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The map label for this gene is emrA [H]

Identifier: 39996581

GI number: 39996581

Start: 1621362

End: 1622480

Strand: Reverse

Name: emrA [H]

Synonym: GSU1481

Alternate gene names: 39996581

Gene position: 1622480-1621362 (Counterclockwise)

Preceding gene: 39996582

Following gene: 39996580

Centisome position: 42.54

GC content: 64.25

Gene sequence:

>1119_bases
ATGACAACGGAACAGGAACTACCGGACCGGGGAGAAAACCGGGAAGCCCCTTCGGCCCAGACGGCGCCACAGGGCAAGGG
GAGCGGCGGCAAACGGAGACGAGCGGGCATTTTCCTACTCATACTGTTCGTGGTTGGAGCGGTTATCGGTCTGCGCTGGC
TCGTCCACGGCATAACGTACATATCCACGGACAACGCCTTCGTGGAATCCCACATCCATGCAGTATCCTCCCGGGTGCCG
GGCACAGTCGCTGCGGTGTATGTCACTGACAACCAAGCCGTGAAAAAGGGGGATCTCCTTGCCGAACTGGATCCCAGCGA
CTACCGGACCCGGGTCAGCGAGGCCACGGCAGCCCTTGCCATGGCCCGCAACGAGACCTCGGGCGACTATGCCCAGGTGG
AAGCGGCGCGTGCCGCGGTCGACCATGCCCGGGCGCGCCTGGCCCAGGCTGACCTGGATTTGACACGCGGTACGGCTTTG
CTGGCAAAAGAGGTCATCCCCCGCGAACAGTTCGACCGGCTCGAGACAGCAAAGCGGGTGGCGGTGGCCCAGGTGCGCGA
GGCAGAGGAGCAGATGCGCAAGGCACAGGCCGAGATCGGTCTGTCGGGAAGCGGTAGCCGCGAAGCCCGGGTGGCGCTAC
GCGATGCCCAACTAGCCACGGCGTCCCTCAACCTTTCCTACACGAAAATCCTGGCGCCCGCCGATGGTTACGTCACGCGC
AAATCGGTGGAGCCAGGCAACACGGTCCAGGCGGGCCAGCCCCTCATGGCCGTGGTCGATCTCGATGACGTCTGGATCAC
TGCCAACTACAAGGAGAGCCAGCTTACCCACATGAAGCCGGGCCAGAAGGTCACCTTTACGGTTGACGCCTATCCTGGCC
GCACCTTCTCGGGCAGGATCGACAGTATCATGGCAGGAACCGGCGCGGCCTTCTCGCTGTTGCCGCCCGAAAACGCCACG
GGCAACTACGTGAAGGTCGTCCAGCGGGTTCCGGTCAAGATCGCCGTGGACAGGGCAAGCGATCCCGGCCACCTGTTGCG
GGTGGGCATGAGCGTGGTGCCGTCGGTGGACGTGGAGCGCTCTCTGGGCGACATCCTCCACGGGCTCTGGCCGTTCTAG

Upstream 100 bases:

>100_bases
AGACACTGCTTACCCAGATAAAGACCGATTATCACCGGGCCGTTTTCGACTTCCAGGTCGCAAAGGCCCGTGTCAGCAAA
GCCATGGGAGAACTGTAGGA

Downstream 100 bases:

>100_bases
AAGGCAGGAGACGTGGAACCGGACACGAAAACCGTCAACAAGTGGCTCATCACCATCACGGTGATGCTGCCGACAATCAT
GGAGATCGTCGACACCTCCG

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTTEQELPDRGENREAPSAQTAPQGKGSGGKRRRAGIFLLILFVVGAVIGLRWLVHGITYISTDNAFVESHIHAVSSRVP
GTVAAVYVTDNQAVKKGDLLAELDPSDYRTRVSEATAALAMARNETSGDYAQVEAARAAVDHARARLAQADLDLTRGTAL
LAKEVIPREQFDRLETAKRVAVAQVREAEEQMRKAQAEIGLSGSGSREARVALRDAQLATASLNLSYTKILAPADGYVTR
KSVEPGNTVQAGQPLMAVVDLDDVWITANYKESQLTHMKPGQKVTFTVDAYPGRTFSGRIDSIMAGTGAAFSLLPPENAT
GNYVKVVQRVPVKIAVDRASDPGHLLRVGMSVVPSVDVERSLGDILHGLWPF

Sequences:

