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The map label for this gene is aroE

Identifier: 39996590

GI number: 39996590

Start: 1633917

End: 1634777

Strand: Direct

Name: aroE

Synonym: GSU1490

Alternate gene names: 39996590

Gene position: 1633917-1634777 (Clockwise)

Preceding gene: 39996589

Following gene: 39996591

Centisome position: 42.84

GC content: 61.44

Gene sequence:

>861_bases
ATGCCGTTTACGGGTGCTACCAGAGTACTGGGAATCATCGGTCAGCCGGTGTCCCATTCGCTTTCGCCTCTCATGCAGAA
TGCGGCGCTGCAGGCCATGGGGCTCGATTATGCGTATGTTCCCTTTGCCGTTGAGGAGGACTGCCTGGCCGACGCGGTGA
GGGGGTTGGCGGCCCTGGGTGTGGTCGGTTTCAATGTGACCATTCCTCATAAATCGGCCATCCTGCCGCTGCTGGACCGG
CTTTCGCCGGAAGCCGAGCTGATCGGCGCCGCCAATGTCGTAAAACGCGAAGGGAGCGATCTGGTCGGATACAACACCGA
CGGCACGGGGTTTATTCAGTCTCTGAGCGAAGATCTCGGTTTTACTCCGGCCGGGTGTCGGATTCTCGTCATGGGGGCCG
GTGGTGCTGCCCGAGCAGCAGTTGCATCGTTGGCCGGTGCCGGGGCGGCATCGGTGGTTATCGCCAACCGGAGCATTGCC
AGGGGGGAAGAGCTGTCGGCGGCGTTCAGGCGGCACTTTATCGGCACACAATTTGCTGCAATTCCCCTCGACCCGGAGAA
CCTGAATCGGTGCGTTCAAAATTTTGACCTTCTGGTCAACACCTCTTCCGTGGGGATGGGGGGGACTGCTTTCCCGGGCA
TGGATCTCTCCCGCATGGGTCCCCACGGTGCCGTGTACGACATGGTCTACGTTCCCGCCGTTACCCCCTTGCTCGCCGAG
GCTGAGCGTTGCGGCATACGCTACGCCAACGGCATCGGCATGCTGGCGGCCCAGGGTGAGTGCGCGCTGGAACTATGGAC
CGGAGTACGGCCTCCCGAGGGACTCATGAAAGCGTGTCTCATGGCGGCTCTGATGAGCTAA

Upstream 100 bases:

>100_bases
GCCAGCAGGGAGCCGAGGAGTTGTCGGCCGCCGCGGCCATAGCCCCCGAGTTGCGGGCACAGGTTGAGCAAGTGCTTGCG
GCCTATGGAGCGAGGTGATC

Downstream 100 bases:

>100_bases
CTACTTCTTGACATTGGACTTTTGACGACCTACGATGGGTTCGTCGCCAATACGCCGGAGAGTCTATGCAGGCTAGCAGA
CTGGGAGAACTCCTGGTTCG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPFTGATRVLGIIGQPVSHSLSPLMQNAALQAMGLDYAYVPFAVEEDCLADAVRGLAALGVVGFNVTIPHKSAILPLLDR
LSPEAELIGAANVVKREGSDLVGYNTDGTGFIQSLSEDLGFTPAGCRILVMGAGGAARAAVASLAGAGAASVVIANRSIA
RGEELSAAFRRHFIGTQFAAIPLDPENLNRCVQNFDLLVNTSSVGMGGTAFPGMDLSRMGPHGAVYDMVYVPAVTPLLAE
AERCGIRYANGIGMLAAQGECALELWTGVRPPEGLMKACLMAALMS

Sequences:

>Translated_286_residues
MPFTGATRVLGIIGQPVSHSLSPLMQNAALQAMGLDYAYVPFAVEEDCLADAVRGLAALGVVGFNVTIPHKSAILPLLDR
LSPEAELIGAANVVKREGSDLVGYNTDGTGFIQSLSEDLGFTPAGCRILVMGAGGAARAAVASLAGAGAASVVIANRSIA
RGEELSAAFRRHFIGTQFAAIPLDPENLNRCVQNFDLLVNTSSVGMGGTAFPGMDLSRMGPHGAVYDMVYVPAVTPLLAE
AERCGIRYANGIGMLAAQGECALELWTGVRPPEGLMKACLMAALMS
>Mature_285_residues
PFTGATRVLGIIGQPVSHSLSPLMQNAALQAMGLDYAYVPFAVEEDCLADAVRGLAALGVVGFNVTIPHKSAILPLLDRL
SPEAELIGAANVVKREGSDLVGYNTDGTGFIQSLSEDLGFTPAGCRILVMGAGGAARAAVASLAGAGAASVVIANRSIAR
GEELSAAFRRHFIGTQFAAIPLDPENLNRCVQNFDLLVNTSSVGMGGTAFPGMDLSRMGPHGAVYDMVYVPAVTPLLAEA
ERCGIRYANGIGMLAAQGECALELWTGVRPPEGLMKACLMAALMS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=288, Percent_Identity=33.6805555555556, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789675, Length=262, Percent_Identity=35.1145038167939, Blast_Score=131, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320332, Length=288, Percent_Identity=28.8194444444444, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_GEOSL (Q74D29)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952541.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q74D29
- SMR:   Q74D29
- GeneID:   2686141
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1490
- NMPDR:   fig|243231.1.peg.1479
- TIGR:   GSU1490
- HOGENOM:   HBG553408
- OMA:   RVEVANR
- ProtClustDB:   CLSK828389
- BioCyc:   GSUL243231:GSU_1490-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29607; Mature: 29475

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFTGATRVLGIIGQPVSHSLSPLMQNAALQAMGLDYAYVPFAVEEDCLADAVRGLAALG
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
VVGFNVTIPHKSAILPLLDRLSPEAELIGAANVVKREGSDLVGYNTDGTGFIQSLSEDLG
HEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHC
FTPAGCRILVMGAGGAARAAVASLAGAGAASVVIANRSIARGEELSAAFRRHFIGTQFAA
CCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHCCHHHHHHHHHHHCCCCEEE
IPLDPENLNRCVQNFDLLVNTSSVGMGGTAFPGMDLSRMGPHGAVYDMVYVPAVTPLLAE
ECCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHH
AERCGIRYANGIGMLAAQGECALELWTGVRPPEGLMKACLMAALMS
HHHCCCEEECCCEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFTGATRVLGIIGQPVSHSLSPLMQNAALQAMGLDYAYVPFAVEEDCLADAVRGLAALG
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
VVGFNVTIPHKSAILPLLDRLSPEAELIGAANVVKREGSDLVGYNTDGTGFIQSLSEDLG
HEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHC
FTPAGCRILVMGAGGAARAAVASLAGAGAASVVIANRSIARGEELSAAFRRHFIGTQFAA
CCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHCCHHHHHHHHHHHCCCCEEE
IPLDPENLNRCVQNFDLLVNTSSVGMGGTAFPGMDLSRMGPHGAVYDMVYVPAVTPLLAE
ECCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHH
AERCGIRYANGIGMLAAQGECALELWTGVRPPEGLMKACLMAALMS
HHHCCCEEECCCEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA