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The map label for this gene is cirA [H]

Identifier: 39996545

GI number: 39996545

Start: 1582943

End: 1584724

Strand: Direct

Name: cirA [H]

Synonym: GSU1445

Alternate gene names: 39996545

Gene position: 1582943-1584724 (Clockwise)

Preceding gene: 39996542

Following gene: 39996546

Centisome position: 41.5

GC content: 55.72

Gene sequence:

>1782_bases
ATGTTTTACGAGGACAAGGAACTGGTTGTGACCCCCACCCGGGACCCCAAGCCCGTCTCTCAGGTGGCCGAAAACATTAC
CGTCATTACCGCCAAAGAAATCAGGAACCTGAATGCCCATACCCTGGCAGACGTTCTGGTCACCATAACCGGTGTCCAGC
AAGACTGGCGGGGTGGTCCCGGCAGTCTCGCCTTCCCCGGTATCCAGGGGTCGAACCCCAATCAGGTACTCGTTCTGATC
GATGGGGTCTCGCAGACCAGTACCTCTTCAAACTTTGCCGATGTGGGCGCTATCCCGGTGCAGAATATCGAGCGGGTCGA
GATCATCAAAGGACCAGCCTCCACCTCCTGGGGGTCGTCCCTTGGCGGCATCATCAACGTCATCACCAAGTCCCCCGAGG
AGAACAGGGCCGCGGCCGGCATGGTGTCGGCGTCTCTGGGTGAGCGGTTCACCGGCGACTACCGGGGCGAACTCACCGGC
ACGGTGGGATCGTTCGGCTATTATCTCTCGGGCGGCAAGCTCCACTCCGACGGACTCCTTCCCCACAACAGCGTTGATAC
CGACCGGGCATATCTGAAGCTGACCCACCAGTTGCCCGACGGCGGAGATCTACGCTTCTCTCTCGGCTACAGCGCCGGCG
ACCGCGGCGACCAAATGGACCCCGTTGCTCGAACGTCCTATGACAATACGTTCGACAATCTGTTGACGACGCTCTCAATC
TCGCTCCCCCTTACCGAGCGGATCGACTGGGACCTTTCGCTCCGCTCCCAGTGGCTGGAATATGACCAGTTTCGCAATGG
TCTCGACACCGGACTCGTTGATGCCTCGCTGCTGGATGACCGTTCCTTCGGAGCCACAACCAAGCTTGTCTGGCGTACCG
GTGACCACAGCCTGACTGTCGGGGCGGAGTTTGACAGGGGTGATTTCAGGCTGGAACAGGAGAGCTCTGGAATTGGACGG
TCTTCTGTCCGTTCACATATTGCAAAATCGGCAATCTTTGCCAACGACACCATTGTGTTTGGGCCTTTGACCATAACCCC
GGGCATCCGTTTTGATCACACGACCACCAATGGGGACTTTCTGAGCCCCAGTCTTGGGGTGACCTGGGGCATTGGTGAAC
ATACGGTGCTACGTGGCGCATTGGCGAGGGGGTTCACGGTCCCTCCCGTTATTTACACTGTCGGTGATGGCTTTGCCCTG
GCCCCTAACCCCGACCTTAAGATGGAAAAGGTTCTTTCCTGGCAGGCAGGCTTCGAGACATCGCTCCTGCGCTACCTGTG
GCTCAAGTCTACTTTTTTTCTGCATGATGTTTCTGATGCTGTTGTTGCTACCATTTTGTCAGATGGGCAGTTTCGGTATG
AAAATCGAGAAAAGCAGCGCCGACAGGGTATGGAGATCGAGGTCAAGACCATTCCTTTTATGTACACTACGCTGGGAGCC
GGTTATACCTTTGTGGATTCGAAAGATCGGAACACGCATCAGCGAATACCCTCGGCGGCTCGGCAGACGGTCAATACAAC
CATACAGTTCGATGACTTAAAGGGTACAAGGGCGAACCTTGTGGGGCGCTACATCTGGTGGAATGCTCCTGATTTCATCC
AAGGTAGCTATACCTCAATGGTCTGGGATCTGAATGTTGCCCGAAATATCTATCGTGATGAACGTTACAGTGTGGAGTTG
TTCCTAGCTGGCCGCAATCTGTTTAATGGTTCACAGTATGTTGACGCCACCCTCAAAAACCCCTGCCGCTGGTTCGAGGG
AGGGATACGGTTCGATTTTTGA

Upstream 100 bases:

>100_bases
TCCCGTGATCGGATTGCTCGGCCTCTCGGTACTGCTTGCCCCGACAGGCTTTAGAGGGTACGCCTGGGCCCAGGCCGACG
AGGAGATGAGAGTCCTCGAG

Downstream 100 bases:

>100_bases
TAATGTGTGGTAATTTAGGGAGTGCTACTCGTATGTTATTGAAAATTATTTGTTGACATGCTGGTGTGTTTACAATTACT
TTTGCTCAAAGCGCCGTGCT

Product: TonB-dependent receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MFYEDKELVVTPTRDPKPVSQVAENITVITAKEIRNLNAHTLADVLVTITGVQQDWRGGPGSLAFPGIQGSNPNQVLVLI
DGVSQTSTSSNFADVGAIPVQNIERVEIIKGPASTSWGSSLGGIINVITKSPEENRAAAGMVSASLGERFTGDYRGELTG
TVGSFGYYLSGGKLHSDGLLPHNSVDTDRAYLKLTHQLPDGGDLRFSLGYSAGDRGDQMDPVARTSYDNTFDNLLTTLSI
SLPLTERIDWDLSLRSQWLEYDQFRNGLDTGLVDASLLDDRSFGATTKLVWRTGDHSLTVGAEFDRGDFRLEQESSGIGR
SSVRSHIAKSAIFANDTIVFGPLTITPGIRFDHTTTNGDFLSPSLGVTWGIGEHTVLRGALARGFTVPPVIYTVGDGFAL
APNPDLKMEKVLSWQAGFETSLLRYLWLKSTFFLHDVSDAVVATILSDGQFRYENREKQRRQGMEIEVKTIPFMYTTLGA
GYTFVDSKDRNTHQRIPSAARQTVNTTIQFDDLKGTRANLVGRYIWWNAPDFIQGSYTSMVWDLNVARNIYRDERYSVEL
FLAGRNLFNGSQYVDATLKNPCRWFEGGIRFDF

Sequences:

>Translated_593_residues
MFYEDKELVVTPTRDPKPVSQVAENITVITAKEIRNLNAHTLADVLVTITGVQQDWRGGPGSLAFPGIQGSNPNQVLVLI
DGVSQTSTSSNFADVGAIPVQNIERVEIIKGPASTSWGSSLGGIINVITKSPEENRAAAGMVSASLGERFTGDYRGELTG
TVGSFGYYLSGGKLHSDGLLPHNSVDTDRAYLKLTHQLPDGGDLRFSLGYSAGDRGDQMDPVARTSYDNTFDNLLTTLSI
SLPLTERIDWDLSLRSQWLEYDQFRNGLDTGLVDASLLDDRSFGATTKLVWRTGDHSLTVGAEFDRGDFRLEQESSGIGR
SSVRSHIAKSAIFANDTIVFGPLTITPGIRFDHTTTNGDFLSPSLGVTWGIGEHTVLRGALARGFTVPPVIYTVGDGFAL
APNPDLKMEKVLSWQAGFETSLLRYLWLKSTFFLHDVSDAVVATILSDGQFRYENREKQRRQGMEIEVKTIPFMYTTLGA
GYTFVDSKDRNTHQRIPSAARQTVNTTIQFDDLKGTRANLVGRYIWWNAPDFIQGSYTSMVWDLNVARNIYRDERYSVEL
FLAGRNLFNGSQYVDATLKNPCRWFEGGIRFDF
>Mature_593_residues
MFYEDKELVVTPTRDPKPVSQVAENITVITAKEIRNLNAHTLADVLVTITGVQQDWRGGPGSLAFPGIQGSNPNQVLVLI
DGVSQTSTSSNFADVGAIPVQNIERVEIIKGPASTSWGSSLGGIINVITKSPEENRAAAGMVSASLGERFTGDYRGELTG
TVGSFGYYLSGGKLHSDGLLPHNSVDTDRAYLKLTHQLPDGGDLRFSLGYSAGDRGDQMDPVARTSYDNTFDNLLTTLSI
SLPLTERIDWDLSLRSQWLEYDQFRNGLDTGLVDASLLDDRSFGATTKLVWRTGDHSLTVGAEFDRGDFRLEQESSGIGR
SSVRSHIAKSAIFANDTIVFGPLTITPGIRFDHTTTNGDFLSPSLGVTWGIGEHTVLRGALARGFTVPPVIYTVGDGFAL
APNPDLKMEKVLSWQAGFETSLLRYLWLKSTFFLHDVSDAVVATILSDGQFRYENREKQRRQGMEIEVKTIPFMYTTLGA
GYTFVDSKDRNTHQRIPSAARQTVNTTIQFDDLKGTRANLVGRYIWWNAPDFIQGSYTSMVWDLNVARNIYRDERYSVEL
FLAGRNLFNGSQYVDATLKNPCRWFEGGIRFDF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4206

COG function: function code H; Outer membrane cobalamin receptor protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=546, Percent_Identity=26.1904761904762, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786798, Length=602, Percent_Identity=24.5847176079734, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790405, Length=528, Percent_Identity=25, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 65530; Mature: 65530

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYEDKELVVTPTRDPKPVSQVAENITVITAKEIRNLNAHTLADVLVTITGVQQDWRGGP
CCCCCCCEEEECCCCCCHHHHHHCCEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHCCCCC
GSLAFPGIQGSNPNQVLVLIDGVSQTSTSSNFADVGAIPVQNIERVEIIKGPASTSWGSS
CCEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCH
LGGIINVITKSPEENRAAAGMVSASLGERFTGDYRGELTGTVGSFGYYLSGGKLHSDGLL
HHHHHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEECCEECCCCCC
PHNSVDTDRAYLKLTHQLPDGGDLRFSLGYSAGDRGDQMDPVARTSYDNTFDNLLTTLSI
CCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHEEE
SLPLTERIDWDLSLRSQWLEYDQFRNGLDTGLVDASLLDDRSFGATTKLVWRTGDHSLTV
ECCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEEEECCCEEEE
GAEFDRGDFRLEQESSGIGRSSVRSHIAKSAIFANDTIVFGPLTITPGIRFDHTTTNGDF
EEEECCCCEEEECCCCCCCHHHHHHHHHHHHEEECCEEEEEEEEECCCCEECCCCCCCCC
LSPSLGVTWGIGEHTVLRGALARGFTVPPVIYTVGDGFALAPNPDLKMEKVLSWQAGFET
CCCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHCCCHHH
SLLRYLWLKSTFFLHDVSDAVVATILSDGQFRYENREKQRRQGMEIEVKTIPFMYTTLGA
HHHHHHHHHHHEEEECHHHHHHHHHHCCCCEEECCHHHHHHCCCEEEEEEECEEEEECCC
GYTFVDSKDRNTHQRIPSAARQTVNTTIQFDDLKGTRANLVGRYIWWNAPDFIQGSYTSM
CEEEECCCCCCHHHHCCHHHHHHHCCEEEEECCCCCHHHHEEEEEEECCCCCCCCCCCEE
VWDLNVARNIYRDERYSVELFLAGRNLFNGSQYVDATLKNPCRWFEGGIRFDF
EEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEHHHCCCHHHHCCCEEECC
>Mature Secondary Structure
MFYEDKELVVTPTRDPKPVSQVAENITVITAKEIRNLNAHTLADVLVTITGVQQDWRGGP
CCCCCCCEEEECCCCCCHHHHHHCCEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHCCCCC
GSLAFPGIQGSNPNQVLVLIDGVSQTSTSSNFADVGAIPVQNIERVEIIKGPASTSWGSS
CCEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCH
LGGIINVITKSPEENRAAAGMVSASLGERFTGDYRGELTGTVGSFGYYLSGGKLHSDGLL
HHHHHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEECCEECCCCCC
PHNSVDTDRAYLKLTHQLPDGGDLRFSLGYSAGDRGDQMDPVARTSYDNTFDNLLTTLSI
CCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHEEE
SLPLTERIDWDLSLRSQWLEYDQFRNGLDTGLVDASLLDDRSFGATTKLVWRTGDHSLTV
ECCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEEEECCCEEEE
GAEFDRGDFRLEQESSGIGRSSVRSHIAKSAIFANDTIVFGPLTITPGIRFDHTTTNGDF
EEEECCCCEEEECCCCCCCHHHHHHHHHHHHEEECCEEEEEEEEECCCCEECCCCCCCCC
LSPSLGVTWGIGEHTVLRGALARGFTVPPVIYTVGDGFALAPNPDLKMEKVLSWQAGFET
CCCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHCCCHHH
SLLRYLWLKSTFFLHDVSDAVVATILSDGQFRYENREKQRRQGMEIEVKTIPFMYTTLGA
HHHHHHHHHHHEEEECHHHHHHHHHHCCCCEEECCHHHHHHCCCEEEEEEECEEEEECCC
GYTFVDSKDRNTHQRIPSAARQTVNTTIQFDDLKGTRANLVGRYIWWNAPDFIQGSYTSM
CEEEECCCCCCHHHHCCHHHHHHHCCEEEEECCCCCHHHHEEEEEEECCCCCCCCCCCEE
VWDLNVARNIYRDERYSVELFLAGRNLFNGSQYVDATLKNPCRWFEGGIRFDF
EEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEHHHCCCHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]