>Translated_372_residues
MTTEQELPDRGENREAPSAQTAPQGKGSGGKRRRAGIFLLILFVVGAVIGLRWLVHGITYISTDNAFVESHIHAVSSRVP
GTVAAVYVTDNQAVKKGDLLAELDPSDYRTRVSEATAALAMARNETSGDYAQVEAARAAVDHARARLAQADLDLTRGTAL
LAKEVIPREQFDRLETAKRVAVAQVREAEEQMRKAQAEIGLSGSGSREARVALRDAQLATASLNLSYTKILAPADGYVTR
KSVEPGNTVQAGQPLMAVVDLDDVWITANYKESQLTHMKPGQKVTFTVDAYPGRTFSGRIDSIMAGTGAAFSLLPPENAT
GNYVKVVQRVPVKIAVDRASDPGHLLRVGMSVVPSVDVERSLGDILHGLWPF
>Mature_371_residues
TTEQELPDRGENREAPSAQTAPQGKGSGGKRRRAGIFLLILFVVGAVIGLRWLVHGITYISTDNAFVESHIHAVSSRVPG
TVAAVYVTDNQAVKKGDLLAELDPSDYRTRVSEATAALAMARNETSGDYAQVEAARAAVDHARARLAQADLDLTRGTALL
AKEVIPREQFDRLETAKRVAVAQVREAEEQMRKAQAEIGLSGSGSREARVALRDAQLATASLNLSYTKILAPADGYVTRK
SVEPGNTVQAGQPLMAVVDLDDVWITANYKESQLTHMKPGQKVTFTVDAYPGRTFSGRIDSIMAGTGAAFSLLPPENATG
NYVKVVQRVPVKIAVDRASDPGHLLRVGMSVVPSVDVERSLGDILHGLWPF

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=349, Percent_Identity=35.8166189111748, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788711, Length=337, Percent_Identity=33.2344213649852, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790519, Length=308, Percent_Identity=32.4675324675325, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1790024, Length=238, Percent_Identity=29.8319327731092, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790012, Length=270, Percent_Identity=27.037037037037, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081796, Length=233, Percent_Identity=29.6137339055794, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081951, Length=320, Percent_Identity=23.75, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789637, Length=312, Percent_Identity=25.3205128205128, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787013, Length=244, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082036, Length=375, Percent_Identity=24.2666666666667, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40007; Mature: 39876

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEQELPDRGENREAPSAQTAPQGKGSGGKRRRAGIFLLILFVVGAVIGLRWLVHGITY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
ISTDNAFVESHIHAVSSRVPGTVAAVYVTDNQAVKKGDLLAELDPSDYRTRVSEATAALA
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHCCCEEEECCCHHHHHHHHHHHHHHH
MARNETSGDYAQVEAARAAVDHARARLAQADLDLTRGTALLAKEVIPREQFDRLETAKRV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCHHHHHHHHHHHHH
AVAQVREAEEQMRKAQAEIGLSGSGSREARVALRDAQLATASLNLSYTKILAPADGYVTR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHEEEEEECCEEEEEEECCCCCEEE
KSVEPGNTVQAGQPLMAVVDLDDVWITANYKESQLTHMKPGQKVTFTVDAYPGRTFSGRI
CCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCH
DSIMAGTGAAFSLLPPENATGNYVKVVQRVPVKIAVDRASDPGHLLRVGMSVVPSVDVER
HHHHCCCCCEEEECCCCCCCCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCHHH
SLGDILHGLWPF
HHHHHHHHHCCC
>Mature Secondary Structure 
TTEQELPDRGENREAPSAQTAPQGKGSGGKRRRAGIFLLILFVVGAVIGLRWLVHGITY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
ISTDNAFVESHIHAVSSRVPGTVAAVYVTDNQAVKKGDLLAELDPSDYRTRVSEATAALA
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHCCCEEEECCCHHHHHHHHHHHHHHH
MARNETSGDYAQVEAARAAVDHARARLAQADLDLTRGTALLAKEVIPREQFDRLETAKRV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCHHHHHHHHHHHHH
AVAQVREAEEQMRKAQAEIGLSGSGSREARVALRDAQLATASLNLSYTKILAPADGYVTR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHEEEEEECCEEEEEEECCCCCEEE
KSVEPGNTVQAGQPLMAVVDLDDVWITANYKESQLTHMKPGQKVTFTVDAYPGRTFSGRI
CCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCH
DSIMAGTGAAFSLLPPENATGNYVKVVQRVPVKIAVDRASDPGHLLRVGMSVVPSVDVER
HHHHCCCCCEEEECCCCCCCCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCHHH
SLGDILHGLWPF
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]