTTCAGCGGTCTGATCGGTAAGAGCAAGAAGATGCGCGAGGTCTACTCCCTGATCGAAAAAGTG
GCGCCAAGTACCGCGAATGTTCTCATTCTCGGTGAGAGCGGCACCGGCAAGGAGCTGGTGGCCCGCGCCATCCACTACAA
CAGCCAACGCAAGGGAAAACCCTTTGTGGCGGTCAACTGCGGCGCCATTCCCGAAACCCTCATGGAGAGTGAATTCTTCG
GTCACAAAAAGGGGGCGTTCACCGGCGCCGTTGGTGACCGGGCGGGGCTCTTCGAGCAGGCCGAGGGTGGTACCCTTTTC
CTGGACGAAATCGGAGAAGTGCCGCTCCAGCTTCAGGCCAAACTTTTGCGGGCCATCCAGGAAAAGGAATTCCGCAGGGT
AGGGGGAACCCTTGACCAGAAGGCCGACGTGCGGCTGGTGGCCGCCTCCAATCGTGATTTGGAAGAGCAGGTGAAGGAAG
GGAGTTTCCGGGAGGATCTCTTTTATCGCCTCAACGTGGTCCAGGTCAAAATGCCCCCACTCCGTGAGCGTGGAGATGAT
ATCCCCATCCTGGTTGAGCACTTTTACAAAAAGTACGTCCAGCCCCCCTACAGCGACCGCATCATAACCCAGGGGGCGCT
GAAGCTGCTCATGTCATACGGATTTCCGGGCAACGTCCGTGAGCTGGAGAACCTGGTCGAGCGCTGCTCCGTGCTCGGCA
ATCGCGAGATCTCGGAAGAATGTCTCCCGCCGCAGCTCCACGCGGGTAAACGGCCTGAATGTGGCGCGGTCACCGAGTGC
GAACTGCCGGAAGAGGGCATGGACCTCGAAGCCTACCTGGACGGCATTGAAAAGCGAATTCTGCTTCAGGCACTGGAACG
CAGCGGCGGTGTGAAAAAGAAGGCGGCCGAACTTTTGAAGCTTACGTTCCGTTCTTTCCGGTATCGCCTGGCAAAATTTG
GCATGGATGAGGAGTGA

Upstream 100 bases:

>100_bases
AAGTACGCCGGGTAAAGGCACTATGTTCGTCATCTTTCTGCCGACTCCCCCATCCAGCGGAGAGTAGGCAATCAGTCAGT
AACCGCCAGAAGGGACTATC

Downstream 100 bases:

>100_bases
AGAGGAGCCAGTGACGAAAATCGTCAGACACAAGTGACGAAATAGGTGGTGAAGGGGTAGGTTGAAGCGGTTGCGTTGTG
TAACGTGCTGAAATTGTAGC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MEIHVLVVDDELSMREFLAILLDREGYTVDQAASAEEALACLERKTYDLVISDVKMPGLDGITLLGRIKEMTPDTAVLLM
TAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKILARNALEKRDLKRENLRLRQEVQERYSFSGLIGKSKKMREVYSLIEKV
APSTANVLILGESGTGKELVARAIHYNSQRKGKPFVAVNCGAIPETLMESEFFGHKKGAFTGAVGDRAGLFEQAEGGTLF
LDEIGEVPLQLQAKLLRAIQEKEFRRVGGTLDQKADVRLVAASNRDLEEQVKEGSFREDLFYRLNVVQVKMPPLRERGDD
IPILVEHFYKKYVQPPYSDRIITQGALKLLMSYGFPGNVRELENLVERCSVLGNREISEECLPPQLHAGKRPECGAVTEC
ELPEEGMDLEAYLDGIEKRILLQALERSGGVKKKAAELLKLTFRSFRYRLAKFGMDEE

Sequences:

>Translated_458_residues
MEIHVLVVDDELSMREFLAILLDREGYTVDQAASAEEALACLERKTYDLVISDVKMPGLDGITLLGRIKEMTPDTAVLLM
TAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKILARNALEKRDLKRENLRLRQEVQERYSFSGLIGKSKKMREVYSLIEKV
APSTANVLILGESGTGKELVARAIHYNSQRKGKPFVAVNCGAIPETLMESEFFGHKKGAFTGAVGDRAGLFEQAEGGTLF
LDEIGEVPLQLQAKLLRAIQEKEFRRVGGTLDQKADVRLVAASNRDLEEQVKEGSFREDLFYRLNVVQVKMPPLRERGDD
IPILVEHFYKKYVQPPYSDRIITQGALKLLMSYGFPGNVRELENLVERCSVLGNREISEECLPPQLHAGKRPECGAVTEC
ELPEEGMDLEAYLDGIEKRILLQALERSGGVKKKAAELLKLTFRSFRYRLAKFGMDEE
>Mature_458_residues
MEIHVLVVDDELSMREFLAILLDREGYTVDQAASAEEALACLERKTYDLVISDVKMPGLDGITLLGRIKEMTPDTAVLLM
TAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKILARNALEKRDLKRENLRLRQEVQERYSFSGLIGKSKKMREVYSLIEKV
APSTANVLILGESGTGKELVARAIHYNSQRKGKPFVAVNCGAIPETLMESEFFGHKKGAFTGAVGDRAGLFEQAEGGTLF
LDEIGEVPLQLQAKLLRAIQEKEFRRVGGTLDQKADVRLVAASNRDLEEQVKEGSFREDLFYRLNVVQVKMPPLRERGDD
IPILVEHFYKKYVQPPYSDRIITQGALKLLMSYGFPGNVRELENLVERCSVLGNREISEECLPPQLHAGKRPECGAVTEC
ELPEEGMDLEAYLDGIEKRILLQALERSGGVKKKAAELLKLTFRSFRYRLAKFGMDEE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=44.273127753304, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=44.5175438596491, Blast_Score=354, Evalue=7e-99,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=39.832285115304, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1788905, Length=381, Percent_Identity=42.257217847769, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI87082117, Length=351, Percent_Identity=41.3105413105413, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789233, Length=304, Percent_Identity=45.0657894736842, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789087, Length=429, Percent_Identity=37.995337995338, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082152, Length=318, Percent_Identity=45.2830188679245, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1786524, Length=407, Percent_Identity=40.7862407862408, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=40.7407407407407, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787583, Length=330, Percent_Identity=36.6666666666667, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789828, Length=268, Percent_Identity=35.8208955223881, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=28.0373831775701, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790863, Length=140, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787375, Length=202, Percent_Identity=30.6930693069307, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=29.9145299145299, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790552, Length=118, Percent_Identity=32.2033898305085, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786599, Length=108, Percent_Identity=34.2592592592593, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789402, Length=108, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787229, Length=126, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=107, Percent_Identity=38.3177570093458, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=174, Percent_Identity=25.2873563218391, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51458; Mature: 51458

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIHVLVVDDELSMREFLAILLDREGYTVDQAASAEEALACLERKTYDLVISDVKMPGLD
CEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHEEEECCCCCCCC
GITLLGRIKEMTPDTAVLLMTAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKILARNALEK
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
RDLKRENLRLRQEVQERYSFSGLIGKSKKMREVYSLIEKVAPSTANVLILGESGTGKELV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
ARAIHYNSQRKGKPFVAVNCGAIPETLMESEFFGHKKGAFTGAVGDRAGLFEQAEGGTLF
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCHHCCHHCCCCCEEE
LDEIGEVPLQLQAKLLRAIQEKEFRRVGGTLDQKADVRLVAASNRDLEEQVKEGSFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCHHHHH
FYRLNVVQVKMPPLRERGDDIPILVEHFYKKYVQPPYSDRIITQGALKLLMSYGFPGNVR
HHEEEEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
ELENLVERCSVLGNREISEECLPPQLHAGKRPECGAVTECELPEEGMDLEAYLDGIEKRI
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LLQALERSGGVKKKAAELLKLTFRSFRYRLAKFGMDEE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEIHVLVVDDELSMREFLAILLDREGYTVDQAASAEEALACLERKTYDLVISDVKMPGLD
CEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHEEEECCCCCCCC
GITLLGRIKEMTPDTAVLLMTAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKILARNALEK
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
RDLKRENLRLRQEVQERYSFSGLIGKSKKMREVYSLIEKVAPSTANVLILGESGTGKELV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
ARAIHYNSQRKGKPFVAVNCGAIPETLMESEFFGHKKGAFTGAVGDRAGLFEQAEGGTLF
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCHHCCHHCCCCCEEE
LDEIGEVPLQLQAKLLRAIQEKEFRRVGGTLDQKADVRLVAASNRDLEEQVKEGSFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCHHHHH
FYRLNVVQVKMPPLRERGDDIPILVEHFYKKYVQPPYSDRIITQGALKLLMSYGFPGNVR
HHEEEEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
ELENLVERCSVLGNREISEECLPPQLHAGKRPECGAVTECELPEEGMDLEAYLDGIEKRI
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LLQALERSGGVKKKAAELLKLTFRSFRYRLAKFGMDEE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]